TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 380.439 | Formula: C25H20N2O2
H donors: 1 H acceptors: 1 LogP: 5.06 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Nc1cccc(c1)C#Cc1ccc2c(c1)C(=O)/C(=C/c1ccc(cc1)N(C)C)/O2
InChi: 1S/C25H20N2O2/c1-27(2)21-11-8-19(9-12-21)16-24-25(28)22-15-18(10-13-23(22)29-24)7-6-17-4-3-5-20(26)14-17/h3-5,8-16H,26H2,1-2H3/b24-16-
InChiKey: QALHXWCSDDJWRF-JLPGSUDCSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	Rap guanine nucleotide exchange factor (GEF) 4	Starlite/ChEMBL	No references
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	corticotropin releasing hormone receptor 2		No references
Homo sapiens	polo-like kinase 1	Starlite/ChEMBL	No references
Homo sapiens	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D	Starlite/ChEMBL	No references
Homo sapiens	RAN, member RAS oncogene family		No references
Homo sapiens	geminin, DNA replication inhibitor	Starlite/ChEMBL	No references
Homo sapiens	v-ets avian erythroblastosis virus E26 oncogene homolog	Starlite/ChEMBL	No references
Homo sapiens	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G	Starlite/ChEMBL	No references
Homo sapiens	corticotropin releasing hormone binding protein		No references
Homo sapiens	snurportin 1		No references
Homo sapiens	karyopherin (importin) beta 1		No references
Homo sapiens	ataxin 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania mexicana	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania donovani	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania braziliensis	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Entamoeba histolytica	serine/threonine protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Plasmodium vivax	importin-beta 2, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Entamoeba histolytica	Ran family GTPase	Get druggable targets OG5_127514	All targets in OG5_127514
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Leishmania braziliensis	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma japonicum	Serine/threonine-protein kinase PLK1, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Trypanosoma brucei	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_130760	All targets in OG5_130760
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Echinococcus multilocularis	GTP binding nuclear protein Ran	Get druggable targets OG5_127514	All targets in OG5_127514
Plasmodium berghei	GTP-binding nuclear protein RAN/TC4, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Candida albicans	karyopherin-beta	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma japonicum	ko:K07936 GTP-binding nuclear protein Ran, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Neospora caninum	GTP-binding nuclear protein Ran, related	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma brucei gambiense	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trichomonas vaginalis	ran, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma japonicum	IPR001879,Hormone receptor, extracellular,domain-containing	Get druggable targets OG5_130760	All targets in OG5_130760
Trypanosoma cruzi	polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	Get druggable targets OG5_130760	All targets in OG5_130760
Brugia malayi	Importin beta-1 subunit	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Cryptosporidium parvum	importin/karyopherin	Get druggable targets OG5_127843	All targets in OG5_127843
Candida albicans	protein serine/threonine kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	importin beta-1, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Neospora caninum	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843
Brugia malayi	Fli-1 protein	Get druggable targets OG5_131947	All targets in OG5_131947
Brugia malayi	N-terminal motif family protein	Get druggable targets OG5_131726	All targets in OG5_131726
Plasmodium yoelii	importin beta-1 subunit	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma japonicum	Importin subunit beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Cryptosporidium hominis	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma congolense	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Echinococcus granulosus	GTP binding nuclear protein Ran	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania mexicana	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Candida albicans	protein serine/threonine kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Candida albicans	Ran, Ras family GTP-binding protein	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Echinococcus multilocularis	importin subunit beta 1	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma japonicum	ko:K06631 polo-like kinase 1, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Schistosoma japonicum	ko:K09435 transcriptional regulator ERG, putative	Get druggable targets OG5_131947	All targets in OG5_131947
