Detailed information for compound 1529905

Basic information

Technical information
  • TDR Targets ID: 1529905
  • Name: N-[(2S)-1-oxo-1-[2-(4-sulfamoylphenyl)ethylam ino]propan-2-yl]furan-2-carboxamide
  • MW: 365.404 | Formula: C16H19N3O5S
  • H donors: 3 H acceptors: 4 LogP: 0.87 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C([C@@H](NC(=O)c1ccco1)C)NCCc1ccc(cc1)S(=O)(=O)N
  • InChi: 1S/C16H19N3O5S/c1-11(19-16(21)14-3-2-10-24-14)15(20)18-9-8-12-4-6-13(7-5-12)25(17,22)23/h2-7,10-11H,8-9H2,1H3,(H,18,20)(H,19,21)(H2,17,22,23)/t11-/m0/s1
  • InChiKey: CPXUWCJVOTVXHQ-NSHDSACASA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[(1S)-1-methyl-2-oxo-2-[2-(4-sulfamoylphenyl)ethylamino]ethyl]furan-2-carboxamide
  • N-[(1S)-1-methyl-2-oxo-2-[2-(4-sulfamoylphenyl)ethylamino]ethyl]-2-furancarboxamide
  • N-[(1S)-2-keto-1-methyl-2-[2-(4-sulfamoylphenyl)ethylamino]ethyl]-2-furamide
  • ZINC03351330
  • MLS000761112
  • SMR000365240
  • T5325390

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0053
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0008 0.0023 0.0023
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0245 0.0839
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.0023 0.0023
Onchocerca volvulus 0.0008 0.0023 0.0079
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0023 0.0023
Loa Loa (eye worm) TYRA-2 protein 0.0008 0.0023 0.0053
Echinococcus granulosus orexin receptor type 2 0.0008 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0023 0.0245 0.0557
Onchocerca volvulus 0.0202 0.2923 1
Echinococcus granulosus tm gpcr rhodopsin 0.0008 0.0023 0.0023
Brugia malayi neuropeptide F receptor 0.0008 0.0023 0.0079
Loa Loa (eye worm) hypothetical protein 0.0017 0.0157 0.0357
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0974 1
Onchocerca volvulus 0.0008 0.0023 0.0079
Echinococcus granulosus neuropeptide FF receptor 2 0.0008 0.0023 0.0023
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0072 0.0974 0.3333
Loa Loa (eye worm) neuropeptide F receptor 0.0008 0.0023 0.0053
Echinococcus granulosus ring and YY1 binding protein 0.0072 0.0974 0.0974
Loa Loa (eye worm) hypothetical protein 0.0072 0.0974 0.2212
Brugia malayi brahma associated protein 60 kDa 0.0202 0.2923 1
Echinococcus multilocularis snurportin 1 0.03 0.4404 0.4404
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0072 0.0974 0.0974
Brugia malayi hypothetical protein 0.0008 0.0023 0.0079
Schistosoma mansoni neuropeptide f receptor 76f 0.0008 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0053
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0181 0.1854
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0053
Echinococcus granulosus fmrfamide receptor 0.0008 0.0023 0.0023
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0093 0.0954
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0008 0.0023 0.0023
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0072 0.0974 0.0974
Schistosoma mansoni importin beta-1 0.0028 0.032 0.032
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0008 0.0023 0.0023
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0008 0.0023 0.0023
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0173 0.0394
Trichomonas vaginalis conserved hypothetical protein 0.0202 0.2923 1
Onchocerca volvulus 0.0008 0.0023 0.0079
Onchocerca volvulus 0.0072 0.0974 0.3333
Brugia malayi Dopamine receptor protein 2 0.0008 0.0023 0.0079
Brugia malayi G-protein coupled receptor 0.0008 0.0023 0.0079
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0008 0.0023 0.0023
Onchocerca volvulus 0.0008 0.0023 0.0079
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0053
Schistosoma mansoni biogenic amine receptor 0.0008 0.0023 0.0023
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0974 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0053
Echinococcus granulosus neuropeptide Y receptor 0.0008 0.0023 0.0023
Echinococcus multilocularis dro:myosuppressin receptor 0.0008 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0053
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0008 0.0023 0.0023
Echinococcus granulosus g protein coupled receptor 0.0008 0.0023 0.0023
Brugia malayi hypothetical protein 0.0008 0.0023 0.0079
Brugia malayi Serotonin receptor 0.0008 0.0023 0.0079
Schistosoma mansoni opsin-like receptor 0.0008 0.0023 0.0023
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.0202 0.2923 0.6637
Schistosoma mansoni hypothetical protein 0.03 0.4404 0.4404
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0053
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0173 0.5
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0053
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0053
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0093 0.0954
Brugia malayi hypothetical protein 0.0008 0.0023 0.0079
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0072 0.0974 1
Schistosoma mansoni zinc finger protein 0.0072 0.0974 0.0974
Onchocerca volvulus 0.0008 0.0023 0.0079
Schistosoma mansoni amine GPCR 0.0008 0.0023 0.0023
