Detailed information for compound 1494506

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 251.306 | Formula: C14H9N3S
  • H donors: 1 H acceptors: 2 LogP: 3.8 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1nc(Nc2ccccc2)c2c(c1)scc2
  • InChi: 1S/C14H9N3S/c15-9-11-8-13-12(6-7-18-13)14(17-11)16-10-4-2-1-3-5-10/h1-8H,(H,16,17)
  • InChiKey: AOBNCLIBTQZINR-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens casein kinase 2, beta polypeptide Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) Csnk2b protein Get druggable targets OG5_126846 All targets in OG5_126846
Cryptosporidium hominis protein kinase Ck2-beta Get druggable targets OG5_126846 All targets in OG5_126846
Trypanosoma congolense Casein kinase II subunit beta, putative Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium vivax casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Schistosoma japonicum ko:K03115 casein kinase 2, beta polypeptide, putative Get druggable targets OG5_126846 All targets in OG5_126846
Echinococcus multilocularis casein kinase ii subunit beta Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium yoelii casein kinase ii beta chain Get druggable targets OG5_126846 All targets in OG5_126846
Babesia bovis protein kinase CK2 regulatory subunit CK2B1 Get druggable targets OG5_126846 All targets in OG5_126846
Toxoplasma gondii casein kinase ii regulatory subunit protein Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium berghei casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium knowlesi casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Echinococcus granulosus casein kinase ii subunit beta Get druggable targets OG5_126846 All targets in OG5_126846
Leishmania donovani Casein kinase II subunit beta, putative Get druggable targets OG5_126846 All targets in OG5_126846
Cryptosporidium parvum putative protein kinase CK2 regulatory subunit CK2B1 Get druggable targets OG5_126846 All targets in OG5_126846
Cryptosporidium parvum putative casein kinase II regulatory subunit; besthit Pf 23508244 Get druggable targets OG5_126846 All targets in OG5_126846
Brugia malayi Csnk2b protein Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Schistosoma mansoni casein kinase II beta subunit Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trypanosoma brucei Casein kinase II subunit beta, putative Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium berghei casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Leishmania infantum protein kinase ck2 regulatory subunit, putative Get druggable targets OG5_126846 All targets in OG5_126846
Neospora caninum casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Leishmania braziliensis protein kinase ck2 regulatory subunit, putative Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium knowlesi casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Entamoeba histolytica casein kinase II regulatory subunit family protein Get druggable targets OG5_126846 All targets in OG5_126846
Theileria parva casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trypanosoma cruzi Casein kinase II subunit beta, putative Get druggable targets OG5_126846 All targets in OG5_126846
Neospora caninum YOR039Wp-like protein, related Get druggable targets OG5_126846 All targets in OG5_126846
Candida albicans Casein kinase II, regulatory (beta-prime) subunit Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium vivax casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Babesia bovis casein kinase II beta 4 subunit, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Candida albicans Casein kinase II, regulatory (beta-prime) subunit Get druggable targets OG5_126846 All targets in OG5_126846
Toxoplasma gondii ck2 beta subunit Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Candida albicans Casein kinase II, regulatory (beta) subunit Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium falciparum casein kinase II beta chain Get druggable targets OG5_126846 All targets in OG5_126846
Leishmania major protein kinase ck2 regulatory subunit, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Schistosoma japonicum ko:K03115 casein kinase 2, beta polypeptide, putative Get druggable targets OG5_126846 All targets in OG5_126846
Entamoeba histolytica casein kinase II regulatory subunit family protein Get druggable targets OG5_126846 All targets in OG5_126846
Leishmania mexicana protein kinase ck2 regulatory subunit, putative Get druggable targets OG5_126846 All targets in OG5_126846
Giardia lamblia Casein kinase II beta chain Get druggable targets OG5_126846 All targets in OG5_126846
