Detailed information for compound 1487472

Basic information

Technical information
  • TDR Targets ID: 1487472
  • Name: MLS000393395
  • MW: 494.369 | Formula: C17H17Cl2N3O6S2
  • H donors: 2 H acceptors: 5 LogP: 2.09 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1cccc(c1)S(=O)(=O)N1CCOCC1)NNS(=O)(=O)c1cccc(c1Cl)Cl
  • InChi: 1S/C17H17Cl2N3O6S2/c18-14-5-2-6-15(16(14)19)29(24,25)21-20-17(23)12-3-1-4-13(11-12)30(26,27)22-7-9-28-10-8-22/h1-6,11,21H,7-10H2,(H,20,23)
  • InChiKey: SAMXWLHIWJPRKU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • SMR000243819
  • T5223331

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus eukaryotic initiation factor 4A 0.0014 0.0067 0.0067
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0012 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0006 0.0002 0.0002
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0244 0.0244
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0006 0.0006 0.0185
Loa Loa (eye worm) hypothetical protein 0.0006 0.0002 0.0002
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0244 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0012 0.0056 0.0056
Schistosoma mansoni jumonji domain containing protein 0.0011 0.0048 0.0046
Brugia malayi hypothetical protein 0.0283 0.2293 0.2292
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0057 0.2264
Schistosoma mansoni caspase-7 (C14 family) 0.0283 0.2293 0.2292
Echinococcus multilocularis bloom syndrome protein 0.0012 0.0057 0.0057
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.041 0.041
Brugia malayi PHD-finger family protein 0.0035 0.0244 0.0243
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0244 1
Brugia malayi Bromodomain containing protein 0.0035 0.0244 0.0243
Echinococcus multilocularis caspase 2 0.0283 0.2293 0.2293
Echinococcus granulosus phd:f box containing protein 0.0011 0.0048 0.0048
Leishmania major eukaryotic initiation factor 4a, putative 0.0014 0.0067 1
Entamoeba histolytica recQ family helicase, putative 0.0006 0.0004 0.0383
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0551 0.4497 0.4496
Echinococcus multilocularis JmjC domain containing protein 4 0.0011 0.0048 0.0048
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0011 0.0048 0.1889
Schistosoma mansoni protein phosphatase 2C 0.0011 0.0048 0.0046
Echinococcus multilocularis potassium voltage gated channel protein 0.002 0.0115 0.0115
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0012 0.0057 0.2264
Onchocerca volvulus 0.0018 0.0103 0.0101
Brugia malayi Cell death protein 3 precursor 0.0283 0.2293 0.2292
Schistosoma mansoni hypothetical protein 0.0012 0.0049 0.0047
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0014 0.0067 0.0067
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0554 0.0554
Entamoeba histolytica recQ family DNA helicase 0.0006 0.0006 0.069
Loa Loa (eye worm) jmjC domain-containing protein 0.0011 0.0048 0.0048
Echinococcus multilocularis ring finger protein 170 0.0006 0.0002 0.0002
Loa Loa (eye worm) RiNg Finger protein family member 0.0006 0.0002 0.0002
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0006 0.0004 0.0102
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0011 0.0048 0.7057
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0244 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0057 0.0055
Schistosoma mansoni phosphatidylserine receptor 0.0011 0.0048 0.0046
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0057 0.8457
Loa Loa (eye worm) RING finger protein 20 0.0006 0.0002 0.0002
Echinococcus granulosus E3 ubiquitin protein ligase RNF146 0.0006 0.0002 0.0002
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.041 0.041
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.002 0.0115 0.0113
Echinococcus granulosus jumonji domain containing 1A 0.0011 0.0048 0.0048
Schistosoma mansoni hypothetical protein 0.0283 0.2293 0.2292
Schistosoma mansoni DNA helicase recq1 0.0012 0.0057 0.0055
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.041 0.0408
Leishmania major DNA repair protein-like protein 0.0006 0.0002 0.0000000065318
