TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 494.631 | Formula: C30H34N6O
H donors: 2 H acceptors: 4 LogP: 7.04 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: CCCCC1(CCCC)Nc2ccccc2C(=O)N1Cc1ccc(cc1)c1ccccc1c1nn[nH]n1
InChi: 1S/C30H34N6O/c1-3-5-19-30(20-6-4-2)31-27-14-10-9-13-26(27)29(37)36(30)21-22-15-17-23(18-16-22)24-11-7-8-12-25(24)28-32-34-35-33-28/h7-18,31H,3-6,19-21H2,1-2H3,(H,32,33,34,35)
InChiKey: NDUJTRKTCCPDSG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Angiotensin II receptor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Onchocerca volvulus		Angiotensin II receptor	359 aa	294 aa	23.8 %
Brugia malayi	GnHR receptor homolog	Angiotensin II receptor	359 aa	364 aa	20.9 %
Loa Loa (eye worm)	neuropeptide F receptor	Angiotensin II receptor	359 aa	356 aa	24.2 %
Schistosoma japonicum	ko:K04134 cholinergic receptor, invertebrate, putative	Angiotensin II receptor	359 aa	336 aa	22.3 %
Loa Loa (eye worm)	hypothetical protein	Angiotensin II receptor	359 aa	330 aa	26.7 %
Schistosoma mansoni	peptide (allatostatin)-like receptor	Angiotensin II receptor	359 aa	314 aa	26.1 %
Echinococcus multilocularis	neuropeptide receptor	Angiotensin II receptor	359 aa	316 aa	25.3 %
Echinococcus granulosus	neuropeptide receptor	Angiotensin II receptor	359 aa	316 aa	25.0 %
Loa Loa (eye worm)	hypothetical protein	Angiotensin II receptor	359 aa	335 aa	23.3 %
Echinococcus multilocularis	allatostatin A receptor	Angiotensin II receptor	359 aa	348 aa	25.9 %
Onchocerca volvulus		Angiotensin II receptor	359 aa	312 aa	19.2 %
Echinococcus granulosus	allatostatin A receptor	Angiotensin II receptor	359 aa	348 aa	25.9 %
Brugia malayi	ORL1-like opioid receptor	Angiotensin II receptor	359 aa	314 aa	20.1 %
Onchocerca volvulus		Angiotensin II receptor	359 aa	314 aa	25.8 %
Echinococcus multilocularis	G-protein coupled receptor, putative	Angiotensin II receptor	359 aa	308 aa	22.4 %
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	Angiotensin II receptor	359 aa	303 aa	22.4 %
Schistosoma mansoni	opsin-like receptor	Angiotensin II receptor	359 aa	299 aa	25.1 %
Onchocerca volvulus	E3 ubiquitin-protein ligase rpm-1 homolog	Angiotensin II receptor	359 aa	352 aa	20.5 %
Schistosoma japonicum	Rhodopsin, putative	Angiotensin II receptor	359 aa	327 aa	24.2 %
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	Angiotensin II receptor	359 aa	351 aa	21.9 %
Schistosoma japonicum	ko:K04209 neuropeptide Y receptor, invertebrate, putative	Angiotensin II receptor	359 aa	311 aa	23.5 %
Echinococcus granulosus	thyrotropin releasing hormone receptor	Angiotensin II receptor	359 aa	337 aa	24.0 %
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	Angiotensin II receptor	359 aa	346 aa	18.2 %
Echinococcus granulosus	growth hormone secretagogue receptor type 1	Angiotensin II receptor	359 aa	351 aa	21.9 %
Brugia malayi	putative neuropeptide receptor NPR1	Angiotensin II receptor	359 aa	295 aa	27.5 %
Echinococcus granulosus	tm gpcr rhodopsin	Angiotensin II receptor	359 aa	303 aa	22.4 %
Onchocerca volvulus		Angiotensin II receptor	359 aa	395 aa	23.0 %
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	Angiotensin II receptor	359 aa	406 aa	20.0 %
Schistosoma mansoni	adenoreceptor	Angiotensin II receptor	359 aa	329 aa	24.0 %
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	Angiotensin II receptor	359 aa	407 aa	19.4 %
Onchocerca volvulus		Angiotensin II receptor	359 aa	386 aa	24.9 %
Onchocerca volvulus		Angiotensin II receptor	359 aa	303 aa	25.1 %
Echinococcus multilocularis	thyrotropin releasing hormone receptor	Angiotensin II receptor	359 aa	334 aa	23.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	proprotein convertase subtilisin:kexin type 5	0.0095	0.1097	0.1165
Brugia malayi	Kringle domain containing protein	0.006	0.0509	0.0726
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0112	0.0565
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0148	0.1983	1