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0181 0.1854
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0181 0.1854
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0181 0.0181
Schistosoma mansoni histamine h1 receptor 0.0008 0.0023 0.0023
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0181 0.7367
Echinococcus multilocularis SWI:SNF matrix associated 0.0202 0.2923 0.2923
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0093 0.0954
Echinococcus granulosus importin subunit beta 1 0.0028 0.032 0.032
Loa Loa (eye worm) hypothetical protein 0.0028 0.032 0.0727
Brugia malayi Serotonin receptor 0.0008 0.0023 0.0079
Onchocerca volvulus 0.0008 0.0023 0.0079
Echinococcus granulosus alpha 1A adrenergic receptor 0.0008 0.0023 0.0023
Echinococcus granulosus neuropeptide receptor 0.0008 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0053
Echinococcus multilocularis orexin receptor type 2 0.0008 0.0023 0.0023
Echinococcus granulosus muscleblind protein 0.0146 0.2085 0.2085
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0173 0.7073
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0245 0.2517
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0008 0.0023 0.0023
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0974 1
Schistosoma mansoni hypothetical protein 0.0008 0.0023 0.0023
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0143 0.5844
Loa Loa (eye worm) hypothetical protein 0.0017 0.0157 0.0357
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0008 0.0023 0.0023
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0008 0.0023 0.0079
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.03 0.4404 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0008 0.0023 0.0023
Trypanosoma brucei unspecified product 0.0013 0.0093 0.0954
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0008 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0053
Schistosoma mansoni amine GPCR 0.0008 0.0023 0.0023
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0008 0.0023 0.0023
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0157 0.6421
Echinococcus multilocularis neuropeptides capa receptor 0.0008 0.0023 0.0023
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.0023 0.0023
Loa Loa (eye worm) neuropeptide F receptor 0.0008 0.0023 0.0053
Onchocerca volvulus 0.0008 0.0023 0.0079
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0173 0.0173
Trichomonas vaginalis importin beta-1, putative 0.0023 0.024 0.0822
Echinococcus multilocularis muscleblind protein 0.0146 0.2085 0.2085
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0008 0.0023 0.0023
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0181 0.1854
Echinococcus multilocularis neuropeptides capa receptor 0.0008 0.0023 0.0023
Leishmania major hypothetical protein, conserved 0.0072 0.0974 1
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0072 0.0974 1
Brugia malayi putative neuropeptide receptor 0.0008 0.0023 0.0079
Echinococcus granulosus dna polymerase kappa 0.0019 0.0181 0.0181
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.0023 0.0023
Leishmania major DNA polymerase eta, putative 0.0019 0.0181 0.1854
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.0202 0.2923 1
Echinococcus multilocularis neuropeptide receptor 0.0008 0.0023 0.0023
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0181 0.0181
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0181 0.041
Schistosoma mansoni neuropeptide receptor 0.0008 0.0023 0.0023
Echinococcus multilocularis SWI:SNF matrix associated 0.0202 0.2923 0.2923
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0181 0.0181
Brugia malayi SWIB/MDM2 domain containing protein 0.0202 0.2923 1
Echinococcus granulosus neuropeptides capa receptor 0.0008 0.0023 0.0023
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0072 0.0974 1
Echinococcus multilocularis ring and YY1 binding protein 0.0072 0.0974 0.0974
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0053
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0008 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0053
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0072 0.0974 1
Schistosoma mansoni hypothetical protein 0.0008 0.0023 0.0023
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0181 0.1854
Echinococcus granulosus neuropeptide Y receptor 0.0008 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0053
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0053
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0008 0.0023 0.0079
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0008 0.0023 0.0023
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0053
Onchocerca volvulus 0.0008 0.0023 0.0079
Echinococcus granulosus neuropeptide receptor A26 0.0008 0.0023 0.0023
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0181 0.7367
Echinococcus multilocularis serotonin receptor 0.0008 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0053
Brugia malayi hypothetical protein 0.0008 0.0023 0.0079
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0181 0.0618
