TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 353.342 | Formula: C16H18F3N5O
H donors: 1 H acceptors: 3 LogP: 0.44 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: N[C@H](Cc1cc(F)c(cc1F)F)CC(=O)N1CCn2c(C1)c(C)nn2
InChi: 1S/C16H18F3N5O/c1-9-15-8-23(2-3-24(15)22-21-9)16(25)6-11(20)4-10-5-13(18)14(19)7-12(10)17/h5,7,11H,2-4,6,8,20H2,1H3/t11-/m1/s1
InChiKey: GWSMNIAMTSPSIW-LLVKDONJSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	orexin receptor type 2	0.0011	0.0171	0.0097
Loa Loa (eye worm)	cytochrome P450 family protein	0.0013	0.0202	0.0152
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0011	0.0171	0.0097
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0011	0.0171	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0061	0.1359	0.2168
Brugia malayi	steroid hormone receptor	0.0116	0.2663	0.4441
Schistosoma mansoni	nuclear hormone receptor	0.0055	0.1202	0.1202
Echinococcus granulosus	neuropeptides capa receptor	0.0011	0.0171	0.0097
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0116	0.2663	0.4441
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0171	0.0098
Echinococcus granulosus	g protein coupled receptor	0.0011	0.0171	0.0097
Brugia malayi	hypothetical protein	0.0061	0.1359	0.2168
Schistosoma mansoni	neuropeptide f receptor 76f	0.0011	0.0171	0.0171
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0011	0.0171	0.0097
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0116	0.2663	0.2663
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0011	0.0171	0.0097
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0055	0.1202	0.1136
Brugia malayi	CXXC zinc finger family protein	0.003	0.0608	0.0859
Schistosoma mansoni	neuropeptide receptor	0.0011	0.0171	0.0171
Echinococcus granulosus	ecdysone induced protein 78C	0.0116	0.2663	0.2608
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0011	0.0171	0.0097
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0011	0.0171	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1202	0.1896
Echinococcus granulosus	neuropeptide FF receptor 2	0.0011	0.0171	0.0097
Brugia malayi	nuclear receptor NHR-88	0.0116	0.2663	0.4441
Echinococcus granulosus	neuropeptides capa receptor	0.0011	0.0171	0.0097
Schistosoma mansoni	nuclear receptor nhr-48	0.0055	0.1202	0.1202
Onchocerca volvulus		0.002	0.0385	0.0859
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0011	0.0171	0.0097
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0011	0.0171	0.0097
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0116	0.2663	0.4441
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0011	0.0171	0.0171
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0011	0.0171	0.0098
Loa Loa (eye worm)	neuropeptide F receptor	0.0011	0.0171	0.0098
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0055	0.1202	0.4139
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0171	0.0098
Brugia malayi	Steroid receptor seven-up type 2	0.0116	0.2663	0.4441
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0011	0.0171	0.0098
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0011	0.0171	0.0171
Echinococcus multilocularis	g protein coupled receptor	0.0011	0.0171	0.0097
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0011	0.0171	0.0171
Echinococcus granulosus	rhodopsin orphan GPCR	0.0011	0.0171	0.0097
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0063	0.1403	0.1403
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0171	0.0098
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0302	0.7117	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0011	0.0171	0.0097
Schistosoma mansoni	amine GPCR	0.0011	0.0171	0.0171
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0011	0.0171	0.0097
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0116	0.2663	0.4441
Loa Loa (eye worm)	steroid hormone receptor	0.0116	0.2663	0.4441
Brugia malayi	nuclear receptor RXR	0.0061	0.1359	0.2168
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0171	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0171	0.0098
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0116	0.2663	0.2608
Brugia malayi	ecdysteroid receptor	0.0116	0.2663	0.4441
Treponema pallidum	fructose-bisphosphate aldolase	0.0302	0.7117	0.5