Candida albicans Casein kinase II, regulatory (beta) subunit Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Theileria parva casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Onchocerca volvulus Casein kinase II subunit beta homolog Get druggable targets OG5_126846 All targets in OG5_126846
Onchocerca volvulus Casein kinase II subunit beta homolog Get druggable targets OG5_126846 All targets in OG5_126846
Trypanosoma cruzi Casein kinase II subunit beta, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trypanosoma brucei gambiense protein kinase ck2 regulatory subunit, putative Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Entamoeba histolytica casein kinase II regulatory subunit family protein Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium falciparum casein kinase II beta chain Get druggable targets OG5_126846 All targets in OG5_126846
Trichomonas vaginalis casein kinase II beta chain, putative Get druggable targets OG5_126846 All targets in OG5_126846
Schistosoma japonicum Casein kinase II subunit beta, putative Get druggable targets OG5_126846 All targets in OG5_126846
Plasmodium yoelii protein kinase Ck2-beta Get druggable targets OG5_126846 All targets in OG5_126846
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0159 0.0357
Loa Loa (eye worm) latrophilin receptor protein 2 0.0064 0.0534 0.0888
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0062 0.0508 0.5712
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0147 0.1479
Toxoplasma gondii HEAT repeat-containing protein 0.0031 0.0147 0.0324
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0119 0.1155
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0203 0.2157 0.3692
Leishmania major heat shock protein 83-1 0.0093 0.0874 1
Plasmodium falciparum heat shock protein 90 0.0093 0.0874 0.2191
Echinococcus granulosus tar DNA binding protein 0.0132 0.1331 0.3148
Schistosoma mansoni tar DNA-binding protein 0.0132 0.1331 0.3453
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0088 0.0807 0.5
Leishmania major heat shock protein 83-1 0.0093 0.0874 1
Entamoeba histolytica hypothetical protein 0.0037 0.0214 0.2268
Loa Loa (eye worm) endoplasmin 0.0093 0.0874 0.1475
Toxoplasma gondii heat shock protein 75, putative 0.0062 0.0508 0.1252
Onchocerca volvulus 0.0255 0.2768 1
Entamoeba histolytica hypothetical protein 0.0025 0.0078 0.0675
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0119 0.0253
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.03 0.102
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0044 0.03 0.3281
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0088 0.0807 1
Leishmania major heat shock protein 83-1 0.0093 0.0874 1
Toxoplasma gondii Hsp90 domain-containing protein 0.0354 0.3918 1
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.0548 0.1355
Leishmania major importin beta-1 subunit, putative 0.0025 0.0078 0.0675
Plasmodium falciparum importin beta, putative 0.0031 0.0147 0.0324
Echinococcus granulosus GPCR family 2 0.0064 0.0534 0.1234
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0159 0.163
Trypanosoma cruzi heat shock protein 90, putative 0.008 0.0717 0.8155
Entamoeba histolytica heat shock protein 90, putative 0.0093 0.0874 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.0548 0.6184
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0159 0.0366
Loa Loa (eye worm) hypothetical protein 0.0139 0.1406 0.2394
Trypanosoma brucei Heat shock protein 83, putative 0.0093 0.0874 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.0548 0.0529
Brugia malayi heat shock protein 90 0.0093 0.0874 0.1505
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0051 0.0073
Leishmania major heat shock protein 83-1 0.0093 0.0874 1
Trichomonas vaginalis heat shock protein, putative 0.008 0.0717 0.2535
Trypanosoma cruzi Heat shock protein 83, putative 0.0093 0.0874 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.03 0.102
Toxoplasma gondii ck2 beta subunit 0.0044 0.03 0.0719
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0064 0.0534 0.1234
Schistosoma mansoni hypothetical protein 0.0345 0.3818 1
Leishmania major hypothetical protein, conserved 0.0029 0.0119 0.1155
Schistosoma mansoni hypothetical protein 0.0064 0.0534 0.1354
Mycobacterium ulcerans heat shock protein 90 0.0088 0.0807 1
Trypanosoma brucei heat shock protein, putative 0.0093 0.0874 1
Plasmodium vivax heat shock protein 86, putative 0.0093 0.0874 0.2191
Schistosoma mansoni hypothetical protein 0.0345 0.3818 1
Giardia lamblia Heat shock protein HSP 90-alpha 0.008 0.0717 0.8155
Toxoplasma gondii heat shock protein 90, putative 0.0093 0.0874 0.2191
Echinococcus multilocularis importin subunit beta 1 0.0031 0.0147 0.0127
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0044 0.03 0.0541
Echinococcus multilocularis geminin 0.0345 0.3818 0.3805
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.0548 0.1268
