TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 310.393 | Formula: C18H22N4O
H donors: 2 H acceptors: 2 LogP: 1.94 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(Nc1cccnc1)NC1CCN(CC1)Cc1ccccc1
InChi: 1S/C18H22N4O/c23-18(21-17-7-4-10-19-13-17)20-16-8-11-22(12-9-16)14-15-5-2-1-3-6-15/h1-7,10,13,16H,8-9,11-12,14H2,(H2,20,21,23)
InChiKey: QLKSLIJLKIAWJY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0176	0.2181	0.6747
Onchocerca volvulus	Cathepsin F homolog	0.0176	0.2181	1
Entamoeba histolytica	cysteine protease, putative	0.0048	0.0185	0.075
Giardia lamblia	Cathepsin B precursor	0.0048	0.0185	0.0506
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0678	1	1
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0048	0.0185	0.0506
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0176	0.2181	0.6747
Entamoeba histolytica	cysteine protease, putative	0.0048	0.0185	0.075
Onchocerca volvulus		0.0176	0.2181	1
Loa Loa (eye worm)	tubulin beta-4 chain	0.0038	0.0024	0.0024
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0048	0.0185	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0116	0.1232	0.1232
Plasmodium vivax	vivapain-2	0.0176	0.2181	1
Entamoeba histolytica	cysteine protease, putative	0.01	0.0994	0.45
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0176	0.2181	0.6747
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0048	0.0185	0.075
Leishmania major	cathepsin L-like protease	0.0176	0.2181	0.6747
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0176	0.2181	0.6747
Onchocerca volvulus		0.0048	0.0185	0.0177
Echinococcus granulosus	cathepsin L cysteine protease	0.01	0.0994	0.0973
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0243	0.3221	0.3205
Brugia malayi	Cathepsin L-like precursor	0.0052	0.0239	0.0239
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0176	0.2181	0.6747
Giardia lamblia	Cathepsin L precursor	0.0048	0.0185	0.0506
Schistosoma mansoni	cathepsin C	0.0048	0.0185	0.0162
Trypanosoma brucei	Eukaryotic initiation factor 4A-1	0.0116	0.1232	0.378
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0185	0.0185
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0048	0.0185	0.075
Leishmania major	hypothetical protein, conserved	0.0046	0.0149	0.0393
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.01	0.0994	0.3036
Entamoeba histolytica	cysteine protease, putative	0.01	0.0994	0.45
Entamoeba histolytica	cysteine protease, putative	0.01	0.0994	0.45
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0678	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0048	0.0185	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0185	0.0185
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0176	0.2181	0.6747
Brugia malayi	Kringle domain containing protein	0.0046	0.0149	0.0149
Entamoeba histolytica	cysteine protease, putative	0.0048	0.0185	0.075
Giardia lamblia	Cysteine protease	0.0048	0.0185	0.0506
Brugia malayi	Papain family cysteine protease containing protein	0.0048	0.0185	0.0185
Brugia malayi	Papain family cysteine protease containing protein	0.01	0.0994	0.0994
Echinococcus granulosus	cathepsin b	0.0678	1	1
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0116	0.1232	0.378
Trypanosoma cruzi	cysteine peptidase, putative	0.0176	0.2181	0.2162
Giardia lamblia	Cysteine protease	0.0048	0.0185	0.0506
Echinococcus granulosus	cathepsin b	0.0678	1	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0048	0.0185	0.0506
Trypanosoma cruzi	cysteine peptidase, putative	0.01	0.0994	0.0973
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.0116	0.1232	0.1211
Echinococcus granulosus	cathepsin l1	0.0176	0.2181	0.2162
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0124	0.1372	0.4217
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0176	0.2181	0.6747
Entamoeba histolytica	DEAD/DEAH box helicase, putative	0.0116	0.1232	0.5603
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0048	0.0185	0.075
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0176	0.2181	0.6747