Brugia malayi	serine/threonine-protein kinase plk-2	Get druggable targets OG5_127396	All targets in OG5_127396
Echinococcus multilocularis	serine:threonine protein kinase PLK1	Get druggable targets OG5_127396	All targets in OG5_127396
Leishmania infantum	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma brucei	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma mansoni	ets-related	Get druggable targets OG5_131947	All targets in OG5_131947
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Cryptosporidium parvum	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	Get druggable targets OG5_131726	All targets in OG5_131726
Toxoplasma gondii	HEAT repeat-containing protein	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Echinococcus granulosus	importin subunit beta 1	Get druggable targets OG5_127843	All targets in OG5_127843
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Giardia lamblia	Kinase, PLK	Get druggable targets OG5_127396	All targets in OG5_127396
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_131808	All targets in OG5_131808
Schistosoma mansoni	ran	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma brucei gambiense	polo-like protein kinase,protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Echinococcus granulosus	snurportin 1	Get druggable targets OG5_131808	All targets in OG5_131808
Trypanosoma congolense	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma brucei gambiense	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania infantum	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Theileria parva	GTP-binding nuclear protein ran, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Candida albicans	Ran, Ras family GTP-binding protein	Get druggable targets OG5_127514	All targets in OG5_127514
Echinococcus multilocularis	snurportin 1	Get druggable targets OG5_131808	All targets in OG5_131808
Trypanosoma cruzi	polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Leishmania infantum	protein kinase, putative,polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Plasmodium knowlesi	GTP-binding nuclear protein RAN/TC4, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Onchocerca volvulus	Serine\/threonine kinase homolog	Get druggable targets OG5_127396	All targets in OG5_127396
Theileria parva	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trypanosoma brucei	polo-like protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trypanosoma cruzi	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania major	importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Leishmania mexicana	protein kinase, putative,polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Leishmania donovani	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Brugia malayi	RNA, U transporter 1	Get druggable targets OG5_131808	All targets in OG5_131808
Echinococcus granulosus	serine:threonine protein kinase PLK1	Get druggable targets OG5_127396	All targets in OG5_127396
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	Get druggable targets OG5_130760	All targets in OG5_130760
Leishmania major	GTP-binding protein, putative	Get druggable targets OG5_127514	All targets in OG5_127514
Trypanosoma congolense	protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Loa Loa (eye worm)	fli-1 protein	Get druggable targets OG5_131947	All targets in OG5_131947
Babesia bovis	importin beta subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium yoelii	GTP-binding nuclear protein ran/tc4	Get druggable targets OG5_127514	All targets in OG5_127514
Trichomonas vaginalis	Importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma japonicum	Snurportin-1, putative	Get druggable targets OG5_131808	All targets in OG5_131808
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	Get druggable targets OG5_131808	All targets in OG5_131808
Plasmodium berghei	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Leishmania braziliensis	protein kinase, putative,polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Cryptosporidium hominis	importin-beta2	Get druggable targets OG5_127843	All targets in OG5_127843
Babesia bovis	GTP-binding nuclear protein Ran	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma mansoni	ran	Get druggable targets OG5_127514	All targets in OG5_127514
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	Get druggable targets OG5_130760	All targets in OG5_130760
Schistosoma japonicum	Importin subunit beta-1, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Trichomonas vaginalis	Importin beta-1 subunit, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium knowlesi	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Brugia malayi	GTP-binding nuclear protein RAN/TC4	Get druggable targets OG5_127514	All targets in OG5_127514
Schistosoma mansoni	importin beta-1	Get druggable targets OG5_127843	All targets in OG5_127843
Candida albicans	karyopherin-beta	Get druggable targets OG5_127843	All targets in OG5_127843
