Detailed information for compound 1528376

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 464.337 | Formula: C15H33IN2O6
  • H donors: 1 H acceptors: 1 LogP: 0.27 Rotable bonds: 17
    Rule of 5 violations (Lipinski): 1
  • SMILES: COCCOCCOCCOCCOC(=O)NCC[N+](C)(C)C.[I-]
  • InChi: 1S/C15H32N2O6.HI/c1-17(2,3)6-5-16-15(18)23-14-13-22-12-11-21-10-9-20-8-7-19-4;/h5-14H2,1-4H3;1H
  • InChiKey: YYWLWRPUFNDSCA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0053 0.1214 0.2007
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0053 0.1214 0.1214
Loa Loa (eye worm) hypothetical protein 0.0019 0.0356 0.0589
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0059 0.0059
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0005 0.0014 0.0023
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0053 0.1214 0.1214
Echinococcus granulosus 7tm_1 domain containing protein 0.0053 0.1214 0.1214
Schistosoma mansoni hypothetical protein 0.0018 0.0344 0.0344
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0356 0.0356
Loa Loa (eye worm) hypothetical protein 0.0053 0.1214 0.2007
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0347 0.0347
Echinococcus multilocularis transcription factor btf3 0.0041 0.0905 0.0905
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0347 0.5
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0356 0.0356
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0344 0.0568
Echinococcus multilocularis allatostatin A receptor 0.0053 0.1214 0.1214
Loa Loa (eye worm) hypothetical protein 0.0019 0.0356 0.0589
Brugia malayi Calcitonin receptor-like protein seb-1 0.0058 0.1341 0.2217
Loa Loa (eye worm) hypothetical protein 0.0053 0.1214 0.2007
Loa Loa (eye worm) hypothetical protein 0.0005 0.0014 0.0023
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.1221 0.1221
Onchocerca volvulus 0.0053 0.1214 1
Brugia malayi Serotonin receptor 0.0053 0.1214 0.2007
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0132 0.0218
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0132 0.0218
Loa Loa (eye worm) hypothetical protein 0.0005 0.0014 0.0023
Echinococcus multilocularis neuropeptide s receptor 0.0053 0.1214 0.1214
Echinococcus granulosus alpha 1A adrenergic receptor 0.0053 0.1214 0.1214
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0356 0.0589
Brugia malayi PXA domain containing protein 0.0019 0.0356 0.0589
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0108 0.2574 1
Echinococcus multilocularis 0.0246 0.6048 0.6048
Loa Loa (eye worm) hypothetical protein 0.0053 0.1214 0.2007
Entamoeba histolytica prenyl cysteine carboxyl methyltransferase, putative 0.0246 0.6048 1
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0347 0.0507
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0053 0.1214 0.2007
Loa Loa (eye worm) neuropeptide F receptor 0.0053 0.1214 0.2007
Echinococcus granulosus neuropeptide Y receptor 0.0053 0.1214 0.1214
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0102 0.0168
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0356 0.0356
Brugia malayi GnHR receptor homolog 0.0053 0.1214 0.2007
Plasmodium vivax basic transcription factor 3b, putative 0.0041 0.0905 0.0979
Echinococcus multilocularis geminin 0.0198 0.4841 0.4841
Echinococcus granulosus neuropeptide s receptor 0.0053 0.1214 0.1214
Brugia malayi Dopamine receptor protein 1 0.0053 0.1214 0.2007
Loa Loa (eye worm) hypothetical protein 0.001 0.0132 0.0218
Loa Loa (eye worm) hypothetical protein 0.0053 0.1214 0.2007
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0102 0.0102
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0356 0.0356
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0356 0.0522
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0053 0.1214 0.1214
Brugia malayi CXXC zinc finger family protein 0.0028 0.0592 0.098
Brugia malayi AKH receptor 0.0053 0.1214 0.2007
Onchocerca volvulus 0.0053 0.1214 1
Trypanosoma brucei prenyl protein specific carboxyl methyltransferase 0.0246 0.6048 1
Echinococcus granulosus g protein coupled receptor 0.0053 0.1214 0.1214
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0356 0.0522
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0132 0.0218
