Detailed information for compound 1482309

Basic information

Technical information
  • TDR Targets ID: 1482309
  • Name: N-(3-methyl-1,1-dioxothiolan-3-yl)morpholine- 4-carboxamide
  • MW: 262.326 | Formula: C10H18N2O4S
  • H donors: 1 H acceptors: 3 LogP: -1.06 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCOCC1)NC1(C)CCS(=O)(=O)C1
  • InChi: 1S/C10H18N2O4S/c1-10(2-7-17(14,15)8-10)11-9(13)12-3-5-16-6-4-12/h2-8H2,1H3,(H,11,13)
  • InChiKey: FFPOYDHJAQQALJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(3-methyl-1,1-dioxo-thiolan-3-yl)morpholine-4-carboxamide
  • N-(3-methyl-1,1-dioxo-3-thiolanyl)-4-morpholinecarboxamide
  • N-(1,1-diketo-3-methyl-thiolan-3-yl)morpholine-4-carboxamide
  • MLS000558229
  • Morpholine-4-carboxylic acid (3-methyl-1,1-dioxo-tetrahydro-1lambda*6*-thiophen-3-yl)-amide
  • SMR000178301
  • STOCK3S-72047
  • BAS 05437617
  • Oprea1_623186

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0058 0.228 0.228
Loa Loa (eye worm) hypothetical protein 0.0058 0.228 0.228
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0084 0.3977 1
Entamoeba histolytica cysteine proteinase, putative 0.0084 0.3977 1
Leishmania major cathepsin L-like protease 0.0084 0.3977 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0084 0.3977 0.3977
Brugia malayi cathepsin L-like precursor 0.0058 0.228 0.228
Brugia malayi Cathepsin L-like precursor 0.0084 0.3977 0.3977
Loa Loa (eye worm) fibroinase 0.0084 0.3977 0.3977
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0 0.5
Plasmodium vivax vivapain-2 0.0084 0.3977 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0084 0.3977 0.3977
Echinococcus multilocularis cysteine protease 0.0084 0.3977 0.3977
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0084 0.3977 1
Brugia malayi Papain family cysteine protease containing protein 0.0046 0.1488 0.1488
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0084 0.3977 1
Brugia malayi Papain family cysteine protease containing protein 0.0084 0.3977 0.3977
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0084 0.3977 1
Onchocerca volvulus 0.0084 0.3977 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.3977 0.3977
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0084 0.3977 1
Brugia malayi Cathepsin L-like precursor 0.0084 0.3977 0.3977
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.1488 0.3743
Trypanosoma cruzi cysteine peptidase, putative 0.0084 0.3977 0.3977
Loa Loa (eye worm) hypothetical protein 0.0026 0.0226 0.0226
Entamoeba histolytica cysteine protease, putative 0.0046 0.1488 0.3743
Entamoeba histolytica cysteine proteinase, putative 0.0046 0.1488 0.3743
Brugia malayi Cathepsin L-like cysteine proteinase 0.0058 0.228 0.228
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0084 0.3977 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0084 0.3977 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0023 0 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.1488 0.3743
Brugia malayi Cathepsin L-like precursor 0.0058 0.228 0.228
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0026 0.0226 0.0226
Echinococcus multilocularis cathepsin L cysteine protease 0.0084 0.3977 0.3977
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0068 0.2949 0.2949
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0084 0.3977 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0068 0.2949 0.7415
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0084 0.3977 1
Entamoeba histolytica cysteine protease, putative 0.0084 0.3977 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0084 0.3977 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0084 0.3977 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0084 0.3977 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0084 0.3977 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0084 0.3977 1
Schistosoma mansoni cathepsin F (C01 family) 0.0084 0.3977 0.3977
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0177 1 1
Echinococcus multilocularis cathepsin b 0.0177 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0084 0.3977 1
Entamoeba histolytica cysteine proteinase, putative 0.0046 0.1488 0.3743
Leishmania major cathepsin L-like protease 0.0084 0.3977 1