Loa Loa (eye worm) hypothetical protein 0.0014 0.0067 0.0067
Loa Loa (eye worm) hypothetical protein 0.0011 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.1218 1 1
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0551 0.4497 0.4497
Echinococcus multilocularis cpg binding protein 0.0019 0.0111 0.0111
Echinococcus granulosus lysine specific demethylase 5A 0.0044 0.0314 0.0314
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0014 0.0067 1
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0012 0.0057 0.0057
Brugia malayi jmjC domain containing protein 0.0044 0.0314 0.0312
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0057
Brugia malayi eukaryotic initiation factor 4A 0.0014 0.0067 0.0065
Echinococcus granulosus RING finger and transmembrane domain containing protein 0.0006 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0035 0.0244 0.0244
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0012 0.0057 0.0057
Echinococcus multilocularis E3 ubiquitin protein ligase LRSAM1 0.0006 0.0002 0.0002
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0012 0.0057 0.0057
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0014 0.0067 0.0065
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.0905 0.0905
Brugia malayi AF-10 protein 0.0012 0.0049 0.0047
Echinococcus granulosus caspase 2 0.0283 0.2293 0.2293
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0014 0.0067 0.0065
Echinococcus multilocularis ring finger protein 113a 0.0006 0.0002 0.0002
Onchocerca volvulus 0.1218 1 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.041 0.0408
Echinococcus granulosus ring finger protein 170 0.0006 0.0002 0.0002
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.1218 1 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0002 0.0002
Loa Loa (eye worm) jmjC domain-containing protein 0.0011 0.0048 0.0048
Echinococcus granulosus cell growth regulator with ring finger domain 0.0006 0.0002 0.0002
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.1218 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.041 0.041
Loa Loa (eye worm) hypothetical protein 0.1218 1 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0057 0.2264
Schistosoma mansoni blooms syndrome DNA helicase 0.0006 0.0004 0.0002
Echinococcus multilocularis E3 ubiquitin protein ligase Bre1 0.0006 0.0002 0.0002
Trichomonas vaginalis DNA helicase recq, putative 0.0012 0.0057 0.8457
Trichomonas vaginalis DNA helicase recq, putative 0.0012 0.0057 0.8457
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0115 0.0113
Brugia malayi Bloom's syndrome protein homolog 0.0012 0.0057 0.0055
Loa Loa (eye worm) hypothetical protein 0.006 0.0452 0.0452
Echinococcus granulosus apoptotic protease activating factor 1 0.0283 0.2293 0.2293
Echinococcus granulosus bloom syndrome protein 0.0012 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0006 0.0002 0.0002
Brugia malayi CXXC zinc finger family protein 0.0018 0.0103 0.0101
Echinococcus multilocularis phd:f box containing protein 0.0011 0.0048 0.0048
Echinococcus granulosus baculoviral IAP repeat containing protein 0.1218 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.041 0.041
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0011 0.0048 0.7057
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0006 0.0006 0.069
Loa Loa (eye worm) hypothetical protein 0.0283 0.2293 0.2293
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0014 0.0067 0.0067
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0014 0.0067 0.2677
Echinococcus granulosus E3 ubiquitin protein ligase MYLIP 0.0006 0.0002 0.0002
Echinococcus multilocularis peregrin 0.0035 0.0244 0.0244
Brugia malayi jmjC domain containing protein 0.0011 0.0048 0.0046
Trypanosoma brucei DNA repair protein, putative 0.0006 0.0002 0.0000000065318
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0057 0.8457
Onchocerca volvulus 0.0283 0.2293 0.2292
Plasmodium vivax RNA helicase-1, putative 0.0014 0.0067 0.2677
Echinococcus granulosus E3 ubiquitin protein ligase LRSAM1 0.0006 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0035 0.0244 0.0243
