TDR Targets

Basic information

Technical information

TDR Targets ID: 149007
Name: 2-[butyl-[[4-[2-(2H-tetrazol-5-yl)phenyl]phen yl]methyl]amino]pyridine-3-carbonitrile
MW: 409.486 | Formula: C24H23N7
H donors: 1 H acceptors: 5 LogP: 4.61 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCCCN(c1ncccc1C#N)Cc1ccc(cc1)c1ccccc1c1n[nH]nn1
InChi: 1S/C24H23N7/c1-2-3-15-31(24-20(16-25)7-6-14-26-24)17-18-10-12-19(13-11-18)21-8-4-5-9-22(21)23-27-29-30-28-23/h4-14H,2-3,15,17H2,1H3,(H,27,28,29,30)
InChiKey: OXPVMMYCWJTHHX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[butyl-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]amino]-3-pyridinecarbonitrile
2-[butyl-[[4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]amino]pyridine-3-carbonitrile
2-[butyl-[4-[2-(2H-tetrazol-5-yl)phenyl]benzyl]amino]nicotinonitrile

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	angiotensin II receptor, type 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	angiotensin II receptor, type 2	363 aa	398 aa	18.3 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	calpain A	0.0123	0.2769	0.1226
Onchocerca volvulus		0.0178	0.4533	0.6996
Schistosoma mansoni	calpain (C02 family)	0.0123	0.2769	0.2773
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0092	0.1758	0.3878
Brugia malayi	Cathepsin L-like precursor	0.0119	0.2641	0.2839
Loa Loa (eye worm)	hypothetical protein	0.0119	0.2641	0.2839
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0123	0.2769	0.6107
Echinococcus granulosus	calpain	0.0123	0.2769	0.1226
Leishmania major	cathepsin L-like protease	0.0178	0.4533	1
Leishmania major	cathepsin L-like protease	0.0178	0.4533	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0178	0.4533	1
Entamoeba histolytica	cysteine proteinase, putative	0.0092	0.1758	0.3878
Echinococcus granulosus	calpain 7 C02 family	0.0123	0.2769	0.1226
Entamoeba histolytica	cysteine proteinase, putative	0.0178	0.4533	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0178	0.4533	0.3367
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0178	0.4533	1
Onchocerca volvulus		0.0178	0.4533	0.6996
Trypanosoma cruzi	cysteine peptidase, putative	0.0059	0.0702	0.1549
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0178	0.4533	1
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0059	0.0702	0.0754
Brugia malayi	cathepsin L-like precursor	0.0119	0.2641	0.2839
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0178	0.4533	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0092	0.1758	0.3878
Schistosoma mansoni	cathepsin F (C01 family)	0.0178	0.4533	0.454
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0178	0.4533	1
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0702	0.0754
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0178	0.4533	1
Leishmania major	calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative	0.0123	0.2769	0.6107
Trypanosoma brucei	calpain-like protein, putative	0.0123	0.2769	0.6107
Entamoeba histolytica	cysteine protease, putative	0.0092	0.1758	0.3878
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0178	0.4533	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0178	0.4533	0.4872
Onchocerca volvulus		0.0178	0.4533	0.6996
Echinococcus multilocularis	calpain family protein 1, d	0.024	0.6536	0.5797
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0123	0.2769	0.6107
Plasmodium vivax	vivapain-2	0.0178	0.4533	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0178	0.4533	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0178	0.4533	1
Brugia malayi	Cathepsin L-like precursor	0.0178	0.4533	0.4872
Echinococcus multilocularis	calpain A	0.0347	1	1
Loa Loa (eye worm)	hypothetical protein	0.0119	0.2641	0.2839
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0178	0.4533	1
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0702	0.0754
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0178	0.4533	1
Trypanosoma brucei	kinesin, putative	0.0086	0.1579	0.3482
Entamoeba histolytica	cysteine protease, putative	0.0092	0.1758	0.3878
Loa Loa (eye worm)	hypothetical protein	0.024	0.6536	0.7024
Entamoeba histolytica	cysteine protease, putative	0.0092	0.1758	0.3878
Leishmania major	kinesin, putative	0.0086	0.1579	0.3482
Onchocerca volvulus		0.0203	0.5346	1
Echinococcus multilocularis	calpain 5	0.0123	0.2769	0.1226
Trypanosoma brucei	calpain-like cysteine peptidase, putative	0.0123	0.2769	0.6107
Onchocerca volvulus		0.0178	0.4533	0.6996
Brugia malayi	cathepsin F-like cysteine proteinase	0.0059	0.0702	0.0754
Loa Loa (eye worm)	fibroinase	0.0178	0.4533	0.4872
Echinococcus multilocularis	cysteine protease	0.0178	0.4533	0.3367
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0123	0.2769	0.6107
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0178	0.4533	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0178	0.4533	1
Plasmodium vivax	calpain, putative	0.0123	0.2769	0.5394
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0178	0.4533	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0178	0.4533	1
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0347	0.9985	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0178	0.4533	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0178	0.4533	1