Giardia lamblia Casein kinase II beta chain 0.0044 0.03 0.3281
Trypanosoma cruzi heat shock protein 85, putative 0.008 0.0717 0.8155
Toxoplasma gondii heat shock protein HSP90 0.0093 0.0874 0.2191
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0051 0.0078
Leishmania major heat shock protein 83-1 0.0093 0.0874 1
Loa Loa (eye worm) TAR-binding protein 0.0132 0.1331 0.2265
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0159 0.0139
Trypanosoma brucei heat shock protein, putative 0.0093 0.0874 1
Echinococcus multilocularis heat shock protein 90 0.008 0.0717 0.0698
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0548 0.1391
Trypanosoma cruzi heat shock protein 85, putative 0.0093 0.0874 1
Echinococcus granulosus snurportin 1 0.0332 0.3662 0.8742
Trypanosoma cruzi heat shock protein 90, putative 0.0039 0.024 0.2574
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0548 0.671
Trypanosoma cruzi heat shock protein 90, putative 0.0093 0.0874 1
Plasmodium vivax heat shock protein, putative 0.0354 0.3918 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.03 0.102
Brugia malayi Calcitonin receptor-like protein seb-1 0.0203 0.2157 0.3714
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0159 0.0357
Echinococcus multilocularis heat shock protein 0.0093 0.0874 0.0856
Echinococcus multilocularis tar DNA binding protein 0.0132 0.1331 0.1314
Brugia malayi isocitrate dehydrogenase 0.0032 0.0159 0.0275
Trypanosoma cruzi heat shock protein 85, putative 0.0093 0.0874 1
Plasmodium falciparum casein kinase II beta chain 0.0044 0.03 0.0719
Entamoeba histolytica hypothetical protein 0.0037 0.0214 0.2268
Giardia lamblia Heat shock protein HSP 90-alpha 0.0093 0.0874 1
Loa Loa (eye worm) hypothetical protein 0.0064 0.0534 0.0888
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0044 0.03 0.3281
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0159 0.0275
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0214 0.051
Loa Loa (eye worm) heat shock protein 75 0.0062 0.0508 0.0843
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0051 0.0053
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0159 0.0139
Brugia malayi Pre-SET motif family protein 0.0224 0.2405 0.4141
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0214 0.0194
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0088 0.0807 0.9215
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0044 0.03 0.3281
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.1197 0.2033
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0062 0.0508 0.1337
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0548 0.671
Trypanosoma brucei importin beta-1 subunit, putative 0.0031 0.0147 0.1479
Brugia malayi Importin beta-1 subunit 0.0031 0.0147 0.0252
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0159 0.0139
Leishmania major heat shock protein 83-1 0.0093 0.0874 1
Trypanosoma cruzi heat shock protein 85, putative 0.0093 0.0874 1
Schistosoma mansoni tar DNA-binding protein 0.0132 0.1331 0.3453
Brugia malayi RNA recognition motif domain containing protein 0.0132 0.1331 0.2292
Schistosoma mansoni ran 0.0023 0.0051 0.008
Trypanosoma brucei heat shock protein 84, putative 0.0062 0.0508 0.5712
Brugia malayi Pre-SET motif family protein 0.0032 0.0159 0.0274
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0146 0.0301
Giardia lamblia Grp94/Hsp90 0.0088 0.0807 0.9215
Entamoeba histolytica hypothetical protein 0.0037 0.0214 0.2268
Trypanosoma brucei heat shock protein 90, putative 0.0093 0.0874 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0159 0.0367
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0078 0.021
Echinococcus granulosus heat shock protein 0.0093 0.0874 0.205
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.008 0.0717 0.1672
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.0548 0.671
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0064 0.0534 0.092
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0051 0.0087
Loa Loa (eye worm) hypothetical protein 0.0032 0.0159 0.024
Plasmodium vivax casein kinase II beta chain, putative 0.0044 0.03 0.0719
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0051 0.0356
Brugia malayi MH2 domain containing protein 0.0121 0.1197 0.2061
Schistosoma mansoni heat shock protein 0.0093 0.0874 0.2249
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0159 0.0139
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0159 0.0366
Trypanosoma brucei heat shock protein, putative 0.0093 0.0874 1
Plasmodium falciparum endoplasmin, putative 0.0068 0.0575 0.1423
Entamoeba histolytica Ran family GTPase 0.0023 0.0051 0.0356
Leishmania major heat shock protein 83-1 0.0093 0.0874 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0159 0.0334