Plasmodium vivax unspecified product 0.0026 0.0226 0.0567
Loa Loa (eye worm) hypothetical protein 0.0058 0.228 0.228
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0084 0.3977 1
Giardia lamblia Cathepsin B precursor 0.0068 0.2949 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0084 0.3977 1
Echinococcus granulosus cathepsin L cysteine protease 0.0046 0.1488 0.1488
Entamoeba histolytica cysteine protease, putative 0.0046 0.1488 0.3743
Echinococcus multilocularis cysteine protease 0.0084 0.3977 0.3977
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0046 0.1488 0.1488
Onchocerca volvulus Cathepsin L homolog 0.0084 0.3977 1
Entamoeba histolytica cysteine proteinase 2 0.0046 0.1488 0.3743
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0084 0.3977 1
Onchocerca volvulus 0.0084 0.3977 1
Brugia malayi Cathepsin L-like precursor 0.0058 0.228 0.228
Entamoeba histolytica cysteine protease, putative 0.0046 0.1488 0.3743
Echinococcus multilocularis cathepsin b 0.0177 1 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0046 0.1488 0.1488
Loa Loa (eye worm) hypothetical protein 0.0177 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0084 0.3977 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.228 0.5734
Entamoeba histolytica cysteine protease, putative 0.0046 0.1488 0.3743
Plasmodium vivax vivapain-2 0.0084 0.3977 1
Entamoeba histolytica cysteine protease, putative 0.0046 0.1488 0.3743
Plasmodium vivax vivapain-1 0.0046 0.1488 0.3743
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0084 0.3977 0.3977
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.1488 0.3743
Trypanosoma cruzi cysteine peptidase, putative 0.0084 0.3977 0.3977
Onchocerca volvulus 0.0084 0.3977 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0084 0.3977 0.3977
Entamoeba histolytica cysteine protease, putative 0.0046 0.1488 0.3743
Echinococcus granulosus cathepsin L cysteine proteinase 0.0084 0.3977 0.3977
Trypanosoma cruzi cysteine protease, putative 0.0046 0.1488 0.1488
Entamoeba histolytica cysteine proteinase, putative 0.0046 0.1488 0.3743
Trypanosoma cruzi cysteine peptidase, putative 0.0084 0.3977 0.3977
Leishmania major cathepsin L-like protease 0.0084 0.3977 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0084 0.3977 1
Giardia lamblia Cathepsin B precursor 0.0068 0.2949 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0084 0.3977 1
Leishmania major cathepsin L-like protease 0.0084 0.3977 1
Entamoeba histolytica cysteine protease, putative 0.0046 0.1488 0.3743
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0084 0.3977 1
Trypanosoma cruzi cruzipain precursor, putative 0.0084 0.3977 0.3977
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0023 0 0.5
Entamoeba histolytica cysteine protease, putative 0.0046 0.1488 0.3743
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0058 0.228 0.5734
Brugia malayi cathepsin F-like cysteine proteinase 0.0026 0.0226 0.0226
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0046 0.1488 0.1488
Trypanosoma cruzi cruzipain precursor, putative 0.0026 0.0226 0.0226
Onchocerca volvulus Cathepsin F homolog 0.0084 0.3977 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.228 0.228
Leishmania major cathepsin L-like protease 0.0084 0.3977 1
Echinococcus multilocularis cathepsin L 0.0046 0.1488 0.1488
Brugia malayi Cathepsin L-like precursor 0.0084 0.3977 0.3977
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0068 0.2949 0.7415
Entamoeba histolytica cysteine protease, putative 0.0046 0.1488 0.3743
Plasmodium falciparum cysteine proteinase falcipain 1 0.0046 0.1488 0.3743
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0084 0.3977 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0226 0.0226
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0084 0.3977 1
Brugia malayi Cathepsin L-like precursor 0.0026 0.0226 0.0226
Trypanosoma brucei cysteine peptidase C (CPC) 0.0068 0.2949 0.7415
Plasmodium vivax unspecified product 0.0046 0.1488 0.3743
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0084 0.3977 1
Schistosoma mansoni cathepsin F (C01 family) 0.0084 0.3977 0.3977
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0046 0.1488 0.1488
