Detailed information for compound 1522156

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1228.97 | Formula: C28H61Br9N8
  • H donors: 6 H acceptors: 0 LogP: 8.44 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 3
  • SMILES: Brc1cc(ccc1CN1CCNCCCNCCNCCC1)CN1CCNCCCNCCNCCC1.Br.Br.Br.Br.Br.Br.Br.Br
  • InChi: 1S/C28H53BrN8.8BrH/c29-28-23-26(24-36-19-3-11-32-15-13-30-7-1-9-34-17-21-36)5-6-27(28)25-37-20-4-12-33-16-14-31-8-2-10-35-18-22-37;;;;;;;;/h5-6,23,30-35H,1-4,7-22,24-25H2;8*1H
  • InChiKey: WLHIIYOVLFFHFC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0087 0.0056 0.0227
Echinococcus multilocularis thymidine phosphorylase 0.5699 1 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0018 0.0038
Brugia malayi EGF-like domain containing protein 0.0545 0.0868 0.1861
Loa Loa (eye worm) hypothetical protein 0.0065 0.0018 0.0038
Loa Loa (eye worm) hypothetical protein 0.0065 0.0018 0.0038
Loa Loa (eye worm) hypothetical protein 0.0065 0.0018 0.0038
Leishmania major histone deacetylase, putative 0.0484 0.076 1
Plasmodium vivax histone deacetylase 2, putative 0.0405 0.0621 0.7219
Trichomonas vaginalis histone deacetylase, putative 0.0484 0.076 1
Toxoplasma gondii histone deacetylase HDAC1 0.0405 0.0621 0.8165
Brugia malayi G-protein coupled receptor 0.0065 0.0018 0.0038
Brugia malayi hypothetical protein 0.01 0.008 0.0172
Echinococcus granulosus Nicastrin 0.01 0.008 0.0063
Schistosoma mansoni slit 0.0069 0.0026 0.0018
Loa Loa (eye worm) hypothetical protein 0.0087 0.0056 0.0121
Brugia malayi Calcium binding EGF domain containing protein 0.0124 0.0123 0.0264
Loa Loa (eye worm) notch protein 0.0124 0.0123 0.0264
Loa Loa (eye worm) hypothetical protein 0.0077 0.004 0.0085
Brugia malayi putative neuropeptide receptor NPR1 0.0065 0.0018 0.0038
Echinococcus multilocularis histone deacetylase 0.0405 0.0621 0.0604
Plasmodium vivax histone deacetylase, putative 0.0405 0.0621 0.7219
Brugia malayi AKH receptor 0.0065 0.0018 0.0038
Loa Loa (eye worm) hypothetical protein 0.0065 0.0018 0.0038
Brugia malayi G protein-coupled receptor F59B2.13 0.0065 0.0018 0.0038
Loa Loa (eye worm) hypothetical protein 0.01 0.008 0.0172
Echinococcus granulosus histone deacetylase 3 0.0484 0.076 0.0744
Schistosoma mansoni histone deacetylase 4 5 0.0405 0.0621 0.1298
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0065 0.0018 0.0038
Brugia malayi Dopamine receptor 0.0065 0.0018 0.0038
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0182 0.0225 0.1216
Loa Loa (eye worm) histone deacetylase 0.0405 0.0621 0.1331
Brugia malayi gamma-secretase subunit pen-2 0.0193 0.0244 0.0524
Brugia malayi hypothetical protein 0.0072 0.003 0.0065
Echinococcus granulosus sodium channel protein 0.0232 0.0314 0.0297
Echinococcus granulosus histone deacetylase 6 0.0405 0.0621 0.0604
Brugia malayi hypothetical protein 0.0065 0.0018 0.0038
Schistosoma mansoni subfamily A22A unassigned peptidase (A22 family) 0.0205 0.0267 0.0536
Echinococcus multilocularis histone deacetylase 8 0.0201 0.0259 0.0241
Echinococcus granulosus histone deacetylase 0.0405 0.0621 0.0604