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0159 0.0366
Trichomonas vaginalis ran, putative 0.0023 0.0051 0.0111
Plasmodium vivax heat shock protein 90, putative 0.0062 0.0508 0.1252
Trypanosoma brucei heat shock protein, putative 0.0093 0.0874 1
Loa Loa (eye worm) hypothetical protein 0.0515 0.5808 1
Brugia malayi latrophilin 2 splice variant baaae 0.0139 0.1406 0.2421
Leishmania major heat shock protein 83-1 0.0093 0.0874 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.03 0.102
Plasmodium falciparum casein kinase II beta chain 0.0044 0.03 0.0719
Trypanosoma brucei heat shock protein, putative 0.0093 0.0874 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0159 0.163
Brugia malayi RNA, U transporter 1 0.0088 0.0816 0.1406
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0377 0.4186 1
Echinococcus granulosus heat shock protein 90 0.0093 0.0874 0.205
Loa Loa (eye worm) Csnk2b protein 0.0044 0.03 0.0484
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0548 0.1391
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0159 0.0366
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0078 0.0675
Plasmodium vivax endoplasmin, putative 0.0093 0.0874 0.2191
Leishmania major heat shock protein, putative 0.0062 0.0508 0.5712
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0044 0.03 0.3281
Brugia malayi Latrophilin receptor protein 2 0.0064 0.0534 0.092
Trichomonas vaginalis heat shock protein, putative 0.0068 0.0575 0.2019
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0119 0.0253
Entamoeba histolytica hypothetical protein 0.0037 0.0214 0.2268
Trichomonas vaginalis set domain proteins, putative 0.0255 0.2768 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.03 0.102
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.03 0.102
Echinococcus granulosus importin subunit beta 1 0.0031 0.0147 0.0303
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0051 0.0356
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0064 0.0534 0.0515
Echinococcus granulosus endoplasmin 0.0088 0.0807 0.1889
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.03 0.102
Leishmania major heat shock protein 83-1 0.0093 0.0874 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0078 0.021
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0548 0.671
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0051 0.0078
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0044 0.03 0.0719
Plasmodium vivax importin-beta 2, putative 0.0031 0.0147 0.0324
Loa Loa (eye worm) heat shock protein 90 0.0093 0.0874 0.1475
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.03 0.102
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0159 0.0241
Schistosoma mansoni casein kinase II beta subunit 0.0044 0.03 0.0738
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0044 0.03 0.3281
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0159 0.0357
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0088 0.0807 1
Schistosoma mansoni hypothetical protein 0.0139 0.1406 0.3649
Leishmania major GTP-binding protein, putative 0.0023 0.0051 0.0356
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0332 0.3662 0.6291
Brugia malayi Csnk2b protein 0.0044 0.03 0.0517
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0078 0.021
Schistosoma mansoni tar DNA-binding protein 0.0132 0.1331 0.3453
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0159 0.0139
Schistosoma mansoni hypothetical protein 0.0332 0.3662 0.9589
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0119 0.1155
Echinococcus multilocularis endoplasmin 0.0088 0.0807 0.0789
Trypanosoma brucei heat shock protein 90, putative 0.0093 0.0874 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0051 0.0356
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0159 0.0139
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0119 0.1155
Trichomonas vaginalis heat shock protein, putative 0.0093 0.0874 0.3108
Leishmania major heat shock protein 83-1 0.0093 0.0874 1
Plasmodium vivax casein kinase II beta chain, putative 0.0044 0.03 0.0719
Brugia malayi TAR-binding protein 0.0132 0.1331 0.2292
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0051 0.003
Trichomonas vaginalis heat shock protein, putative 0.0088 0.0807 0.2864
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0051 0.0078
Leishmania major heat shock protein 83-1 0.0093 0.0874 1
Schistosoma mansoni tar DNA-binding protein 0.0132 0.1331 0.3453
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.03 0.102
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0062 0.0508 0.1171
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.03 0.102
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0214 0.0465