Entamoeba histolytica	cysteine protease, putative	0.0092	0.1758	0.3878
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0178	0.4533	1
Brugia malayi	Cathepsin L-like precursor	0.0059	0.0702	0.0754
Entamoeba histolytica	protein kinase, putative	0.0086	0.1579	0.3482
Plasmodium vivax	vivapain-2	0.0178	0.4533	1
Loa Loa (eye worm)	calpain family protein 1	0.024	0.6536	0.7024
Brugia malayi	Cathepsin L-like precursor	0.0178	0.4533	0.4872
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0347	0.9985	0.9982
Entamoeba histolytica	cysteine protease, putative	0.0178	0.4533	1
Trypanosoma brucei	calpain-like protein, putative	0.0123	0.2769	0.6107
Entamoeba histolytica	cysteine proteinase, putative	0.0092	0.1758	0.3878
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0178	0.4533	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0178	0.4533	0.3367
Trypanosoma cruzi	cruzipain precursor, putative	0.0178	0.4533	1
Leishmania major	cathepsin L-like protease	0.0178	0.4533	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0178	0.4533	1
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0123	0.2769	0.6107
Schistosoma mansoni	calpain C (C02 family)	0.0123	0.2769	0.2773
Plasmodium vivax	vivapain-1	0.0092	0.1758	0.2757
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0178	0.4533	1
Trypanosoma cruzi	kinesin, putative	0.0086	0.1579	0.3482
Echinococcus multilocularis	calpain 7 (C02 family)	0.0123	0.2769	0.1226
Trypanosoma cruzi	cysteine proteinase, putative	0.0092	0.1758	0.3878
Onchocerca volvulus		0.0178	0.4533	0.6996
Trypanosoma cruzi	cysteine peptidase, putative	0.0178	0.4533	1
Plasmodium vivax	vivapain-3	0.0092	0.1758	0.2757
Echinococcus granulosus	cathepsin l1	0.0119	0.2641	0.1071
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0178	0.4533	0.3367
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0123	0.2769	0.6107
Echinococcus multilocularis	hypothetical protein	0.0123	0.2769	0.1226
Brugia malayi	calpain 5	0.0086	0.1579	0.1697
Loa Loa (eye worm)	calpain	0.0123	0.2769	0.2976
Trypanosoma cruzi	cysteine protease, putative	0.0092	0.1758	0.3878
Schistosoma mansoni	cathepsin F (C01 family)	0.0178	0.4533	0.454
Brugia malayi	Cathepsin L-like precursor	0.0119	0.2641	0.2839
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0092	0.1758	0.3878
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0178	0.4533	1
Trypanosoma cruzi	kinesin, putative	0.0086	0.1579	0.3482
Brugia malayi	Cathepsin L-like precursor	0.0178	0.4533	0.4872
Schistosoma mansoni	calpain-7 (C02 family)	0.0123	0.2769	0.2773
Leishmania major	cathepsin L-like protease	0.0178	0.4533	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0178	0.4533	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0178	0.4533	0.3367
Entamoeba histolytica	cysteine proteinase, putative	0.0119	0.2641	0.5826
Onchocerca volvulus		0.0178	0.4533	0.6996
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0178	0.4533	1
Brugia malayi	calpain family protein 1	0.0326	0.9304	1
Loa Loa (eye worm)	hypothetical protein	0.0289	0.8114	0.8721
Entamoeba histolytica	cysteine protease, putative	0.0092	0.1758	0.3878
Entamoeba histolytica	cysteine proteinase, putative	0.0178	0.4533	1
Loa Loa (eye worm)	hypothetical protein	0.0203	0.5346	0.5745
Echinococcus multilocularis	cysteine protease	0.0178	0.4533	0.3367
Trypanosoma cruzi	cruzipain precursor, putative	0.0059	0.0702	0.1549
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0178	0.4533	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0119	0.2641	0.2645
Loa Loa (eye worm)	ctsf protein	0.0178	0.4533	0.4872
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0178	0.4533	1
Brugia malayi	calpain 7	0.0123	0.2769	0.2976
Trypanosoma brucei	cysteine peptidase, Clan CA, family C2, putative	0.0123	0.2769	0.6107
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0119	0.2641	0.5826
Trypanosoma brucei	calpain-like protein, putative	0.0123	0.2769	0.6107
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0178	0.4533	1
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0347	0.9985	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0178	0.4533	1
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0123	0.2769	0.6107
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0326	0.9304	0.9318
Entamoeba histolytica	cysteine protease, putative	0.0092	0.1758	0.3878
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0178	0.4533	1
Brugia malayi	Papain family cysteine protease containing protein	0.0092	0.1758	0.189
Echinococcus multilocularis	calpain	0.0123	0.2769	0.1226
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0347	0.9985	0.9982
Plasmodium vivax	unspecified product	0.0092	0.1758	0.2757
Entamoeba histolytica	cysteine protease, putative	0.0092	0.1758	0.3878
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0123	0.2769	0.6107
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0123	0.2769	0.6107
Leishmania major	cysteine peptidase A (CPA)	0.0178	0.4533	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0178	0.4533	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0178	0.4533	1
Brugia malayi	Cathepsin L-like precursor	0.0178	0.4533	0.4872