Giardia lamblia	Cathepsin B precursor	0.0048	0.0185	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0137	0.1574	0.1574
Schistosoma mansoni	hypothetical protein	0.0046	0.0149	0.0126
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0048	0.0185	0.0506
Brugia malayi	Cathepsin L-like precursor	0.0176	0.2181	0.2181
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0052	0.0239	0.0239
Loa Loa (eye worm)	tubulin beta-1 chain	0.0038	0.0024	0.0024
Toxoplasma gondii	cathepsin CPC1	0.0048	0.0185	0.0506
Entamoeba histolytica	cysteine proteinase 1, putative	0.01	0.0994	0.45
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0176	0.2181	0.2162
Leishmania major	cathepsin L-like protease	0.0176	0.2181	0.6747
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0185	0.0185
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0176	0.2181	0.6747
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0176	0.2181	0.6747
Plasmodium falciparum	serine repeat antigen 4	0.0048	0.0185	0.075
Echinococcus multilocularis	cathepsin b	0.0678	1	1
Giardia lamblia	Cysteine protease	0.0048	0.0185	0.0506
Plasmodium vivax	vivapain-2	0.0176	0.2181	1
Toxoplasma gondii	cathepsin CPL	0.0176	0.2181	0.6747
Schistosoma mansoni	cathepsin s	0.0052	0.0239	0.0216
Entamoeba histolytica	cysteine proteinase, putative	0.0176	0.2181	1
Onchocerca volvulus		0.0124	0.1372	0.6018
Loa Loa (eye worm)	cathepsin B	0.0243	0.3221	0.3221
Trypanosoma cruzi	Eukaryotic initiation factor 4A-1	0.0116	0.1232	0.1211
Echinococcus multilocularis	eukaryotic initiation factor 4A III	0.0116	0.1232	0.1211
Plasmodium vivax	serine-repeat antigen (SERA)	0.0048	0.0185	0.075
Giardia lamblia	Cathepsin L precursor	0.0048	0.0185	0.0506
Brugia malayi	Trypsin family protein	0.0137	0.1574	0.1574
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0176	0.2181	0.6747
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0048	0.0185	0.0506
Giardia lamblia	Cathepsin L precursor	0.0048	0.0185	0.0506
Giardia lamblia	Translation initiation factor eIF-4A, putative	0.0116	0.1232	0.378
Brugia malayi	cathepsin L-like cysteine proteinase	0.0048	0.0185	0.0185
Trypanosoma cruzi	cysteine peptidase, putative	0.0176	0.2181	0.2162
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0048	0.0185	0.0506
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0048	0.0185	0.0506
Echinococcus multilocularis	cathepsin L	0.01	0.0994	0.0973
Onchocerca volvulus		0.0176	0.2181	1
Schistosoma mansoni	cathepsin B (C01 family)	0.0048	0.0185	0.0162
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0176	0.2181	0.6747
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0048	0.0185	0.0506
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0048	0.0185	0.0506
Plasmodium falciparum	serine repeat antigen 7	0.0048	0.0185	0.075
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0176	0.2181	0.2162
Onchocerca volvulus	Cathepsin L homolog	0.0048	0.0185	0.0177
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0176	0.2181	0.6747
Giardia lamblia	Cathepsin B precursor	0.0243	0.3221	1
Onchocerca volvulus		0.0176	0.2181	1
Entamoeba histolytica	cysteine protease, putative	0.01	0.0994	0.45
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0048	0.0185	0.0162
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0176	0.2181	0.6747
Plasmodium vivax	vivapain-3	0.01	0.0994	0.45
Loa Loa (eye worm)	TK/ROR protein kinase	0.0046	0.0149	0.0149
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0052	0.0239	0.0239
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0176	0.2181	0.2162
Giardia lamblia	Hypothetical protein	0.0048	0.0185	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0185	0.0185
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0176	0.2181	0.6747
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0176	0.2181	0.6747
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0243	0.3221	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.01	0.0994	0.0973