Echinococcus granulosus casein kinase ii subunit beta 0.0044 0.03 0.0673
Schistosoma mansoni heat shock protein 0.0093 0.0874 0.2249
Echinococcus multilocularis heat shock protein 90 0.0093 0.0874 0.0856
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0159 0.163
Loa Loa (eye worm) hypothetical protein 0.0029 0.0119 0.017
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.002 0.0035
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0159 0.163
Brugia malayi Hsp90 protein 0.0062 0.0508 0.0875
Schistosoma mansoni endoplasmin 0.0093 0.0874 0.2249
Plasmodium falciparum heat shock protein 90, putative 0.0354 0.3918 1
Leishmania major heat shock protein 83-1 0.0093 0.0874 1
Echinococcus granulosus heat shock protein 90 0.008 0.0717 0.1672
Echinococcus multilocularis casein kinase ii subunit beta 0.0044 0.03 0.0281
Schistosoma mansoni hypothetical protein 0.0064 0.0534 0.1354
Trichomonas vaginalis endoplasmin, putative 0.0068 0.0575 0.2019
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0159 0.0357
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0044 0.03 0.3281
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0044 0.03 0.0541
Trypanosoma brucei heat shock protein, putative 0.0093 0.0874 1
Schistosoma mansoni tar DNA-binding protein 0.0132 0.1331 0.3453
Leishmania major heat shock protein 83-1 0.0093 0.0874 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.03 0.102
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0119 0.0253
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.03 0.102
Treponema pallidum heat shock protein 90 0.0088 0.0807 1
Schistosoma mansoni ran 0.0023 0.0051 0.008
Schistosoma mansoni heat shock protein 0.0062 0.0508 0.1285
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0159 0.0334
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0119 0.0253
Leishmania major heat shock protein 83-1 0.0093 0.0874 1
Brugia malayi hypothetical protein 0.0029 0.0119 0.0205
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0159 0.0139
Echinococcus multilocularis snurportin 1 0.0332 0.3662 0.3649
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0159 0.1769
Schistosoma mansoni hypothetical protein 0.0064 0.0534 0.1354
Trypanosoma brucei heat shock protein, putative 0.0093 0.0874 1
Trichomonas vaginalis heat shock protein, putative 0.0054 0.0418 0.1446
Echinococcus multilocularis GPCR, family 2 0.0064 0.0534 0.0515
Leishmania major heat shock protein 83-1 0.0093 0.0874 1
Leishmania major heat shock protein 83-1 0.0093 0.0874 1
Brugia malayi Endoplasmin precursor 0.0093 0.0874 0.1505
Leishmania major heat shock protein 83-1 0.0093 0.0874 1
Trypanosoma brucei heat shock protein, putative 0.0093 0.0874 1
Schistosoma mansoni hypothetical protein 0.0037 0.0214 0.051
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0224 0.2405 0.4121
Brugia malayi RNA binding protein 0.0132 0.1331 0.2292
Brugia malayi hypothetical protein 0.0037 0.0214 0.0368
Plasmodium falciparum heat shock protein 90, putative 0.0054 0.0418 0.1019
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0159 0.163
Loa Loa (eye worm) RNA binding protein 0.0132 0.1331 0.2265
Loa Loa (eye worm) hypothetical protein 0.0031 0.0147 0.0218
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0062 0.0508 0.0489
Schistosoma mansoni endoplasmin 0.0093 0.0874 0.2249
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.03 0.102
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0377 0.4186 0.4174
Echinococcus granulosus geminin 0.0345 0.3818 0.9117
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.03 0.102
Schistosoma mansoni importin beta-1 0.0031 0.0147 0.0333
Entamoeba histolytica heat shock protein 90, putative 0.0093 0.0874 1
Trichomonas vaginalis heat shock protein, putative 0.0088 0.0807 0.2864
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0044 0.03 0.3281
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0515 0.5808 1
Trypanosoma cruzi heat shock protein, putative 0.0062 0.0508 0.5712
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0132 0.1331 0.2265
Schistosoma mansoni hypothetical protein 0.0064 0.0534 0.1354
Plasmodium vivax SET domain protein, putative 0.0032 0.0159 0.0357
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0051 0.0356
Trichomonas vaginalis casein kinase II beta chain, putative 0.0044 0.03 0.102
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.1197 0.2033
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0159 0.0357

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 2.5 uM Inhibition of human recombinant CK2 assessed as inhibition of [gamma33P]ATP incorporation into substrate by luminescence assay ChEMBL. 21174434

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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