Loa Loa (eye worm)	hypothetical protein	0.002	0.0385	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0171	0.0098
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0011	0.0171	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0171	0.0098
Echinococcus granulosus	FTZ F1 alpha	0.0116	0.2663	0.2608
Brugia malayi	tailless protein	0.0055	0.1202	0.1895
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0171	0.0098
Brugia malayi	RE15519p	0.0011	0.0171	0.0098
Echinococcus multilocularis	g-protein coupled receptor	0.0011	0.0171	0.0097
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0116	0.2663	0.4441
Echinococcus multilocularis	neuropeptide receptor	0.0011	0.0171	0.0097
Loa Loa (eye worm)	G-protein coupled receptor	0.0011	0.0171	0.0098
Brugia malayi	G-protein coupled receptor	0.0011	0.0171	0.0098
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0116	0.2663	0.4441
Echinococcus granulosus	nuclear receptor nhr 48	0.0055	0.1202	0.1136
Brugia malayi	hypothetical protein	0.0011	0.0171	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0171	0.0098
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0116	0.2663	0.4441
Echinococcus multilocularis	ecdysone induced protein 78C	0.0116	0.2663	0.2608
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0171	0.0098
Brugia malayi	Serotonin receptor	0.0011	0.0171	0.0098
Schistosoma mansoni	cpg binding protein	0.0031	0.0648	0.0648
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0011	0.0171	0.0098
Echinococcus granulosus	7TM GPCR rhodopsin	0.0011	0.0171	0.0097
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0061	0.1359	0.1359
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0171	0.0098
Echinococcus granulosus	g protein coupled receptor	0.0011	0.0171	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0171	0.0098
Echinococcus multilocularis	serotonin receptor	0.0011	0.0171	0.0097
Echinococcus granulosus	cpg binding protein	0.0031	0.0648	0.0578
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1202	0.1896
Loa Loa (eye worm)	hypothetical protein	0.0061	0.1359	0.2168
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.0148	0.3424	0.5
Plasmodium falciparum	LCCL domain-containing protein	0.002	0.0385	0.5
Echinococcus multilocularis	somatostatin receptor	0.0011	0.0171	0.0097
Echinococcus granulosus	neuropeptide receptor A26	0.0011	0.0171	0.0097
Brugia malayi	Nuclear hormone receptor E75	0.0055	0.1202	0.1895
Echinococcus granulosus	neuropeptide Y receptor	0.0011	0.0171	0.0097
Schistosoma mansoni	nuclear receptor	0.0055	0.1202	0.1202
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0171	0.0098
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0116	0.2663	0.4441
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0055	0.1202	0.1896
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0171	0.0098
Brugia malayi	G protein-coupled receptor F59B2.13	0.0011	0.0171	0.0098
Echinococcus granulosus	rhodopsin orphan GPCR	0.0011	0.0171	0.0097
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0116	0.2663	0.2608
Echinococcus granulosus	rhodopsin orphan GPCR	0.0011	0.0171	0.0097
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0302	0.7117	0.5
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0116	0.2663	0.2663
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0171	0.0098
Echinococcus multilocularis	sex peptide receptor	0.0011	0.0171	0.0097
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0011	0.0171	0.0171
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0116	0.2663	0.2663
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0171	0.0098
Echinococcus granulosus	rhodopsin orphan GPCR	0.0011	0.0171	0.0097
Echinococcus multilocularis	neuropeptide Y receptor	0.0011	0.0171	0.0097
Schistosoma mansoni	hypothetical protein	0.0011	0.0171	0.0171
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0302	0.7117	1
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1202	0.1896
Trypanosoma cruzi	cytochrome P450, putative	0.0013	0.0202	0.5
Echinococcus multilocularis	orexin receptor type 2	0.0011	0.0171	0.0097
Schistosoma mansoni	biogenic amine receptor	0.0011	0.0171	0.0171
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0011	0.0171	0.0097
Brugia malayi	nuclear receptor NHR-88	0.0055	0.1202	0.1895
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0171	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1202	0.1896