Loa Loa (eye worm) G-protein coupled receptor 0.0065 0.0018 0.0038
Echinococcus multilocularis notch 0.0127 0.0127 0.011
Loa Loa (eye worm) hypothetical protein 0.0065 0.0018 0.0038
Brugia malayi hypothetical protein 0.0072 0.003 0.0065
Brugia malayi RE15519p 0.0065 0.0018 0.0038
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0087 0.0056 0.0121
Schistosoma mansoni notch 0.0127 0.0127 0.0237
Loa Loa (eye worm) hypothetical protein 0.0065 0.0018 0.0038
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0065 0.0018 0.0038
Echinococcus granulosus neurogenic locus protein delta 0.0069 0.0026 0.0008
Giardia lamblia Histone deacetylase 0.0484 0.076 0.5
Loa Loa (eye worm) hypothetical protein 0.0065 0.0018 0.0038
Brugia malayi ORL1-like opioid receptor 0.0065 0.0018 0.0038
Echinococcus multilocularis histone deacetylase 1 0.0484 0.076 0.0744
Loa Loa (eye worm) hypothetical protein 0.0077 0.004 0.0085
Echinococcus granulosus neurogenic locus notch protein 4 0.0077 0.004 0.0022
Toxoplasma gondii hypothetical protein 0.0058 0.0006 0.0073
Echinococcus multilocularis presenilin 0.0205 0.0267 0.025
Brugia malayi sulfakinin receptor protein 0.1383 0.2354 0.5047
Brugia malayi hypothetical protein 0.0065 0.0018 0.0038
Schistosoma mansoni voltage-gated potassium channel 0.0098 0.0077 0.0128
Brugia malayi hypothetical protein 0.0065 0.0018 0.0038
Echinococcus multilocularis neurogenic locus notch protein 0.1026 0.1721 0.1706
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0065 0.0018 0.0038
Loa Loa (eye worm) hypothetical protein 0.0979 0.1637 0.3511
Trypanosoma brucei histone deacetylase 1 0.0484 0.076 0.4308
Echinococcus multilocularis Nicastrin 0.01 0.008 0.0063
Brugia malayi Calcium binding EGF domain containing protein 0.0124 0.0123 0.0264
Trichomonas vaginalis histone deacetylase, putative 0.0484 0.076 1
Schistosoma mansoni histone deacetylase hda2 0.0201 0.0259 0.0519
Loa Loa (eye worm) transmembrane cell adhesion receptor mua-3 0.0093 0.0067 0.0143
Brugia malayi hypothetical protein 0.0072 0.003 0.0065
Loa Loa (eye worm) hypothetical protein 0.0065 0.0018 0.0038
Loa Loa (eye worm) gamma-secretase subunit pen-2 0.0193 0.0244 0.0524
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0065 0.0018 0.0038
Loa Loa (eye worm) hypothetical protein 0.0087 0.0056 0.0121
Trichomonas vaginalis Nicastrin precursor, putative 0.01 0.008 0.069
Loa Loa (eye worm) hypothetical protein 0.1383 0.2354 0.5047
Loa Loa (eye worm) hypothetical protein 0.0065 0.0018 0.0038
Echinococcus multilocularis Nicastrin 0.01 0.008 0.0063
Trypanosoma cruzi Aph-1 protein, putative 0.1047 0.1758 1
Schistosoma mansoni notch 0.0069 0.0026 0.0018
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0065 0.0018 0.0038
Trichomonas vaginalis histone deacetylase, putative 0.0484 0.076 1
Brugia malayi Presenilin-like protein At2g29900 0.0072 0.003 0.0065
Echinococcus granulosus presenilin enhancer 2 0.0193 0.0244 0.0227
Brugia malayi hypothetical protein 0.1383 0.2354 0.5047
Echinococcus multilocularis neurogenic locus protein delta 0.0069 0.0026 0.0008