Echinococcus multilocularis	eukaryotic initiation factor 4A	0.0116	0.1232	0.1211
Plasmodium falciparum	eukaryotic initiation factor 4A	0.0116	0.1232	0.5603
Brugia malayi	cathepsin L-like precursor	0.0124	0.1372	0.1372
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.0116	0.1232	0.1211
Entamoeba histolytica	cysteine protease, putative	0.01	0.0994	0.45
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0048	0.0185	0.075
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0048	0.0185	0.0185
Brugia malayi	cathepsin F-like cysteine proteinase	0.0048	0.0185	0.0185
Brugia malayi	Cathepsin L-like precursor	0.0124	0.1372	0.1372
Treponema pallidum	ATP-dependent RNA helicase	0.0116	0.1232	0.5
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0048	0.0185	0.0162
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0116	0.1232	0.378
Trypanosoma cruzi	hypothetical protein, conserved	0.0046	0.0149	0.0126
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0678	1	1
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0149	0.0149
Giardia lamblia	Cathepsin B precursor	0.0048	0.0185	0.0506
Onchocerca volvulus		0.0176	0.2181	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0678	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0176	0.2181	0.6747
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0185	0.0185
Entamoeba histolytica	cysteine protease, putative	0.01	0.0994	0.45
Brugia malayi	Papain family cysteine protease containing protein	0.01	0.0994	0.0994
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0048	0.0185	0.0506
Entamoeba histolytica	cysteine proteinase, putative	0.0124	0.1372	0.625
Loa Loa (eye worm)	hypothetical protein	0.0124	0.1372	0.1372
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0048	0.0185	0.0506
Echinococcus multilocularis	cathepsin L	0.0048	0.0185	0.0162
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.01	0.0994	0.0973
Echinococcus multilocularis	cathepsin L cysteine protease	0.0176	0.2181	0.2162
Trypanosoma cruzi	cysteine peptidase, putative	0.0176	0.2181	0.2162
Entamoeba histolytica	cysteine proteinase 2	0.01	0.0994	0.45
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0048	0.0185	0.0185
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0176	0.2181	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0176	0.2181	0.6747
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0243	0.3221	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0176	0.2181	0.2162
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0176	0.2181	0.6747
Entamoeba histolytica	cysteine proteinase, putative	0.01	0.0994	0.45
Entamoeba histolytica	cysteine protease, putative	0.01	0.0994	0.45
Echinococcus multilocularis	tissue type plasminogen activator	0.0046	0.0149	0.0126
Leishmania major	cysteine peptidase A (CPA)	0.0176	0.2181	0.6747
Plasmodium falciparum	serine repeat antigen 1	0.0048	0.0185	0.075
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0048	0.0185	0.0185
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0048	0.0185	0.0506
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0239	0.0239
Leishmania major	cathepsin L-like protease	0.0176	0.2181	0.6747
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0176	0.2181	0.2181
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0048	0.0185	0.075
Plasmodium vivax	unspecified product	0.01	0.0994	0.45
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0176	0.2181	0.6747
Brugia malayi	Cathepsin L-like precursor	0.0176	0.2181	0.2181
Onchocerca volvulus		0.0176	0.2181	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0176	0.2181	0.6747
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0176	0.2181	0.6747
Onchocerca volvulus		0.0176	0.2181	1
Onchocerca volvulus	Cathepsin L homolog	0.0176	0.2181	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0239	0.0239
Entamoeba histolytica	cysteine protease, putative	0.0176	0.2181	1
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0048	0.0185	0.075
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0048	0.0185	0.0506