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0057	0.1262	0.1196
Schistosoma mansoni	opsin-like receptor	0.0011	0.0171	0.0171
Schistosoma mansoni	rab6-interacting	0.002	0.0385	0.0385
Echinococcus multilocularis	fmrfamide receptor	0.0011	0.0171	0.0097
Brugia malayi	hypothetical protein	0.0011	0.0171	0.0098
Echinococcus multilocularis	neuropeptide Y receptor	0.0011	0.0171	0.0097
Loa Loa (eye worm)	G-protein coupled receptor	0.0011	0.0171	0.0098
Schistosoma mansoni	thyroid hormone receptor	0.0116	0.2663	0.2663
Schistosoma mansoni	hypothetical protein	0.002	0.0385	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0171	0.0098
Echinococcus granulosus	neuropeptide s receptor	0.0011	0.0171	0.0097
Schistosoma mansoni	myosin xvIII	0.0011	0.0171	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1202	0.1896
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0116	0.2663	0.2608
Echinococcus granulosus	serotonin receptor	0.0011	0.0171	0.0097
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0055	0.1202	0.1202
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0056	0.1242	0.5
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0171	0.0098
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0116	0.2663	0.4441
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0011	0.0171	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0171	0.0098
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0116	0.2663	0.2608
Brugia malayi	ecdysone receptor	0.0055	0.1202	0.1895
Loa Loa (eye worm)	CXXC zinc finger family protein	0.003	0.0608	0.0859
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0011	0.0171	0.0171
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0118	0.0044
Echinococcus granulosus	rhodopsin orphan GPCR	0.0011	0.0171	0.0097
Echinococcus multilocularis	g protein coupled receptor	0.0011	0.0171	0.0097
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0118	0.0044
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1202	0.1896
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0116	0.2663	0.4441
Echinococcus granulosus	lipoxygenase domain containing protein	0.002	0.0385	0.0313
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0055	0.1202	0.1136
Loa Loa (eye worm)	hypothetical protein	0.002	0.0385	0.0472
Schistosoma mansoni	nuclear hormone receptor	0.0116	0.2663	0.2663
Echinococcus granulosus	G protein coupled receptor 139	0.0011	0.0171	0.0097
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0011	0.0171	0.0097
Echinococcus multilocularis	lipoxygenase domain containing protein	0.002	0.0385	0.0313
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0171	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0171	0.0098
Schistosoma mansoni	neuropeptide F-like receptor	0.0011	0.0171	0.0171
Schistosoma mansoni	opsin-like receptor	0.0011	0.0171	0.0171
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0302	0.7117	1
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0055	0.1202	0.1136
Onchocerca volvulus		0.003	0.0608	0.1752
Echinococcus multilocularis	RUN	0.002	0.0385	0.0313
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0116	0.2663	0.4441
Schistosoma mansoni	cpg binding protein	0.003	0.0608	0.0608
Schistosoma mansoni	amine GPCR	0.0011	0.0171	0.0171
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0061	0.1359	0.1359
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0011	0.0171	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0171	0.0098
Loa Loa (eye worm)	melatonin receptor type 1A	0.0011	0.0171	0.0098
Plasmodium vivax	multidomain scavenger receptor, putative	0.002	0.0385	0.5
Onchocerca volvulus		0.002	0.0385	0.0859
Onchocerca volvulus		0.0055	0.1202	0.4139
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0011	0.0171	0.0097
Echinococcus multilocularis	lipoxygenase domain containing protein	0.002	0.0385	0.0313
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0055	0.1202	0.1136
Brugia malayi	nuclear receptor RXR	0.0055	0.1202	0.1895
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0011	0.0171	0.0098
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0116	0.2663	0.2608
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0011	0.0171	0.0171
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0116	0.2663	0.2608