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0012 0.0049 0.7239
Treponema pallidum ATP-dependent RNA helicase 0.0014 0.0067 1
Onchocerca volvulus Cell death protein 3 homolog 0.0283 0.2293 0.2292
Loa Loa (eye worm) hypothetical protein 0.0006 0.0006 0.0006
Echinococcus granulosus max protein X 0.0551 0.4497 0.4497
Schistosoma mansoni DNA helicase recq5 0.0012 0.0057 0.0055
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0244 0.0244
Echinococcus granulosus dnaJ subfamily B 0.0257 0.2077 0.2077
Schistosoma mansoni hypothetical protein 0.1218 1 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0006 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0006 0.0002 0.0002
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0358 0.0358
Brugia malayi jmjC domain containing protein 0.0115 0.0905 0.0904
Loa Loa (eye worm) CXXC zinc finger family protein 0.0018 0.0103 0.0103
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0006 0.0004 0.0102
Loa Loa (eye worm) hypothetical protein 0.0006 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0006 0.0002 0.0002
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0013 0.0058 0.2312
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0011 0.0048 0.7057
Echinococcus granulosus potassium voltage gated channel subfamily A 0.002 0.0115 0.0115
Echinococcus multilocularis RING finger protein 185 0.0006 0.0002 0.0002
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.1218 1 1
Echinococcus multilocularis dnaJ subfamily B 0.0257 0.2077 0.2077
Echinococcus granulosus lysine specific demethylase 6a 0.0011 0.0048 0.0048
Brugia malayi jmjC domain containing protein 0.0011 0.0048 0.0046
Echinococcus granulosus RING finger protein 185 0.0006 0.0002 0.0002
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0014 0.0067 1
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0057 0.8457
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0011 0.0048 0.1889
Plasmodium vivax JmjC domain containing protein 0.0011 0.0048 0.1889
Onchocerca volvulus Alhambra homolog 0.0035 0.0244 0.0243
Echinococcus multilocularis apoptotic protease activating factor 1 0.0283 0.2293 0.2293
Schistosoma mansoni blooms syndrome DNA helicase 0.0006 0.0006 0.0004
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0006 0.0006 0.069
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0014 0.0067 1
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0014 0.0067 1
Echinococcus multilocularis jumonji domain containing 1A 0.0011 0.0048 0.0048
Entamoeba histolytica recQ family helicase, putative 0.0012 0.0057 0.8457
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.0306 0.0306
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0012 0.0057 0.0057
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.041 0.041
Schistosoma mansoni hypothetical protein 0.0257 0.2077 0.2075
Echinococcus granulosus inhibitor of apoptosis protein 0.1218 1 1
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0014 0.0067 1
Echinococcus granulosus peregrin 0.0035 0.0244 0.0244
Echinococcus granulosus E3 ubiquitin protein ligase Bre1 0.0006 0.0002 0.0002
Plasmodium falciparum phd finger protein, putative 0.0035 0.0244 1
Giardia lamblia Sgs1 DNA helicase, putative 0.0012 0.0057 0.2264
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0011 0.0048 0.0046
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0094 0.0093
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0014 0.0067 1
Schistosoma mansoni cpg binding protein 0.0018 0.0103 0.0101
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0012 0.0057 0.0057
Schistosoma mansoni bhlhzip transcription factor bigmax 0.0551 0.4497 0.4496
Brugia malayi jmjC domain containing protein 0.0011 0.0048 0.0046
Echinococcus granulosus E3 ubiquitin protein ligase mib1 0.0006 0.0002 0.0002
Schistosoma mansoni phd/f-box containing protein 0.0011 0.0048 0.0046
Echinococcus multilocularis RING finger and transmembrane domain containing protein 0.0006 0.0002 0.0002
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0012 0.0049 0.7239
Schistosoma mansoni cpg binding protein 0.0019 0.0111 0.011
