Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | cathepsin L-like protease | 0.0294 | 0.2268 | 0.7498 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0294 | 0.2268 | 0.7498 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0164 | 0.0694 | 0.0488 |
Echinococcus granulosus | cathepsin b | 0.093 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0164 | 0.0694 | 0.0651 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0294 | 0.2268 | 0.1789 |
Brugia malayi | Cathepsin L-like precursor | 0.0294 | 0.2268 | 0.2268 |
Loa Loa (eye worm) | fibroinase | 0.0294 | 0.2268 | 0.2268 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0164 | 0.0694 | 0.0488 |
Leishmania major | cysteine peptidase A (CPA) | 0.0294 | 0.2268 | 0.7498 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0294 | 0.2268 | 0.2223 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0294 | 0.2268 | 0.7498 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0294 | 0.2268 | 0.7498 |
Giardia lamblia | Cathepsin B precursor | 0.034 | 0.283 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0294 | 0.2268 | 0.2268 |
Loa Loa (eye worm) | DEAH box polypeptide 35 | 0.0293 | 0.2256 | 0.2256 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0294 | 0.2268 | 0.7498 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0205 | 0.1195 | 0.2719 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0294 | 0.2268 | 0.7498 |
Onchocerca volvulus | 0.0294 | 0.2268 | 1 | |
Plasmodium vivax | vivapain-2 | 0.0294 | 0.2268 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0164 | 0.0694 | 0.0651 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.034 | 0.283 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0294 | 0.2268 | 0.7498 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0164 | 0.0694 | 0.0694 |
Loa Loa (eye worm) | hypothetical protein | 0.0205 | 0.1195 | 0.1195 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0294 | 0.2268 | 0.7498 |
Entamoeba histolytica | cysteine protease, putative | 0.0164 | 0.0694 | 0.0651 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0294 | 0.2268 | 0.7498 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0155 | 0.0584 | 0.0528 |
Leishmania major | cathepsin L-like protease | 0.0294 | 0.2268 | 0.7498 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0155 | 0.0584 | 0.0528 |
Leishmania major | cathepsin L-like protease | 0.0294 | 0.2268 | 0.7498 |
Plasmodium vivax | unspecified product | 0.0164 | 0.0694 | 0.0651 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.034 | 0.283 | 1 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0164 | 0.0694 | 0.0116 |
Brugia malayi | Probable ATP-dependent helicase DHX35 | 0.0293 | 0.2256 | 0.2256 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0294 | 0.2268 | 0.1789 |
Loa Loa (eye worm) | hypothetical protein | 0.0294 | 0.2268 | 0.2268 |
Entamoeba histolytica | cysteine proteinase 1, putative | 0.0164 | 0.0694 | 0.0651 |
Plasmodium vivax | vivapain-1 | 0.0164 | 0.0694 | 0.0651 |
Entamoeba histolytica | cysteine protease, putative | 0.0164 | 0.0694 | 0.0651 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0155 | 0.0584 | 0.0528 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0294 | 0.2268 | 0.2223 |
Entamoeba histolytica | cysteine protease, putative | 0.0164 | 0.0694 | 0.0651 |
Brugia malayi | cathepsin L-like precursor | 0.0205 | 0.1195 | 0.1195 |
Entamoeba histolytica | cysteine protease, putative | 0.0164 | 0.0694 | 0.0651 |
Brugia malayi | Cathepsin L-like precursor | 0.0294 | 0.2268 | 0.2268 |
Giardia lamblia | Cathepsin B precursor | 0.034 | 0.283 | 1 |
Brugia malayi | eukaryotic initiation factor 4A | 0.0155 | 0.0584 | 0.0584 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0294 | 0.2268 | 0.7498 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0294 | 0.2268 | 0.1789 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0151 | 0.0534 | 0.0534 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0164 | 0.0694 | 0.0116 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0294 | 0.2268 | 0.7498 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0294 | 0.2268 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0294 | 0.2268 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.093 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0294 | 0.2268 | 0.7498 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0294 | 0.2268 | 0.7498 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0294 | 0.2268 | 0.2268 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0294 | 0.2268 | 0.2268 |
Entamoeba histolytica | cysteine protease, putative | 0.0164 | 0.0694 | 0.0651 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0294 | 0.2268 | 0.7498 |
Leishmania major | cathepsin L-like protease | 0.0294 | 0.2268 | 0.7498 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.034 | 0.283 | 0.2386 |
Plasmodium falciparum | cysteine proteinase falcipain 1 | 0.0164 | 0.0694 | 0.0651 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0294 | 0.2268 | 0.7498 |
Brugia malayi | Trypsin family protein | 0.0151 | 0.0534 | 0.0534 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0294 | 0.2268 | 0.1789 |