Giardia lamblia	Cathepsin B precursor	0.0048	0.0185	0.0506
Brugia malayi	Cathepsin L-like precursor	0.0124	0.1372	0.1372
Schistosoma mansoni	cathepsin F (C01 family)	0.0124	0.1372	0.1351
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0176	0.2181	0.6747
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0048	0.0185	0.0506
Schistosoma mansoni	cathepsin S (C01 family)	0.0048	0.0185	0.0162
Onchocerca volvulus	Cathepsin L homolog	0.0176	0.2181	1
Giardia lamblia	Cathepsin L precursor	0.0048	0.0185	0.0506
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0176	0.2181	0.6747
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0048	0.0185	0.075
Loa Loa (eye worm)	tubulin beta chain	0.0038	0.0024	0.0024
Echinococcus multilocularis	cysteine protease	0.0176	0.2181	0.2162
Plasmodium vivax	vivapain-1	0.01	0.0994	0.45
Giardia lamblia	Encystation-specific protease	0.0048	0.0185	0.0506
Trypanosoma cruzi	major cysteine proteinase, putative	0.0048	0.0185	0.0162
Plasmodium falciparum	serine repeat antigen 9	0.0048	0.0185	0.075
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0048	0.0185	0.0506
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0048	0.0185	0.075
Trypanosoma cruzi	cysteine peptidase, putative	0.0052	0.0239	0.0216
Giardia lamblia	Cathepsin B precursor	0.0048	0.0185	0.0506
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0048	0.0185	0.075
Entamoeba histolytica	cysteine proteinase, putative	0.01	0.0994	0.45
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0048	0.0185	0.0162
Entamoeba histolytica	cysteine protease, putative	0.01	0.0994	0.45
Brugia malayi	cathepsin L precursor	0.0048	0.0185	0.0185
Brugia malayi	Papain family cysteine protease containing protein	0.0048	0.0185	0.0185
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0048	0.0185	0.075
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0176	0.2181	0.6747
Giardia lamblia	Cathepsin L precursor	0.0048	0.0185	0.0506
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0048	0.0185	0.0162
Mycobacterium tuberculosis	Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog)	0.0116	0.1232	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0176	0.2181	0.6747
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0048	0.0185	0.0162
Giardia lamblia	Cathepsin L-like protease	0.0048	0.0185	0.0506
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0176	0.2181	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0176	0.2181	0.6747
Trypanosoma cruzi	cruzipain precursor, putative	0.0176	0.2181	0.2162
Entamoeba histolytica	cysteine protease, putative	0.01	0.0994	0.45
Brugia malayi	Cathepsin L-like precursor	0.0176	0.2181	0.2181
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0046	0.0149	0.0583
Echinococcus granulosus	tissue type plasminogen activator	0.0046	0.0149	0.0126
Brugia malayi	eukaryotic initiation factor 4A	0.0116	0.1232	0.1232
Plasmodium falciparum	cysteine repeat modular protein 1	0.0046	0.0149	0.0583
Loa Loa (eye worm)	BEN-1 protein	0.0038	0.0024	0.0024
Echinococcus multilocularis	cathepsin b	0.0678	1	1
Brugia malayi	Papain family cysteine protease containing protein	0.0176	0.2181	0.2181
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0048	0.0185	0.075
Giardia lamblia	Cathepsin L-like protease	0.0048	0.0185	0.0506
Brugia malayi	cathepsin F-like cysteine proteinase	0.0052	0.0239	0.0239
Entamoeba histolytica	cysteine proteinase, putative	0.0176	0.2181	1
Toxoplasma gondii	kringle domain-containing protein	0.0046	0.0149	0.0393
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0176	0.2181	0.6747
Schistosoma mansoni	DEAD box ATP-dependent RNA helicase	0.0116	0.1232	0.1211
Leishmania major	eukaryotic initiation factor 4a, putative	0.0116	0.1232	0.378
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0048	0.0185	0.0506
Plasmodium vivax	RNA helicase-1, putative	0.0116	0.1232	0.5603
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0048	0.0185	0.0162
