Detailed information for compound 151254

Basic information

Technical information
  • TDR Targets ID: 151254
  • Name: 6-(4-fluorophenyl)-7-[2-[[(1R)-1-phenylethyl] amino]pyrimidin-4-yl]-2,3-dihydro-1H-pyrazolo [1,2-a]pyrazol-5-one
  • MW: 415.463 | Formula: C24H22FN5O
  • H donors: 1 H acceptors: 3 LogP: 4.09 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)c1c(=O)n2n(c1c1ccnc(n1)N[C@@H](c1ccccc1)C)CCC2
  • InChi: 1S/C24H22FN5O/c1-16(17-6-3-2-4-7-17)27-24-26-13-12-20(28-24)22-21(18-8-10-19(25)11-9-18)23(31)30-15-5-14-29(22)30/h2-4,6-13,16H,5,14-15H2,1H3,(H,26,27,28)/t16-/m1/s1
  • InChiKey: TWWUNSJOKCOGKZ-MRXNPFEDSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-(4-fluorophenyl)-7-[2-[[(1R)-1-phenylethyl]amino]-4-pyrimidinyl]-2,3-dihydro-1H-pyrazolo[1,2-a]pyrazol-5-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens mitogen-activated protein kinase 13 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania braziliensis mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis mitogen activated protein kinase 14 Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma cruzi mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus granulosus mitogen activated protein kinase 11 Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis mitogen activated protein kinase 11 Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania mexicana mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis mitogen activated protein kinase 11 Get druggable targets OG5_128610 All targets in OG5_128610
Candida albicans MAP kinase involved in osmoregulation Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus granulosus mitogen activated protein kinase 14 Get druggable targets OG5_128610 All targets in OG5_128610
Candida albicans MAP kinase involved in osmoregulation Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma congolense mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma cruzi mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis mitogen activated protein kinase 14 Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania infantum mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Brugia malayi P38 map kinase family protein 2 Get druggable targets OG5_128610 All targets in OG5_128610
Schistosoma japonicum ko:K04441 p38 MAP kinase, putative Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma brucei gambiense mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma brucei mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania donovani mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 13 365 aa 366 aa 30.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi thymidylate synthase 0.013 0.0026 0.0037
Trypanosoma cruzi cyclin 6, putative 0.0905 0.1702 0.2433
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0183 0.014 0.065
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0473 0.0769 0.0898
Trypanosoma cruzi cdc2-related kinase 3 0.0631 0.1109 0.1587
Echinococcus granulosus mitogen activated protein kinase 14 0.0473 0.0769 0.0769
Onchocerca volvulus 0.013 0.0026 0.0151
Entamoeba histolytica cell division protein kinase 2, putative 0.0631 0.1109 0.1587
Loa Loa (eye worm) hypothetical protein 0.0538 0.0908 0.106
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0545 0.0924 0.1079
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.2687 0.5556 0.7945
Brugia malayi cell division control protein 2 homolog 0.0631 0.1109 0.1587
Trichomonas vaginalis CMGC family protein kinase 0.0831 0.1543 0.2206
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0831 0.1543 0.1543
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0183 0.014 0.02
Schistosoma mansoni hypothetical protein 0.056 0.0957 0.0957
Schistosoma mansoni tyrosine kinase 0.0276 0.0343 0.0343
Echinococcus granulosus cyclins 0.0488 0.0801 0.0801
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0473 0.0769 0.1099
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0473 0.0769 0.1099
Trichomonas vaginalis cyclins, putative 0.0905 0.1702 0.2433
Echinococcus granulosus cyclins 0.0488 0.0801 0.0801
Schistosoma mansoni serine/threonine protein kinase 0.0631 0.1109 0.1109
Giardia lamblia Cyclin A 0.0488 0.0801 0.239
Entamoeba histolytica hypothetical protein 0.2687 0.5556 0.7945
Trypanosoma brucei protein kinase, putative 0.0831 0.1543 0.7155
Echinococcus multilocularis Zinc finger, PHD finger 0.045 0.0719 0.0719
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.1469 0.2922 0.4179
Plasmodium vivax glycogen synthase kinase 3, putative 0.0831 0.1543 1
Echinococcus granulosus tyrosine protein kinase shark 0.0239 0.0262 0.0262
Plasmodium falciparum phosphatidylinositol 3-kinase 0.045 0.0719 0.466
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.045 0.0719 0.1028
