TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 539.104 | Formula: C28H43ClN2O6
H donors: 3 H acceptors: 6 LogP: 2.87 Rotable bonds: 14
Rule of 5 violations (Lipinski): 2
SMILES: OC(=O)/C=C/C(=O)O.CCCCN(C(=O)C(C1(O)CCN(CC1)CCc1ccccc1Cl)C)CCCC
InChi: 1S/C24H39ClN2O2.C4H4O4/c1-4-6-15-27(16-7-5-2)23(28)20(3)24(29)13-18-26(19-14-24)17-12-21-10-8-9-11-22(21)25;5-3(6)1-2-4(7)8/h8-11,20,29H,4-7,12-19H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1+
InChiKey: PMDLOOFAUFGMIR-WLHGVMLRSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	tyrosine kinase	0.0322	0.4747	0.522
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0131	0.1549	1
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0054	0.0258	0.0277
Brugia malayi	Fibronectin type III domain containing protein	0.0071	0.0556	0.0532
Schistosoma mansoni	tyrosine kinase	0.0351	0.5232	0.5754
Brugia malayi	serine/threonine protein kinase 6	0.0131	0.1549	0.1633
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0071	0.0556	0.0612
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0183	0.2426	0.2663
Loa Loa (eye worm)	SRC-1	0.0043	0.0077	0.0077
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0131	0.1549	1
Loa Loa (eye worm)	STE/STE20/PAKA protein kinase	0.0054	0.0267	0.0286
Trichomonas vaginalis	CAMK family protein kinase	0.0111	0.1218	0.7435
Echinococcus multilocularis	serine:threonine protein kinase PAK 3	0.0106	0.1139	0.1226
Echinococcus granulosus	serine:threonine protein kinase PAK 1	0.0048	0.0166	0.0139
Trichomonas vaginalis	AGC family protein kinase	0.0131	0.1549	1
Echinococcus granulosus	hemicentin 1	0.0051	0.0222	0.0195
Schistosoma mansoni	protein kinase	0.0052	0.0234	0.0258
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0071	0.0556	0.0612
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0111	0.1218	0.1193
Trichomonas vaginalis	mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative	0.0054	0.0267	0.0065
Schistosoma mansoni	tyrosine kinase	0.033	0.4888	0.5376
Brugia malayi	Dual specificity mitogen-activated protein kinase kinase mek-2	0.0088	0.0838	0.0844
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0131	0.1549	0.1678
Echinococcus granulosus	serine:threonine protein kinase PAK 3	0.0106	0.1139	0.1114
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0043	0.0077	0.0054
Echinococcus granulosus	dual specificity mitogen activated protein	0.0088	0.0838	0.0812
Giardia lamblia	Kinase, PLK	0.0111	0.1218	0.7435
Schistosoma mansoni	serine/threonine protein kinase	0.0054	0.0267	0.0293
Trichomonas vaginalis	CAMK family protein kinase	0.0111	0.1218	0.7435
Schistosoma mansoni	serine/threonine protein kinase	0.0131	0.1549	0.1703
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0043	0.0077	0.0054
Echinococcus granulosus	defective proboscis extension response	0.0071	0.0556	0.053
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0123	0.1424	0.1401
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0167	0.2157	0.2135
Schistosoma mansoni	titin	0.0051	0.0222	0.0245
Onchocerca volvulus	Serine\/threonine protein kinase homolog	0.0183	0.2426	0.3076
Onchocerca volvulus		0.0451	0.6904	0.8755
Brugia malayi	Raf kinase	0.0253	0.3585	0.3891
Loa Loa (eye worm)	STE/STE20/PAKB protein kinase	0.0244	0.3446	0.3785
Echinococcus granulosus	Immunoglobulin	0.0071	0.0556	0.053
Echinococcus multilocularis	neural Wiskott Aldrich syndrome protein	0.0052	0.0234	0.0228
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0556	0.8664	0.9529
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0167	0.2157	0.2349
Echinococcus multilocularis	serine:threonine protein kinase PAK 3	0.0106	0.1139	0.1226
Trichomonas vaginalis	STE family protein kinase	0.0088	0.0838	0.4491
Echinococcus granulosus	twitchin	0.0097	0.0978	0.0953
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0043	0.0077	0.0054
Echinococcus granulosus	aurora kinase A	0.0131	0.1549	0.1525