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0036	0.0112	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0416	0.0591
Brugia malayi	Cathepsin L-like precursor	0.0036	0.0112	0.0148
Trichomonas vaginalis	cyclins, putative	0.0043	0.0231	0.1166
Trichomonas vaginalis	cyclin A, putative	0.0043	0.0231	0.1166
Loa Loa (eye worm)	hypothetical protein	0.0214	0.3099	0.45
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0032	0.0041	0.0047
Trichomonas vaginalis	cyclin B, putative	0.0043	0.0231	0.1166
Mycobacterium ulcerans	hypothetical protein	0.0032	0.0041	0.5
Toxoplasma gondii	microneme protein, putative	0.0054	0.0416	0.0308
Trichomonas vaginalis	cyclins, putative	0.0043	0.0231	0.1166
Echinococcus multilocularis	Furin 1	0.0037	0.0121	0.0119
Trichomonas vaginalis	cyclin B, putative	0.0043	0.0231	0.1166
Schistosoma mansoni	cercarial elastase (S01 family)	0.0032	0.0041	0.0047
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0032	0.0041	0.0045
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0032	0.0041	0.0047
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0112	0.0565
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0037	0.0121	0.061
Toxoplasma gondii	PAN domain-containing protein	0.0624	1	1
Giardia lamblia	High cysteine membrane protein Group 2	0.0058	0.0477	0.2371
Loa Loa (eye worm)	TK/ROR protein kinase	0.006	0.0509	0.0726
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0036	0.0112	0.0565
Echinococcus granulosus	tm gpcr rhodopsin	0.0585	0.9342	1
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0009	0.0043
Echinococcus granulosus	cathepsin b	0.0439	0.6875	0.7357
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0148	0.1983	1
Echinococcus multilocularis	neuroendocrine convertase 2	0.0098	0.1151	0.1223
Onchocerca volvulus		0.0054	0.0416	0.1314
Toxoplasma gondii	subtilisin SUB12	0.0061	0.0529	0.0421
Schistosoma mansoni	inhibitor of apoptosis (iap) domain family member	0.0146	0.195	0.2827
Onchocerca volvulus		0.0054	0.0416	0.1314
Onchocerca volvulus		0.0036	0.0112	0.0329
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0032	0.0041	0.0033
Toxoplasma gondii	1,3(4)-beta-glucanase	0.0054	0.0416	0.0308
Onchocerca volvulus		0.0054	0.0416	0.1314
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0009	0.0043
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0036	0.0112	0.0565
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0112	0.0565
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0112	0.0565
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0112	0.0148
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0041	0.0045
Trypanosoma cruzi	cyclin 6, putative	0.0043	0.0231	0.0176
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0037	0.0121	0.061
Onchocerca volvulus		0.0054	0.0416	0.1314
Loa Loa (eye worm)	hypothetical protein	0.006	0.0509	0.0726
Loa Loa (eye worm)	PAN domain-containing protein	0.0054	0.0416	0.0591
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0036	0.0112	0.0565
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0032	0.0041	0.0033
Echinococcus granulosus	family C2 unassigned peptidase C02 family	0.0061	0.0527	0.0553
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0416	0.0591
Trypanosoma cruzi	hypothetical protein, conserved	0.006	0.0509	0.0587
Loa Loa (eye worm)	hypothetical protein	0.0146	0.195	0.2825
Schistosoma mansoni	hypothetical protein	0.0146	0.195	0.2827
Echinococcus multilocularis	cysteine protease	0.0036	0.0112	0.0109
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0032	0.0041	0.0047
Brugia malayi	proprotein convertase 2	0.0098	0.1151	0.1662
Echinococcus multilocularis	inhibitor of apoptosis protein	0.0146	0.195	0.2078
Brugia malayi	Cathepsin L-like precursor	0.0036	0.0112	0.0148
Brugia malayi	PAN domain containing protein	0.0054	0.0416	0.0591
Toxoplasma gondii	cathepsin B	0.0148	0.1983	0.1892
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0036	0.0112	0.0148