Loa Loa (eye worm) hypothetical protein 0.0065 0.0018 0.0038
Loa Loa (eye worm) hypothetical protein 0.0065 0.0018 0.0038
Trypanosoma cruzi histone deacetylase, putative 0.0405 0.0621 0.2416
Toxoplasma gondii histone deacetylase HDAC4 0.0201 0.0259 0.3401
Loa Loa (eye worm) histone deacetylase 3 0.0484 0.076 0.163
Trypanosoma cruzi presenilin-like aspartic peptidase, putative 0.0205 0.0267 0.0054
Trichomonas vaginalis Clan AD, family A22, presenilin-like aspartic peptidase 0.0205 0.0267 0.3245
Trypanosoma cruzi Aph-1 protein, putative 0.1047 0.1758 1
Schistosoma mansoni histone deacetylase 0.0484 0.076 0.1599
Brugia malayi Dopamine receptor protein 2 0.0065 0.0018 0.0038
Echinococcus multilocularis histone deacetylase 6 0.0412 0.0632 0.0616
Loa Loa (eye worm) hypothetical protein 0.0069 0.0026 0.0055
Echinococcus multilocularis slit 2 protein 0.0069 0.0026 0.0008
Brugia malayi putative neuropeptide receptor 0.0065 0.0018 0.0038
Loa Loa (eye worm) hypothetical protein 0.0065 0.0018 0.0038
Onchocerca volvulus Histone deacetylase 10 homolog 0.0201 0.0259 0.1415
Onchocerca volvulus 0.0095 0.0071 0.0315
Brugia malayi Histone deacetylase family protein 0.0405 0.0621 0.1331
Loa Loa (eye worm) neuropeptide F receptor 0.0065 0.0018 0.0038
Echinococcus granulosus histone deacetylase 8 0.0201 0.0259 0.0241
Brugia malayi neuropeptide F receptor 0.0065 0.0018 0.0038
Echinococcus multilocularis neurogenic locus notch protein 4 0.0077 0.004 0.0022
Loa Loa (eye worm) hypothetical protein 0.0065 0.0018 0.0038
Onchocerca volvulus 0.0069 0.0026 0.0048
Leishmania major histone deacetylase, putative 0.0484 0.076 1
Echinococcus multilocularis presenilin enhancer 2 0.0193 0.0244 0.0227
Brugia malayi hypothetical protein 0.0065 0.0018 0.0038
Echinococcus granulosus histone deacetylase 1 0.0484 0.076 0.0744
Brugia malayi Presenilin spe-4 0.0072 0.003 0.0065
Brugia malayi histone deacetylase 11 0.0201 0.0259 0.0555
Schistosoma mansoni notch 0.0413 0.0635 0.133
Leishmania major histone deacetylase, putative 0.0405 0.0621 0.8152
Brugia malayi neuropeptide F receptor 0.0065 0.0018 0.0038
Echinococcus granulosus slit 2 protein 0.0069 0.0026 0.0008
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0091 0.0065 0.0047
Loa Loa (eye worm) hypothetical protein 0.0065 0.0018 0.0038
Echinococcus multilocularis histone deacetylase 7 0.0405 0.0621 0.0604
Brugia malayi G-protein coupled receptor 0.0065 0.0018 0.0038
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0065 0.0018 0.0038
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0065 0.0018 0.0038
Brugia malayi histone deacetylase 3 (HD3) 0.0484 0.076 0.163
Loa Loa (eye worm) hypothetical protein 0.0204 0.0265 0.0568
Loa Loa (eye worm) hypothetical protein 0.0065 0.0018 0.0038
Loa Loa (eye worm) hypothetical protein 0.0065 0.0018 0.0038
Trypanosoma cruzi presenilin-like aspartic peptidase, putative 0.0205 0.0267 0.0054
Schistosoma mansoni hypothetical protein 0.0095 0.0071 0.0115
Loa Loa (eye worm) presenilin spe-4 0.0072 0.003 0.0065
Echinococcus granulosus histone deacetylase 7 0.0405 0.0621 0.0604