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_127843	All targets in OG5_127843
Plasmodium falciparum	importin beta, putative	Get druggable targets OG5_127843	All targets in OG5_127843
Loa Loa (eye worm)	PLK/PLK1 protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_131726	All targets in OG5_131726
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %
Loa Loa (eye worm)	pigment dispersing factor receptor c	corticotropin releasing hormone receptor 2	438 aa	383 aa	26.1 %
Brugia malayi	Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X	geminin, DNA replication inhibitor	209 aa	176 aa	27.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.0139	0.0544
Toxoplasma gondii	LsmAD domain-containing protein	0.003	0.0139	0.0159
Echinococcus multilocularis	snurportin 1	0.0372	1	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.003	0.0117	0.0117
Echinococcus multilocularis	glycoprotein Antigen 5	0.003	0.0117	0.0117
Brugia malayi	Trypsin-like protease protein 5	0.003	0.0117	0.0119
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0087	0.1786	0.1786
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0559	0.0559
Echinococcus granulosus	tissue type plasminogen activator	0.0072	0.1334	0.1334
Loa Loa (eye worm)	hypothetical protein	0.0038	0.036	0.036
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.003	0.0117	0.0117
Loa Loa (eye worm)	hypothetical protein	0.003	0.0117	0.0117
Schistosoma mansoni	hypothetical protein	0.0038	0.036	0.036
Plasmodium falciparum	cysteine repeat modular protein 1	0.0072	0.1334	1
Loa Loa (eye worm)	fli-1 protein	0.0265	0.6931	0.6931
Loa Loa (eye worm)	hypothetical protein	0.003	0.0117	0.0117
Loa Loa (eye worm)	hypothetical protein	0.003	0.0117	0.0117
Schistosoma mansoni	cercarial elastase (S01 family)	0.003	0.0117	0.0117
Echinococcus granulosus	laminin	0.0045	0.0559	0.0559
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.2555	1
Toxoplasma gondii	HEAT repeat-containing protein	0.0035	0.0266	0.0304
Echinococcus granulosus	transmembrane protease serine 3	0.003	0.0117	0.0117
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0045	0.0559	0.064
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.003	0.0117	0.0117
Loa Loa (eye worm)	trypsin family protein	0.003	0.0117	0.0117
Brugia malayi	Importin beta-1 subunit	0.0035	0.0266	0.0271
Toxoplasma gondii	PAN domain-containing protein	0.0328	0.8731	1
Leishmania major	importin beta-1 subunit, putative	0.0028	0.0075	0.0295
Echinococcus granulosus	GA binding protein alpha chain	0.0087	0.1786	0.1786
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.0139	0.1042
Schistosoma mansoni	hypothetical protein	0.0038	0.036	0.036
Brugia malayi	Calcitonin receptor-like protein seb-1	0.012	0.2738	0.2793
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0114	0.2555	0.2517
Loa Loa (eye worm)	TK/ROR protein kinase	0.0072	0.1334	0.1334
Brugia malayi	Fibulin-1 precursor	0.0045	0.0559	0.057
Schistosoma mansoni	egf-like domain protein	0.0045	0.0559	0.0559
Brugia malayi	Protein kinase domain containing protein	0.0072	0.1334	0.136
Trichomonas vaginalis	importin beta-1, putative	0.0028	0.0075	0.0295
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.0139	0.0544
Echinococcus granulosus	enteropeptidase	0.003	0.0117	0.0117
Echinococcus multilocularis	enteropeptidase	0.003	0.0117	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0306	0.8089	0.8089
Schistosoma mansoni	ets-related	0.0265	0.6931	0.6931
Schistosoma mansoni	kinase	0.0058	0.0935	0.0935
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0306	0.8089	0.825
Loa Loa (eye worm)	bone morphogenetic protein 1b	0.0045	0.0559	0.0559
Schistosoma mansoni	cercarial elastase (S01 family)	0.003	0.0117	0.0117
Trypanosoma brucei	importin beta-1 subunit, putative	0.0035	0.0266	0.1039
Echinococcus multilocularis	laminin	0.0045	0.0559	0.0559
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0218	0.5558	0.5617
Echinococcus granulosus	GPCR family 2	0.0038	0.036	0.036
Giardia lamblia	Kinase, PLK	0.0114	0.2555	1
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.2555	1
Brugia malayi	Low-density lipoprotein receptor repeat class B containing protein	0.0045	0.0559	0.057
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.2555	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.003	0.0117	0.0117
Schistosoma mansoni	cercarial elastase (S01 family)	0.003	0.0117	0.0117
Loa Loa (eye worm)	hypothetical protein	0.003	0.0117	0.0117
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0223	0.5711	0.5711
Schistosoma mansoni	cercarial elastase (S01 family)	0.003	0.0117	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0559	0.0559
Loa Loa (eye worm)	hypothetical protein	0.003	0.0117	0.0117
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.2555	1
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.003	0.0117	0.0117
Brugia malayi	Ets-domain containing protein	0.0087	0.1786	0.1822
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.2555	1