Echinococcus multilocularis	Mastin	0.0032	0.0041	0.0033
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0112	0.0565
Echinococcus granulosus	enteropeptidase	0.0032	0.0041	0.0033
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0009	0.0043
Brugia malayi	hypothetical protein	0.0032	0.0041	0.0045
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0061	0.0527	0.0754
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0112	0.0565
Plasmodium falciparum	cysteine repeat modular protein 1	0.006	0.0509	1
Loa Loa (eye worm)	PAN domain-containing protein	0.0054	0.0416	0.0591
Onchocerca volvulus		0.0032	0.0041	0.0099
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0036	0.0112	0.0565
Toxoplasma gondii	microneme protein MIC17A	0.0054	0.0416	0.0308
Toxoplasma gondii	PAN domain-containing protein	0.0054	0.0416	0.0308
Trichomonas vaginalis	neuroendocrine convertase 2 precursor, putative	0.003	0.0009	0.0043
Trichomonas vaginalis	cyclin B, putative	0.0043	0.0231	0.1166
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0148	0.1983	0.2766
Brugia malayi	PAN domain containing protein	0.0054	0.0416	0.0591
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0036	0.0112	0.0565
Echinococcus granulosus	neuroendocrine convertase 2	0.0098	0.1151	0.1223
Brugia malayi	Protein kinase domain containing protein	0.006	0.0509	0.0726
Loa Loa (eye worm)	PAN domain-containing protein	0.0054	0.0416	0.0591
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0009	0.0043
Echinococcus granulosus	cathepsin b	0.0439	0.6875	0.7357
Echinococcus multilocularis	calpain A	0.0061	0.0527	0.0553
Onchocerca volvulus		0.0032	0.0041	0.0099
Schistosoma mansoni	cercarial elastase (S01 family)	0.0032	0.0041	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0231	0.0322
Onchocerca volvulus	Cathepsin F homolog	0.0036	0.0112	0.0329
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0112	0.0148
Onchocerca volvulus		0.0214	0.3099	1
Onchocerca volvulus		0.0036	0.0112	0.0329
Brugia malayi	Trypsin family protein	0.0032	0.0041	0.0045
Onchocerca volvulus		0.006	0.0509	0.1614
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.006	0.0509	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0037	0.0121	0.061
Brugia malayi	celfurPC protein	0.0126	0.1619	0.2344
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0439	0.6875	1
Leishmania major	cyclin	0.0043	0.0231	0.0637
Brugia malayi	PAN domain containing protein	0.0054	0.0416	0.0591
Echinococcus multilocularis	transmembrane protease serine 3	0.0032	0.0041	0.0033
Echinococcus multilocularis	calpain family protein 1, d	0.0043	0.0223	0.0228
Echinococcus multilocularis	glycoprotein Antigen 5	0.0032	0.0041	0.0033
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0095	0.1097	0.5533
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0037	0.0121	0.061
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0032	0.0041	0.0033
Echinococcus multilocularis	cathepsin L cysteine protease	0.0036	0.0112	0.0109
Brugia malayi	cathepsin B-like cysteine proteinase	0.0439	0.6875	1
Brugia malayi	Cathepsin L-like precursor	0.0036	0.0112	0.0148
Onchocerca volvulus		0.0036	0.0112	0.0329
Toxoplasma gondii	microneme protein MIC4	0.0054	0.0416	0.0308
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0009	0.0043
Brugia malayi	Cathepsin L-like precursor	0.0036	0.0112	0.0148
Echinococcus granulosus	furin	0.0156	0.2127	0.2269
Onchocerca volvulus		0.0032	0.0041	0.0099
Trichomonas vaginalis	cyclins, putative	0.0043	0.0231	0.1166
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0061	0.0527	0.0553
Trypanosoma cruzi	cyclin, putative	0.0043	0.0231	0.0176
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0095	0.1097	0.5533
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0416	0.0591
Onchocerca volvulus		0.0036	0.0112	0.0329
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0036	0.0112	0.0148
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0439	0.6875	1
