Detailed information for compound 1528367

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1272.2 | Formula: C32H72Br8N8O4
  • H donors: 10 H acceptors: 4 LogP: 7.11 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 3
  • SMILES: C1CNCCN(CCCNCCNC1)Cc1ccc2c(c1)ccc(c2)CN1CCNCCCNCCNCCC1.Br.Br.Br.Br.Br.Br.Br.Br.O.O.O.O
  • InChi: 1S/C32H56N8.8BrH.4H2O/c1-9-33-15-17-35-13-3-21-39(23-19-37-11-1)27-29-5-7-32-26-30(6-8-31(32)25-29)28-40-22-4-14-36-18-16-34-10-2-12-38-20-24-40;;;;;;;;;;;;/h5-8,25-26,33-38H,1-4,9-24,27-28H2;8*1H;4*1H2
  • InChiKey: BPEYJPZTBSHSNT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0067 0.0111
Loa Loa (eye worm) DR-78 0.0005 0.0024 0.004
Echinococcus granulosus axis inhibition protein axin 0.002 0.0379 0.0379
Schistosoma mansoni nuclear hormone receptor 0.0005 0.0024 0.0024
Echinococcus multilocularis nuclear receptor nhr 48 0.0005 0.0024 0.0024
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0379 0.0379
Brugia malayi ecdysteroid receptor 0.001 0.0156 0.0258
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.037 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0067 0.0111
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0379 0.0627
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.037 0.0613
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0005 0.0024 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0067 0.0111
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0005 0.0024 0.0024
Echinococcus granulosus thyroid hormone receptor alpha 0.0005 0.0024 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0067 0.0111
Brugia malayi CXXC zinc finger family protein 0.0029 0.0615 0.1017
Onchocerca volvulus 0.0005 0.0024 0.0389
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.037 0.0613
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0156 0.2532
Echinococcus multilocularis expressed protein 0.0381 0.9118 0.9118
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0067 0.0111
Echinococcus granulosus Nuclear hormone receptor HR96 0.0005 0.0024 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0156 0.0258
Mycobacterium ulcerans hypothetical protein 0.0111 0.2587 1
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.037 0.0613
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0379 0.0379
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0379 0.0379
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0156 0.0258
Loa Loa (eye worm) hypothetical protein 0.0005 0.0038 0.0063
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.141 0.141
Brugia malayi nuclear receptor RXR 0.0005 0.0038 0.0063
Loa Loa (eye worm) hypothetical protein 0.002 0.0379 0.0627
Trichomonas vaginalis protein-S isoprenylcysteine O-methyltransferase, putative 0.0254 0.6046 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0082 0.0082
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0379 0.0379
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0379 0.0627
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0156 0.0258
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0005 0.0038 0.0063
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0156 0.0156
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0067 0.0111
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0156 0.0156
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.037 0.037
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0156 0.0258
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0156 0.0258
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0156 0.0156
Echinococcus granulosus Nuclear hormone receptor HR96 0.0005 0.0024 0.0024
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0156 0.0258
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0005 0.0024 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0379 0.0627
Schistosoma mansoni ap endonuclease 0.0019 0.037 0.037
Brugia malayi protein-S isoprenylcysteine O-methyltransferase, putative 0.0254 0.6046 1
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.001 0.0156 0.0258
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0156 0.0258
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0156 0.2532
Brugia malayi PXA domain containing protein 0.002 0.0379 0.0627
Loa Loa (eye worm) hypothetical protein 0.002 0.0379 0.0627
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0156 0.0156
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0156 0.0156
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0379 0.0627
Loa Loa (eye worm) hypothetical protein 0.002 0.0379 0.0627
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0005 0.0024 0.0024
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0156 0.0156
Schistosoma mansoni regulator of G protein signaling 0.002 0.0379 0.0379
Loa Loa (eye worm) nuclear receptor NHR-67 0.0005 0.0024 0.004
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0156 0.0156