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0116	0.2663	0.4441
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0171	0.0098
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0116	0.2663	0.4441
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0055	0.1202	0.1136
Echinococcus multilocularis	fmrfamide receptor	0.0011	0.0171	0.0097
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0011	0.0171	0.0097
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0011	0.0171	0.0098
Onchocerca volvulus		0.0116	0.2663	1
Brugia malayi	hypothetical protein	0.0011	0.0171	0.0098
Onchocerca volvulus		0.0055	0.1202	0.4139
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0011	0.0171	0.0098
Echinococcus multilocularis	neuropeptide receptor	0.0011	0.0171	0.0097
Echinococcus granulosus	g-protein coupled receptor	0.0011	0.0171	0.0097
Brugia malayi	Nuclear hormone receptor-like 1	0.0116	0.2663	0.4441
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0055	0.1202	0.1896
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0116	0.2663	0.4441
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0074	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1202	0.1896
Brugia malayi	orphan nuclear receptor NR2E1	0.0055	0.1202	0.1895
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0171	0.0098
Echinococcus multilocularis	neuropeptide receptor A26	0.0011	0.0171	0.0097
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0011	0.0171	0.0097
Echinococcus granulosus	tm gpcr rhodopsin	0.0011	0.0171	0.0097
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0011	0.0171	0.0171
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0061	0.1359	0.1294
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0061	0.1359	0.1294
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1202	0.1896
Loa Loa (eye worm)	hypothetical protein	0.0116	0.2663	0.4441
Leishmania major	cytochrome p450-like protein	0.0013	0.0202	0.5
Giardia lamblia	Fructose-bisphosphate aldolase	0.0302	0.7117	0.5
Loa Loa (eye worm)	hypothetical protein	0.0116	0.2663	0.4441
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0171	0.0098
Echinococcus granulosus	thyroid hormone receptor alpha	0.0055	0.1202	0.1136
Brugia malayi	hypothetical protein	0.002	0.0385	0.0471
Echinococcus granulosus	Polycystic kidney disease protein	0.002	0.0385	0.0313
Schistosoma mansoni	neuropeptide receptor	0.0011	0.0171	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0171	0.0098
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0011	0.0171	0.0171
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0249	0.5852	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0116	0.2663	0.2663
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0302	0.7117	1
Brugia malayi	Nuclear hormone receptor E75	0.0055	0.1202	0.1895
Echinococcus multilocularis	Polycystic kidney disease protein	0.002	0.0385	0.0313
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0116	0.2663	0.4441
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0171	0.0098
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0116	0.2663	0.2663
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0011	0.0171	0.0097
Brugia malayi	nuclear hormone receptor	0.0055	0.1202	0.1895
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0011	0.0171	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0116	0.2663	0.4441
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0011	0.0171	0.0171
Echinococcus granulosus	RUN	0.002	0.0385	0.0313
Loa Loa (eye worm)	hypothetical protein	0.0116	0.2663	0.4441
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0011	0.0171	0.0098
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0116	0.2663	0.2608
Echinococcus granulosus	fmrfamide receptor	0.0011	0.0171	0.0097
Brugia malayi	nuclear receptor NHR-67	0.0055	0.1202	0.1895
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0011	0.0171	0.0171
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0116	0.2663	1
Brugia malayi	G protein-coupled receptor	0.0011	0.0171	0.0098
Echinococcus granulosus	rhodopsin orphan GPCR	0.0011	0.0171	0.0097
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0011	0.0171	0.0097
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0011	0.0171	0.0097
Echinococcus granulosus	neuropeptide receptor	0.0011	0.0171	0.0097