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0178	0.4533	1
Leishmania major	calpain, putative,cysteine peptidase, Clan CA, family C2, putative	0.0123	0.2769	0.6107
Toxoplasma gondii	cathepsin CPL	0.0178	0.4533	1
Loa Loa (eye worm)	hypothetical protein	0.0178	0.4533	0.4872
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0092	0.1758	0.3878
Loa Loa (eye worm)	cysteine protease	0.0178	0.4533	0.4872
Loa Loa (eye worm)	hypothetical protein	0.0119	0.2641	0.2839
Loa Loa (eye worm)	hypothetical protein	0.0326	0.9304	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0178	0.4533	1
Leishmania major	cathepsin L-like protease	0.0178	0.4533	1
Trypanosoma brucei	calpain-like protein, putative	0.0123	0.2769	0.6107
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0178	0.4533	1
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C2, putative	0.0123	0.2769	0.6107
Onchocerca volvulus	Cathepsin L homolog	0.0178	0.4533	0.6996
Entamoeba histolytica	cysteine proteinase 2	0.0092	0.1758	0.3878
Onchocerca volvulus		0.0178	0.4533	0.6996
Schistosoma mansoni	calpain-7 (C02 family)	0.0123	0.2769	0.2773
Onchocerca volvulus	Cathepsin L homolog	0.0178	0.4533	0.6996
Leishmania major	cathepsin L-like protease	0.0178	0.4533	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0092	0.1758	0.1761
Trypanosoma brucei	antigen, putative	0.0123	0.2769	0.6107
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0092	0.1758	0.1761
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0178	0.4533	1
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0119	0.2641	0.2839
Entamoeba histolytica	cysteine protease, putative	0.0092	0.1758	0.3878
Entamoeba histolytica	cysteine protease, putative	0.0092	0.1758	0.3878
Brugia malayi	calpain family protein 1	0.0326	0.9304	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0119	0.2641	0.5826
Entamoeba histolytica	cysteine protease, putative	0.0092	0.1758	0.3878
Onchocerca volvulus	Cathepsin F homolog	0.0178	0.4533	0.6996
Entamoeba histolytica	cysteine protease, putative	0.0092	0.1758	0.3878
Echinococcus granulosus	calpain 5	0.0123	0.2769	0.1226
Brugia malayi	Papain family cysteine protease containing protein	0.0178	0.4533	0.4872
Echinococcus multilocularis	cathepsin L cysteine protease	0.0178	0.4533	0.3367
Leishmania major	cathepsin L-like protease	0.0178	0.4533	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0092	0.1758	0.3878
Entamoeba histolytica	cysteine protease, putative	0.0092	0.1758	0.3878
Loa Loa (eye worm)	calpain family protein 1	0.0326	0.9304	1
Echinococcus granulosus	cathepsin l1	0.0178	0.4533	0.3367
Schistosoma mansoni	Mername-AA248 (C02 family)	0.0123	0.2769	0.2773
Leishmania major	cathepsin L-like protease	0.0178	0.4533	1
Entamoeba histolytica	cysteine proteinase, putative	0.0092	0.1758	0.3878
Loa Loa (eye worm)	calpain 5	0.0086	0.1579	0.1697
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0059	0.0702	0.0754
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0092	0.1758	0.3878
Loa Loa (eye worm)	hypothetical protein	0.0059	0.0702	0.0754
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0092	0.1758	0.3878
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0178	0.4533	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0092	0.1758	0.3878
Entamoeba histolytica	calpain large subunit domain III containing protein	0.0086	0.1579	0.3482
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0178	0.4533	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0178	0.4533	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0178	0.4533	0.3367
Trypanosoma cruzi	cysteine proteinase, putative	0.0092	0.1758	0.3878
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0178	0.4533	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0119	0.2641	0.5826
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0178	0.4533	0.4872
Brugia malayi	Papain family cysteine protease containing protein	0.0092	0.1758	0.189
Entamoeba histolytica	cysteine proteinase, putative	0.0092	0.1758	0.3878
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0178	0.4533	1
Brugia malayi	Cathepsin L-like precursor	0.0178	0.4533	0.4872
Trypanosoma cruzi	calpain-like cysteine peptidase, putative	0.0123	0.2769	0.6107
Schistosoma mansoni	cathepsin s	0.0059	0.0702	0.0703
Brugia malayi	Cathepsin L-like precursor	0.0178	0.4533	0.4872
Trypanosoma cruzi	cysteine peptidase, putative	0.0178	0.4533	1
Entamoeba histolytica	cysteine protease, putative	0.0092	0.1758	0.3878
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0178	0.4533	1
Trypanosoma cruzi	calpain cysteine peptidase, putative	0.0123	0.2769	0.6107
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0092	0.1758	0.1761

Activities

Activity type	Activity value	Assay description	Source	Reference
Kd (binding)	= 7.68	Potency of the compound to antagonize the ability of angiotensin II to contract rabbit aorta	ChEMBL.	8410980
pA2 (binding)	= 7.68	Potency of the compound to antagonize the ability of angiotensin II to contract rabbit aorta	ChEMBL.	8410980

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 15657996

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 149007