Echinococcus multilocularis rhodopsin orphan GPCR 0.0053 0.1214 0.1214
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.1221 0.2018
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.1221 0.1221
Echinococcus multilocularis rhodopsin orphan GPCR 0.0053 0.1214 0.1214
Brugia malayi hypothetical protein 0.0005 0.0014 0.0023
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0132 0.0132
Brugia malayi hypothetical protein 0.0019 0.0356 0.0589
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0356 0.0356
Loa Loa (eye worm) hypothetical protein 0.0019 0.0356 0.0589
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0356 0.0356
Brugia malayi nuclear hormone receptor 0.001 0.0132 0.0218
Brugia malayi putative neuropeptide receptor NPR1 0.0053 0.1214 0.2007
Echinococcus granulosus g protein coupled receptor 0.0053 0.1214 0.1214
Echinococcus multilocularis neuropeptide Y receptor 0.0053 0.1214 0.1214
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0132 0.0132
Schistosoma mansoni neuropeptide receptor 0.0053 0.1214 0.1214
Echinococcus granulosus tm gpcr rhodopsin 0.0053 0.1214 0.1214
Leishmania major prenyl protein specific carboxyl methyltransferase, putative 0.0246 0.6048 1
Onchocerca volvulus 0.0053 0.1214 1
Plasmodium vivax protein-S-isoprenylcysteine O-methyltransferase, putative 0.0246 0.6048 1
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0356 0.0522
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0053 0.1214 0.2007
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0132 0.0132
Echinococcus granulosus fmrfamide receptor 0.0053 0.1214 0.1214
Schistosoma mansoni alpha-1 adrenergic receptor 0.0053 0.1214 0.1214
Brugia malayi sulfakinin receptor protein 0.0053 0.1214 0.2007
Schistosoma mansoni neuropeptide F-like receptor 0.0053 0.1214 0.1214
Echinococcus granulosus peptide allatostatin:somatostatin 0.0053 0.1214 0.1214
Loa Loa (eye worm) hypothetical protein 0.0053 0.1214 0.2007
Echinococcus multilocularis neuropeptides capa receptor 0.0053 0.1214 0.1214
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0347 0.5
Schistosoma mansoni opsin-like receptor 0.0053 0.1214 0.1214
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0132 0.0132
Brugia malayi hypothetical protein 0.0019 0.0356 0.0589
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0005 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0053 0.1214 0.2007
Brugia malayi Tachykinin-like peptides receptor 99D 0.0053 0.1214 0.2007
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0132 0.0218
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0053 0.1214 0.1214
Schistosoma mansoni hypothetical protein 0.0018 0.0344 0.0344
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0053 0.1214 0.2007
Loa Loa (eye worm) hypothetical protein 0.0053 0.1214 0.2007
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0132 0.0218
Brugia malayi hypothetical protein 0.0053 0.1214 0.2007
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0356 0.0356
Loa Loa (eye worm) TYRA-2 protein 0.0053 0.1214 0.2007
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0053 0.1214 0.1214
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0053 0.1214 0.2007
Echinococcus granulosus FTZ F1 alpha 0.001 0.0132 0.0132
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0053 0.1214 0.2007
Echinococcus multilocularis serotonin receptor 0.0053 0.1214 0.1214
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0356 0.0356
Schistosoma mansoni nuclear hormone receptor 0.001 0.0132 0.0132
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0053 0.1214 0.2007
Echinococcus granulosus tm gpcr rhodopsin 0.0053 0.1214 0.1214
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0053 0.1214 0.1214
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0356 0.0356
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0132 0.0218
Schistosoma mansoni cpg binding protein 0.003 0.0633 0.0633
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0356 0.0589
Echinococcus multilocularis G-protein coupled receptor, putative 0.0053 0.1214 0.1214
Echinococcus multilocularis serotonin receptor 0.0053 0.1214 0.1214