Leishmania major hypothetical protein, conserved 0.0011 0.0048 0.7057
Schistosoma mansoni jumonji/arid domain-containing protein 0.0044 0.0314 0.0312
Brugia malayi PHD-finger family protein 0.0013 0.0057 0.0056
Echinococcus multilocularis E3 ubiquitin protein ligase mib1 0.0006 0.0002 0.0002
Plasmodium vivax hypothetical protein, conserved 0.0013 0.0058 0.2312
Loa Loa (eye worm) hypothetical protein 0.0006 0.0002 0.0002
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0086 0.0084
Schistosoma mansoni inhibitor of apoptosis protein 0.1218 1 1
Echinococcus granulosus cpg binding protein 0.0019 0.0111 0.0111
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.041 0.0408
Schistosoma mansoni cpg binding protein 0.0019 0.0111 0.011
Echinococcus multilocularis inhibitor of apoptosis protein 0.1218 1 1
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0019 0.0108 0.0108
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0057 0.0055
Loa Loa (eye worm) hypothetical protein 0.0283 0.2293 0.2293
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0358 0.0358
Toxoplasma gondii SWI2/SNF2-containing protein RAD5 0.0006 0.0002 0.0000000017485
Loa Loa (eye worm) hypothetical protein 0.0013 0.0057 0.0057
Echinococcus multilocularis 0.0006 0.0002 0.0002
Echinococcus granulosus ring finger protein 113a 0.0006 0.0002 0.0002
Schistosoma mansoni jumonji domain containing protein 0.0092 0.071 0.0708
Giardia lamblia PHD finger protein 15 0.0035 0.0244 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0034 0.0236 0.9665
Plasmodium falciparum eukaryotic initiation factor 4A 0.0014 0.0067 0.2677
Schistosoma mansoni voltage-gated potassium channel 0.002 0.0115 0.0113
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0244 0.0244
Echinococcus granulosus potassium voltage gated channel protein 0.002 0.0115 0.0115
Onchocerca volvulus Deterin homolog 0.1218 1 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0044 0.0314 0.0312
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.0905 0.0905
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0012 0.0057 0.2264
Echinococcus multilocularis E3 ubiquitin protein ligase MYLIP 0.0006 0.0002 0.0002
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0014 0.0067 0.2677
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0006 0.0006 0.0185
Loa Loa (eye worm) jmjC domain-containing protein 0.0011 0.0048 0.0048
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0244 0.0243
Brugia malayi jmjC domain containing protein 0.0011 0.0048 0.0046
Loa Loa (eye worm) hypothetical protein 0.002 0.0115 0.0115
Plasmodium falciparum JmjC domain-containing protein, putative 0.0011 0.0048 0.1889
Loa Loa (eye worm) RecQ helicase 0.0012 0.0057 0.0057
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0014 0.0067 0.0067
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0014 0.0067 1
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0012 0.0049 0.1938
Trichomonas vaginalis DNA helicase recq1, putative 0.0012 0.0057 0.8457
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0014 0.0067 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.041 0.0408
Loa Loa (eye worm) hypothetical protein 0.0006 0.0002 0.0002
Toxoplasma gondii PHD-finger domain-containing protein 0.0012 0.0049 0.1938
Echinococcus multilocularis max protein X 0.0551 0.4497 0.4497
Plasmodium vivax DNA repair protein RAD5, putative 0.0006 0.0002 0.0000000017485
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0038 0.027 0.0268
Loa Loa (eye worm) jmjC domain-containing protein 0.0044 0.0314 0.0314
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0014 0.0067 0.0065
Schistosoma mansoni bhlhzip transcription factor bigmax 0.0551 0.4497 0.4496
Echinococcus granulosus JmjC domain containing protein 4 0.0011 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0011 0.0048 0.0048
Echinococcus multilocularis lysine specific demethylase 6a 0.0011 0.0048 0.0048
Leishmania major eukaryotic initiation factor 4a, putative 0.0014 0.0067 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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