Loa Loa (eye worm) hypothetical protein 0.0065 0.0018 0.0038
Onchocerca volvulus 0.0095 0.0071 0.0315
Schistosoma mansoni histone deacetylase hda2 0.0412 0.0632 0.1323
Loa Loa (eye worm) hypothetical protein 0.0065 0.0018 0.0038
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0484 0.076 1
Loa Loa (eye worm) Notch2 0.0654 0.1061 0.2275
Toxoplasma gondii sushi domain (scr repeat) domain-containing protein 0.0095 0.0071 0.0937
Trichomonas vaginalis histone deacetylase, putative 0.0484 0.076 1
Trypanosoma cruzi histone deacetylase, putative 0.0405 0.0621 0.2416
Brugia malayi Histone deacetylase family protein 0.0405 0.0621 0.1331
Loa Loa (eye worm) hypothetical protein 0.0065 0.0018 0.0038
Plasmodium falciparum histone deacetylase 1 0.0484 0.076 1
Toxoplasma gondii hypothetical protein 0.0072 0.003 0.0397
Brugia malayi notch-like transmembrane receptor 0.0979 0.1637 0.3511
Loa Loa (eye worm) hypothetical protein 0.0087 0.0056 0.0121
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0065 0.0018 0.0038
Loa Loa (eye worm) hypothetical protein 0.0124 0.0123 0.0264
Echinococcus granulosus histone deacetylase 6 0.0412 0.0632 0.0616
Trypanosoma brucei histone deacetylase 3 0.0405 0.0621 0.3511
Leishmania major histone deacetylase, putative 0.0405 0.0621 0.8152
Brugia malayi Melatonin receptor type 1A 0.0065 0.0018 0.0038
Brugia malayi gamma-secretase subunit aph-1 0.2687 0.4663 1
Onchocerca volvulus Neurogenic locus notch homolog 0.0095 0.0071 0.0315
Loa Loa (eye worm) hypothetical protein 0.0065 0.0018 0.0038
Toxoplasma gondii histone deacetylase HDAC5 0.0201 0.0259 0.3403
Loa Loa (eye worm) hypothetical protein 0.0065 0.0018 0.0038
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0484 0.076 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0065 0.0018 0.0038
Loa Loa (eye worm) hypothetical protein 0.0065 0.0018 0.0038
Loa Loa (eye worm) hypothetical protein 0.0065 0.0018 0.0038
Trichomonas vaginalis Clan AD, family A22, presenilin-like aspartic peptidase 0.0205 0.0267 0.3245
Loa Loa (eye worm) hypothetical protein 0.0065 0.0018 0.0038
Loa Loa (eye worm) hypothetical protein 0.0484 0.076 0.163
Onchocerca volvulus Slit protein homolog 0.0069 0.0026 0.0048
Brugia malayi histone deacetylase 1 (HD1) 0.0484 0.076 0.163
Loa Loa (eye worm) hypothetical protein 0.0077 0.004 0.0085
Plasmodium vivax histone deacetylase 1, putative 0.0484 0.076 1
Mycobacterium tuberculosis Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) 0.5699 1 1
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0484 0.076 1
Toxoplasma gondii histone deacetylase HDAC2 0.0484 0.076 1
Echinococcus multilocularis sodium channel protein 0.0232 0.0314 0.0297
Toxoplasma gondii histone deacetylase HDAC3 0.0484 0.076 1
Brugia malayi Histone deacetylase 1 0.0484 0.076 0.163
Schistosoma mansoni gamma-secretase subunit aph-1 0.2687 0.4663 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0018 0.0038
Brugia malayi GnHR receptor homolog 0.0065 0.0018 0.0038
Loa Loa (eye worm) hypothetical protein 0.0065 0.0018 0.0038
Mycobacterium leprae Probable anthranilate phosphoribosyltransferase TrpD 0.1609 0.2753 0.5