Echinococcus granulosus cpg binding protein 0.003 0.0633 0.0633
Loa Loa (eye worm) hypothetical protein 0.0053 0.1214 0.2007
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0053 0.1214 0.1214
Echinococcus multilocularis rhodopsin orphan GPCR 0.0053 0.1214 0.1214
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0356 0.0356
Schistosoma mansoni amine GPCR 0.0053 0.1214 0.1214
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0356 0.0589
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0132 0.0132
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0053 0.1214 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0132 0.0132
Echinococcus multilocularis expressed protein 0.0369 0.9115 0.9115
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0132 0.0132
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0347 0.0347
Schistosoma mansoni biogenic amine receptor 0.0053 0.1214 0.1214
Brugia malayi hypothetical protein 0.0053 0.1214 0.2007
Schistosoma mansoni ap endonuclease 0.0019 0.0347 0.0347
Loa Loa (eye worm) ICD-1 protein 0.0041 0.0905 0.1497
Loa Loa (eye worm) hypothetical protein 0.0053 0.1214 0.2007
Brugia malayi putative neuropeptide receptor 0.0053 0.1214 0.2007
Trypanosoma cruzi transcription factor btf3, putative 0.0041 0.0905 0.0979
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0344 0.0568
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0347 0.0574
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0356 0.0356
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0356 0.0356
Brugia malayi hypothetical protein 0.0053 0.1214 0.2007
Loa Loa (eye worm) hypothetical protein 0.0053 0.1214 0.2007
Loa Loa (eye worm) hypothetical protein 0.001 0.0132 0.0218
Echinococcus granulosus rhodopsin orphan GPCR 0.0053 0.1214 0.1214
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0132 0.0132
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0005 0.0014 0.0014
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0053 0.1214 0.1214
Echinococcus granulosus g-protein coupled receptor 0.0053 0.1214 0.1214
Brugia malayi larval opioid receptor 0.0053 0.1214 0.2007
Leishmania major basic transcription factor 3a, putative 0.0041 0.0905 0.0979
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0053 0.1214 0.1214
Brugia malayi RE15519p 0.0053 0.1214 0.2007
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0053 0.1214 0.1214
Schistosoma mansoni neuropeptide F-like receptor 0.0053 0.1214 0.1214
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0132 0.0132
Schistosoma mansoni amine GPCR 0.0053 0.1214 0.1214
Echinococcus granulosus hypothetical protein 0.0053 0.1214 0.1214
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0356 0.0356
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0356 0.0522
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0059 0.0059
Schistosoma mansoni hypothetical protein 0.0198 0.4841 0.4841
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0053 0.1214 0.1214
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0356 0.0356
Loa Loa (eye worm) hypothetical protein 0.0053 0.1214 0.2007
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0132 0.0218
Echinococcus multilocularis neuropeptide FF receptor 2 0.0053 0.1214 0.1214
Schistosoma mansoni hypothetical protein 0.0198 0.4841 0.4841
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0132 0.0218
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0356 0.0356
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0132 0.1088
Brugia malayi hypothetical protein 0.0053 0.1214 0.2007
Brugia malayi hypothetical protein 0.0053 0.1214 0.2007
Onchocerca volvulus 0.0053 0.1214 1
Schistosoma mansoni hypothetical protein 0.0053 0.1214 0.1214
Schistosoma mansoni myosin xvIII 0.0053 0.1214 0.1214
Echinococcus granulosus expressed protein 0.0369 0.9115 0.9115
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0132 0.0132
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0132 0.0218
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0344 0.0344
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.1221 0.1221
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0053 0.1214 0.1214
Brugia malayi G protein-coupled receptor F59B2.13 0.0053 0.1214 0.2007