Schistosoma mansoni opsin-like receptor 0.0008 0.0023 0.0023
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0053
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0143 0.5844
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0181 0.1854
Loa Loa (eye worm) hypothetical protein 0.0017 0.0157 0.0357
Schistosoma mansoni neuropeptide receptor 0.0008 0.0023 0.0023
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0008 0.0023 0.0023
Schistosoma mansoni hypothetical protein 0.0202 0.2923 0.2923
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0245 1
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0072 0.0974 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0245 1
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0173 0.7073
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0245 1
Leishmania major hypothetical protein, conserved 0.0072 0.0974 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0008 0.0023 0.0023
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0072 0.0974 0.3333
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0053
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0143 0.5844
Schistosoma mansoni fusion 0.0072 0.0974 0.0974
Echinococcus multilocularis neuropeptide receptor 0.0008 0.0023 0.0023
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0245 1
Brugia malayi hypothetical protein 0.0008 0.0023 0.0079
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.032 0.1095
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0008 0.0023 0.0023
Plasmodium vivax importin-beta 2, putative 0.0028 0.032 0.1095
Echinococcus multilocularis g protein coupled receptor 0.0008 0.0023 0.0023
Brugia malayi G-protein coupled receptor 0.0008 0.0023 0.0079
Brugia malayi neuropeptide F receptor 0.0008 0.0023 0.0079
Loa Loa (eye worm) hypothetical protein 0.0023 0.0245 0.0557
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0008 0.0023 0.0023
Schistosoma mansoni amine GPCR 0.0008 0.0023 0.0023
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0008 0.0023 0.0023
Echinococcus granulosus rhodopsin orphan GPCR 0.0008 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0146 0.2085 0.4734
Onchocerca volvulus 0.0008 0.0023 0.0079
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0181 0.1854
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.024 0.0822
Schistosoma mansoni RNA binding protein 0.0072 0.0974 0.0974
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0053
Echinococcus multilocularis sex peptide receptor 0.0008 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0023 0.0245 0.0557
Echinococcus granulosus zinc finger protein Ran binding 0.0072 0.0974 0.0974
Toxoplasma gondii ran binding protein 0.0072 0.0974 0.3333
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0053
Echinococcus multilocularis zinc finger protein Ran binding 0.0072 0.0974 0.0974
Echinococcus granulosus g protein coupled receptor 0.0008 0.0023 0.0023
Echinococcus multilocularis G-protein coupled receptor, putative 0.0008 0.0023 0.0023
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0245 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0053
Onchocerca volvulus Neuropeptide F receptor homolog 0.0008 0.0023 0.0079
Schistosoma mansoni hypothetical protein 0.0008 0.0023 0.0023
Echinococcus multilocularis dna polymerase eta 0.0019 0.0181 0.0181
Schistosoma mansoni opsin-like receptor 0.0008 0.0023 0.0023
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0072 0.0974 0.3333
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0053
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0173 0.0593
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0008 0.0023 0.0023
Schistosoma mansoni biogenic amine (5HT) receptor 0.0008 0.0023 0.0023
Brugia malayi G protein-coupled receptor F59B2.13 0.0008 0.0023 0.0079
Echinococcus multilocularis g protein coupled receptor 0.0008 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0072 0.0974 0.2212
Echinococcus granulosus g protein coupled receptor 0.0008 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0072 0.0974 0.2212
Loa Loa (eye worm) hypothetical protein 0.0072 0.0974 0.2212
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0053
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0023 0.0023
Brugia malayi hypothetical protein 0.0008 0.0023 0.0079
Echinococcus granulosus hypothetical protein 0.0008 0.0023 0.0023
Echinococcus granulosus serotonin receptor 0.0008 0.0023 0.0023
Echinococcus granulosus tm gpcr rhodopsin 0.0008 0.0023 0.0023
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0181 0.0618
Echinococcus granulosus somatostatin receptor 0.0008 0.0023 0.0023
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0245 1
Echinococcus multilocularis SWI:SNF matrix associated 0.0202 0.2923 0.2923
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0023 0.0023
Onchocerca volvulus 0.0023 0.0245 0.0839
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0053
Brugia malayi ORL1-like opioid receptor 0.0008 0.0023 0.0079
Schistosoma mansoni hypothetical protein 0.0202 0.2923 0.2923
Schistosoma mansoni hypothetical protein 0.0072 0.0974 0.0974
