Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.0948 | 0.0948 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.0012 | 0.0012 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0087 | 0.0948 | 0.5 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0087 | 0.0948 | 0.0948 |
Plasmodium falciparum | amino acid transporter, putative | 0.0087 | 0.0948 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0087 | 0.0948 | 0.0948 |
Echinococcus granulosus | acetylcholinesterase | 0.0113 | 0.1504 | 0.1504 |
Brugia malayi | Carboxylesterase family protein | 0.0113 | 0.1504 | 0.1504 |
Loa Loa (eye worm) | hypothetical protein | 0.051 | 1 | 1 |
Plasmodium vivax | amine transporter, putative | 0.0087 | 0.0948 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0113 | 0.1504 | 0.1504 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.051 | 1 | 0.5 |
Brugia malayi | hypothetical protein | 0.0043 | 0.0012 | 0.0012 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0113 | 0.1504 | 0.1504 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0087 | 0.0948 | 0.0948 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0113 | 0.1504 | 0.1504 |
Echinococcus multilocularis | uncharacterized sodium dependent transporter | 0.0087 | 0.0948 | 0.0948 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0087 | 0.0948 | 0.0948 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0012 | 0.5 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.0087 | 0.0948 | 0.0948 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0087 | 0.0948 | 0.0948 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.0948 | 0.0948 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0012 | 0.0012 |
Loa Loa (eye worm) | serotonin transporter b | 0.051 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0113 | 0.1504 | 0.1504 |
Echinococcus multilocularis | sodium:chloride dependent neurotransmitter | 0.0087 | 0.0948 | 0.0948 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.0948 | 0.0948 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0087 | 0.0948 | 0.0948 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.0948 | 0.0948 |
Loa Loa (eye worm) | hypothetical protein | 0.051 | 1 | 1 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0087 | 0.0948 | 0.0948 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0012 | 0.5 |
Brugia malayi | Sodium:neurotransmitter symporter family protein 1, putative | 0.0087 | 0.0948 | 0.0948 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0087 | 0.0948 | 0.0948 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0087 | 0.0948 | 0.0948 |
Onchocerca volvulus | 0.051 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.027 | 0.487 | 0.487 |
Brugia malayi | NNMT/PNMT/TEMT family protein | 0.027 | 0.487 | 0.487 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.1504 | 0.1504 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0087 | 0.0948 | 0.5 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.051 | 1 | 1 |
Echinococcus multilocularis | serotonin transporter | 0.051 | 1 | 1 |
Echinococcus granulosus | serotonin transporter | 0.051 | 1 | 1 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0087 | 0.0948 | 0.0948 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0087 | 0.0948 | 0.0948 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0012 | 0.5 |
Loa Loa (eye worm) | norepinephrine transporter | 0.051 | 1 | 1 |
Onchocerca volvulus | 0.0087 | 0.0948 | 0.0948 | |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0087 | 0.0948 | 0.0948 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.0087 | 0.0948 | 0.0948 |
Echinococcus granulosus | sodium:chloride dependent neurotransmitter | 0.0087 | 0.0948 | 0.0948 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.0087 | 0.0948 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.027 | 0.487 | 0.487 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0113 | 0.1504 | 0.1504 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0087 | 0.0948 | 0.0948 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0087 | 0.0948 | 0.0948 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.0087 | 0.0948 | 0.0948 |
Toxoplasma gondii | hypothetical protein | 0.0087 | 0.0948 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.0948 | 0.0948 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0012 | 0.5 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.0087 | 0.0948 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.051 | 1 | 1 |
Onchocerca volvulus | 0.0087 | 0.0948 | 0.0948 | |
Echinococcus multilocularis | sodium dependent neurotransmitter transporter | 0.0087 | 0.0948 | 0.0948 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.0012 | 0.0012 |
Plasmodium vivax | hypothetical protein, conserved | 0.0087 | 0.0948 | 0.5 |
Echinococcus granulosus | sodium dependent neurotransmitter transporter | 0.0087 | 0.0948 | 0.0948 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.0948 | 0.0948 |
Echinococcus granulosus | carboxylesterase 5A | 0.0113 | 0.1504 | 0.1504 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.1504 | 0.1504 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0087 | 0.0948 | 0.0948 |
Brugia malayi | Carboxylesterase family protein | 0.0113 | 0.1504 | 0.1504 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0087 | 0.0948 | 0.0948 |
Onchocerca volvulus | 0.0087 | 0.0948 | 0.0948 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0113 | 0.1504 | 0.1504 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.0087 | 0.0948 | 0.0948 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.051 | 1 | 1 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.0087 | 0.0948 | 0.0948 |
Loa Loa (eye worm) | carboxylesterase | 0.0113 | 0.1504 | 0.1504 |
Schistosoma mansoni | sodium-dependent amino acid transporter | 0.0087 | 0.0948 | 0.0948 |
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.027 | 0.487 | 0.487 |
Brugia malayi | hypothetical protein | 0.0087 | 0.0948 | 0.0948 |
Plasmodium falciparum | transporter, putative | 0.0087 | 0.0948 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0087 | 0.0948 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.0948 | 0.0948 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.0012 | 0.0012 |
Loa Loa (eye worm) | hypothetical protein | 0.051 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 500 uM | Compound was tested for its ability to inhibit the thrombin-induced platelet aggregation in washed human platelets | ChEMBL. | 9873606 |
IC50 (functional) | > 500 uM | Compound was tested for its ability to inhibit the thrombin-induced platelet aggregation in washed human platelets | ChEMBL. | 9873606 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.