Trichomonas vaginalis	leucine-rich repeat protein, BspA family	0.003	0.0009	0.0043
Giardia lamblia	Cathepsin B precursor	0.0148	0.1983	1
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0148	0.1983	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0041	0.0045
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0439	0.6875	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0036	0.0112	0.0565
Echinococcus granulosus	transmembrane protease serine 3	0.0032	0.0041	0.0033
Schistosoma mansoni	subfamily S8B non-peptidase homologue (S08 family)	0.0037	0.0121	0.0164
Schistosoma mansoni	furin-1 (S08 family)	0.0068	0.0643	0.0924
Onchocerca volvulus		0.0054	0.0416	0.1314
Brugia malayi	Inhibitor of Apoptosis domain containing protein	0.0146	0.195	0.2825
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0482	0.0687
Onchocerca volvulus		0.0054	0.0416	0.1314
Onchocerca volvulus		0.0036	0.0112	0.0329
Toxoplasma gondii	PAN domain-containing protein	0.0054	0.0416	0.0308
Onchocerca volvulus		0.0043	0.0231	0.0715
Schistosoma mansoni	cercarial elastase (S01 family)	0.0032	0.0041	0.0047
Trichomonas vaginalis	proprotein convertase subtilisin/kexin type, putative	0.003	0.0009	0.0043
Toxoplasma gondii	PAN/Apple domain-containing protein	0.0054	0.0416	0.0308
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0531	0.0758
Brugia malayi	Trypsin family protein	0.0214	0.3099	0.45
Giardia lamblia	G2/mitotic-specific cyclin B	0.0043	0.0231	0.1127
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0036	0.0112	0.0565
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0036	0.0112	0.0109
Onchocerca volvulus		0.0054	0.0416	0.1314
Echinococcus multilocularis	tissue type plasminogen activator	0.006	0.0509	0.0534
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0112	0.0565
Onchocerca volvulus	Cathepsin L homolog	0.0036	0.0112	0.0329
Schistosoma mansoni	cercarial elastase (S01 family)	0.0032	0.0041	0.0047
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0009	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0371	0.0525
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0032	0.0041	0.0047
Toxoplasma gondii	hypothetical protein	0.0054	0.0416	0.0308
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0112	0.0565
Schistosoma mansoni	hypothetical protein	0.006	0.0509	0.0729
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0009	0.0043
Schistosoma mansoni	cercarial elastase (S01 family)	0.0032	0.0041	0.0047
Echinococcus granulosus	inhibitor of apoptosis protein	0.0146	0.195	0.2078
Loa Loa (eye worm)	cysteine protease	0.0036	0.0112	0.0148
Echinococcus multilocularis	cathepsin b	0.0439	0.6875	0.7357
Brugia malayi	PAN domain containing protein	0.0054	0.0416	0.0591
Loa Loa (eye worm)	proprotein convertase 2	0.0037	0.0121	0.0161
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0009	0.0043
Onchocerca volvulus		0.0182	0.2559	0.8251
Loa Loa (eye worm)	calpain family protein 1	0.0058	0.0482	0.0687
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0112	0.0565
Brugia malayi	PAN domain containing protein	0.0054	0.0416	0.0591
Brugia malayi	calpain family protein 1	0.0058	0.0482	0.0687
Schistosoma mansoni	cercarial elastase (S01 family)	0.0032	0.0041	0.0047
Schistosoma mansoni	hypothetical protein	0.003	0.001	0.0002
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0037	0.0121	0.061
Echinococcus multilocularis	cyclin B	0.0043	0.0231	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0223	0.031
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0041	0.0045
Echinococcus multilocularis	baculoviral IAP repeat containing protein	0.0146	0.195	0.2078
Brugia malayi	Inhibitor of Apoptosis domain containing protein	0.0146	0.195	0.2825
Loa Loa (eye worm)	PAN domain-containing protein	0.0054	0.0416	0.0591
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0041	0.0045
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0112	0.0565
