TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 357.877 | Formula: C20H24ClN3O
H donors: 1 H acceptors: 1 LogP: 3.44 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CC(=O)Nc1cccc(c1)N1CC[N+]2(CC1)CCc1c2cccc1.[Cl-]
InChi: 1S/C20H23N3O.ClH/c1-16(24)21-18-6-4-7-19(15-18)22-10-13-23(14-11-22)12-9-17-5-2-3-8-20(17)23;/h2-8,15H,9-14H2,1H3;1H
InChiKey: KQUDMPIZCOILTK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0425	0.1748
Echinococcus granulosus	cathepsin l1	0.0026	0.0905	0.0838
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0905	0.372
Loa Loa (eye worm)	glutathione reductase	0.0037	0.1567	0.1854
Echinococcus multilocularis	cathepsin L cysteine protease	0.0026	0.0905	0.0838
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0905	0.372
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0051	0.2432	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0425	0.1748
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0025	0.0852	0.3505
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0026	0.0905	0.1041
Mycobacterium tuberculosis	Probable oxidoreductase	0.0094	0.5077	1
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0905	0.0993
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0019	0.0425	0.1492
Leishmania major	trypanothione reductase	0.0037	0.1567	0.6332
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0019	0.0425	0.1492
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0044	0.1977	0.8129
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0905	0.372
Trypanosoma cruzi	cruzipain precursor, putative	0.0026	0.0905	0.1041
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0142	0.8062	0.8048
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0019	0.0425	0.1748
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0905	0.372
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0026	0.0905	0.0838
Leishmania major	cathepsin L-like protease	0.0026	0.0905	0.3525
Plasmodium vivax	vivapain-2	0.0026	0.0905	0.4368
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0149	0.845	0.8438
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0905	0.372
Trypanosoma cruzi	cysteine peptidase, putative	0.0026	0.0905	0.1041
Schistosoma mansoni	hypothetical protein	0.0174	1	1
Schistosoma mansoni	cathepsin F (C01 family)	0.0026	0.0905	0.0838
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0905	0.0993
Brugia malayi	hypothetical protein	0.0126	0.7031	0.8306
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0905	0.372
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0013	0.0073	0.5
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0019	0.0425	0.1748
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0905	0.372
Plasmodium vivax	vivapain-2	0.0026	0.0905	0.4368
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0094	0.5077	1
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0044	0.1977	0.8129
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0026	0.0905	0.372
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0051	0.2432	0.2953
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0905	0.0993
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0425	0.1748
Trypanosoma cruzi	cysteine peptidase, putative	0.0026	0.0905	0.1041
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0019	0.0425	0.0354
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0025	0.0852	0.0785
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0142	0.8062	0.8048
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0013	0.0073	0.0301
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0425	0.1748
Echinococcus multilocularis	geminin	0.0174	1	1
Loa Loa (eye worm)	hypothetical protein	0.0126	0.7031	0.8321
Entamoeba histolytica	cysteine proteinase, putative	0.0026	0.0905	0.3614
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0019	0.0425	0.0354
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0026	0.0905	0.0993
Schistosoma mansoni	hypothetical protein	0.0174	1	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0905	0.372
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0425	0.1748
Trypanosoma cruzi	target of rapamycin kinase 3	0.0019	0.0425	0.044
Entamoeba histolytica	cysteine proteinase, putative	0.0026	0.0905	0.3614
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0084	0.4495	0.8837
Plasmodium falciparum	glutathione reductase	0.0037	0.1567	0.8894
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0905	0.372
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0084	0.4495	0.8837
Echinococcus multilocularis	cathepsin b	0.0142	0.8062	0.8048
Entamoeba histolytica	cysteine proteinase, putative	0.0026	0.0905	0.3614
Echinococcus granulosus	thioredoxin glutathione reductase	0.0038	0.1597	0.1536
Leishmania major	cathepsin L-like protease	0.0026	0.0905	0.3525
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0905	0.0993
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0425	0.1748
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0425	0.1748
Brugia malayi	Thioredoxin reductase	0.0037	0.1567	0.1783
Toxoplasma gondii	cathepsin B	0.0051	0.2432	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0905	0.372
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0425	0.1748
Echinococcus multilocularis	serine protein kinase ATM	0.0025	0.0852	0.0785
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0425	0.1748
Entamoeba histolytica	acetyltransferase, GNAT family	0.004	0.1753	1
Echinococcus granulosus	cathepsin b	0.0142	0.8062	0.8048
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0019	0.0425	0.1748
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0425	0.1748
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0905	0.372
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0425	0.1748