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0053 0.1214 0.1214
Trypanosoma cruzi transcription factor btf3, putative 0.0041 0.0905 0.0979
Echinococcus multilocularis neuropeptides capa receptor 0.0053 0.1214 0.1214
Toxoplasma gondii NAC domain-containing protein 0.0041 0.0905 0.0979
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.1221 0.1221
Echinococcus multilocularis neuropeptide Y receptor 0.0053 0.1214 0.1214
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0053 0.1214 0.2007
Loa Loa (eye worm) hypothetical protein 0.0053 0.1214 0.2007
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0053 0.1214 0.1214
Echinococcus multilocularis g-protein coupled receptor 0.0053 0.1214 0.1214
Schistosoma mansoni biogenic amine (5HT) receptor 0.0053 0.1214 0.1214
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0347 0.0574
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0132 0.0218
Schistosoma mansoni neuropeptide receptor 0.0053 0.1214 0.1214
Loa Loa (eye worm) hypothetical protein 0.0053 0.1214 0.2007
Onchocerca volvulus 0.0053 0.1214 1
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0132 0.1088
Brugia malayi beta-NAC-like protein 0.0041 0.0905 0.1497
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0132 0.0132
Echinococcus multilocularis fmrfamide receptor 0.0053 0.1214 0.1214
Echinococcus granulosus rhodopsin orphan GPCR 0.0053 0.1214 0.1214
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0132 0.0132
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0053 0.1214 0.1214
Loa Loa (eye worm) hypothetical protein 0.0053 0.1214 0.2007
Echinococcus multilocularis cpg binding protein 0.003 0.0633 0.0633
Loa Loa (eye worm) hypothetical protein 0.0053 0.1214 0.2007
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0053 0.1214 0.1214
Echinococcus granulosus dro:myosuppressin receptor 0.0053 0.1214 0.1214
Schistosoma mansoni hypothetical protein 0.0053 0.1214 0.1214
Trypanosoma cruzi prenyl protein specific carboxyl methyltransferase, putative 0.0246 0.6048 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0053 0.1214 0.1214
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0356 0.0356
Onchocerca volvulus 0.0053 0.1214 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0356 0.0589
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.1221 0.1221
Loa Loa (eye worm) hypothetical protein 0.0005 0.0014 0.0023
Echinococcus granulosus rhodopsin orphan GPCR 0.0053 0.1214 0.1214
Loa Loa (eye worm) melatonin receptor type 1A 0.0053 0.1214 0.2007
Echinococcus granulosus transcription factor btf3 0.0041 0.0905 0.0905
Echinococcus multilocularis rhodopsin orphan GPCR 0.0053 0.1214 0.1214
Loa Loa (eye worm) hypothetical protein 0.0053 0.1214 0.2007
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0132 0.0132
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0132 0.0218
Plasmodium falciparum basic transcription factor 3b, putative 0.0041 0.0905 0.0979
Loa Loa (eye worm) hypothetical protein 0.0053 0.1214 0.2007
Echinococcus granulosus sex peptide receptor 0.0053 0.1214 0.1214
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0053 0.1214 0.1214
Echinococcus multilocularis orexin receptor type 2 0.0053 0.1214 0.1214
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0356 0.0589
Loa Loa (eye worm) hypothetical protein 0.0053 0.1214 0.2007
Echinococcus granulosus rhodopsin orphan GPCR 0.0053 0.1214 0.1214
Echinococcus multilocularis g protein coupled receptor 0.0053 0.1214 0.1214
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0356 0.0589
Loa Loa (eye worm) hypothetical protein 0.0053 0.1214 0.2007
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0132 0.0218
Echinococcus granulosus serotonin receptor 0.0053 0.1214 0.1214
Loa Loa (eye worm) hypothetical protein 0.0053 0.1214 0.2007
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0356 0.0356
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0053 0.1214 0.1214
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.1389 0.1389
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0344 0.0344
Brugia malayi hypothetical protein 0.0053 0.1214 0.2007
Brugia malayi G-protein coupled receptor 0.0053 0.1214 0.2007