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0036	0.0112	0.0565
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0061	0.0527	0.0754
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0043	0.0231	0.0322
Brugia malayi	calpain family protein 1	0.0058	0.0482	0.0687
Onchocerca volvulus		0.0054	0.0416	0.1314
Brugia malayi	Trypsin family protein	0.0032	0.0041	0.0045
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0585	0.9342	1
Trypanosoma cruzi	cyclin, putative	0.0043	0.0231	0.0176
Echinococcus multilocularis	cathepsin b	0.0439	0.6875	0.7357
Schistosoma mansoni	caspase-7 (C14 family)	0.003	0.001	0.0002
Onchocerca volvulus	Cathepsin L homolog	0.0036	0.0112	0.0329
Toxoplasma gondii	microneme protein MIC17C	0.0054	0.0416	0.0308
Echinococcus granulosus	baculoviral IAP repeat containing protein	0.0146	0.195	0.2078
Schistosoma mansoni	hypothetical protein	0.0032	0.0041	0.0047
Onchocerca volvulus	Deterin homolog	0.0146	0.195	0.6278
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.0156	0.2127	0.3086
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0416	0.0591
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0416	0.0591
Loa Loa (eye worm)	hypothetical protein	0.0214	0.3099	0.45
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0214	0.3099	0.4501
Onchocerca volvulus		0.0054	0.0416	0.1314
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0036	0.0112	0.0565
Schistosoma mansoni	cercarial elastase (S01 family)	0.0032	0.0041	0.0047
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0036	0.0112	0.0109
Trichomonas vaginalis	cyclins, putative	0.0043	0.0231	0.1166
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0036	0.0112	0.0565
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0112	0.0565
Loa Loa (eye worm)	endoprotease bli-4	0.0156	0.2127	0.3084
Loa Loa (eye worm)	trypsin family protein	0.0032	0.0041	0.0045
Brugia malayi	PAN domain containing protein	0.0054	0.0416	0.0591
Echinococcus granulosus	tissue type plasminogen activator	0.006	0.0509	0.0534
Loa Loa (eye worm)	cathepsin B	0.0148	0.1983	0.2873
Echinococcus multilocularis	proprotein convertase subtilisin:kexin type 5	0.0095	0.1097	0.1165
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0009	0.0043
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0037	0.0121	0.061
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0112	0.0565
Echinococcus multilocularis	cathepsin L cysteine protease	0.0036	0.0112	0.0109
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0214	0.3099	0.4501
Brugia malayi	neuroendocrine convertase 1 precursor	0.0098	0.1151	0.1662
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0036	0.0112	0.0565
Toxoplasma gondii	microneme protein MIC17B	0.0054	0.0416	0.0308
Schistosoma mansoni	cyclin B	0.0043	0.0231	0.0324
Onchocerca volvulus		0.0032	0.0041	0.0099
Echinococcus multilocularis	cysteine protease	0.0036	0.0112	0.0109
Onchocerca volvulus		0.0036	0.0112	0.0329
Toxoplasma gondii	hypothetical protein	0.0054	0.0416	0.0308
Brugia malayi	Papain family cysteine protease containing protein	0.0036	0.0112	0.0148
Brugia malayi	PAN domain containing protein	0.0054	0.0416	0.0591
Trypanosoma brucei	mitotic cyclin 6	0.0043	0.0231	0.0637
Echinococcus granulosus	cathepsin l1	0.0036	0.0112	0.0109
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0148	0.1983	0.2875
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0416	0.0591
Echinococcus multilocularis	enteropeptidase	0.0032	0.0041	0.0033
Giardia lamblia	Cathepsin B precursor	0.0148	0.1983	1
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0032	0.0041	0.0047
Schistosoma mansoni	cercarial elastase (S01 family)	0.0032	0.0041	0.0047
Loa Loa (eye worm)	ctsf protein	0.0036	0.0112	0.0148
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0032	0.0041	0.0033
Echinococcus granulosus	glycoprotein Antigen 5	0.0032	0.0041	0.0033
Schistosoma mansoni	cathepsin F (C01 family)	0.0036	0.0112	0.0151