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0019	0.0425	0.044
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0019	0.0425	0.1492
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0905	0.372
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0019	0.0425	0.0354
Echinococcus granulosus	serine protein kinase ATM	0.0025	0.0852	0.0785
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0905	0.372
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0905	0.372
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0013	0.0073	0.0301
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0026	0.0905	0.0838
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0905	0.372
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0051	0.2432	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0905	0.372
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0905	0.0993
Leishmania major	cathepsin L-like protease	0.0026	0.0905	0.3525
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0905	0.1071
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0905	0.372
Plasmodium falciparum	thioredoxin reductase	0.0037	0.1567	0.8894
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0019	0.0425	0.042
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0425	0.1748
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0905	0.372
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0425	0.1748
Giardia lamblia	Histone acetyltransferase GCN5	0.004	0.1753	0.7119
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0019	0.0425	0.1748
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0051	0.2432	1
Giardia lamblia	Cathepsin B precursor	0.0051	0.2432	1
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0013	0.0073	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0905	0.372
Trypanosoma brucei	trypanothione reductase	0.0037	0.1567	0.6442
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0094	0.5077	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0425	0.1748
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0425	0.1748
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0084	0.4495	0.8837
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0425	0.1748
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0019	0.0427	0.0443
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0013	0.0073	0.5
Brugia malayi	cathepsin L-like precursor	0.0026	0.0905	0.0993
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0026	0.0905	0.4952
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0425	0.1748
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0026	0.0905	0.0838
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0013	0.0073	0.0301
Mycobacterium tuberculosis	Probable dehydrogenase	0.0084	0.4495	0.8837
Trichomonas vaginalis	mercuric reductase, putative	0.0013	0.0073	0.0301
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0905	0.372
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0905	0.372
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0019	0.0425	0.0354
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0425	0.1748
Mycobacterium tuberculosis	Probable reductase	0.0084	0.4495	0.8837
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0026	0.0905	0.4952
Loa Loa (eye worm)	ctsf protein	0.0026	0.0905	0.1071
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0905	0.372
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0149	0.845	0.8438
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0425	0.1748
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0038	0.1597	0.1536
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0051	0.2432	0.2376
Loa Loa (eye worm)	phosphatidylinositol 3	0.0019	0.0425	0.0503
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0905	0.0993
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0019	0.0425	0.044
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0425	0.1748
Echinococcus granulosus	cathepsin b	0.0142	0.8062	0.8048
Loa Loa (eye worm)	cysteine protease	0.0026	0.0905	0.1071
Trypanosoma cruzi	trypanothione reductase, putative	0.0037	0.1567	0.187
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0019	0.0425	0.042
Loa Loa (eye worm)	fibroinase	0.0026	0.0905	0.1071
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0905	0.372
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0905	0.372
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0013	0.0073	0.0301
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0044	0.1977	0.1918
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0025	0.0852	0.0975
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0019	0.0425	0.0354
Entamoeba histolytica	cysteine protease, putative	0.0026	0.0905	0.3614
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0044	0.1977	1
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0013	0.0073	0.5
Echinococcus multilocularis	cysteine protease	0.0026	0.0905	0.0838
Leishmania major	cathepsin L-like protease	0.0026	0.0905	0.3525
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0905	0.372
Trypanosoma cruzi	cysteine peptidase, putative	0.0026	0.0905	0.1041
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0144	0.8192	0.8179
Loa Loa (eye worm)	acetyltransferase	0.0149	0.845	1
Entamoeba histolytica	hypothetical protein	0.0025	0.0852	0.3219
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0019	0.0425	0.0354
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0013	0.0073	0.0301
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0026	0.0905	0.372
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0019	0.0427	0.1501
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0142	0.8062	0.8048
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0425	0.1748
Toxoplasma gondii	thioredoxin reductase	0.0037	0.1567	0.6442
