TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 334.408 | Formula: C22H22O3
H donors: 0 H acceptors: 1 LogP: 4.37 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: O=C1C[C@@H](CC(=C1)c1c(C)cc(cc1C)C)c1ccc2c(c1)OCO2
InChi: 1S/C22H22O3/c1-13-6-14(2)22(15(3)7-13)18-8-17(9-19(23)10-18)16-4-5-20-21(11-16)25-12-24-20/h4-7,10-11,17H,8-9,12H2,1-3H3/t17-/m1/s1
InChiKey: PYNKHNOLCHSTQI-QGZVFWFLSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references
Homo sapiens	TAR DNA binding protein	Starlite/ChEMBL	No references
Human immunodeficiency virus 1	Aberrant vpr protein	Starlite/ChEMBL	No references
Homo sapiens	ATPase family, AAA domain containing 5	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Brugia malayi	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Echinococcus granulosus	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	RNA recognition motif domain containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	Get druggable targets OG5_139225	All targets in OG5_139225

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0091	0.0852	0.6092
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.013	0.0928
Schistosoma mansoni	smad1 5 8 and	0.001	0.0015	0.0033
Schistosoma mansoni	smad	0.001	0.0015	0.0033
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0207	1
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0023	0.0155	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0023	0.0155	1
Brugia malayi	Animal haem peroxidase family protein	0.0026	0.0182	0.1298
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0016	0.0075	0.017
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.013	0.7152
Leishmania major	importin beta-1 subunit, putative	0.0023	0.0152	0.9586
Brugia malayi	RNA binding protein	0.0076	0.0701	0.5015
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0084	0.1199
Brugia malayi	Animal haem peroxidase family protein	0.0026	0.0182	0.1298
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0182	0.0595
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0016	0.0075	0.0075
Brugia malayi	hypothetical protein	0.0026	0.0182	0.1298
Brugia malayi	TAR-binding protein	0.0076	0.0701	0.5015
Echinococcus granulosus	Smad4	0.001	0.0015	0.0048
Trichomonas vaginalis	importin beta-1, putative	0.0023	0.0152	1
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0021	0.013	0.6257
Brugia malayi	Hypothetical tyrosinase-like protein F21C3.2 in chromosome I	0.0091	0.0852	0.6092
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0155	1
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0075	0.0075
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0021	0.013	0.416
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0182	0.0595
Brugia malayi	MH2 domain containing protein	0.001	0.0015	0.0104
Echinococcus multilocularis	isocitrate dehydrogenase	0.0016	0.0075	0.0075
Onchocerca volvulus		0.0026	0.0182	0.2131
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0155	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0084	0.1199
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.001	0.0015	0.0015
Schistosoma mansoni	peroxidasin	0.0026	0.0182	0.0415
Schistosoma mansoni	peroxidasin	0.0026	0.0182	0.0415
Mycobacterium ulcerans	hypothetical protein	0.0023	0.0155	1
Onchocerca volvulus		0.0091	0.0852	1
Onchocerca volvulus	Peroxidase homolog	0.0026	0.0182	0.2131
Loa Loa (eye worm)	RNA binding protein	0.0076	0.0701	0.2297
Onchocerca volvulus		0.0023	0.0155	0.1822
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0023	0.0155	1
Loa Loa (eye worm)	tyrosinase 1	0.0091	0.0852	0.279
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0701	0.1604
Leishmania major	GTP-binding protein, putative	0.0021	0.013	0.6856
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0155	0.0508
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0023	0.0155	1
Onchocerca volvulus		0.0026	0.0182	0.2131
Loa Loa (eye worm)	ShTK domain-containing protein	0.0091	0.0852	0.279
Plasmodium vivax	acyl-CoA synthetase, putative	0.0018	0.0094	0.147
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0155	1
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0701	0.1604
Echinococcus multilocularis	Smad4	0.001	0.0015	0.0015
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0084	0.1199
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0182	0.0595
Schistosoma mansoni	Smad4	0.001	0.0015	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0182	0.0595
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0182	0.0595
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0094	0.0308
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.013	0.0425
Onchocerca volvulus	Peroxidase homolog	0.0026	0.0182	0.2131
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0094	0.0308
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0023	0.0155	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0155	1
Echinococcus granulosus	smad	0.001	0.0015	0.0048
Schistosoma mansoni	smad1 5 8 and	0.001	0.0015	0.0033
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0701	0.1604
Brugia malayi	Animal haem peroxidase family protein	0.0026	0.0182	0.1298
Entamoeba histolytica	acyl-coA synthetase, putative	0.0023	0.0155	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0155	1
Loa Loa (eye worm)	Smad1	0.001	0.0015	0.0048
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0016	0.0075	0.0244
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0182	0.0595
Toxoplasma gondii	HEAT repeat-containing protein	0.0029	0.0207	1
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0094	0.0308
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0075	0.0075
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.0701	0.2297
Brugia malayi	Animal haem peroxidase family protein	0.0026	0.0182	0.1298
Plasmodium falciparum	acyl-CoA synthetase	0.0018	0.0094	0.147
Entamoeba histolytica	hypothetical protein	0.0023	0.0152	0.8684
Onchocerca volvulus	Peroxidasin homolog	0.0026	0.0182	0.2131
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0182	0.0595
Echinococcus multilocularis	importin subunit beta 1	0.0029	0.0207	0.0207
Brugia malayi	Common central domain of tyrosinase family protein	0.0091	0.0852	0.6092
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0155	0.0508
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0155	0.111
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.1398	0.458
Echinococcus granulosus	mothers against decapentaplegic 5	0.001	0.0015	0.0048