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0048	0.0185	0.0506
Loa Loa (eye worm)	BEN-1 protein	0.0038	0.0024	0.0024
Entamoeba histolytica	cysteine protease, putative	0.0048	0.0185	0.075
Echinococcus multilocularis	cysteine protease	0.0176	0.2181	0.2162
Brugia malayi	Cathepsin L-like precursor	0.0176	0.2181	0.2181
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0176	0.2181	0.6747
Schistosoma mansoni	cathepsin F (C01 family)	0.0176	0.2181	0.2162
Plasmodium vivax	serine-repeat antigen (SERA)	0.0048	0.0185	0.075
Loa Loa (eye worm)	fibroinase	0.0176	0.2181	0.2181
Plasmodium falciparum	serine repeat antigen 3	0.0048	0.0185	0.075
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0124	0.1372	0.4217
Leishmania major	cathepsin L-like protease	0.0176	0.2181	0.6747
Toxoplasma gondii	cathepsin B	0.0243	0.3221	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0048	0.0185	0.0185
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0124	0.1372	0.1351
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0137	0.1574	0.1555
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0176	0.2181	0.6747
Giardia lamblia	Cathepsin B precursor	0.0243	0.3221	1
Loa Loa (eye worm)	tubulin beta-2A chain	0.0038	0.0024	0.0024
Echinococcus granulosus	eukaryotic initiation factor 4A III	0.0116	0.1232	0.1211
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0048	0.0185	0.0506
Entamoeba histolytica	cysteine protease, putative	0.01	0.0994	0.45
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.01	0.0994	0.0973
Trypanosoma cruzi	cysteine proteinase, putative	0.01	0.0994	0.0973
Trypanosoma cruzi	major cysteine proteinase, putative	0.0048	0.0185	0.0162
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.01	0.0994	0.3036
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.01	0.0994	0.3036
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0137	0.1574	0.1555
Entamoeba histolytica	cysteine protease, putative	0.0048	0.0185	0.075
Brugia malayi	fibroinase precursor	0.0048	0.0185	0.0185
Toxoplasma gondii	eukaryotic initiation factor-4A, putative	0.0116	0.1232	0.378
Entamoeba histolytica	cysteine proteinase, putative	0.01	0.0994	0.45
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0048	0.0185	0.0506
Plasmodium falciparum	cysteine proteinase falcipain 1	0.01	0.0994	0.45
Plasmodium falciparum	serine repeat antigen 2	0.0048	0.0185	0.075
Loa Loa (eye worm)	hypothetical protein	0.0176	0.2181	0.2181
Entamoeba histolytica	cysteine protease, putative	0.01	0.0994	0.45
Onchocerca volvulus	Eukaryotic initiation factor 4A homolog	0.0116	0.1232	0.533
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0176	0.2181	0.6747
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0048	0.0185	0.0162
Giardia lamblia	Hypothetical protein	0.0048	0.0185	0.0506
Trypanosoma cruzi	cysteine peptidase, putative	0.0176	0.2181	0.2162
Plasmodium vivax	unspecified product	0.0048	0.0185	0.075
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0124	0.1372	0.1372
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0048	0.0185	0.075
Leishmania major	eukaryotic initiation factor 4a, putative	0.0116	0.1232	0.378
Leishmania major	cathepsin L-like protease	0.0176	0.2181	0.6747
Echinococcus granulosus	cathepsin L	0.01	0.0994	0.0973
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.01	0.0994	0.3036
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0176	0.2181	0.2162
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0176	0.2181	0.6747
Leishmania major	cathepsin L-like protease	0.0176	0.2181	0.6747
Plasmodium falciparum	serine repeat antigen 5	0.0048	0.0185	0.075
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0048	0.0185	0.0162
Entamoeba histolytica	hypothetical protein	0.0048	0.0185	0.075
Onchocerca volvulus		0.0176	0.2181	1
Giardia lamblia	Cathepsin B precursor	0.0243	0.3221	1
Plasmodium falciparum	serine repeat antigen 8	0.0048	0.0185	0.075
Loa Loa (eye worm)	hypothetical protein	0.0137	0.1574	0.1574
Echinococcus granulosus	cysteine protease	0.01	0.0994	0.0973