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0132 0.0132
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0053 0.1214 0.1214
Loa Loa (eye worm) hypothetical protein 0.001 0.0132 0.0218
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0053 0.1214 0.1214
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0356 0.0356
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0005 0.0014 0.0014
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0053 0.1214 0.1214
Loa Loa (eye worm) hypothetical protein 0.0053 0.1214 0.2007
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0356 0.0356
Onchocerca volvulus 0.0053 0.1214 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0053 0.1214 0.1214
Loa Loa (eye worm) hypothetical protein 0.001 0.0132 0.0218
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0356 0.0356
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0132 0.0218
Schistosoma mansoni hypothetical protein 0.0018 0.0344 0.0344
Entamoeba histolytica hypothetical protein 0.0041 0.0905 0.0979
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0356 0.0356
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0053 0.1214 0.1214
Onchocerca volvulus 0.0053 0.1214 1
Echinococcus multilocularis dnaJ subfamily B 0.0404 1 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.1214 0.2007
Echinococcus multilocularis G protein coupled receptor 139 0.0053 0.1214 0.1214
Brugia malayi hypothetical protein 0.0053 0.1214 0.2007
Echinococcus multilocularis dro:myosuppressin receptor 0.0053 0.1214 0.1214
Onchocerca volvulus 0.0053 0.1214 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.1221 0.1221
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0132 0.0218
Schistosoma mansoni hypothetical protein 0.0053 0.1214 0.1214
Toxoplasma gondii isoprenylcysteine carboxyl methyltransferase (icmt) family protein 0.0246 0.6048 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0132 0.0218
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0347 0.0507
Loa Loa (eye worm) hypothetical protein 0.0053 0.1214 0.2007
Schistosoma mansoni neuropeptide receptor 0.0053 0.1214 0.1214
Echinococcus granulosus allatostatin A receptor 0.0053 0.1214 0.1214
Schistosoma mansoni hypothetical protein 0.004 0.0879 0.0879
Brugia malayi neuropeptide F receptor 0.0053 0.1214 0.2007
Echinococcus granulosus neuropeptides capa receptor 0.0053 0.1214 0.1214
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0053 0.1214 0.1214
Loa Loa (eye worm) hypothetical protein 0.0053 0.1214 0.2007
Brugia malayi Serotonin receptor 0.0053 0.1214 0.2007
Onchocerca volvulus 0.0053 0.1214 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0053 0.1214 0.1214
Schistosoma mansoni cpg binding protein 0.0028 0.0592 0.0592
Echinococcus multilocularis neuropeptide receptor A26 0.0053 0.1214 0.1214
Brugia malayi follicle stimulating hormone receptor 0.0053 0.1214 0.2007
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0356 0.0356
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0356 0.0589
Entamoeba histolytica hypothetical protein 0.0019 0.0356 0.0016
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0132 0.0218
Brugia malayi Dopamine receptor 0.0053 0.1214 0.2007
Loa Loa (eye worm) hypothetical protein 0.001 0.0132 0.0218
Brugia malayi ORL1-like opioid receptor 0.0053 0.1214 0.2007
Onchocerca volvulus 0.0053 0.1214 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0053 0.1214 0.1214
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0592 0.098
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0058 0.1341 0.2217
Onchocerca volvulus 0.0053 0.1214 1
Brugia malayi hypothetical protein 0.0005 0.0014 0.0023
Trypanosoma brucei transcription factor BTF3, putative 0.0041 0.0905 0.0979
Entamoeba histolytica prenyl cysteine carboxyl methyltransferase, putative 0.0246 0.6048 1
Schistosoma mansoni hypothetical protein 0.0053 0.1214 0.1214
Echinococcus granulosus neuropeptide FF receptor 2 0.0053 0.1214 0.1214
Echinococcus granulosus rhodopsin orphan GPCR 0.0053 0.1214 0.1214
Echinococcus granulosus geminin 0.0198 0.4841 0.4841
Schistosoma mansoni protein-s-isoprenylcysteine o-methyltransferase 0.0246 0.6048 0.6048