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0055	0.1202	0.4139
Schistosoma mansoni	biogenic amine receptor	0.0011	0.0171	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0061	0.1359	0.2168
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0171	0.0098
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0055	0.1202	0.1202
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0171	0.0098
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0011	0.0171	0.0097
Brugia malayi	Nuclear hormone receptor-like 1	0.0061	0.1359	0.2168
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0055	0.1202	0.1136
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1202	0.1896
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0011	0.0171	0.0097
Schistosoma mansoni	rab6-interacting	0.002	0.0385	0.0385
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0171	0.0098
Schistosoma mansoni	neuropeptide F-like receptor	0.0011	0.0171	0.0171
Brugia malayi	hypothetical protein	0.002	0.0385	0.0471
Schistosoma mansoni	histamine h1 receptor	0.0011	0.0171	0.0171
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0011	0.0171	0.0097
Schistosoma mansoni	hypothetical protein	0.0011	0.0171	0.0171
Loa Loa (eye worm)	cytochrome P450 family protein	0.0013	0.0202	0.0152
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1202	0.1896
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1202	0.1896
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0011	0.0171	0.0171
Brugia malayi	hypothetical protein	0.0061	0.1359	0.2168
Brugia malayi	ORL1-like opioid receptor	0.0011	0.0171	0.0098
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0302	0.7117	0.5
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0302	0.7117	1
Loa Loa (eye worm)	hypothetical protein	0.0116	0.2663	0.4441
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0171	0.0098
Echinococcus granulosus	dro:myosuppressin receptor	0.0011	0.0171	0.0097
Loa Loa (eye worm)	TYRA-2 protein	0.0011	0.0171	0.0098
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0011	0.0171	0.0097
Brugia malayi	hypothetical protein	0.0011	0.0171	0.0098
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0011	0.0171	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0171	0.0098
Onchocerca volvulus	Bile acid receptor homolog	0.0116	0.2663	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0116	0.2663	0.4441
Brugia malayi	Dopamine receptor	0.0011	0.0171	0.0098
Brugia malayi	hypothetical protein	0.0011	0.0171	0.0098
Brugia malayi	Nuclear hormone receptor-like 1	0.0061	0.1359	0.2168
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0116	0.2663	0.4441
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0011	0.0171	0.0171
Echinococcus granulosus	7tm_1 domain containing protein	0.0011	0.0171	0.0097
Schistosoma mansoni	hypothetical protein	0.0011	0.0171	0.0171
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0116	0.2663	0.4441
Schistosoma mansoni	neuropeptide receptor	0.0011	0.0171	0.0171
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0116	0.2663	0.2663
Brugia malayi	follicle stimulating hormone receptor	0.0249	0.5852	1
Loa Loa (eye worm)	CYP4Cod1	0.0013	0.0202	0.0152
Brugia malayi	hypothetical protein	0.0055	0.1202	0.1895
Schistosoma mansoni	hypothetical protein	0.0011	0.0171	0.0171
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0057	0.1262	0.1196
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0116	0.2663	0.2608
Echinococcus multilocularis	nuclear receptor nhr 48	0.0055	0.1202	0.1136
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0011	0.0171	0.0171
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0011	0.0171	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0171	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0171	0.0098
Echinococcus granulosus	biogenic amine 5HT receptor	0.0011	0.0171	0.0097
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0011	0.0171	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0171	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1202	0.1896
Echinococcus multilocularis	G protein coupled receptor 139	0.0011	0.0171	0.0097
Brugia malayi	sulfakinin receptor protein	0.0011	0.0171	0.0098
Schistosoma mansoni	retinoic acid receptor RXR	0.0116	0.2663	0.2663