Loa Loa (eye worm)	cysteine protease	0.0176	0.2181	0.2181
Leishmania major	cathepsin L-like protease	0.0176	0.2181	0.6747
Brugia malayi	Cathepsin L-like precursor	0.0176	0.2181	0.2181
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0176	0.2181	0.6747
Plasmodium falciparum	serine repeat antigen 6	0.0048	0.0185	0.075
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0678	1	1
Echinococcus granulosus	cathepsin L	0.0048	0.0185	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0678	1	1
Echinococcus granulosus	eukaryotic initiation factor 4A	0.0116	0.1232	0.1211
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0048	0.0185	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0239	0.0239
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0176	0.2181	0.6747
Trichomonas vaginalis	DEAD box ATP-dependent RNA helicase, putative	0.0116	0.1232	0.378
Entamoeba histolytica	cysteine protease, putative	0.01	0.0994	0.45
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0048	0.0185	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0185	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0124	0.1372	0.1372
Trichomonas vaginalis	conserved hypothetical protein	0.0048	0.0185	0.0506
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0243	0.3221	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0176	0.2181	0.6747
Trypanosoma cruzi	cysteine protease, putative	0.01	0.0994	0.0973
Giardia lamblia	Cysteine protease	0.0048	0.0185	0.0506
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0048	0.0185	0.0506
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0176	0.2181	0.2181
Brugia malayi	Cathepsin L-like precursor	0.0176	0.2181	0.2181
Toxoplasma gondii	cathepsin CPC2	0.0048	0.0185	0.0506
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0176	0.2181	1
Entamoeba histolytica	cysteine protease, putative	0.0048	0.0185	0.075
Entamoeba histolytica	cysteine protease, putative	0.01	0.0994	0.45
Entamoeba histolytica	cysteine proteinase, putative	0.01	0.0994	0.45
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.01	0.0994	0.0973
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0048	0.0185	0.075
Brugia malayi	Tubulin beta-1 chain	0.0038	0.0024	0.0024
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0243	0.3221	0.3205
Trypanosoma cruzi	cysteine proteinase, putative	0.01	0.0994	0.0973
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0176	0.2181	0.6747
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0048	0.0185	0.075
Onchocerca volvulus		0.0137	0.1574	0.7016
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0048	0.0185	0.0506
Loa Loa (eye worm)	beta-tubulin	0.0038	0.0024	0.0024
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0048	0.0185	0.0506
Leishmania major	cathepsin L-like protease	0.0176	0.2181	0.6747
Onchocerca volvulus		0.0102	0.1028	0.4328
Loa Loa (eye worm)	hypothetical protein	0.0124	0.1372	0.1372
Plasmodium vivax	unspecified product	0.0052	0.0239	0.0999
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0048	0.0185	0.0185
Brugia malayi	beta-tubulin, identical	0.0038	0.0024	0.0024
Brugia malayi	Papain family cysteine protease containing protein	0.0048	0.0185	0.0185
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0048	0.0185	0.075
Brugia malayi	Protein kinase domain containing protein	0.0046	0.0149	0.0149
Loa Loa (eye worm)	ctsf protein	0.0176	0.2181	0.2181
Schistosoma mansoni	cathepsin F (C01 family)	0.0176	0.2181	0.2162
Echinococcus granulosus	cathepsin l1	0.0124	0.1372	0.1351
Trypanosoma cruzi	cruzipain precursor, putative	0.0052	0.0239	0.0216
Giardia lamblia	Cathepsin L precursor	0.0048	0.0185	0.0506

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	> 100 uM	Inhibition of Trypanosoma cruzi trypanothione reductase assessed as inhibition of thionitrobenzoate formation by microplate reader analysis	ChEMBL.	19364854

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1652419

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1488347