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0132 0.0218
Loa Loa (eye worm) hypothetical protein 0.0053 0.1214 0.2007
Loa Loa (eye worm) hypothetical protein 0.001 0.0132 0.0218
Loa Loa (eye worm) hypothetical protein 0.0053 0.1214 0.2007
Brugia malayi latrophilin 2 splice variant baaae 0.004 0.0879 0.1454
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0356 0.0356
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0059 0.0059
Echinococcus granulosus g protein coupled receptor 0.0053 0.1214 0.1214
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0053 0.1214 0.1214
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0132 0.0132
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0344 0.0568
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0053 0.1214 0.1214
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0356 0.0356
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0099 0.0164
Echinococcus granulosus protein S isoprenylcysteine O methyltransferase 0.0246 0.6048 0.6048
Schistosoma mansoni adenoreceptor 0.0053 0.1214 0.1214
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0356 0.0589
Schistosoma mansoni coup transcription factor 0.001 0.0132 0.0132
Schistosoma mansoni biogenic amine receptor 0.0053 0.1214 0.1214
Loa Loa (eye worm) hypothetical protein 0.0053 0.1214 0.2007
Brugia malayi neuropeptide F receptor 0.0053 0.1214 0.2007
Schistosoma mansoni hypothetical protein 0.0018 0.0344 0.0344
Loa Loa (eye worm) hypothetical protein 0.0019 0.0356 0.0589
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0053 0.1214 0.1214
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0053 0.1214 0.1214
Loa Loa (eye worm) hypothetical protein 0.0053 0.1214 0.2007
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0053 0.1214 0.1214
Schistosoma mansoni amine GPCR 0.0053 0.1214 0.1214
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0053 0.1214 0.1214
Onchocerca volvulus 0.0053 0.1214 1
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0014 0.0023
Echinococcus granulosus tm gpcr rhodopsin 0.0053 0.1214 0.1214
Giardia lamblia Isoprenylcysteine carboxyl methyltransferase 0.0246 0.6048 1
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0356 0.0356
Echinococcus multilocularis g protein coupled receptor 0.0053 0.1214 0.1214
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0356 0.0589
Echinococcus granulosus tachykinin peptides receptor 99D 0.0053 0.1214 0.1214
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0053 0.1214 0.1214
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0059 0.0059
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0053 0.1214 0.1214
Trichomonas vaginalis protein-S isoprenylcysteine O-methyltransferase, putative 0.0246 0.6048 1
Entamoeba histolytica hypothetical protein 0.0019 0.0356 0.0016
Brugia malayi Melatonin receptor type 1A 0.0053 0.1214 0.2007
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0053 0.1214 0.2007
Loa Loa (eye worm) hypothetical protein 0.001 0.0132 0.0218
Echinococcus multilocularis neuropeptide receptor 0.0053 0.1214 0.1214
Echinococcus multilocularis GPCR, family 2 0.0018 0.0344 0.0344
Trichomonas vaginalis protein-S isoprenylcysteine O-methyltransferase, putative 0.0246 0.6048 1
Schistosoma mansoni transcription factor btf3 0.0041 0.0905 0.0905
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0356 0.0522
Schistosoma mansoni biogenic amine receptor 0.0053 0.1214 0.1214
Echinococcus multilocularis rhodopsin orphan GPCR 0.0053 0.1214 0.1214
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0356 0.0589
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0058 0.1341 0.2217
Echinococcus multilocularis sex peptide receptor 0.0053 0.1214 0.1214
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0059 0.0059
Echinococcus granulosus rhodopsin orphan GPCR 0.0053 0.1214 0.1214
Brugia malayi hypothetical protein 0.0053 0.1214 0.2007
Loa Loa (eye worm) hypothetical protein 0.0053 0.1214 0.2007
Brugia malayi hypothetical protein 0.0053 0.1214 0.2007
Echinococcus granulosus biogenic amine 5HT receptor 0.0053 0.1214 0.1214
Echinococcus multilocularis g protein coupled receptor 0.0053 0.1214 0.1214