Brugia malayi	Protein kinase domain containing protein	0.0322	0.4747	0.518
Loa Loa (eye worm)	P21-Rho-binding domain-containing protein	0.0052	0.0234	0.0251
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0111	0.1218	0.1313
Echinococcus granulosus	epidermal growth factor receptor	0.0351	0.5232	0.5219
Brugia malayi	hypothetical protein	0.0071	0.0556	0.0532
Schistosoma mansoni	hypothetical protein	0.0052	0.0234	0.0258
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0071	0.0556	0.0583
Trichomonas vaginalis	STE family protein kinase	0.0058	0.0335	0.0593
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0043	0.0077	0.0049
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0167	0.2157	0.2349
Echinococcus granulosus	contactin	0.0051	0.0222	0.0195
Schistosoma mansoni	cell adhesion molecule	0.0085	0.0779	0.0856
Onchocerca volvulus	Tyrosine kinase homolog	0.051	0.7886	1
Echinococcus granulosus	serine:threonine protein kinase PAK 3	0.0106	0.1139	0.1114
Echinococcus granulosus	serine:threonine protein kinase:endoribonuclease	0.0115	0.1285	0.1261
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0556	0.0605
Brugia malayi	Serine/threonine-protein kinase Pim-3	0.0183	0.2426	0.2605
Giardia lamblia	Aurora kinase	0.0131	0.1549	1
Echinococcus multilocularis	c src tyrosine kinase	0.0043	0.0077	0.0054
Entamoeba histolytica	protein kinase domain containing protein	0.0131	0.1549	1
Schistosoma mansoni	tyrosine kinase	0.033	0.4888	0.5376
Entamoeba histolytica	cell division protein kinase 2, putative	0.0054	0.0258	0.0181
Brugia malayi	P21-Rho-binding domain containing protein	0.0052	0.0234	0.0175
Entamoeba histolytica	protein kinase, putative	0.0058	0.0335	0.0763
Loa Loa (eye worm)	hypothetical protein	0.01	0.1039	0.1136
Onchocerca volvulus	Basement membrane proteoglycan homolog	0.0051	0.0222	0.0282
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0043	0.0077	0.0049
Loa Loa (eye worm)	AUR protein kinase	0.0131	0.1549	0.1698
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0556	0.8664	0.9525
Trichomonas vaginalis	AGC family protein kinase	0.0131	0.1549	1
Trichomonas vaginalis	CAMK family protein kinase	0.0111	0.1218	0.7435
Echinococcus multilocularis		0.0173	0.2263	0.2466
Loa Loa (eye worm)	STE/STE20/PAKA protein kinase	0.0054	0.0267	0.0286
Loa Loa (eye worm)	IRE protein kinase	0.0115	0.1285	0.1407
Loa Loa (eye worm)	STE/STE7/MEK1 protein kinase	0.0088	0.0838	0.0915
Schistosoma mansoni	tyrosine kinase	0.0271	0.3899	0.4288
Giardia lamblia	Kinase, STE STE20	0.0106	0.1139	0.6825
Trichomonas vaginalis	STE family protein kinase	0.0106	0.1139	0.6825
Echinococcus granulosus	neural Wiskott Aldrich syndrome protein	0.0052	0.0234	0.0207
Schistosoma mansoni	tyrosine kinase	0.0043	0.0077	0.0084
Echinococcus multilocularis	serine:threonine protein kinase:endoribonuclease	0.0115	0.1285	0.1387
Entamoeba histolytica	protein kinase, putative	0.0131	0.1549	1
Echinococcus multilocularis	hemicentin 1	0.0051	0.0222	0.0215
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0043	0.0077	0.0054
Loa Loa (eye worm)	AUR protein kinase	0.0131	0.1549	0.1698
Echinococcus multilocularis	cyclin dependent kinase 1	0.0054	0.0258	0.0254
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0043	0.0077	0.0049
Schistosoma mansoni	serine/threonine protein kinase	0.0062	0.0394	0.0433
Echinococcus multilocularis	tyrosine protein kinase shark	0.0271	0.3899	0.4271
Echinococcus granulosus	cyclin dependent kinase	0.0054	0.0258	0.0231
Schistosoma mansoni	protein kinase	0.0131	0.1549	0.1703
Echinococcus granulosus	serine:threonine protein kinase PAK 4	0.0192	0.2573	0.2553
Schistosoma mansoni	serine/threonine protein kinase	0.0192	0.2574	0.2831
Echinococcus multilocularis	PAK box P21 Rho binding	0.0058	0.0335	0.0339
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0043	0.0077	0.0054
Schistosoma mansoni	serine/threonine protein kinase	0.0183	0.2426	0.2668
Entamoeba histolytica	protein kinase, putative	0.0131	0.1549	1
