Detailed information for compound 1514903

Basic information

Technical information
  • TDR Targets ID: 1514903
  • Name: 6-dimethylamino-4-hydroxynaphthalene-2-sulfon ic acid
  • MW: 267.301 | Formula: C12H13NO4S
  • H donors: 2 H acceptors: 4 LogP: 1.69 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(c1ccc2c(c1)c(O)cc(c2)S(=O)(=O)O)C
  • InChi: 1S/C12H13NO4S/c1-13(2)9-4-3-8-5-10(18(15,16)17)7-12(14)11(8)6-9/h3-7,14H,1-2H3,(H,15,16,17)
  • InChiKey: LRPIENHBUQIGPP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 6-dimethylamino-4-hydroxy-naphthalene-2-sulfonic acid
  • 6-dimethylamino-4-hydroxy-2-naphthalenesulfonic acid
  • 6259-50-3
  • 6-Dimethylamino-4-hydroxynaphthalene-2-sulphonic acid
  • EINECS 228-404-4
  • 2-Naphthalenesulfonic acid, 6-(dimethylamino)-4-hydroxy-
  • NSC8637
  • 161829_ALDRICH

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens Wolf-Hirschhorn syndrome candidate 1 Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Homo sapiens glutaminase Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens peptidylprolyl cis/trans isomerase, NIMA-interacting 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium ulcerans glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_130029 All targets in OG5_130029
Leishmania mexicana peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Loa Loa (eye worm) glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis histone lysine N methyltransferase NSD3 Get druggable targets OG5_130029 All targets in OG5_130029
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum Histone-lysine N-methyltransferase NSD3, putative Get druggable targets OG5_130029 All targets in OG5_130029
Echinococcus granulosus expressed protein Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni SET domain protein Get druggable targets OG5_130029 All targets in OG5_130029
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania donovani peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_128367 All targets in OG5_128367
Toxoplasma gondii peptidylprolyl isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma japonicum expressed protein Get druggable targets OG5_130029 All targets in OG5_130029
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K09578 peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, putative Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans peptidylprolyl cis/trans isomerase isolated by functional complementation of S. cerevisiae ESS1 (YJR017C) which interacts with t Get druggable targets OG5_128367 All targets in OG5_128367
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi glutaminase DH11.1 Get druggable targets OG5_129245 All targets in OG5_129245
Schistosoma mansoni rotamase Get druggable targets OG5_128367 All targets in OG5_128367
Babesia bovis peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Cryptosporidium parvum protein with 4 PHD domains plus a SET domain and associated cysteine cluster at the C-terminus Get druggable targets OG5_130029 All targets in OG5_130029
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum ko:K05302 histone-lysine N-methyltransferase [EC2.1.1.43], putative Get druggable targets OG5_130029 All targets in OG5_130029
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis glutaminase, putative Get druggable targets OG5_129245 All targets in OG5_129245
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma congolense peptidyl-prolyl cis-trans isomerase/rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania infantum peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei gambiense peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Theileria parva peptidyl-prolyl cis-trans isomerase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) glutaminase 2 Get druggable targets OG5_129245 All targets in OG5_129245
Trichomonas vaginalis rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Echinococcus granulosus histone lysine N methyltransferase NSD3 Get druggable targets OG5_130029 All targets in OG5_130029
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 Get druggable targets OG5_128367 All targets in OG5_128367
Trichomonas vaginalis rotamase, putative Get druggable targets OG5_128367 All targets in OG5_128367
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis expressed protein Get druggable targets OG5_128367 All targets in OG5_128367
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Neospora caninum peptidyl-prolyl cis-trans isomerase NIMA- interacting 1, putative Get druggable targets OG5_128367 All targets in OG5_128367
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase Get druggable targets OG5_128367 All targets in OG5_128367
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania major peptidyl-prolyl cis-trans isomerase, putative peptidylprolyl cis/trans isomerase, NIMA-interacting 1 163 aa 133 aa 27.8 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi RNA binding protein 0.0076 0.1924 0.1734
Trichomonas vaginalis AGC family protein kinase 0.0112 0.3056 0.2892
Brugia malayi hypothetical protein 0.0035 0.0613 0.0392
Plasmodium vivax ataxin-2 like protein, putative 0.0055 0.1231 0.5
Toxoplasma gondii LsmAD domain-containing protein 0.0055 0.1231 1
Schistosoma mansoni hypothetical protein 0.0034 0.0579 0.0357
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.1039 0.1401
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1924 0.1734
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1924 0.1734
Giardia lamblia DINP protein human, muc B family 0.0023 0.023 0.5
Schistosoma mansoni rotamase 0.004 0.0773 0.0555
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.1231 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.023 0.5
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.121 0.1003
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0698 0.4675
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0039 0.0742 0.5118
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0112 0.3056 0.2892
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.004 0.0773 0.0555
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0108 0.2935 0.2768
Trichomonas vaginalis rotamase, putative 0.0039 0.0742 0.0524
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0025 0.027 0.0068
Entamoeba histolytica protein kinase, putative 0.0112 0.3056 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.1039 0.0828
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.1039 0.0828
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.1039 0.1401
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.023 0.1871
Trichomonas vaginalis rotamase, putative 0.004 0.0773 0.0555
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0039 0.0742 0.1812
Loa Loa (eye worm) hypothetical protein 0.0074 0.1844 0.1652
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.1231 0.5
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0742 0.5118
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.023 0.1871
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.023 0.1871
Schistosoma mansoni DNA polymerase eta 0.0054 0.121 0.1003
