Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Candida albicans | beta-1,3-glucan synthase similar to S. cerevisiae GSC2 (YGR032W) and FKS1 (YLR342W) beta-1,3-glucan synthase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0458 | 0.1796 | 0.1628 |
Trypanosoma cruzi | p21-activated kinase 3, putative | 0.019 | 0.0035 | 0.5 |
Echinococcus multilocularis | p21 activated protein kinase 1 Dpak1 | 0.0458 | 0.1796 | 0.1628 |
Trypanosoma cruzi | STE/STE20 serine/threonine-protein kinase, putative | 0.019 | 0.0035 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0273 | 0.0578 | 0.0277 |
Schistosoma mansoni | protein kinase | 0.0458 | 0.1796 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0453 | 0.1762 | 0.1733 |
Trichomonas vaginalis | STE family protein kinase | 0.0458 | 0.1796 | 1 |
Echinococcus multilocularis | PAK box P21 Rho binding | 0.0273 | 0.0578 | 0.0045 |
Entamoeba histolytica | p21-activated kinase | 0.0458 | 0.1796 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0268 | 0.0544 | 0.2889 |
Schistosoma mansoni | protein kinase | 0.0458 | 0.1796 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0268 | 0.0544 | 0.2889 |
Schistosoma mansoni | hypothetical protein | 0.0268 | 0.0544 | 0.2889 |
Schistosoma mansoni | hypothetical protein | 0.0268 | 0.0544 | 0.2889 |
Brugia malayi | P21-Rho-binding domain containing protein | 0.0268 | 0.0544 | 0.0511 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0458 | 0.1796 | 0.218 |
Schistosoma mansoni | wiskott-aldrich syndrome protein | 0.0268 | 0.0544 | 0.2889 |
Toxoplasma gondii | 1,3-beta-glucan synthase component protein | 0.0256 | 0.0468 | 0.5 |
Brugia malayi | P21-Rho-binding domain containing protein | 0.0268 | 0.0544 | 0.0511 |
Echinococcus granulosus | 3'partial|serine:threonine protein kinase PAK 2 | 0.0268 | 0.0544 | 0.066 |
Loa Loa (eye worm) | P21-Rho-binding domain-containing protein | 0.0268 | 0.0544 | 0.0511 |
Trichomonas vaginalis | STE family protein kinase | 0.0273 | 0.0578 | 0.3086 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0458 | 0.1796 | 0.1628 |
Brugia malayi | WH1 domain containing protein | 0.0268 | 0.0544 | 0.0511 |
Echinococcus granulosus | serine:threonine protein kinase PAK 4 | 0.1436 | 0.8238 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0273 | 0.0578 | 0.0277 |
Echinococcus granulosus | p21 activated protein kinase 1 Dpak1 | 0.0458 | 0.1796 | 0.218 |
Entamoeba histolytica | protein kinase, putative | 0.0273 | 0.0578 | 0.0277 |
Trichomonas vaginalis | STE family protein kinase | 0.0458 | 0.1796 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 4 | 0.1436 | 0.8238 | 1 |
Schistosoma mansoni | protein kinase | 0.0268 | 0.0544 | 0.2889 |
Giardia lamblia | Kinase, STE STE20 | 0.0458 | 0.1796 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.0458 | 0.1796 | 1 |
Brugia malayi | Protein kinase domain | 0.0458 | 0.1796 | 0.1768 |
Trichomonas vaginalis | STE family protein kinase | 0.0458 | 0.1796 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0458 | 0.1796 | 0.218 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0453 | 0.1762 | 0.9803 |
Trichomonas vaginalis | STE family protein kinase | 0.0458 | 0.1796 | 1 |
Echinococcus granulosus | neural Wiskott Aldrich syndrome protein | 0.0268 | 0.0544 | 0.066 |
Echinococcus granulosus | PAK box P21 Rho binding | 0.0268 | 0.0544 | 0.066 |
Schistosoma mansoni | tyrosine kinase | 0.0268 | 0.0544 | 0.2889 |
Schistosoma mansoni | protein kinase | 0.0273 | 0.0578 | 0.3086 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.