Brugia malayi	Ribonuclease 2-5A family protein	0.0115	0.1285	0.134
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0186	0.2479	0.2664
Echinococcus granulosus	cyclin dependent kinase 5	0.0054	0.0258	0.0231
Echinococcus multilocularis	aurora kinase A	0.0131	0.1549	0.1678
Entamoeba histolytica	protein kinase , putative	0.0131	0.1549	1
Schistosoma mansoni	serine/threonine protein kinase	0.0111	0.1218	0.1339
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0123	0.1424	0.1541
Loa Loa (eye worm)	hypothetical protein	0.008	0.0693	0.0756
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0071	0.0556	0.0532
Loa Loa (eye worm)	TK/ROR protein kinase	0.004	0.0028	0.0023
Schistosoma mansoni	hypothetical protein	0.0052	0.0234	0.0258
Schistosoma mansoni	hypothetical protein	0.0052	0.0234	0.0258
Schistosoma mansoni	tyrosine kinase	0.0053	0.025	0.0275
Schistosoma mansoni	kinase	0.0059	0.0352	0.0387
Schistosoma mansoni	protein kinase	0.0106	0.1139	0.1253
Trichomonas vaginalis	STE family protein kinase	0.0106	0.1139	0.6825
Brugia malayi	Protein kinase domain containing protein	0.0054	0.0258	0.0201
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0043	0.0077	0.0049
Brugia malayi	Protein kinase domain containing protein	0.0192	0.2574	0.277
Trypanosoma cruzi	polo-like protein kinase, putative	0.0111	0.1218	0.7435
Trichomonas vaginalis	CAMK family protein kinase	0.0111	0.1218	0.7435
Loa Loa (eye worm)	AUR protein kinase	0.0131	0.1549	0.1698
Schistosoma mansoni	serine/threonine protein kinase	0.0181	0.2384	0.2622
Echinococcus multilocularis	epidermal growth factor receptor	0.0351	0.5232	0.5741
Echinococcus granulosus	raf serine:threonine protein kinase	0.0261	0.3726	0.3709
Schistosoma mansoni	tyrosine kinase	0.0582	0.9092	1
Schistosoma mansoni	wiskott-aldrich syndrome protein	0.0052	0.0234	0.0258
Trypanosoma cruzi	aurora B kinase, putative	0.0131	0.1549	1
Echinococcus granulosus	epidermal growth factor receptor	0.0582	0.9092	0.909
Trypanosoma brucei	aurora B kinase	0.0131	0.1549	1
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0556	0.0605
Schistosoma mansoni	vesicular amine transporter	0.0071	0.0556	0.0612
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0158	0.0167
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0043	0.0077	0.0054
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0556	0.0605
Giardia lamblia	Kinase, STE STE20	0.0088	0.0838	0.4491
Echinococcus granulosus	p21 activated protein kinase 1 Dpak1	0.0106	0.1139	0.1114
Echinococcus multilocularis	neuroglian	0.0091	0.0878	0.0938
Brugia malayi	Protein kinase domain containing protein	0.01	0.1037	0.1065
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0043	0.0077	0.0054
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0322	0.4747	0.4732
Leishmania major	mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860	0.0088	0.0838	0.4491
Echinococcus granulosus	neuroglian	0.0091	0.0878	0.0853
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0054	0.0258	0.0277
Entamoeba histolytica	p21-activated kinase	0.0106	0.1139	0.6882
Entamoeba histolytica	cell division protein kinase 2, putative	0.0054	0.0258	0.0181
Echinococcus granulosus	tyrosine protein kinase shark	0.0271	0.3899	0.3882
Echinococcus multilocularis	PAK box P21 Rho binding	0.0052	0.0234	0.0228
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0131	0.1549	0.1525
Schistosoma mansoni	tyrosine kinase	0.0167	0.2157	0.2372
Brugia malayi	cell division control protein 2 homolog	0.0054	0.0258	0.0201
Schistosoma mansoni	protein kinase	0.0058	0.0335	0.0368
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0043	0.0077	0.0054
Entamoeba histolytica	protein kinase, putative	0.0058	0.0335	0.0763
Schistosoma mansoni	tyrosine kinase	0.0073	0.0578	0.0636
Brugia malayi	serine/threonine-protein kinase plk-2	0.0111	0.1218	0.1266
Echinococcus multilocularis	dual specificity mitogen activated protein	0.0088	0.0838	0.0894