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1115 0.2156 0.3083
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1115 0.2156 0.2156
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.3352 0.6993 1
Trichomonas vaginalis cyclins, putative 0.0534 0.09 0.1287
Echinococcus granulosus cyclin B3 1 0.0488 0.0801 0.0801
Brugia malayi intracellular kinase 0.0831 0.1543 0.2206
Onchocerca volvulus 0.0831 0.1543 0.9065
Mycobacterium ulcerans thymidylate synthase 0.013 0.0026 0.5
Brugia malayi Cyclin, N-terminal domain containing protein 0.0645 0.1139 0.1629
Onchocerca volvulus 0.0905 0.1702 1
Echinococcus multilocularis mitogen activated protein kinase 14 0.0473 0.0769 0.0769
Trichomonas vaginalis cyclins, putative 0.0905 0.1702 0.2433
Loa Loa (eye worm) TK/FAK protein kinase 0.028 0.035 0.0408
Giardia lamblia Kinase, CMGC CDK 0.0631 0.1109 0.3309
Brugia malayi Cyclin, N-terminal domain containing protein 0.0905 0.1702 0.2433
Toxoplasma gondii hypothetical protein 0.0371 0.0547 0.3543
Giardia lamblia Kinase, CMGC GSK 0.0831 0.1543 0.4601
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.3249 0.6772 0.9684
Loa Loa (eye worm) cyclin domain-containing protein 0.131 0.2577 0.301
Plasmodium falciparum protein kinase 5 0.0631 0.1109 0.7193
Echinococcus multilocularis cyclin dependent kinase 0.0631 0.1109 0.1109
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.1012 0.1935 0.2766
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0631 0.1109 0.1296
Trichomonas vaginalis cyclin B, putative 0.0905 0.1702 0.2433
Echinococcus multilocularis cyclins 0.0488 0.0801 0.0801
Loa Loa (eye worm) hypothetical protein 0.2134 0.4359 0.5091
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.131 0.2577 0.2577
Echinococcus granulosus cyclins 0.0488 0.0801 0.0801
Trichomonas vaginalis CMGC family protein kinase 0.0631 0.1109 0.1587
Trypanosoma cruzi cyclin, putative 0.0905 0.1702 0.2433
Echinococcus granulosus cyclins 0.0488 0.0801 0.0801
Schistosoma mansoni tyrosine kinase 0.0234 0.025 0.025
Echinococcus multilocularis protein tyrosine kinase 0.0276 0.0343 0.0343
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.3352 0.6993 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.3352 0.6993 1
Schistosoma mansoni serine/threonine protein kinase 0.0545 0.0924 0.0924
Trypanosoma cruzi cdc2-related kinase 3 0.0631 0.1109 0.1587
Echinococcus multilocularis cyclins 0.0488 0.0801 0.0801
Schistosoma mansoni cyclins 0.0488 0.0801 0.0801
Echinococcus multilocularis thymidylate synthase 0.013 0.0026 0.0026
Giardia lamblia G2/mitotic-specific cyclin B 0.0905 0.1702 0.5076
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.3352 0.6993 1
Brugia malayi P38 map kinase family protein 2 0.0473 0.0769 0.1099
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0183 0.014 0.0823
Plasmodium vivax protein kinase Crk2 0.0631 0.1109 0.7193
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.045 0.0719 0.0719
Echinococcus granulosus cyclins 0.0488 0.0801 0.0801
Loa Loa (eye worm) thymidylate synthase 0.013 0.0026 0.003
Echinococcus granulosus cyclin dependent kinase 5 0.0631 0.1109 0.1109
Trichomonas vaginalis cyclins, putative 0.0488 0.0801 0.1146
Trypanosoma cruzi cyclin, putative 0.0905 0.1702 0.2433
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.1115 0.2156 0.3083
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.1391 0.2752 0.3936
Brugia malayi Cyclin, N-terminal domain containing protein 0.0905 0.1702 0.2433
Brugia malayi Stress-activated protein kinase jnk-1 0.0545 0.0924 0.1322
Trichomonas vaginalis cyclin B3, putative 0.0488 0.0801 0.1146
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0473 0.0769 0.3566
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.3352 0.6993 1
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0183 0.014 0.0908
Plasmodium falciparum cyclin 0.0488 0.0801 0.5196
Echinococcus multilocularis cyclin dependent kinase 5 activator 1 0.1123 0.2174 0.2174
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.045 0.0719 0.1028
Schistosoma mansoni tyrosine kinase 0.0239 0.0262 0.0262
Echinococcus granulosus kinesin family 1 0.0644 0.1138 0.1138
Trichomonas vaginalis cyclins, putative 0.0905 0.1702 0.2433
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.045 0.0719 0.3335
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.3352 0.6993 1
Entamoeba histolytica cell division protein kinase 2, putative 0.0631 0.1109 0.1587
Entamoeba histolytica protein kinase domain containing protein 0.0831 0.1543 0.2206
Echinococcus multilocularis cyclin b3 0.0488 0.0801 0.0801
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0831 0.1543 0.9065
Echinococcus granulosus thymidylate synthase 0.013 0.0026 0.0026
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0631 0.1109 0.652