Schistosoma mansoni histone deacetylase 1 2 3 0.0201 0.0259 0.0519
Schistosoma mansoni hypothetical protein 0.01 0.008 0.0135
Brugia malayi Presenilin spe-4 0.0072 0.003 0.0065
Onchocerca volvulus Neurogenic locus notch homolog 0.1026 0.1721 1
Trypanosoma cruzi histone deacetylase, putative 0.0405 0.0621 0.2416
Loa Loa (eye worm) hypothetical protein 0.0065 0.0018 0.0038
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.2687 0.4663 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0018 0.0038
Echinococcus multilocularis gamma secretase subunit aph 1 0.2687 0.4663 0.4654
Mycobacterium ulcerans thymidine phosphorylase 0.5699 1 1
Brugia malayi hypothetical protein 0.0065 0.0018 0.0038
Loa Loa (eye worm) neuropeptide F receptor 0.0065 0.0018 0.0038
Loa Loa (eye worm) G-protein coupled receptor 0.0065 0.0018 0.0038
Loa Loa (eye worm) hypothetical protein 0.0065 0.0018 0.0038
Brugia malayi Serotonin receptor 0.0065 0.0018 0.0038
Brugia malayi EGF-like domain containing protein 0.0069 0.0026 0.0055
Echinococcus granulosus notch 0.0127 0.0127 0.011
Loa Loa (eye worm) hypothetical protein 0.0115 0.0107 0.0229
Brugia malayi hypothetical protein 0.0065 0.0018 0.0038
Loa Loa (eye worm) hypothetical protein 0.0065 0.0018 0.0038
Loa Loa (eye worm) hypothetical protein 0.0065 0.0018 0.0038
Brugia malayi Serotonin receptor 0.0065 0.0018 0.0038
Loa Loa (eye worm) hypothetical protein 0.0065 0.0018 0.0038
Loa Loa (eye worm) histone deacetylase 1 0.0484 0.076 0.163
Loa Loa (eye worm) hypothetical protein 0.0065 0.0018 0.0038
Brugia malayi Presenilin spe-4 0.0072 0.003 0.0065
Brugia malayi Dopamine receptor protein 1 0.0065 0.0018 0.0038
Loa Loa (eye worm) hypothetical protein 0.0081 0.0047 0.01
Leishmania major presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative 0.0205 0.0267 0.3461
Echinococcus multilocularis histone deacetylase 6 0.0405 0.0621 0.0604
Brugia malayi hypothetical protein 0.0065 0.0018 0.0038
Toxoplasma gondii notch (dsl) domain-containing protein 0.0095 0.0071 0.0937
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0091 0.0065 0.0139
Schistosoma mansoni histone deacetylase 0.0484 0.076 0.1599
Trypanosoma brucei histone deacetylase, putative 0.0405 0.0621 0.3511
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0232 0.0314 0.4082
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0065 0.0018 0.0038
Echinococcus multilocularis histone deacetylase 3 0.0484 0.076 0.0744
Loa Loa (eye worm) hypothetical protein 0.0065 0.0018 0.0038
Loa Loa (eye worm) hypothetical protein 0.0124 0.0123 0.0264
Trypanosoma brucei histone deacetylase 2 0.0201 0.0259 0.1444
Loa Loa (eye worm) hypothetical protein 0.0065 0.0018 0.0038
Brugia malayi Presenilin family protein 0.0205 0.0267 0.0572
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0232 0.0314 0.0297
Loa Loa (eye worm) hypothetical protein 0.0211 0.0276 0.0592
Loa Loa (eye worm) hypothetical protein 0.0065 0.0018 0.0038
Trichomonas vaginalis Clan AD, family A22, presenilin-like aspartic peptidase 0.0205 0.0267 0.3245
Echinococcus multilocularis histone deacetylase 6 0.0405 0.0621 0.0604