Echinococcus granulosus	somatostatin receptor	0.0011	0.0171	0.0097
Schistosoma mansoni	amine GPCR	0.0011	0.0171	0.0171
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0011	0.0171	0.0097
Brugia malayi	hypothetical protein	0.0011	0.0171	0.0098
Echinococcus granulosus	neuropeptide receptor	0.0011	0.0171	0.0097
Brugia malayi	larval opioid receptor	0.0011	0.0171	0.0098
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0116	0.2663	0.4441
Schistosoma mansoni	neuropeptide receptor	0.0011	0.0171	0.0171
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.0148	0.3424	1
Brugia malayi	neuropeptide F receptor	0.0011	0.0171	0.0098
Echinococcus multilocularis	dro:myosuppressin receptor	0.0011	0.0171	0.0097
Schistosoma mansoni	polycystin 1-related	0.002	0.0385	0.0385
Trypanosoma brucei	cytochrome P450, putative	0.0013	0.0202	0.5
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0055	0.1202	0.1895
Loa Loa (eye worm)	hypothetical protein	0.0116	0.2663	0.4441
Echinococcus granulosus	neuropeptide Y receptor	0.0011	0.0171	0.0097
Echinococcus granulosus	hypothetical protein	0.0011	0.0171	0.0097
Echinococcus multilocularis	FTZ F1 alpha	0.0116	0.2663	0.2608
Brugia malayi	Cytochrome P450 family protein	0.0013	0.0202	0.0152
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0061	0.1359	0.2168
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0116	0.2663	0.2608
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0171	0.0098
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0302	0.7117	1
Schistosoma mansoni	adenoreceptor	0.0011	0.0171	0.0171
Echinococcus granulosus	biogenic amine 5HT receptor	0.0011	0.0171	0.0097
Brugia malayi	hypothetical protein	0.0011	0.0171	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0171	0.0098
Brugia malayi	Dopamine receptor protein 2	0.0011	0.0171	0.0098
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0116	0.2663	0.2608
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0011	0.0171	0.0097
Brugia malayi	GnHR receptor homolog	0.0011	0.0171	0.0098
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0011	0.0171	0.0098
Schistosoma mansoni	growth hormone secretagogue receptor	0.0011	0.0171	0.0171
Loa Loa (eye worm)	DR-78	0.0055	0.1202	0.1896
Schistosoma mansoni	nuclear receptor	0.0055	0.1202	0.1202
Echinococcus granulosus	rhodopsin orphan GPCR	0.0011	0.0171	0.0097
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0011	0.0171	0.0098
Echinococcus granulosus	sex peptide receptor	0.0011	0.0171	0.0097
Schistosoma mansoni	nuclear hormone receptor	0.0055	0.1202	0.1202
Loa Loa (eye worm)	hypothetical protein	0.0116	0.2663	0.4441
Echinococcus multilocularis	g protein coupled receptor	0.0011	0.0171	0.0097
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0011	0.0171	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0171	0.0098
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0055	0.1202	0.1136
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0116	0.2663	0.2663
Echinococcus granulosus	lipoxygenase domain containing protein	0.002	0.0385	0.0313
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0011	0.0171	0.0097
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0011	0.0171	0.0171
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0116	0.2663	0.4441
Loa Loa (eye worm)	neuropeptide F receptor	0.0011	0.0171	0.0098
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0055	0.1202	0.1136
Echinococcus multilocularis	neuropeptide s receptor	0.0011	0.0171	0.0097
Echinococcus granulosus	g protein coupled receptor	0.0011	0.0171	0.0097
Schistosoma mansoni	zinc finger protein	0.0055	0.1202	0.1202
Echinococcus granulosus	tm gpcr rhodopsin	0.0011	0.0171	0.0097
Brugia malayi	nuclear hormone receptor family member odr-7	0.0055	0.1202	0.1895
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0055	0.1202	0.1136
Brugia malayi	Doublecortin family protein	0.002	0.0385	0.0471
Brugia malayi	AKH receptor	0.0011	0.0171	0.0098
Echinococcus granulosus	tm gpcr rhodopsin	0.0011	0.0171	0.0097
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0011	0.0171	0.0097
Schistosoma mansoni	amine GPCR	0.0011	0.0171	0.0171
Brugia malayi	putative neuropeptide receptor	0.0011	0.0171	0.0098
Brugia malayi	Serotonin receptor	0.0011	0.0171	0.0098
