Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Equus caballus | Butyrylcholinesterase | Starlite/ChEMBL | References |
Electrophorus electricus | Acetylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 633 aa | 620 aa | 28.4 % |
Onchocerca volvulus | Butyrylcholinesterase | 602 aa | 551 aa | 30.1 % | |
Echinococcus multilocularis | neuroligin | Acetylcholinesterase | 633 aa | 507 aa | 23.9 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 633 aa | 517 aa | 25.1 % |
Onchocerca volvulus | Acetylcholinesterase | 633 aa | 648 aa | 25.3 % | |
Onchocerca volvulus | Putative nuclear protein | Butyrylcholinesterase | 602 aa | 573 aa | 41.4 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 633 aa | 597 aa | 25.1 % |
Echinococcus multilocularis | BC026374 protein (S09 family) | Acetylcholinesterase | 633 aa | 690 aa | 32.3 % |
Onchocerca volvulus | Molybdopterin synthase catalytic subunit homolog | Acetylcholinesterase | 633 aa | 576 aa | 28.8 % |
Echinococcus granulosus | BC026374 protein S09 family | Acetylcholinesterase | 633 aa | 690 aa | 31.7 % |
Onchocerca volvulus | Carnitine O-palmitoyltransferase 2, mitochondrial homolog | Butyrylcholinesterase | 602 aa | 554 aa | 35.9 % |
Drosophila melanogaster | CG10175 gene product from transcript CG10175-RE | Acetylcholinesterase | 633 aa | 549 aa | 30.4 % |
Echinococcus granulosus | neuroligin | Butyrylcholinesterase | 602 aa | 492 aa | 24.2 % |
Onchocerca volvulus | Butyrylcholinesterase | 602 aa | 578 aa | 25.4 % | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Acetylcholinesterase | 633 aa | 622 aa | 24.9 % |
Schistosoma mansoni | gliotactin | Butyrylcholinesterase | 602 aa | 587 aa | 28.1 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 633 aa | 576 aa | 23.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | recombinase RecA | 0.0105 | 0.0354 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.0276 | 0.1044 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0164 | 0.0703 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.0703 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.0703 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0136 | 0.0541 | 0.7667 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.0276 | 0.1044 |
Loa Loa (eye worm) | carboxylesterase | 0.0164 | 0.0703 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0158 | 0.0672 | 0.9272 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0158 | 0.0672 | 0.9272 |
Trichomonas vaginalis | hypothetical protein | 0.049 | 0.2641 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0164 | 0.0703 | 1 |
Wolbachia endosymbiont of Brugia malayi | recombinase A | 0.0105 | 0.0354 | 0.5 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.0092 | 0.0276 | 0.5 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.0092 | 0.0276 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0164 | 0.0703 | 1 |
Mycobacterium ulcerans | recombinase A | 0.0105 | 0.0354 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.049 | 0.2641 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.049 | 0.2641 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.049 | 0.2641 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.049 | 0.2641 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0136 | 0.0541 | 0.7667 |
Giardia lamblia | Kinase, PLK | 0.0092 | 0.0276 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.0703 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0164 | 0.0703 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.049 | 0.2641 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.0703 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.0276 | 0.1044 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.0703 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0092 | 0.0276 | 0.3862 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.0276 | 0.1044 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.0703 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0158 | 0.0672 | 0.9272 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0092 | 0.0276 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.049 | 0.2641 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.0276 | 0.1044 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.0276 | 0.1044 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.0703 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.0703 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0158 | 0.0672 | 0.9272 |
Trichomonas vaginalis | CAMK family protein kinase | 0.0092 | 0.0276 | 0.1044 |
Trypanosoma brucei | polo-like protein kinase | 0.0092 | 0.0276 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.049 | 0.2641 | 1 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.0092 | 0.0276 | 0.5 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0158 | 0.0672 | 0.9272 |
Treponema pallidum | recombinase A | 0.0105 | 0.0354 | 0.5 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0616 | 0.339 | 1 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.0092 | 0.0276 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.