Echinococcus multilocularis allatostatin A receptor 0.0008 0.0023 0.0023
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0023 0.0023
Brugia malayi RE15519p 0.0008 0.0023 0.0079
Onchocerca volvulus 0.0008 0.0023 0.0079
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0245 0.0839
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0202 0.2923 1
Echinococcus multilocularis neuropeptide receptor A26 0.0008 0.0023 0.0023
Brugia malayi hypothetical protein 0.0008 0.0023 0.0079
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0181 0.1854
Schistosoma mansoni neuropeptide F-like receptor 0.0008 0.0023 0.0023
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0053
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0008 0.0023 0.0023
Echinococcus granulosus tm gpcr rhodopsin 0.0008 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0053
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0173 0.178
Echinococcus granulosus SWI:SNF matrix associated 0.0202 0.2923 0.2923
Schistosoma mansoni biogenic amine receptor 0.0008 0.0023 0.0023
Echinococcus granulosus dro:myosuppressin receptor 0.0008 0.0023 0.0023
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0008 0.0023 0.0023
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0072 0.0974 0.3333
Entamoeba histolytica hypothetical protein 0.0023 0.024 0.9805
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0008 0.0023 0.0053
Onchocerca volvulus 0.0008 0.0023 0.0079
Echinococcus multilocularis neuropeptide Y receptor 0.0008 0.0023 0.0023
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0008 0.0023 0.0023
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0023 0.0023
Echinococcus granulosus biogenic amine 5HT receptor 0.0008 0.0023 0.0023
Echinococcus multilocularis neuropeptide s receptor 0.0008 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0053
Brugia malayi hypothetical protein 0.0008 0.0023 0.0079
Leishmania major hypothetical protein, conserved 0.0072 0.0974 1
Echinococcus multilocularis neuropeptide Y receptor 0.0008 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0053
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0008 0.0023 0.0023
Schistosoma mansoni myosin xvIII 0.0008 0.0023 0.0023
Schistosoma mansoni biogenic amine receptor 0.0008 0.0023 0.0023
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0245 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0008 0.0023 0.0079
Echinococcus multilocularis somatostatin receptor 0.0008 0.0023 0.0023
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0181 0.0618
Onchocerca volvulus 0.0008 0.0023 0.0079
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0173 0.5
Schistosoma mansoni amine GPCR 0.0008 0.0023 0.0023
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0143 0.5844
Echinococcus granulosus Zinc finger RanBP2 type 0.0072 0.0974 0.0974
Schistosoma mansoni hypothetical protein 0.0008 0.0023 0.0023
Echinococcus granulosus neuropeptide s receptor 0.0008 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0053
Onchocerca volvulus 0.0072 0.0974 0.3333
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0181 0.0181
Echinococcus granulosus dna polymerase eta 0.0019 0.0181 0.0181
Loa Loa (eye worm) hypothetical protein 0.0146 0.2085 0.4734
Echinococcus multilocularis importin subunit beta 1 0.0028 0.032 0.032
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.0023 0.0023
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0008 0.0023 0.0053
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0008 0.0023 0.0053
Schistosoma mansoni ap endonuclease 0.0018 0.0173 0.0173
Schistosoma mansoni hypothetical protein 0.0202 0.2923 0.2923
Schistosoma mansoni biogenic amine (5HT) receptor 0.0008 0.0023 0.0023
Leishmania major importin beta-1 subunit, putative 0.0023 0.024 0.2467
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0181 0.1854
Leishmania major hypothetical protein, conserved 0.0072 0.0974 1
Echinococcus multilocularis g-protein coupled receptor 0.0008 0.0023 0.0023
Echinococcus multilocularis microtubule associated protein 2 0.0674 1 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0157 0.0357
Schistosoma mansoni brg-1 associated factor 0.0202 0.2923 0.2923
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.0023 0.0023
Echinococcus granulosus rhodopsin orphan GPCR 0.0008 0.0023 0.0023
Echinococcus granulosus rhodopsin orphan GPCR 0.0008 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0053
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0072 0.0974 0.0974
Brugia malayi RNA, U transporter 1 0.008 0.1098 0.3758
Echinococcus multilocularis g protein coupled receptor 0.0008 0.0023 0.0023
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0181 0.0181
Schistosoma mansoni amine GPCR 0.0008 0.0023 0.0023
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0245 0.2517
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0008 0.0023 0.0079
Loa Loa (eye worm) G-protein coupled receptor 0.0008 0.0023 0.0053
Trypanosoma brucei unspecified product 0.0019 0.0181 0.1854