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.045 0.0719 0.1028
Echinococcus multilocularis cyclin B 0.0905 0.1702 0.1702
Giardia lamblia Kinase, CMGC CDK 0.0631 0.1109 0.3309
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.2134 0.4359 0.4359
Brugia malayi Protein kinase domain containing protein 0.028 0.035 0.05
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0183 0.014 0.0908
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.045 0.0719 0.1028
Loa Loa (eye worm) phosphatidylinositol 3 0.1012 0.1935 0.2259
Loa Loa (eye worm) hypothetical protein 0.0538 0.0908 0.106
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0831 0.1543 0.1801
Trichomonas vaginalis cyclin B, putative 0.0905 0.1702 0.2433
Entamoeba histolytica protein kinase, putative 0.0831 0.1543 0.2206
Entamoeba histolytica cyclin family protein 0.0488 0.0801 0.1146
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.045 0.0719 0.084
Trichomonas vaginalis cyclins, putative 0.0905 0.1702 0.2433
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.045 0.0719 0.4225
Echinococcus granulosus protein tyrosine kinase 0.0276 0.0343 0.0343
Trypanosoma cruzi CYC2-like cyclin, putative 0.0905 0.1702 0.2433
Trichomonas vaginalis CMGC family protein kinase 0.0831 0.1543 0.2206
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0631 0.1109 0.1296
Trypanosoma brucei cdc2-related kinase 1 0.0631 0.1109 0.5146
Echinococcus multilocularis cyclins 0.0488 0.0801 0.0801
Trypanosoma cruzi cdc2-related kinase 1 0.0631 0.1109 0.1587
Schistosoma mansoni cyclin B 0.0905 0.1702 0.1702
Echinococcus granulosus protein kinase shaggy 0.0831 0.1543 0.1543
Trichomonas vaginalis CMGC family protein kinase 0.0631 0.1109 0.1587
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.1115 0.2156 0.3083
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.045 0.0719 0.466
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.1115 0.2156 0.3083
Trichomonas vaginalis cyclin B, putative 0.0905 0.1702 0.2433
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.045 0.0719 0.1028
Giardia lamblia Kinase, CMGC GSK 0.0831 0.1543 0.4601
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0201 0.0179 0.0209
Schistosoma mansoni cyclin-dependent kinase 5 activator 0.1123 0.2174 0.2174
Echinococcus multilocularis mitogen activated protein kinase 11 0.0473 0.0769 0.0769
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.045 0.0719 0.1028
Schistosoma mansoni cyclin B3 0.131 0.2577 0.2577
Trypanosoma brucei cdc2-related kinase 3 0.0631 0.1109 0.5146
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0905 0.1702 1
Echinococcus granulosus cyclin dependent kinase 1 0.0631 0.1109 0.1109
Echinococcus granulosus cyclin dependent kinase 5 activator 1 0.1123 0.2174 0.2174
Entamoeba histolytica protein kinase domain containing protein 0.0831 0.1543 0.2206
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.013 0.0026 0.0026
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0631 0.1109 0.1109
Brugia malayi Protein kinase domain containing protein 0.0631 0.1109 0.1587
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.013 0.0026 0.5
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0201 0.0179 0.1052
Trichomonas vaginalis cyclin B, putative 0.0905 0.1702 0.2433
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0831 0.1543 0.1543
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.2333 0.479 0.6849
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.1115 0.2156 0.3083
Echinococcus multilocularis cyclin dependent kinase 1 0.0631 0.1109 0.1109
Loa Loa (eye worm) hypothetical protein 0.1123 0.2174 0.2539
Leishmania major cyclin 0.0905 0.1702 1
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0831 0.1543 0.1801
Echinococcus multilocularis mitogen activated protein kinase 11 0.0473 0.0769 0.0769
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.045 0.0719 0.1028
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.013 0.0026 0.5
Echinococcus granulosus cyclin dependent kinase 0.0631 0.1109 0.1109
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.1115 0.2156 0.3083
Echinococcus granulosus cyclin B 0.0905 0.1702 0.1702
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0201 0.0179 0.0179
Echinococcus granulosus mitogen activated protein kinase 11 0.0473 0.0769 0.0769
Echinococcus granulosus c-Jun N-terminal kinases 0.0545 0.0924 0.0924
Schistosoma mansoni serine/threonine protein kinase 0.0631 0.1109 0.1109
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0201 0.0179 0.0256
Schistosoma mansoni serine/threonine protein kinase 0.0201 0.0179 0.0179
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0631 0.1109 0.652
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0201 0.0179 0.0209