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0156 0.0258
Loa Loa (eye worm) hypothetical protein 0.0005 0.0038 0.0063
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0379 0.0627
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.037 0.037
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0067 0.0111
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0111 0.2587 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0156 0.0258
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0005 0.0038 0.0038
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0126 0.0208
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0005 0.0038 0.0038
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0156 0.0258
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0067 0.0111
Giardia lamblia Isoprenylcysteine carboxyl methyltransferase 0.0254 0.6046 1
Trypanosoma cruzi prenyl protein specific carboxyl methyltransferase, putative 0.0254 0.6046 1
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.037 0.0613
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.037 0.0613
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0156 0.0156
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0005 0.0024 0.0024
Schistosoma mansoni axis inhibition protein axin 0.002 0.0379 0.0379
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0379 0.0379
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.1249 0.2066
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0379 0.0379
Trypanosoma cruzi prenyl protein specific carboxyl methyltransferase, putative 0.0254 0.6046 1
Loa Loa (eye worm) hypothetical protein 0.0005 0.0024 0.004
Loa Loa (eye worm) hypothetical protein 0.001 0.0156 0.0258
Echinococcus granulosus expressed protein 0.0381 0.9118 0.9118
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0067 0.0111
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0126 0.0126
Brugia malayi nuclear hormone receptor 0.001 0.0156 0.0258
Brugia malayi nuclear hormone receptor family member nhr-6 0.0005 0.0024 0.004
Loa Loa (eye worm) RGS-3 protein 0.002 0.0379 0.0627
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0123 0.0203
Trypanosoma brucei prenyl protein specific carboxyl methyltransferase 0.0254 0.6046 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0156 0.0258
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0005 0.0024 0.004
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0379 0.0627
Brugia malayi hypothetical protein 0.0005 0.0024 0.004
Echinococcus granulosus FTZ F1 alpha 0.001 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.002 0.0379 0.0627
Onchocerca volvulus 0.0029 0.0615 1
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0379 0.0627
Loa Loa (eye worm) hypothetical protein 0.0005 0.0038 0.0063
Brugia malayi Nuclear hormone receptor E75 0.0005 0.0024 0.004
Loa Loa (eye worm) hypothetical protein 0.0005 0.0024 0.004
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0005 0.0024 0.0389
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0615 0.1017
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0156 0.0156
Echinococcus multilocularis cpg binding protein 0.0031 0.0655 0.0655
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0082 0.0082
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.0379 0.0627
Onchocerca volvulus 0.001 0.0156 0.2532
Loa Loa (eye worm) hypothetical protein 0.001 0.0156 0.0258
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0067 0.0111
Schistosoma mansoni z-protein (S1r protein) 0.002 0.0379 0.0379
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0156 0.0258
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0379 0.0627
Brugia malayi ecdysone receptor 0.0005 0.0024 0.004
Loa Loa (eye worm) hypothetical protein 0.002 0.0379 0.0627
Schistosoma mansoni thyroid hormone receptor 0.001 0.0156 0.0156
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0005 0.0038 0.0038
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0082 0.0082
Plasmodium vivax protein-S-isoprenylcysteine O-methyltransferase, putative 0.0254 0.6046 1
Entamoeba histolytica hypothetical protein 0.002 0.0379 0.0627
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0156 0.0156
Brugia malayi hypothetical protein 0.0005 0.0038 0.0063
Loa Loa (eye worm) hypothetical protein 0.0005 0.0024 0.004
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.037 0.5
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.0379 0.0627
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0004 0.0008 0.0008
Entamoeba histolytica prenyl cysteine carboxyl methyltransferase, putative 0.0254 0.6046 1
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0379 0.0379
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0379 0.0627
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0067 0.0111
Schistosoma mansoni cpg binding protein 0.0031 0.0655 0.0655
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0156 0.0258