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0065 0.0018 0.0038
Brugia malayi hypothetical protein 0.01 0.008 0.0172
Echinococcus granulosus histone deacetylase 6 0.0405 0.0621 0.0604
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0091 0.0065 0.0139
Brugia malayi hypothetical protein 0.0065 0.0018 0.0038
Brugia malayi EGF-like domain containing protein 0.0095 0.0071 0.0153
Brugia malayi G protein-coupled receptor 0.0065 0.0018 0.0038
Loa Loa (eye worm) hypothetical protein 0.0065 0.0018 0.0038
Loa Loa (eye worm) hypothetical protein 0.0069 0.0026 0.0055
Trichomonas vaginalis Nicastrin precursor, putative 0.01 0.008 0.069
Trypanosoma brucei histone deacetylase 4 0.0405 0.0621 0.3511
Loa Loa (eye worm) hypothetical protein 0.0065 0.0018 0.0038
Toxoplasma gondii sushi domain (scr repeat) domain-containing protein 0.0095 0.0071 0.0937
Brugia malayi larval opioid receptor 0.0065 0.0018 0.0038
Trypanosoma brucei presenilin-like aspartic peptidase, putative 0.0205 0.0267 0.1491
Trichomonas vaginalis histone deacetylase, putative 0.0484 0.076 1
Trypanosoma brucei Aph-1 protein, putative 0.1047 0.1758 1
Schistosoma mansoni voltage-gated potassium channel 0.0098 0.0077 0.0128
Loa Loa (eye worm) TYRA-2 protein 0.0065 0.0018 0.0038
Toxoplasma gondii microneme protein MIC12 0.0093 0.0067 0.0879
Loa Loa (eye worm) hypothetical protein 0.0095 0.0071 0.0153
Brugia malayi Tachykinin-like peptides receptor 99D 0.0065 0.0018 0.0038
Loa Loa (eye worm) histone deacetylase 11 0.0201 0.0259 0.0555
Trichomonas vaginalis histone deacetylase, putative 0.0484 0.076 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0018 0.0038
Brugia malayi hypothetical protein 0.0065 0.0018 0.0038
Trypanosoma cruzi histone deacetylase 1, putative 0.0484 0.076 0.3347
Schistosoma mansoni histone deacetylase 4 5 0.0405 0.0621 0.1298
Loa Loa (eye worm) hypothetical protein 0.0065 0.0018 0.0038
Echinococcus granulosus gamma secretase subunit aph 1 0.2687 0.4663 0.4654
Echinococcus granulosus neurogenic locus notch protein 0.1026 0.1721 0.1706
Brugia malayi follicle stimulating hormone receptor 0.0065 0.0018 0.0038
Trypanosoma cruzi histone deacetylase 1, putative 0.0484 0.076 0.3347
Loa Loa (eye worm) hypothetical protein 0.0069 0.0026 0.0055
Loa Loa (eye worm) hypothetical protein 0.0065 0.0018 0.0038
Loa Loa (eye worm) hypothetical protein 0.0065 0.0018 0.0038
Echinococcus granulosus presenilin 0.0205 0.0267 0.025
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0091 0.0065 0.0047
Loa Loa (eye worm) hypothetical protein 0.0201 0.0259 0.0555
Loa Loa (eye worm) histone deacetylase 7A 0.0405 0.0621 0.1331
Entamoeba histolytica histone deacetylase, putative 0.0484 0.076 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0018 0.0038

Activities

Activity type Activity value Assay description Source Reference
CC50 (functional) > 203 uM Concentration required to reduce the viability of mock-infected MT-4 cells ChEMBL. 7830280

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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