Schistosoma mansoni	amine GPCR	0.0011	0.0171	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0171	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0061	0.1359	0.2168
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0011	0.0171	0.0097
Schistosoma mansoni	biogenic amine receptor	0.0011	0.0171	0.0171
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0116	0.2663	0.4441
Onchocerca volvulus	Protein ultraspiracle homolog	0.0116	0.2663	1
Brugia malayi	neuropeptide F receptor	0.0011	0.0171	0.0098
Brugia malayi	photoreceptor-specific nuclear receptor	0.0116	0.2663	0.4441
Brugia malayi	hypothetical protein	0.0055	0.1202	0.1895
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0011	0.0171	0.0171
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0011	0.0171	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0061	0.1359	0.2168
Schistosoma mansoni	opsin-like receptor	0.0011	0.0171	0.0171
Brugia malayi	Dopamine receptor protein 1	0.0011	0.0171	0.0098
Schistosoma mansoni	coup transcription factor	0.0116	0.2663	0.2663
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.0148	0.3424	0.5
Schistosoma mansoni	cpg binding protein	0.0031	0.0648	0.0648
Echinococcus multilocularis	serotonin receptor	0.0011	0.0171	0.0097
Echinococcus multilocularis	allatostatin A receptor	0.0011	0.0171	0.0097
Schistosoma mansoni	thyroid hormone receptor	0.0116	0.2663	0.2663
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0011	0.0171	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0055	0.1202	0.1896
Loa Loa (eye worm)	nuclear hormone receptor	0.0055	0.1202	0.1896
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0118	0.0005
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0116	0.2663	0.2608
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0011	0.0171	0.0097
Echinococcus granulosus	allatostatin A receptor	0.0011	0.0171	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0171	0.0098
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0011	0.0171	0.0171
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0011	0.0171	0.0171
Brugia malayi	G-protein coupled receptor	0.0011	0.0171	0.0098
Trypanosoma cruzi	cytochrome P450, putative	0.0013	0.0202	0.5
Schistosoma mansoni	RAR-like nuclear receptor	0.0116	0.2663	0.2663
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0302	0.7117	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0116	0.2663	0.2608
Brugia malayi	conserved hypotetical protein	0.0055	0.1202	0.1895
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0302	0.7117	1
Brugia malayi	Cytochrome P450 family protein	0.0013	0.0202	0.0152
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0116	0.2663	0.2608
Schistosoma mansoni	loxhd1	0.002	0.0385	0.0385
Brugia malayi	Melatonin receptor type 1A	0.0011	0.0171	0.0098
Loa Loa (eye worm)	doublecortin family protein	0.002	0.0385	0.0472
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0171	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0171	0.0098
Echinococcus multilocularis	cpg binding protein	0.0031	0.0648	0.0578
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0011	0.0171	0.0097
Brugia malayi	hypothetical protein	0.0011	0.0171	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0171	0.0098
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0116	0.2663	0.2608
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0171	0.0098
Brugia malayi	nuclear hormone receptor	0.0116	0.2663	0.4441
Echinococcus multilocularis	neuropeptides capa receptor	0.0011	0.0171	0.0097
Brugia malayi	hypothetical protein	0.0011	0.0171	0.0098
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0011	0.0171	0.0171
Brugia malayi	hypothetical protein	0.0011	0.0171	0.0098
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0055	0.1202	0.1895
Brugia malayi	putative neuropeptide receptor NPR1	0.0011	0.0171	0.0098
Echinococcus multilocularis	neuropeptides capa receptor	0.0011	0.0171	0.0097
Schistosoma mansoni	lipoxygenase	0.0057	0.1262	0.1262
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0011	0.0171	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0116	0.2663	0.4441
Schistosoma mansoni	lipoxygenase	0.002	0.0385	0.0385
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0011	0.0171	0.0097

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1739373

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1514342