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0556	0.0605
Trypanosoma cruzi	polo-like protein kinase, putative	0.0111	0.1218	0.7435
Trichomonas vaginalis	AGC family protein kinase	0.0131	0.1549	1
Brugia malayi	Protein kinase domain	0.0106	0.1139	0.1178
Brugia malayi	WH1 domain containing protein	0.0052	0.0234	0.0175
Echinococcus granulosus	roundabout 2	0.0104	0.11	0.1076
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0351	0.5232	0.5219
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0556	0.0605
Trypanosoma brucei	mitogen-activated protein kinase kinase 5	0.0088	0.0838	0.4491
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0043	0.0077	0.0054
Schistosoma mansoni	serine/threonine protein kinase	0.0054	0.0258	0.0284
Echinococcus granulosus	insulin receptor	0.0322	0.4747	0.4732
Echinococcus multilocularis	serine:threonine protein kinase PAK 4	0.0192	0.2573	0.2808
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0111	0.1218	0.7435
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0183	0.2426	0.2663
Toxoplasma gondii	aurora kinase	0.0131	0.1549	1
Schistosoma mansoni	tyrosine kinase	0.0351	0.5232	0.5754
Schistosoma mansoni	tyrosine kinase	0.0322	0.4747	0.522
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0043	0.0077	0.0054
Entamoeba histolytica	protein kinase, putative	0.0106	0.1139	0.6882
Trichomonas vaginalis	AGC family protein kinase	0.0131	0.1549	1
Schistosoma mansoni	serine/threonine protein kinase	0.0054	0.0267	0.0293
Brugia malayi	serine/threonine-protein kinase 6	0.0131	0.1549	0.1633
Trichomonas vaginalis	conserved hypothetical protein	0.01	0.1039	0.6047
Trichomonas vaginalis	STE family protein kinase	0.0088	0.0838	0.4491
Echinococcus granulosus	c src tyrosine kinase	0.0043	0.0077	0.0049
Schistosoma mansoni	tyrosine kinase	0.0257	0.3665	0.4031
Trichomonas vaginalis	CAMK family protein kinase	0.0111	0.1218	0.7435
Trypanosoma cruzi	mitogen-activated protein kinase kinase 5	0.0088	0.0838	0.4491
Brugia malayi	Furin-like cysteine rich region family protein	0.0582	0.9092	1
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0054	0.0258	0.0277
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0043	0.0077	0.0049
Echinococcus multilocularis	proto oncogene serine:threonine protein kinase	0.0183	0.2426	0.2645
Echinococcus multilocularis	roundabout 2	0.0104	0.11	0.1183
Loa Loa (eye worm)	CAMK/CAMKL/CHK1 protein kinase	0.0192	0.2574	0.2826
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0111	0.1218	0.1544
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0131	0.1549	1
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0054	0.0258	0.0231
Trichomonas vaginalis	CAMK family protein kinase	0.0111	0.1218	0.7435
Schistosoma mansoni	tyrosine kinase	0.0043	0.0077	0.0084
Trypanosoma cruzi	STE/STE20 serine/threonine-protein kinase, putative	0.0054	0.0267	0.0065
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0043	0.0077	0.0054
Schistosoma mansoni	tyrosine kinase	0.0043	0.0077	0.0084
Echinococcus multilocularis	cyclin dependent kinase 5	0.0054	0.0258	0.0254
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0049	0.0177	0.015
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0261	0.3726	0.408
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0043	0.0077	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0308	0.4509	0.4956
Trichomonas vaginalis	STE family protein kinase	0.0106	0.1139	0.6825
Echinococcus granulosus	cyclin dependent kinase 1	0.0054	0.0258	0.0231
Loa Loa (eye worm)	hypothetical protein	0.0085	0.0779	0.085
Entamoeba histolytica	protein kinase, putative	0.0115	0.1285	0.7993
Trypanosoma cruzi	p21-activated kinase 3, putative	0.0054	0.0267	0.0065
Echinococcus multilocularis	p21 activated protein kinase 1 Dpak1	0.0106	0.1139	0.1226
Trichomonas vaginalis	conserved hypothetical protein	0.0056	0.0294	0.0275
Echinococcus multilocularis	cyclin dependent kinase 1	0.0054	0.0258	0.0254