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0156 0.0156
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0005 0.0038 0.0063
Loa Loa (eye worm) protein-S isoprenylcysteine O-methyltransferase 0.0254 0.6046 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0156 0.0156
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0156 0.0156
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0379 0.0379
Trichomonas vaginalis protein-S isoprenylcysteine O-methyltransferase, putative 0.0254 0.6046 1
Schistosoma mansoni regulator of G protein signaling 0.002 0.0379 0.0379
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0156 0.0156
Brugia malayi conserved hypotetical protein 0.0005 0.0024 0.004
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.037 0.0613
Schistosoma mansoni nuclear hormone receptor 0.0005 0.0024 0.0024
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0156 0.0156
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0156 0.0258
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0005 0.0024 0.0024
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0005 0.0024 0.0024
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0156 0.0156
Echinococcus granulosus protein S isoprenylcysteine O methyltransferase 0.0254 0.6046 0.6046
Brugia malayi nuclear receptor NHR-88 0.0005 0.0024 0.004
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0379 0.0379
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0156 0.0258
Loa Loa (eye worm) hypothetical protein 0.0005 0.0038 0.0063
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.037 0.1432
Loa Loa (eye worm) hypothetical protein 0.001 0.0156 0.0258
Schistosoma mansoni protein-s-isoprenylcysteine o-methyltransferase 0.0254 0.6046 0.6046
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0067 0.0111
Schistosoma mansoni axis inhibition protein axin 0.002 0.0379 0.0379
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0156 0.0156
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0156 0.0258
Plasmodium falciparum protein-S-isoprenylcysteine O-methyltransferase, putative 0.0254 0.6046 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0156 0.2532
Schistosoma mansoni nuclear receptor 0.0005 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0005 0.0024 0.004
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.037 0.0613
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.037 0.0613
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0067 0.0111
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0379 0.0379
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0379 0.0379
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0379 0.0379
Onchocerca volvulus 0.0005 0.0024 0.0389
Loa Loa (eye worm) hypothetical protein 0.0005 0.0024 0.004
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0156 0.0156
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.0379 0.0379
Loa Loa (eye worm) hypothetical protein 0.0005 0.0024 0.004
Echinococcus multilocularis 0.0254 0.6046 0.6046
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0379 0.0379
Loa Loa (eye worm) hypothetical protein 0.0005 0.0024 0.004
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0379 0.0379
Echinococcus granulosus nuclear receptor nhr 48 0.0005 0.0024 0.0024
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0067 0.0111
Loa Loa (eye worm) hypothetical protein 0.002 0.0379 0.0627
Trichomonas vaginalis protein-S isoprenylcysteine O-methyltransferase, putative 0.0254 0.6046 1
Entamoeba histolytica prenyl cysteine carboxyl methyltransferase, putative 0.0254 0.6046 1
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0379 0.0627
Schistosoma mansoni thyroid hormone receptor 0.001 0.0156 0.0156
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0005 0.0024 0.0024
Entamoeba histolytica hypothetical protein 0.002 0.0379 0.0627
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0156 0.0156
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0379 0.0379
Trichomonas vaginalis helicase, putative 0.0007 0.0067 0.0111
Loa Loa (eye worm) hypothetical protein 0.0005 0.0024 0.004
Loa Loa (eye worm) hypothetical protein 0.001 0.0156 0.0258
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.037 0.0613
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0038 0.0063
Toxoplasma gondii exonuclease III APE 0.0019 0.037 0.0613
Loa Loa (eye worm) hypothetical protein 0.001 0.0156 0.0258
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0038 0.0063
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0379 0.0627
Brugia malayi nuclear hormone receptor family member odr-7 0.0005 0.0024 0.004
Leishmania major prenyl protein specific carboxyl methyltransferase, putative 0.0254 0.6046 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0126 0.0126
Brugia malayi steroid hormone receptor 0.001 0.0156 0.0258
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0156 0.0258