Toxoplasma gondii	NADPH-glutathione reductase	0.0013	0.0073	0.0301
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0905	0.372
Onchocerca volvulus	Huntingtin homolog	0.0126	0.7031	1
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0084	0.4495	0.8837
Plasmodium vivax	thioredoxin reductase, putative	0.0037	0.1567	0.7845
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0013	0.0073	0.5
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0905	0.0993
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0905	0.372
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0019	0.0425	0.044
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0425	0.1748
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0022	0.0632	0.07
Brugia malayi	acetyltransferase, GNAT family protein	0.0149	0.845	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0026	0.0905	0.4952
Leishmania major	cathepsin L-like protease	0.0026	0.0905	0.3525
Loa Loa (eye worm)	thioredoxin reductase	0.0037	0.1567	0.1854
Schistosoma mansoni	cathepsin F (C01 family)	0.0026	0.0905	0.0838
Brugia malayi	cathepsin B-like cysteine proteinase	0.0142	0.8062	0.9538
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0905	0.372
Giardia lamblia	Cathepsin B precursor	0.0051	0.2432	1
Loa Loa (eye worm)	cathepsin B	0.0051	0.2432	0.2879
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0037	0.1567	0.2985
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0425	0.1748
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0905	0.372
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0425	0.1748
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0044	0.1977	0.8129
Brugia malayi	glutathione reductase	0.0037	0.1567	0.1783
Treponema pallidum	NADH oxidase	0.0013	0.0073	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0905	0.372
Toxoplasma gondii	FATC domain-containing protein	0.0025	0.0852	0.3505
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0026	0.0905	0.0838
Echinococcus multilocularis	cathepsin L cysteine protease	0.0026	0.0905	0.0838
Brugia malayi	Papain family cysteine protease containing protein	0.0026	0.0905	0.0993
Plasmodium falciparum	histone acetyltransferase GCN5	0.004	0.1753	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0905	0.372
Giardia lamblia	Cathepsin B precursor	0.0051	0.2432	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0026	0.0905	0.1041
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0094	0.5077	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0905	0.372
Trichomonas vaginalis	glutathione reductase, putative	0.0013	0.0073	0.0301
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0905	0.1071
Echinococcus multilocularis	cathepsin b	0.0142	0.8062	0.8048
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0425	0.1748
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0425	0.1748
Leishmania major	cathepsin L-like protease	0.0026	0.0905	0.3525
Plasmodium vivax	glutathione reductase, putative	0.0037	0.1567	0.7845
Leishmania major	cysteine peptidase A (CPA)	0.0026	0.0905	0.3525
Loa Loa (eye worm)	hypothetical protein	0.0126	0.7031	0.8321
Toxoplasma gondii	cathepsin CPL	0.0026	0.0905	0.372
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0142	0.8062	1
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0013	0.0073	0.5
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0019	0.0425	0.1492
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0905	0.1071
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0632	0.0748
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0019	0.0425	0.1492
Echinococcus granulosus	cathepsin l1	0.0026	0.0905	0.0838
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0019	0.0425	0.044
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0425	0.1748
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0026	0.0905	0.1071
Giardia lamblia	GTOR	0.0019	0.0425	0.1492
Brugia malayi	Cathepsin L-like precursor	0.0026	0.0905	0.0993
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0905	0.372
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0026	0.0905	0.372
Loa Loa (eye worm)	hypothetical protein	0.0142	0.8062	0.9542
Leishmania major	cathepsin L-like protease	0.0026	0.0905	0.3525
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0026	0.0905	0.372
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0026	0.0905	0.1071
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0026	0.0905	0.372
Leishmania major	cathepsin L-like protease	0.0026	0.0905	0.3525
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0044	0.1977	0.8129
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0025	0.0852	0.093
Schistosoma mansoni	cathepsin F (C01 family)	0.0026	0.0905	0.0838
Loa Loa (eye worm)	phosphatidylinositol 3	0.0019	0.0425	0.0503
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0425	0.1748
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0019	0.0425	0.1748
Echinococcus multilocularis	cysteine protease	0.0026	0.0905	0.0838
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0019	0.0425	0.1748
Onchocerca volvulus	Huntingtin homolog	0.0126	0.7031	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0019	0.0425	0.1748
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0142	0.8062	0.8048
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0905	0.1071
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0025	0.0852	0.3505

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 39 %	Analgesic activity in mouse assessed as inhibition of acetic acid-induced writhing at 20 umol/kg, sc administered 30 mins before to acetic acid challenge measured after 5 mins for 10 mins relative to control	ChEMBL.	21216141

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1669089

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1503172