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1924 0.1734
Toxoplasma gondii peptidylprolyl isomerase 0.0039 0.0742 0.0831
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0579 0.0357
Echinococcus granulosus expressed protein 0.004 0.0773 0.0939
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0579 0.0357
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.1039 0.0828
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.023 0.1871
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.023 0.5
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.004 0.0748 0.0897
Leishmania major hypothetical protein, conserved 0.0055 0.1231 1
Trypanosoma brucei DNA polymerase eta, putative 0.0054 0.121 0.9829
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0112 0.3056 0.2892
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0039 0.0742 0.6031
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0579 0.0603
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.023 0.1871
Schistosoma mansoni hypothetical protein 0.0205 0.6004 0.591
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.1039 0.1401
Trypanosoma brucei unspecified product 0.0023 0.023 0.1871
Schistosoma mansoni serine/threonine protein kinase 0.0112 0.3056 0.2892
Schistosoma mansoni hypothetical protein 0.0074 0.1844 0.1652
Echinococcus multilocularis dna polymerase eta 0.0054 0.121 0.1697
Schistosoma mansoni hypothetical protein 0.0034 0.0579 0.0357
Echinococcus multilocularis tar DNA binding protein 0.0076 0.1924 0.2934
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0039 0.0742 0.5118
Echinococcus multilocularis GPCR, family 2 0.0034 0.0579 0.0603
Echinococcus granulosus tar DNA binding protein 0.0076 0.1924 0.2934
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.023 0.1871
Loa Loa (eye worm) RNA binding protein 0.0076 0.1924 0.1734
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0773 0.0555
Leishmania major DNA polymerase eta, putative 0.0054 0.121 0.979
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0112 0.3056 0.4893
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.1231 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.023 0.1871
Echinococcus granulosus geminin 0.0205 0.6004 1
Schistosoma mansoni hypothetical protein 0.0025 0.027 0.004
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 0.121 0.979
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.023 0.1871
Echinococcus granulosus GPCR family 2 0.0034 0.0579 0.0603
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.023 0.1871
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.004 0.0748 0.0897
Echinococcus multilocularis geminin 0.0205 0.6004 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0579 0.0357
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0112 0.3056 0.4893
Brugia malayi Protein kinase domain containing protein 0.0112 0.3056 0.2892
Brugia malayi Calcitonin receptor-like protein seb-1 0.0108 0.2935 0.2768
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.023 0.1871
Loa Loa (eye worm) hypothetical protein 0.0054 0.121 0.1003
Schistosoma mansoni hypothetical protein 0.0034 0.0579 0.0357
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.1231 0.5
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.023 0.1871
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0579 0.0603
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1924 0.1734
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0108 0.2935 0.2768
Leishmania major DNA polymerase eta, putative 0.0038 0.0698 0.4675
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.004 0.0773 0.0555
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0579 0.0357
Echinococcus multilocularis expressed protein 0.004 0.0773 0.0939
Loa Loa (eye worm) hypothetical protein 0.0108 0.2935 0.2768
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.1924 0.1734
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.1039 0.0828
Echinococcus granulosus dna polymerase eta 0.0054 0.121 0.1697
Schistosoma mansoni tar DNA-binding protein 0.0076 0.1924 0.1734
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.1039 0.0828
Brugia malayi phosphoinositide-dependent protein kinase I 0.0112 0.3056 0.2892
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.1924 0.1734
Schistosoma mansoni hypothetical protein 0.0034 0.0579 0.0357
Trichomonas vaginalis AGC family protein kinase 0.0112 0.3056 0.2892
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0025 0.027 0.0068
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.023 0.1871
Trypanosoma brucei PAB1-binding protein , putative 0.0055 0.1231 1
Brugia malayi latrophilin 2 splice variant baaae 0.0074 0.1844 0.1652
Brugia malayi hypothetical protein 0.0055 0.1231 0.1024
Schistosoma mansoni hypothetical protein 0.0205 0.6004 0.591
Loa Loa (eye worm) hypothetical protein 0.0055 0.1231 0.1024
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.1039 0.1401
Schistosoma mansoni SET domain protein 0.004 0.0748 0.053
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0579 0.0603
Trichomonas vaginalis AGC family protein kinase 0.0112 0.3056 0.2892
Loa Loa (eye worm) TAR-binding protein 0.0076 0.1924 0.1734
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.023 0.1871
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0579 0.0603
Brugia malayi TAR-binding protein 0.0076 0.1924 0.1734

Activities

Activity type Activity value Assay description Source Reference
AC50 (binding) 0.747 uM PubChem BioAssay. Development of Small Molecule Probes of the Histone Methyltransferase, NSD2 Measured in Biochemical System Using Plate Reader - 7053-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 42.95 uM PubChem BioAssay. Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - Primary and Confirmatory Screens. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 89.99 uM PubChem BioAssay. An HIV-1 Tat-TAR Fluorescence Polarization (FP) Counter Screen to evaluate Inhibitors Targeting HIV-1 Vif-dependent Degradation of Human APOBEC3G. (Class of assay: confirmatory) ChEMBL. No reference
Max_Activity_Concent (functional) 0.38 uM PubChem BioAssay. Thermal shift assay to identify compound binding to Kelch domain of Keap1 protein Measured in Biochemical System Using RT-PCR - 2119-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.5929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.5283 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 19.0115 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 21.3313 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1: Hit Validation. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 23.7781 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 26.8545 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1: Hit Validation using Tamra Binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 59.7279 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Iota: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 100 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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