Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0026 | 0.0477 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.0397 | 0.0397 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0026 | 0.0477 |
Echinococcus granulosus | smad | 0.001 | 0.0041 | 0.0143 |
Brugia malayi | Importin beta-1 subunit | 0.0035 | 0.0238 | 0.0238 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.014 | 0.1054 | 0.1054 |
Schistosoma mansoni | Smad4 | 0.001 | 0.0041 | 0.0143 |
Entamoeba histolytica | Ran family GTPase | 0.0026 | 0.0166 | 0.8795 |
Schistosoma mansoni | cpg binding protein | 0.0034 | 0.0229 | 0.0799 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0397 | 0.1387 |
Schistosoma mansoni | smad1 5 8 and | 0.001 | 0.0041 | 0.0143 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0008 | 0.0032 | 0.0111 |
Giardia lamblia | GTP-binding nuclear protein RAN/TC4 | 0.0026 | 0.0166 | 0.5 |
Plasmodium falciparum | GTP-binding nuclear protein RAN/TC4 | 0.0026 | 0.0166 | 0.6744 |
Echinococcus multilocularis | transportin 1 | 0.0007 | 0.0018 | 0.0063 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.001 | 0.0041 | 0.0143 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0026 | 0.0477 |
Brugia malayi | MH2 domain containing protein | 0.001 | 0.0041 | 0.0041 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0035 | 0.0238 | 0.0832 |
Plasmodium vivax | GTP-binding nuclear protein RAN/TC4, putative | 0.0026 | 0.0166 | 0.6744 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0026 | 0.0477 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0372 | 0.2859 | 0.2859 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0008 | 0.0032 | 0.0111 |
Schistosoma mansoni | cpg binding protein | 0.0036 | 0.0243 | 0.0851 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0026 | 0.0477 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0397 | 0.1387 |
Brugia malayi | GTP-binding nuclear protein RAN/TC4 | 0.0026 | 0.0166 | 0.0166 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0238 | 0.0238 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0026 | 0.0477 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0397 | 0.1387 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0397 | 0.1387 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0026 | 0.0477 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.014 | 0.1054 | 0.1054 |
Toxoplasma gondii | GTP-binding nuclear protein ran/tc4 | 0.0026 | 0.0166 | 0.3334 |
Loa Loa (eye worm) | importin-beta domain-containing protein | 0.0007 | 0.0018 | 0.0018 |
Schistosoma mansoni | importin-beta 2 | 0.0007 | 0.0018 | 0.0063 |
Schistosoma mansoni | smad | 0.001 | 0.0041 | 0.0143 |
Echinococcus granulosus | translational activator gcn1 | 0.0007 | 0.0018 | 0.0063 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.001 | 0.0041 | 0.0041 |
Echinococcus multilocularis | snurportin 1 | 0.0372 | 0.2859 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1289 | 1 | 1 |
Trypanosoma brucei | GTP-binding nuclear protein rtb2, putative | 0.0026 | 0.0166 | 0.6744 |
Brugia malayi | MH2 domain containing protein | 0.014 | 0.1054 | 0.1054 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0026 | 0.0477 |
Trichomonas vaginalis | importin beta-1, putative | 0.0028 | 0.0187 | 1 |
Loa Loa (eye worm) | histone methyltransferase | 0.001 | 0.0048 | 0.0048 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0035 | 0.0238 | 1 |
Echinococcus granulosus | cpg binding protein | 0.0036 | 0.0243 | 0.0851 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0008 | 0.0032 | 0.0111 |
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.1289 | 1 | 1 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.001 | 0.0041 | 0.0143 |
Schistosoma mansoni | importin beta-1 | 0.0035 | 0.0238 | 0.0832 |
Loa Loa (eye worm) | GTP-binding nuclear protein RAN/TC4 | 0.0026 | 0.0166 | 0.0166 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.001 | 0.0048 | 0.0167 |
Brugia malayi | CXXC zinc finger family protein | 0.0034 | 0.0229 | 0.0229 |
Loa Loa (eye worm) | Smad1 | 0.001 | 0.0041 | 0.0041 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0026 | 0.0477 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0008 | 0.0032 | 0.0111 |
Plasmodium falciparum | importin beta, putative | 0.0035 | 0.0238 | 1 |
Echinococcus granulosus | snurportin 1 | 0.0372 | 0.2859 | 1 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0028 | 0.0187 | 1 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0026 | 0.0477 |