Brugia malayi	Trypsin family protein	0.0032	0.0041	0.0045
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0416	0.0591
Leishmania major	hypothetical protein, conserved	0.006	0.0509	0.2122
Onchocerca volvulus		0.0054	0.0416	0.1314
Onchocerca volvulus		0.0036	0.0112	0.0329
Onchocerca volvulus		0.0146	0.195	0.6278
Loa Loa (eye worm)	calpain family protein 1	0.0043	0.0223	0.031
Trichomonas vaginalis	hypothetical protein	0.003	0.0009	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0146	0.195	0.2825
Schistosoma mansoni	cercarial elastase (S01 family)	0.0032	0.0041	0.0047
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0009	0.0043
Schistosoma mansoni	hypothetical protein	0.0032	0.0041	0.0047
Loa Loa (eye worm)	fibroinase	0.0036	0.0112	0.0148
Schistosoma mansoni	cercarial elastase (S01 family)	0.0032	0.0041	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0439	0.6875	1
Echinococcus granulosus	cyclin B	0.0043	0.0231	0.0237
Brugia malayi	PAN domain containing protein	0.0054	0.0416	0.0591
Giardia lamblia	Cathepsin B precursor	0.0148	0.1983	1
Onchocerca volvulus		0.0032	0.0041	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0231	0.0322
Leishmania major	CYC2-like cyclin, putative,cyclin 6, putative	0.0043	0.0231	0.0637
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0058	0.0482	0.069
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0112	0.0565
Echinococcus granulosus	calpain A	0.0061	0.0527	0.0553
Brugia malayi	endoprotease bli-4 precursor	0.0156	0.2127	0.3084
Brugia malayi	Trypsin-like protease protein 5	0.0032	0.0041	0.0045
Brugia malayi	PAN domain containing protein	0.0054	0.0416	0.0591
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0041	0.0045
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0439	0.6875	1
Onchocerca volvulus		0.0054	0.0416	0.1314
Brugia malayi	PAN domain containing protein	0.0054	0.0416	0.0591
Echinococcus multilocularis		0.0126	0.1619	0.1724
Schistosoma mansoni	inhibitor of apoptosis protein	0.0146	0.195	0.2827
Trichomonas vaginalis	conserved hypothetical protein	0.003	0.0009	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0156	0.2127	0.3084
Brugia malayi	Cathepsin L-like precursor	0.0036	0.0112	0.0148
Trypanosoma cruzi	CYC2-like cyclin, putative	0.0043	0.0231	0.0176
Schistosoma mansoni	cercarial elastase (S01 family)	0.0032	0.0041	0.0047
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0036	0.0112	0.0109
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0439	0.6875	1
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0043	0.0231	0.0322
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0036	0.0112	0.0565
Toxoplasma gondii	PAN domain-containing protein	0.0054	0.0416	0.0308
Loa Loa (eye worm)	PAN domain-containing protein	0.0054	0.0416	0.0591
Toxoplasma gondii	kringle domain-containing protein	0.006	0.0509	0.0401
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0032	0.0041	0.0047
Entamoeba histolytica	cyclin, putative	0.0043	0.0231	1
Echinococcus granulosus	Furin 1	0.0037	0.0121	0.0119
Trichomonas vaginalis	cyclin B, putative	0.0043	0.0231	0.1166
Toxoplasma gondii	PAN domain-containing protein	0.0054	0.0416	0.0308
Brugia malayi	Cathepsin L-like precursor	0.0036	0.0112	0.0148
Onchocerca volvulus		0.0036	0.0112	0.0329
Schistosoma mansoni	cathepsin F (C01 family)	0.0036	0.0112	0.0151
Echinococcus granulosus	Mastin	0.0032	0.0041	0.0033

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 13 uM	Concentration required for 50% inhibition of binding against Angiotensin II receptor in the rat adrenal cortex tissue	ChEMBL.	No reference
IC50 (binding)	= 13 uM	Concentration required for 50% inhibition of binding against Angiotensin II receptor in the rat adrenal cortex tissue	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

No literature references available for this target.

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Detailed information for compound 15332