Brugia malayi Dopamine receptor protein 1 0.0008 0.0023 0.0079
Echinococcus granulosus g-protein coupled receptor 0.0008 0.0023 0.0023
Leishmania major hypothetical protein, conserved 0.0072 0.0974 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0008 0.0023 0.0023
Echinococcus granulosus allatostatin A receptor 0.0008 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0053
Onchocerca volvulus 0.0008 0.0023 0.0079
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0008 0.0023 0.0079
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.0202 0.2923 0.2923
Echinococcus granulosus biogenic amine 5HT receptor 0.0008 0.0023 0.0023
Schistosoma mansoni growth hormone secretagogue receptor 0.0008 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0053
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0008 0.0023 0.0053
Schistosoma mansoni alpha-1 adrenergic receptor 0.0008 0.0023 0.0023
Echinococcus granulosus tachykinin peptides receptor 99D 0.0008 0.0023 0.0023
Echinococcus multilocularis muscleblind protein 1 0.0146 0.2085 0.2085
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0072 0.0974 0.3333
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0181 0.1854
Schistosoma mansoni TRABID protein (C64 family) 0.0072 0.0974 0.0974
Echinococcus multilocularis fmrfamide receptor 0.0008 0.0023 0.0023
Schistosoma mansoni neuropeptide receptor 0.0008 0.0023 0.0023
Mycobacterium ulcerans hypothetical protein 0.0023 0.0245 1
Brugia malayi brahma associated protein 60 kDa 0.0202 0.2923 1
Schistosoma mansoni neuropeptide receptor 0.0008 0.0023 0.0023
Brugia malayi YY1-associated factor 2 0.0072 0.0974 0.3333
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0008 0.0023 0.0023
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0181 0.1854
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0245 0.2517
Schistosoma mansoni ap endonuclease 0.0018 0.0173 0.0173
Trypanosoma cruzi WLM domain containing protein, putative 0.0072 0.0974 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0008 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0053
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0245 1
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0008 0.0023 0.0023
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0245 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0008 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0053
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0245 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0181 0.1854
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0181 0.1854
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.032 0.3287
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.024 0.2467
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0245 1
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0157 0.0539
Schistosoma mansoni microtubule-associated protein tau 0.0674 1 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0008 0.0023 0.0023
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0181 0.0618
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0181 0.7367
Loa Loa (eye worm) G-protein coupled receptor 0.0008 0.0023 0.0053
Echinococcus multilocularis fmrfamide receptor 0.0008 0.0023 0.0023
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0181 0.1854
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0008 0.0023 0.0079
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0173 0.0593
Onchocerca volvulus 0.0072 0.0974 0.3333
Giardia lamblia DINP protein human, muc B family 0.0019 0.0181 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.024 0.0822
Echinococcus granulosus neuropeptides capa receptor 0.0008 0.0023 0.0023
Brugia malayi G protein-coupled receptor 0.0008 0.0023 0.0079
Loa Loa (eye worm) hypothetical protein 0.0072 0.0974 0.2212
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0023 0.0023
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0202 0.2923 1
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.0202 0.2923 1
Brugia malayi putative neuropeptide receptor NPR1 0.0008 0.0023 0.0079
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0181 0.7367
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0053
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0173 0.178
Brugia malayi hypothetical protein 0.0008 0.0023 0.0079
Onchocerca volvulus 0.0008 0.0023 0.0079
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0023 0.0023
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0173 0.0593
Schistosoma mansoni adenoreceptor 0.0008 0.0023 0.0023
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0008 0.0023 0.0023
Echinococcus granulosus sex peptide receptor 0.0008 0.0023 0.0023
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0173 0.0593
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0181 0.1854
Trypanosoma cruzi WLM domain containing protein, putative 0.0072 0.0974 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0053
Chlamydia trachomatis SWIB complex protein 0.0202 0.2923 1
Brugia malayi Importin beta-1 subunit 0.0028 0.032 0.1095
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0008 0.0023 0.0023