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0114	0.2555	0.2555
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.003	0.0117	0.0117
Brugia malayi	Ets-domain containing protein	0.0087	0.1786	0.1822
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.2555	1
Brugia malayi	Fli-1 protein	0.0265	0.6931	0.7069
Echinococcus multilocularis	geminin	0.0205	0.5172	0.5172
Loa Loa (eye worm)	hypothetical protein	0.0072	0.1334	0.1334
Entamoeba histolytica	hypothetical protein	0.0028	0.0075	0.0295
Brugia malayi	Latrophilin receptor protein 2	0.0038	0.036	0.0367
Trypanosoma brucei	importin beta-1 subunit, putative	0.0035	0.0266	0.1039
Loa Loa (eye worm)	low-density lipoprotein receptor repeat class B containing protein	0.0045	0.0559	0.0559
Echinococcus granulosus	importin subunit beta 1	0.0035	0.0266	0.0266
Schistosoma mansoni	hypothetical protein	0.0082	0.1638	0.1638
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0114	0.2555	0.2555
Echinococcus multilocularis	tissue type plasminogen activator	0.0072	0.1334	0.1334
Toxoplasma gondii	kringle domain-containing protein	0.0072	0.1334	0.1527
Mycobacterium ulcerans	hypothetical protein	0.003	0.0117	0.5
Echinococcus granulosus	Tolloid protein 1	0.0045	0.0559	0.0559
Brugia malayi	hypothetical protein	0.003	0.0139	0.0142
Loa Loa (eye worm)	hypothetical protein	0.0218	0.5558	0.5558
Leishmania major	hypothetical protein, conserved	0.003	0.0139	0.0544
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.0139	0.1042
Plasmodium vivax	ataxin-2 like protein, putative	0.003	0.0139	0.1042
Trichomonas vaginalis	CAMK family protein kinase	0.0056	0.0891	0.3487
Schistosoma mansoni	hypothetical protein	0.0372	1	1
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.003	0.0117	0.0117
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0028	0.0075	0.0295
Loa Loa (eye worm)	hypothetical protein	0.0082	0.1638	0.1638
Trypanosoma brucei	PAB1-binding protein , putative	0.003	0.0139	0.0544
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0038	0.036	0.036
Brugia malayi	latrophilin 2 splice variant baaae	0.0082	0.1638	0.167
Brugia malayi	hypothetical protein	0.0365	0.9804	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0072	0.1334	0.5219
Brugia malayi	hypothetical protein	0.003	0.0117	0.0119
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0114	0.2555	1
Echinococcus multilocularis	Tolloid protein 1	0.0045	0.0559	0.0559
Loa Loa (eye worm)	hypothetical protein	0.0075	0.142	0.142
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0045	0.0559	0.064
Schistosoma mansoni	subfamily M12A unassigned peptidase (M12 family)	0.0045	0.0559	0.0559
Plasmodium vivax	importin-beta 2, putative	0.0035	0.0266	0.1992
Trypanosoma brucei	polo-like protein kinase	0.0114	0.2555	1
Echinococcus granulosus	Mastin	0.003	0.0117	0.0117
Schistosoma mansoni	serine/threonine protein kinase	0.0114	0.2555	0.2555
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0266	0.0266
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0223	0.5711	0.5711
Loa Loa (eye worm)	multiple epidermal growth factor-like domains 6	0.0045	0.0559	0.0559
Onchocerca volvulus	Arrow homolog	0.0045	0.0559	0.0456
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.003	0.0117	0.0119
Schistosoma mansoni	importin beta-1	0.0035	0.0266	0.0266
Echinococcus granulosus	geminin	0.0205	0.5172	0.5172
Schistosoma mansoni	cercarial elastase (S01 family)	0.003	0.0117	0.0117
Schistosoma mansoni	hypothetical protein	0.0038	0.036	0.036
Brugia malayi	serine/threonine-protein kinase plk-2	0.0114	0.2555	0.2606
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0038	0.036	0.036
Echinococcus granulosus	glycoprotein Antigen 5	0.003	0.0117	0.0117
Echinococcus multilocularis	importin subunit beta 1	0.0035	0.0266	0.0266
Schistosoma mansoni	hypothetical protein	0.0205	0.5172	0.5172
Echinococcus multilocularis	transmembrane protease serine 3	0.003	0.0117	0.0117
Trypanosoma cruzi	polo-like protein kinase, putative	0.0114	0.2555	1
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0028	0.0075	0.0295
Echinococcus multilocularis	GA binding protein alpha chain	0.0087	0.1786	0.1786
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0038	0.036	0.0367
Loa Loa (eye worm)	hypothetical protein	0.003	0.0139	0.0139
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.003	0.0117	0.0117
Schistosoma mansoni	gabp alpha	0.0087	0.1786	0.1786
Schistosoma mansoni	cercarial elastase (S01 family)	0.003	0.0117	0.0117
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.012	0.2738	0.2738
Plasmodium falciparum	importin beta, putative	0.0035	0.0266	0.1992
Schistosoma mansoni	cercarial elastase (S01 family)	0.003	0.0117	0.0117
Loa Loa (eye worm)	hypothetical protein	0.003	0.0117	0.0117
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.003	0.0117	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0365	0.9804	0.9804
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0072	0.1334	1