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.2134 0.4359 0.6234
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.045 0.0719 0.466
Entamoeba histolytica cyclin, putative 0.0905 0.1702 0.2433
Echinococcus multilocularis cyclin B3 1 0.0488 0.0801 0.0801
Loa Loa (eye worm) cyclin domain-containing protein 0.0645 0.1139 0.133
Echinococcus multilocularis cyclins 0.0488 0.0801 0.0801
Echinococcus multilocularis cyclins 0.0488 0.0801 0.0801
Schistosoma mansoni phosphatidylinositol 4-kinase 0.045 0.0719 0.0719
Leishmania major phosphatidylinositol 3-kinase, putative 0.045 0.0719 0.4225
Loa Loa (eye worm) phosphatidylinositol 3 0.4078 0.8563 1
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0545 0.0924 0.0924
Brugia malayi hypothetical protein 0.0538 0.0908 0.1298
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.3352 0.6993 1
Loa Loa (eye worm) hypothetical protein 0.0612 0.1069 0.1248
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.1115 0.2156 0.3083
Echinococcus multilocularis kinesin family 1 0.0644 0.1138 0.1138
Echinococcus granulosus G2:mitotic specific cyclin B3 0.131 0.2577 0.2577
Trichomonas vaginalis cyclin B, putative 0.0488 0.0801 0.1146
Loa Loa (eye worm) hypothetical protein 0.0905 0.1702 0.1987
Echinococcus multilocularis cyclin dependent kinase 1 0.0631 0.1109 0.1109
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.045 0.0719 0.0719
Trypanosoma cruzi cdc2-related kinase 1 0.0631 0.1109 0.1587
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.1668 0.3353 1
Trichomonas vaginalis conserved hypothetical protein 0.0488 0.0801 0.1146
Giardia lamblia Hypothetical protein 0.0488 0.0801 0.239
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.2333 0.479 0.6849
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0473 0.0769 0.4518
Echinococcus multilocularis tyrosine protein kinase shark 0.0239 0.0262 0.0262
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0631 0.1109 0.7193
Echinococcus multilocularis mitogen activated protein kinase 14 0.0473 0.0769 0.0769
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0183 0.014 0.0908
Brugia malayi Protein kinase domain containing protein 0.0201 0.0179 0.0256
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.4742 1 1
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.045 0.0719 0.466
Plasmodium falciparum glycogen synthase kinase 3 0.0831 0.1543 1
Trichomonas vaginalis cyclin D, putative 0.0488 0.0801 0.1146
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0831 0.1543 0.1543
Brugia malayi Cyclin, N-terminal domain containing protein 0.131 0.2577 0.3686
Plasmodium vivax multidrug resistance-associated protein 1, putative 0.0338 0.0477 0.309
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.4742 1 1
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0831 0.1543 0.2206
Trichomonas vaginalis CMGC family protein kinase 0.0631 0.1109 0.1587
Trichomonas vaginalis cyclin A, putative 0.0905 0.1702 0.2433
Echinococcus multilocularis protein kinase shaggy 0.0831 0.1543 0.1543
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0201 0.0179 0.0179
Loa Loa (eye worm) hypothetical protein 0.1218 0.2379 0.2778
Echinococcus multilocularis cyclins 0.0488 0.0801 0.0801
Entamoeba histolytica cyclin, putative 0.0488 0.0801 0.1146
Loa Loa (eye worm) hypothetical protein 0.0416 0.0645 0.0754
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1115 0.2156 1
Entamoeba histolytica cyclin family protein 0.0488 0.0801 0.1146
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0767 0.1403 0.4186
Loa Loa (eye worm) hypothetical protein 0.0905 0.1702 0.1987
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.045 0.0719 0.0719
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.045 0.0719 0.1028
Trypanosoma brucei mitotic cyclin 6 0.0905 0.1702 0.7893
Echinococcus multilocularis cyclin dependent kinase 5 0.0631 0.1109 0.1109
Trichomonas vaginalis cyclin D, putative 0.0488 0.0801 0.1146
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0831 0.1543 1
Echinococcus multilocularis cyclins 0.0488 0.0801 0.0801
Echinococcus granulosus cyclin b3 0.0488 0.0801 0.0801
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.045 0.0719 0.0719
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0631 0.1109 0.1296
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.2134 0.4359 0.4359

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 27 nM Inhibitory activity against LPS-stimulated TNF-alpha production in human monocytic cells (THP-1) ChEMBL. 15139749
IC50 (functional) = 27 nM Inhibitory activity against LPS-stimulated TNF-alpha production in human monocytic cells (THP-1) ChEMBL. 15139749

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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