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0053 0.1214 0.1214
Echinococcus granulosus rhodopsin orphan GPCR 0.0053 0.1214 0.1214
Loa Loa (eye worm) protein-S isoprenylcysteine O-methyltransferase 0.0246 0.6048 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.1214 0.2007
Onchocerca volvulus 0.0053 0.1214 1
Plasmodium falciparum protein-S-isoprenylcysteine O-methyltransferase, putative 0.0246 0.6048 1
Onchocerca volvulus 0.0028 0.0592 0.4882
Loa Loa (eye worm) hypothetical protein 0.0053 0.1214 0.2007
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0053 0.1214 0.2007
Loa Loa (eye worm) neuropeptide F receptor 0.0053 0.1214 0.2007
Loa Loa (eye worm) hypothetical protein 0.0058 0.1341 0.2217
Echinococcus granulosus somatostatin receptor 0.0053 0.1214 0.1214
Loa Loa (eye worm) hypothetical protein 0.0005 0.0014 0.0023
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0356 0.0589
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0356 0.0356
Onchocerca volvulus 0.001 0.0132 0.1088
Schistosoma mansoni biogenic amine (5HT) receptor 0.0053 0.1214 0.1214
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.1221 0.1221
Schistosoma mansoni thyroid hormone receptor 0.001 0.0132 0.0132
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0053 0.1214 0.2007
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0014 0.0023
Schistosoma mansoni histamine h1 receptor 0.0053 0.1214 0.1214
Loa Loa (eye worm) hypothetical protein 0.0053 0.1214 0.2007
Trypanosoma cruzi prenyl protein specific carboxyl methyltransferase, putative 0.0246 0.6048 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0132 0.0218
Onchocerca volvulus 0.0053 0.1214 1
Echinococcus multilocularis neuropeptide receptor 0.0053 0.1214 0.1214
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.1228 0.1545
Loa Loa (eye worm) hypothetical protein 0.0019 0.0356 0.0589
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0053 0.1214 0.1214
Echinococcus granulosus orexin receptor type 2 0.0053 0.1214 0.1214
Echinococcus granulosus G protein coupled receptor 139 0.0053 0.1214 0.1214
Loa Loa (eye worm) hypothetical protein 0.0053 0.1214 0.2007
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0344 0.0344
Schistosoma mansoni opsin-like receptor 0.0053 0.1214 0.1214
Echinococcus granulosus neuropeptide receptor A26 0.0053 0.1214 0.1214
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0132 0.0218
Brugia malayi G-protein coupled receptor 0.0053 0.1214 0.2007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0132 0.0218
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0132 0.0218
Schistosoma mansoni hypothetical protein 0.0404 1 1
Entamoeba histolytica transcription factor BTF3, putative 0.0041 0.0905 0.0979
Echinococcus granulosus 7TM GPCR rhodopsin 0.0053 0.1214 0.1214
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0132 0.0132
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0053 0.1214 0.1214
Loa Loa (eye worm) hypothetical protein 0.0053 0.1214 0.2007
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0102 0.0102
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0053 0.1214 0.1214
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0132 0.0218
Brugia malayi protein-S isoprenylcysteine O-methyltransferase, putative 0.0246 0.6048 1
Onchocerca volvulus 0.0053 0.1214 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0053 0.1214 0.1214
Loa Loa (eye worm) hypothetical protein 0.0053 0.1214 0.2007
Echinococcus multilocularis rhodopsin orphan GPCR 0.0053 0.1214 0.1214
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0132 0.0132
Onchocerca volvulus 0.0053 0.1214 1
Echinococcus granulosus neuropeptide receptor 0.0053 0.1214 0.1214
Brugia malayi Dopamine receptor protein 2 0.0053 0.1214 0.2007
Loa Loa (eye worm) hypothetical protein 0.0053 0.1214 0.2007
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0356 0.0356
Loa Loa (eye worm) hypothetical protein 0.0053 0.1214 0.2007
Brugia malayi steroid hormone receptor 0.001 0.0132 0.0218
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0053 0.1214 0.1214
Brugia malayi PXA domain containing protein 0.0019 0.0356 0.0589
Echinococcus granulosus GPCR family 2 0.0018 0.0344 0.0344