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.003	0.0117	0.0117
Brugia malayi	N-terminal motif family protein	0.0218	0.5558	0.5669
Schistosoma mansoni	cercarial elastase (S01 family)	0.003	0.0117	0.0117
Schistosoma mansoni	hypothetical protein	0.003	0.0117	0.0117
Schistosoma mansoni	hypothetical protein	0.0072	0.1334	0.1334
Echinococcus multilocularis	fibrillin 1	0.0045	0.0559	0.0559
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0559	0.0559
Brugia malayi	RNA, U transporter 1	0.0099	0.2121	0.2163
Schistosoma mansoni	hypothetical protein	0.0205	0.5172	0.5172
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.003	0.0117	0.0117
Brugia malayi	Trypsin family protein	0.003	0.0117	0.0119
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0028	0.0075	0.0295
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0559	0.0559
Brugia malayi	Trypsin family protein	0.003	0.0117	0.0119
Brugia malayi	Calcium binding EGF domain containing protein	0.0045	0.0559	0.057
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0114	0.2555	1
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0114	0.2555	0.2555
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0038	0.036	0.036
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.003	0.0117	0.0117
Schistosoma mansoni	cercarial elastase (S01 family)	0.003	0.0117	0.0117
Brugia malayi	Trypsin family protein	0.003	0.0117	0.0119
Onchocerca volvulus		0.0365	0.9804	1
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.003	0.0117	0.0117
Schistosoma mansoni	hypothetical protein	0.003	0.0117	0.0117
Trichomonas vaginalis	CAMK family protein kinase	0.0056	0.0891	0.3487
Echinococcus multilocularis	GPCR, family 2	0.0038	0.036	0.036
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.2555	1
Schistosoma mansoni	hypothetical protein	0.0038	0.036	0.036
Leishmania major	hypothetical protein, conserved	0.0072	0.1334	0.5219
Echinococcus multilocularis	Mastin	0.003	0.0117	0.0117
Onchocerca volvulus		0.0072	0.1334	0.1256
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.003	0.0117	0.0117
Trypanosoma cruzi	polo-like protein kinase, putative	0.0114	0.2555	1
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0372	1	1
Brugia malayi	Trypsin family protein	0.003	0.0117	0.0119
Loa Loa (eye worm)	hypothetical protein	0.003	0.0117	0.0117
Brugia malayi	Kringle domain containing protein	0.0072	0.1334	0.136
Toxoplasma gondii	PAN domain-containing protein	0.0328	0.8731	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0559	0.0559

Activities

Activity type	Activity value	Assay description	Source	Reference
EC50 (functional)	= 5.04 uM	PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS hits for small molecule agonists of the CRF-binding protein and CRF-R2 receptor complex. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	0.7943 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	2.8184 uM	PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	3.1623 uM	PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	3.7686 uM	PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	4.4668 uM	PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	4.6109 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	5.1735 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	7.0795 uM	PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	7.0795 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273]	ChEMBL.	No reference
Potency (functional)	7.9433 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RanGTP induced Rango (Ran-regulated importin-beta cargo) - Importin beta complex dissociation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540262]	ChEMBL.	No reference
Potency (functional)	12.5168 uM	PubChem BioAssay. qHTS for inhibitors of Vif-A3F interactions: Cherry picks. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	14.0441 uM	PubChem BioAssay. qHTS for inhibitors of Vif-A3G interactions: Cherry picks. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	15.7578 uM	PubChem BioAssay. qHTS for inhibitors of Vif-A3F interactions: Cherry picks counterscreen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	17.6805 uM	PubChem BioAssay. qHTS for inhibitors of Vif-A3G interactions: Cherry picks counterscreen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	22.3872 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	25.1189 uM	PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	28.1838 uM	PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	29.0929 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference
Potency (functional)	39.8107 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference
Potency (functional)	44.6684 uM	PUBCHEM_BIOASSAY: qHTS Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID485342, AID485388]	ChEMBL.	No reference
Potency (functional)	63.0957 uM	PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1719414

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1483247