Loa Loa (eye worm)	animal heme peroxidase	0.0026	0.0182	0.0595
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.0084	0.1199
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.013	0.0425
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0182	0.0595
Onchocerca volvulus	Peroxidasin homolog	0.0026	0.0182	0.2131
Loa Loa (eye worm)	animal heme peroxidase	0.0026	0.0182	0.0595
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0182	0.0595
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0094	0.0308
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0021	0.013	0.416
Echinococcus granulosus	snurportin 1	0.0305	0.3053	1
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0016	0.0075	0.0075
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.0094	0.2422
Schistosoma mansoni	smad1 5 8 and	0.001	0.0015	0.0033
Echinococcus granulosus	peroxidasin	0.0026	0.0182	0.0595
Brugia malayi	Isocitrate dehydrogenase	0.0016	0.0075	0.0533
Schistosoma mansoni	tyrosinase precursor	0.0433	0.4371	1
Plasmodium vivax	importin-beta 2, putative	0.0029	0.0207	1
Loa Loa (eye worm)	blistered cuticle protein 3	0.0026	0.0182	0.0595
Onchocerca volvulus		0.0091	0.0852	1
Echinococcus granulosus	importin subunit beta 1	0.0029	0.0207	0.068
Loa Loa (eye worm)	ShTK domain-containing protein	0.0091	0.0852	0.279
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0018	0.0094	0.5
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0182	0.0595
Schistosoma mansoni	importin beta-1	0.0029	0.0207	0.0475
Onchocerca volvulus		0.0091	0.0852	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0182	0.0595
Brugia malayi	Importin beta-1 subunit	0.0029	0.0207	0.1484
Brugia malayi	MH2 domain containing protein	0.001	0.0015	0.0104
Brugia malayi	ShTK domain containing protein	0.0091	0.0852	0.6092
Toxoplasma gondii	isocitrate dehydrogenase	0.0016	0.0075	0.3592
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0207	0.068
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0155	0.111
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0182	0.0595
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0152	1
Loa Loa (eye worm)	MH1 domain-containing protein	0.001	0.0015	0.0048
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.0701	0.5015
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0023	0.0152	1
Brugia malayi	Blistered cuticle protein 3	0.0026	0.0182	0.1298
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0023	0.0155	1
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.013	0.013
Echinococcus multilocularis	tar DNA binding protein	0.0076	0.0701	0.0701
Loa Loa (eye worm)	animal heme peroxidase	0.0026	0.0182	0.0595
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0182	0.0595
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0021	0.013	1
Toxoplasma gondii	isocitrate dehydrogenase	0.0016	0.0075	0.3592
Schistosoma mansoni	ran	0.0021	0.013	0.0297
Schistosoma mansoni	ran	0.0021	0.013	0.0297
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0023	0.0155	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.1398	0.458
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0155	0.0508
Echinococcus granulosus	TGF beta signal transducer SmadC	0.001	0.0015	0.0048
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0852	0.279
Brugia malayi	MH2 domain containing protein	0.0144	0.1398	1
Schistosoma mansoni	tyrosinase precursor	0.0433	0.4371	1
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0305	0.3053	1
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.001	0.0015	0.0033
Echinococcus multilocularis	peroxidasin	0.0026	0.0182	0.0182
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0016	0.0075	0.0244
Leishmania major	4-coumarate:coa ligase-like protein	0.0023	0.0155	1
Brugia malayi	MH1 domain containing protein	0.001	0.0015	0.0104
Onchocerca volvulus		0.0026	0.0182	0.2131
Echinococcus granulosus	tar DNA binding protein	0.0076	0.0701	0.2297
Brugia malayi	MH1 domain containing protein	0.001	0.0015	0.0104
Brugia malayi	Peroxidasin	0.0026	0.0182	0.1298
Echinococcus multilocularis	snurportin 1	0.0305	0.3053	0.3053
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0852	0.279
Mycobacterium ulcerans	acyl-CoA synthetase	0.0023	0.0155	1
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0701	0.1604
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0207	1
Plasmodium falciparum	importin beta, putative	0.0029	0.0207	1
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0701	0.1604
Schistosoma mansoni	hypothetical protein	0.0305	0.3053	0.6985
Brugia malayi	Animal haem peroxidase family protein	0.0026	0.0182	0.1298
Brugia malayi	AMP-binding enzyme family protein	0.0023	0.0155	0.111
Loa Loa (eye worm)	animal heme peroxidase	0.0026	0.0182	0.0595
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0094	0.0308
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.0701	0.2297
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0091	0.0852	0.6092
Loa Loa (eye worm)	MH2 domain-containing protein	0.001	0.0015	0.0048
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0091	0.0852	0.6092
Brugia malayi	isocitrate dehydrogenase	0.0016	0.0075	0.0533
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0155	0.5
Onchocerca volvulus		0.0091	0.0852	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0182	0.0595
Onchocerca volvulus	Dual oxidase homolog	0.0026	0.0182	0.2131
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0021	0.013	0.416
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0023	0.0152	1
Echinococcus multilocularis	smad	0.001	0.0015	0.0015
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0021	0.013	0.7152
Onchocerca volvulus	Chorion peroxidase homolog	0.0026	0.0182	0.2131
Echinococcus multilocularis	mothers against decapentaplegic 5	0.001	0.0015	0.0015
Brugia malayi	Smad1	0.001	0.0015	0.0104
Brugia malayi	RNA, U transporter 1	0.0081	0.075	0.5361
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0023	0.0155	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	1.6511 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	15.8489 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	16.3535 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125]	ChEMBL.	No reference
Potency (functional)	17.7828 uM	PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	112.2018 uM	PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1699423

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1499645