Loa Loa (eye worm) hypothetical protein 0.001 0.0156 0.0258
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0082 0.0082
Schistosoma mansoni cpg binding protein 0.0031 0.0655 0.0655
Brugia malayi tailless protein 0.0005 0.0024 0.004
Echinococcus granulosus axis inhibition protein axin 0.002 0.0379 0.0379
Brugia malayi hypothetical protein 0.002 0.0379 0.0627
Echinococcus multilocularis dnaJ subfamily B 0.0417 1 1
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0379 0.0379
Schistosoma mansoni hypothetical protein 0.0417 1 1
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.002 0.0379 0.0627
Brugia malayi orphan nuclear receptor NR2E1 0.0005 0.0024 0.004
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0156 0.0156
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0156 0.0156
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0005 0.0024 0.0389
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0156 0.0156
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0156 0.0258
Schistosoma mansoni zinc finger protein 0.0005 0.0024 0.0024
Brugia malayi hypothetical protein 0.0005 0.0038 0.0063
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0005 0.0024 0.004
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0156 0.0258
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0156 0.0258
Loa Loa (eye worm) nuclear hormone receptor 0.0005 0.0024 0.004
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0156 0.0258
Schistosoma mansoni coup transcription factor 0.001 0.0156 0.0156
Brugia malayi nuclear receptor NHR-88 0.001 0.0156 0.0258
Brugia malayi PXA domain containing protein 0.002 0.0379 0.0627
Loa Loa (eye worm) hypothetical protein 0.0005 0.0024 0.004
Brugia malayi hypothetical protein 0.0005 0.0024 0.004
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0005 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0005 0.0024 0.004
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0156 0.0258
Loa Loa (eye worm) hypothetical protein 0.001 0.0156 0.0258
Schistosoma mansoni nuclear receptor nhr-48 0.0005 0.0024 0.0024
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0156 0.0156
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.037 0.0613
Schistosoma mansoni regulator of G protein signaling 0.002 0.0379 0.0379
Loa Loa (eye worm) hypothetical protein 0.0005 0.0024 0.004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0067 0.0111
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0379 0.0379
Schistosoma mansoni ap endonuclease 0.0019 0.037 0.037
Schistosoma mansoni cpg binding protein 0.0029 0.0615 0.0615
Toxoplasma gondii isoprenylcysteine carboxyl methyltransferase (icmt) family protein 0.0254 0.6046 1
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0379 0.0379
Brugia malayi Nuclear hormone receptor E75 0.0005 0.0024 0.004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0156 0.0258
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0156 0.0258
Brugia malayi nuclear hormone receptor 0.0005 0.0024 0.004
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0379 0.0627
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.037 0.0613
Brugia malayi nuclear receptor NHR-67 0.0005 0.0024 0.004
Schistosoma mansoni regulator of G protein signaling 0.002 0.0379 0.0379
Brugia malayi nuclear receptor RXR 0.0005 0.0024 0.004
Schistosoma mansoni nuclear receptor 0.0005 0.0024 0.0024
Schistosoma mansoni nuclear hormone receptor 0.001 0.0156 0.0156
Echinococcus granulosus cpg binding protein 0.0031 0.0655 0.0655
Loa Loa (eye worm) hypothetical protein 0.0005 0.0024 0.004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0067 0.0111
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0379 0.0627
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0082 0.0082
Schistosoma mansoni regulator of G protein signaling 0.002 0.0379 0.0379
Loa Loa (eye worm) hypothetical protein 0.0005 0.0024 0.004
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0156 0.0156
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.0379 0.0379
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0379 0.0379
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0379 0.0379
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.0379 0.0627
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0379 0.0379
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.037 0.0613
Brugia malayi hypothetical protein 0.002 0.0379 0.0627
Entamoeba histolytica hypothetical protein 0.002 0.0379 0.0627
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0005 0.0024 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0067 0.0111

Activities

Activity type Activity value Assay description Source Reference
CC50 (functional) = 55 uM Concentration required to reduce the viability of mock-infected MT-4 cells ChEMBL. 7830280

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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