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0043	0.0077	0.0084
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0085	0.0779	0.0753
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0111	0.1218	0.1333
Echinococcus granulosus	PAK box P21 Rho binding	0.0052	0.0234	0.0207
Echinococcus multilocularis	cyclin dependent kinase	0.0054	0.0258	0.0254
Loa Loa (eye worm)	TK/INSR protein kinase	0.0322	0.4747	0.5217
Brugia malayi	Protein kinase domain containing protein	0.0183	0.2426	0.2605
Echinococcus multilocularis	Immunoglobulin	0.0071	0.0556	0.0583
Echinococcus granulosus	3'partial\|serine:threonine protein kinase PAK 2	0.0052	0.0234	0.0207
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0167	0.2157	0.2135
Schistosoma mansoni	serine/threonine protein kinase	0.0261	0.3726	0.4098
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0131	0.1549	1
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0131	0.1549	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0043	0.0077	0.0049
Echinococcus multilocularis	insulin receptor	0.0322	0.4747	0.5206
Schistosoma mansoni	serine/threonine protein kinase	0.0054	0.0258	0.0284
Brugia malayi	P21-Rho-binding domain containing protein	0.0052	0.0234	0.0175
Trichomonas vaginalis	serine threonine-protein kinase, putative	0.0056	0.0294	0.0275
Schistosoma mansoni	nephrin	0.0091	0.0878	0.0966
Schistosoma mansoni	protein kinase	0.0106	0.1139	0.1253
Brugia malayi	p21/Cdc42/Rac1-activated kinase	0.0054	0.0267	0.0211
Schistosoma mansoni	tyrosine kinase	0.033	0.4888	0.5376
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0111	0.1218	0.7482
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0322	0.4747	0.5206
Loa Loa (eye worm)	raf kinase	0.024	0.3382	0.3715
Loa Loa (eye worm)	TK protein kinase	0.0186	0.2479	0.2721
Brugia malayi	Protein kinase domain containing protein	0.0322	0.475	0.5184
Entamoeba histolytica	protein kinase, putative	0.0115	0.1285	0.7993
Trichomonas vaginalis	CAMK family protein kinase	0.0111	0.1218	0.7435
Trichomonas vaginalis	CAMK family protein kinase	0.0058	0.0328	0.0544
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0582	0.9092	1
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0043	0.0077	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0104	0.11	0.1204
Echinococcus multilocularis	epidermal growth factor receptor	0.0582	0.9092	1
Trichomonas vaginalis	STE family protein kinase	0.0106	0.1139	0.6825
Leishmania major	protein kinase, putative	0.0131	0.1549	1
Trichomonas vaginalis	STE family protein kinase	0.0088	0.0838	0.4491
Entamoeba histolytica	protein kinase, putative	0.0058	0.0335	0.0763
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0156	0.1977	0.2168
Trichomonas vaginalis	CAMK family protein kinase	0.0058	0.0328	0.0544
Loa Loa (eye worm)	hypothetical protein	0.0123	0.1417	0.1552
Echinococcus granulosus	proto oncogene serine:threonine protein kinase	0.0183	0.2426	0.2405
Brugia malayi	serine/threonine-protein kinase PAK 7	0.0244	0.3446	0.3737
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0556	0.0605
Schistosoma mansoni	protein kinase	0.0088	0.0838	0.0921
Echinococcus multilocularis	Immunoglobulin	0.0071	0.0556	0.0583
Brugia malayi	serine/threonine kinase 12	0.0131	0.1549	0.1633
Schistosoma mansoni	tyrosine kinase	0.0043	0.0077	0.0084
Trypanosoma brucei	polo-like protein kinase	0.0111	0.1218	0.7435

Activities

Activity type	Activity value	Assay description	Source	Reference
ED50 (functional)	< 30 mg kg-1	Analgesic activity using PQW test, oral administration	ChEMBL.	6600791
ED50 (functional)	< 50 mg kg-1	Analgesic activity in tail flick test, subcutaneous administration	ChEMBL.	6600791
ED50 (functional)	< 100 mg kg-1	Analgesic activity in tail flick test, oral administration	ChEMBL.	6600791

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1744188

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1518042