Loa Loa (eye worm) cysteine protease 0.0084 0.3977 0.3977
Trypanosoma cruzi cysteine proteinase, putative 0.0046 0.1488 0.1488
Onchocerca volvulus 0.0084 0.3977 1
Loa Loa (eye worm) cathepsin B 0.0068 0.2949 0.2949
Loa Loa (eye worm) ctsf protein 0.0084 0.3977 0.3977
Trypanosoma cruzi cysteine peptidase, putative 0.0046 0.1488 0.1488
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0084 0.3977 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0084 0.3977 1
Schistosoma mansoni cathepsin F (C01 family) 0.0058 0.228 0.228
Echinococcus granulosus cathepsin l1 0.0084 0.3977 0.3977
Entamoeba histolytica cysteine proteinase, putative 0.0058 0.228 0.5734
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0084 0.3977 1
Leishmania major cathepsin L-like protease 0.0084 0.3977 1
Leishmania major cathepsin L-like protease 0.0084 0.3977 1
Brugia malayi Cathepsin L-like precursor 0.0084 0.3977 0.3977
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0084 0.3977 1
Toxoplasma gondii cathepsin CPL 0.0084 0.3977 1
Schistosoma mansoni cathepsin s 0.0026 0.0226 0.0226
Onchocerca volvulus 0.0084 0.3977 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0177 1 1
Entamoeba histolytica cysteine protease, putative 0.0046 0.1488 0.3743
Echinococcus granulosus cysteine protease 0.0046 0.1488 0.1488
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0084 0.3977 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0084 0.3977 1
Echinococcus granulosus cathepsin b 0.0177 1 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0026 0.0226 0.0226
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0084 0.3977 1
Trypanosoma cruzi cysteine proteinase, putative 0.0046 0.1488 0.1488
Echinococcus granulosus cathepsin L 0.0046 0.1488 0.1488
Entamoeba histolytica cysteine protease, putative 0.0046 0.1488 0.3743
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0084 0.3977 0.3977
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0084 0.3977 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0084 0.3977 1
Echinococcus granulosus cathepsin l1 0.0058 0.228 0.228
Loa Loa (eye worm) hypothetical protein 0.0026 0.0226 0.0226
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0177 1 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0084 0.3977 1
Trypanosoma cruzi cysteine peptidase, putative 0.0026 0.0226 0.0226
Entamoeba histolytica cysteine protease, putative 0.0046 0.1488 0.3743
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0084 0.3977 1
Entamoeba histolytica cysteine protease, putative 0.0046 0.1488 0.3743
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0177 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0046 0.1488 0.3743
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0177 1 1
Brugia malayi Cathepsin L-like precursor 0.0084 0.3977 0.3977
Entamoeba histolytica cysteine proteinase 1, putative 0.0046 0.1488 0.3743
Echinococcus multilocularis cathepsin L cysteine protease 0.0084 0.3977 0.3977
Leishmania major cysteine peptidase A (CPA) 0.0084 0.3977 1
Onchocerca volvulus Cathepsin L homolog 0.0084 0.3977 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0084 0.3977 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0084 0.3977 1
Plasmodium vivax vivapain-3 0.0046 0.1488 0.3743
Onchocerca volvulus 0.0084 0.3977 1
Brugia malayi Cathepsin L-like precursor 0.0084 0.3977 0.3977
Toxoplasma gondii cathepsin B 0.0068 0.2949 0.7415
Entamoeba histolytica cysteine proteinase, putative 0.0046 0.1488 0.3743
Onchocerca volvulus 0.0084 0.3977 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0068 0.2949 0.2949
Echinococcus granulosus cathepsin b 0.0177 1 1
Leishmania major cathepsin L-like protease 0.0084 0.3977 1
Giardia lamblia Cathepsin B precursor 0.0068 0.2949 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0084 0.3977 1
Trypanosoma cruzi cysteine peptidase, putative 0.0084 0.3977 0.3977
Brugia malayi Papain family cysteine protease containing protein 0.0046 0.1488 0.1488
Entamoeba histolytica cysteine proteinase, putative 0.0084 0.3977 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0251 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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