Loa Loa (eye worm) hypothetical protein 0.0053 0.1214 0.2007
Brugia malayi nuclear receptor RXR 0.0005 0.0014 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0905 0.1436
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0053 0.1214 0.1214
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0132 0.0218
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0053 0.1214 0.1214
Loa Loa (eye worm) G-protein coupled receptor 0.0053 0.1214 0.2007
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0053 0.1214 0.2007
Schistosoma mansoni opsin-like receptor 0.0053 0.1214 0.1214
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0053 0.1214 0.2007
Brugia malayi ecdysteroid receptor 0.001 0.0132 0.0218
Schistosoma mansoni thyroid hormone receptor 0.001 0.0132 0.0132
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0356 0.0356
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0132 0.0132
Echinococcus multilocularis somatostatin receptor 0.0053 0.1214 0.1214
Loa Loa (eye worm) G-protein coupled receptor 0.0053 0.1214 0.2007
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0132 0.1088
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0905 0.1436
Loa Loa (eye worm) hypothetical protein 0.004 0.0879 0.1454
Schistosoma mansoni neuropeptide receptor 0.0053 0.1214 0.1214
Loa Loa (eye worm) hypothetical protein 0.0053 0.1214 0.2007
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0356 0.0356
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0356 0.0356
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0344 0.0344
Brugia malayi nuclear receptor NHR-88 0.001 0.0132 0.0218
Echinococcus multilocularis fmrfamide receptor 0.0053 0.1214 0.1214
Schistosoma mansoni ap endonuclease 0.0019 0.0347 0.0347
Echinococcus granulosus neuropeptide Y receptor 0.0053 0.1214 0.1214
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0356 0.0522
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0905 0.1436
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0132 0.0132
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0132 0.0132
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0132 0.0132
Echinococcus granulosus neuropeptide receptor 0.0053 0.1214 0.1214
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0356 0.0356
Onchocerca volvulus Neuropeptide F receptor homolog 0.0053 0.1214 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0053 0.1214 0.1214
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0018 0.0344 0.0568
Echinococcus granulosus neuropeptides capa receptor 0.0053 0.1214 0.1214
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0053 0.1214 0.1214
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0053 0.1214 0.2007
Schistosoma mansoni amine GPCR 0.0053 0.1214 0.1214
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.1221 0.2018
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0132 0.0218
Echinococcus granulosus biogenic amine 5HT receptor 0.0053 0.1214 0.1214
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0005 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.001 0.0132 0.0218
Schistosoma mansoni amine GPCR 0.0053 0.1214 0.1214
Brugia malayi G protein-coupled receptor 0.0053 0.1214 0.2007
Mycobacterium ulcerans hypothetical protein 0.0108 0.2574 1
Schistosoma mansoni cpg binding protein 0.003 0.0633 0.0633
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0356 0.0356
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0356 0.0356
Loa Loa (eye worm) hypothetical protein 0.0053 0.1214 0.2007
Entamoeba histolytica hypothetical protein 0.0019 0.0356 0.0016
Brugia malayi hypothetical protein 0.0053 0.1214 0.2007
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0005 0.0014 0.0023
Loa Loa (eye worm) hypothetical protein 0.0053 0.1214 0.2007
Schistosoma mansoni growth hormone secretagogue receptor 0.0053 0.1214 0.1214
Trichomonas vaginalis protein-S isoprenylcysteine O-methyltransferase, putative 0.0246 0.6048 1
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0356 0.0522
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0356 0.0589

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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