Schistosoma mansoni | ran | 0.0026 | 0.0166 | 0.0582 |
Echinococcus granulosus | Smad4 | 0.001 | 0.0041 | 0.0143 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0008 | 0.0026 | 0.0477 |
Schistosoma mansoni | smad1 5 8 and | 0.001 | 0.0041 | 0.0143 |
Entamoeba histolytica | hypothetical protein | 0.0028 | 0.0187 | 1 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.001 | 0.0047 | 0.0047 |
Plasmodium vivax | importin-beta 2, putative | 0.0035 | 0.0238 | 1 |
Loa Loa (eye worm) | kap beta 3 protein | 0.0007 | 0.0018 | 0.0018 |
Echinococcus granulosus | transportin 1 | 0.0007 | 0.0018 | 0.0063 |
Echinococcus multilocularis | translational activator gcn1 | 0.0007 | 0.0018 | 0.0063 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0035 | 0.0238 | 0.4943 |
Echinococcus granulosus | GTP binding nuclear protein Ran | 0.0026 | 0.0166 | 0.0582 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0026 | 0.0477 |
Loa Loa (eye worm) | hypothetical protein | 0.0005 | 0.0008 | 0.0008 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0071 | 0.0522 | 0.1825 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0008 | 0.0032 | 0.0111 |
Brugia malayi | MH2 domain containing protein | 0.001 | 0.0041 | 0.0041 |
Trichomonas vaginalis | helicase, putative | 0.0008 | 0.0026 | 0.0477 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0026 | 0.0477 |
Schistosoma mansoni | cpg binding protein | 0.0036 | 0.0243 | 0.0851 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.0397 | 0.0397 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0026 | 0.0477 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0005 | 0.0004 | 0.0015 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.001 | 0.0041 | 0.0143 |
Echinococcus granulosus | importin subunit beta 1 | 0.0035 | 0.0238 | 0.0832 |
Brugia malayi | kap beta 3 protein | 0.0007 | 0.0018 | 0.0018 |
Brugia malayi | MH1 domain containing protein | 0.001 | 0.0041 | 0.0041 |
Leishmania major | importin beta-1 subunit, putative | 0.0028 | 0.0187 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0026 | 0.0477 |
Schistosoma mansoni | ran | 0.0026 | 0.0166 | 0.0582 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.001 | 0.0041 | 0.0143 |
Echinococcus multilocularis | smad | 0.001 | 0.0041 | 0.0143 |
Echinococcus multilocularis | Smad4 | 0.001 | 0.0041 | 0.0143 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0064 | 0.0463 | 1 |
Brugia malayi | MH1 domain containing protein | 0.0005 | 0.0008 | 0.0008 |
Schistosoma mansoni | hypothetical protein | 0.0372 | 0.2859 | 1 |
Brugia malayi | MH1 domain containing protein | 0.001 | 0.0041 | 0.0041 |
Echinococcus granulosus | importin 5 | 0.0007 | 0.0018 | 0.0063 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.0397 | 0.1387 |
Schistosoma mansoni | smad1 5 8 and | 0.001 | 0.0041 | 0.0143 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0035 | 0.0238 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.0397 | 0.1387 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0028 | 0.0187 | 1 |
Brugia malayi | Smad1 | 0.001 | 0.0041 | 0.0041 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.001 | 0.0041 | 0.0143 |
Echinococcus multilocularis | GTP binding nuclear protein Ran | 0.0026 | 0.0166 | 0.0582 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0034 | 0.0229 | 0.0229 |
Onchocerca volvulus | 0.0034 | 0.0229 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.1289 | 1 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0008 | 0.0026 | 0.0477 |
Loa Loa (eye worm) | nuclear factor I | 0.0005 | 0.0008 | 0.0008 |
Leishmania major | GTP-binding protein, putative | 0.0026 | 0.0166 | 0.8795 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.0397 | 0.1387 |
Brugia malayi | MH1 domain containing protein | 0.0005 | 0.0008 | 0.0008 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0028 | 0.0187 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0008 | 0.0026 | 0.0477 |
Trichomonas vaginalis | ran, putative | 0.0026 | 0.0166 | 0.8795 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.001 | 0.0041 | 0.0041 |
Echinococcus multilocularis | cpg binding protein | 0.0036 | 0.0243 | 0.0851 |
Brugia malayi | RNA, U transporter 1 | 0.0099 | 0.0737 | 0.0737 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.001 | 0.0048 | 0.0167 |
Echinococcus multilocularis | importin 5 | 0.0007 | 0.0018 | 0.0063 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 32.6427 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.