Chlamydia trachomatis DNA topoisomerase I 0.0202 0.2923 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0157 0.6421
Echinococcus granulosus rhodopsin orphan GPCR 0.0008 0.0023 0.0023
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0173 0.0593
Echinococcus granulosus snurportin 1 0.03 0.4404 0.4404
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0173 0.178
Echinococcus multilocularis serotonin receptor 0.0008 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0053
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0181 0.7367
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0072 0.0974 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0173 0.178
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0072 0.0974 0.3333
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0008 0.0023 0.0023
Plasmodium vivax hypothetical protein, conserved 0.0202 0.2923 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0157 0.0357
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0173 0.0173
Echinococcus granulosus Upstream activation factor subunit UAF30 0.0202 0.2923 0.2923
Brugia malayi Dopamine receptor 0.0008 0.0023 0.0079
Brugia malayi larval opioid receptor 0.0008 0.0023 0.0079
Echinococcus granulosus 7tm_1 domain containing protein 0.0008 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0053
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0053
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0053
Brugia malayi hypothetical protein 0.0008 0.0023 0.0079
Leishmania major DNA polymerase kappa, putative 0.0019 0.0181 0.1854
Brugia malayi Melatonin receptor type 1A 0.0008 0.0023 0.0079
Toxoplasma gondii exonuclease III APE 0.0018 0.0173 0.0593
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0181 0.1854
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0053
Loa Loa (eye worm) melatonin receptor type 1A 0.0008 0.0023 0.0053
Echinococcus granulosus neuropeptide receptor 0.0008 0.0023 0.0023
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0008 0.0023 0.0053
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0008 0.0023 0.0023
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0072 0.0974 0.3333
Onchocerca volvulus 0.0008 0.0023 0.0079
Onchocerca volvulus 0.0008 0.0023 0.0079
Echinococcus granulosus peptide allatostatin:somatostatin 0.0008 0.0023 0.0023
Trypanosoma brucei unspecified product 0.0013 0.0093 0.0954
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0173 0.7073
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0245 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0245 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0053
Brugia malayi sulfakinin receptor protein 0.0008 0.0023 0.0079
Brugia malayi Muscleblind-like protein 0.0146 0.2085 0.7132
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0053
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0157 0.0539
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0008 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0008 0.0023 0.0053
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0245 1
Schistosoma mansoni neuropeptide F-like receptor 0.0008 0.0023 0.0023
Loa Loa (eye worm) brahma associated protein 0.0202 0.2923 0.6637
Loa Loa (eye worm) hypothetical protein 0.0019 0.0181 0.041
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0008 0.0023 0.0023
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0974 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0181 0.1854
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0181 0.1854
Echinococcus granulosus rhodopsin orphan GPCR 0.0008 0.0023 0.0023
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0072 0.0974 1
Echinococcus granulosus G protein coupled receptor 139 0.0008 0.0023 0.0023
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.0202 0.2923 1
Schistosoma mansoni DNA polymerase eta 0.0019 0.0181 0.0181
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0181 0.1854
Brugia malayi follicle stimulating hormone receptor 0.0008 0.0023 0.0079
Echinococcus multilocularis G protein coupled receptor 139 0.0008 0.0023 0.0023
Onchocerca volvulus 0.0008 0.0023 0.0079
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0181 0.1854
Brugia malayi GnHR receptor homolog 0.0008 0.0023 0.0079
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.032 0.3287
Brugia malayi AKH receptor 0.0008 0.0023 0.0079
Onchocerca volvulus 0.0072 0.0974 0.3333
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0245 0.0839
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0974 1
Plasmodium falciparum importin beta, putative 0.0028 0.032 0.1095
Echinococcus granulosus rhodopsin orphan GPCR 0.0008 0.0023 0.0023
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0008 0.0023 0.0023
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0008 0.0023 0.0079
Echinococcus multilocularis rhodopsin orphan GPCR 0.0008 0.0023 0.0023

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 23.1093 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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