Echinococcus multilocularis | cysteine protease | 0.0294 | 0.2268 | 0.2223 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0294 | 0.2268 | 0.2268 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0164 | 0.0694 | 0.0651 |
Onchocerca volvulus | Cathepsin F homolog | 0.0294 | 0.2268 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.093 | 1 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.093 | 1 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0164 | 0.0694 | 0.0694 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0294 | 0.2268 | 0.7498 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0164 | 0.0694 | 0.0651 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0164 | 0.0694 | 0.0651 |
Onchocerca volvulus | 0.0294 | 0.2268 | 1 | |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.093 | 1 | 1 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0155 | 0.0584 | 0.0584 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0294 | 0.2268 | 0.7498 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0164 | 0.0694 | 0.0116 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0112 | 0.0059 | 0.0059 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0205 | 0.1195 | 0.1195 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0164 | 0.0694 | 0.0694 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0294 | 0.2268 | 0.7498 |
Entamoeba histolytica | cysteine protease, putative | 0.0294 | 0.2268 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0294 | 0.2268 | 0.7498 |
Loa Loa (eye worm) | ctsf protein | 0.0294 | 0.2268 | 0.2268 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0164 | 0.0694 | 0.0116 |
Entamoeba histolytica | cysteine protease, putative | 0.0164 | 0.0694 | 0.0651 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0155 | 0.0584 | 0.0288 |
Echinococcus multilocularis | cathepsin b | 0.093 | 1 | 1 |
Onchocerca volvulus | 0.0294 | 0.2268 | 1 | |
Brugia malayi | Papain family cysteine protease containing protein | 0.0294 | 0.2268 | 0.2268 |
Toxoplasma gondii | cathepsin B | 0.034 | 0.283 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0294 | 0.2268 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0294 | 0.2268 | 0.7498 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0294 | 0.2268 | 0.7498 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0294 | 0.2268 | 0.7498 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0294 | 0.2268 | 0.7498 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0155 | 0.0584 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0294 | 0.2268 | 0.7498 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0294 | 0.2268 | 0.2223 |
Onchocerca volvulus | Cathepsin L homolog | 0.0294 | 0.2268 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.0584 | 0.0584 |
Entamoeba histolytica | cysteine protease, putative | 0.0164 | 0.0694 | 0.0651 |
Echinococcus granulosus | cathepsin l1 | 0.0205 | 0.1195 | 0.1143 |
Brugia malayi | Cathepsin L-like precursor | 0.0205 | 0.1195 | 0.1195 |
Loa Loa (eye worm) | cathepsin B | 0.034 | 0.283 | 0.283 |
Onchocerca volvulus | 0.0294 | 0.2268 | 1 | |
Entamoeba histolytica | cysteine protease, putative | 0.0164 | 0.0694 | 0.0651 |
Leishmania major | cathepsin L-like protease | 0.0294 | 0.2268 | 0.7498 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0164 | 0.0694 | 0.0488 |
Entamoeba histolytica | cysteine protease, putative | 0.0164 | 0.0694 | 0.0651 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0294 | 0.2268 | 0.7498 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0294 | 0.2268 | 0.7498 |
Onchocerca volvulus | 0.0294 | 0.2268 | 1 | |
Onchocerca volvulus | 0.0205 | 0.1195 | 0.381 | |
Plasmodium vivax | vivapain-3 | 0.0164 | 0.0694 | 0.0651 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0294 | 0.2268 | 0.7498 |
Loa Loa (eye worm) | cysteine protease | 0.0294 | 0.2268 | 0.2268 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0294 | 0.2268 | 0.2223 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0294 | 0.2268 | 0.7498 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0294 | 0.2268 | 0.2223 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0112 | 0.0059 | 0.0059 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0294 | 0.2268 | 1 |
Onchocerca volvulus | 0.0294 | 0.2268 | 1 | |
Toxoplasma gondii | cathepsin CPL | 0.0294 | 0.2268 | 0.7498 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0155 | 0.0584 | 0.0528 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0294 | 0.2268 | 0.7498 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0294 | 0.2268 | 0.7498 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0205 | 0.1195 | 0.0649 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0294 | 0.2268 | 0.7498 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0294 | 0.2268 | 0.7498 |
Echinococcus granulosus | cathepsin l1 | 0.0294 | 0.2268 | 0.2223 |
Leishmania major | cathepsin L-like protease | 0.0294 | 0.2268 | 0.7498 |
Loa Loa (eye worm) | hypothetical protein | 0.0205 | 0.1195 | 0.1195 |
Brugia malayi | Cathepsin L-like precursor | 0.0205 | 0.1195 | 0.1195 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0294 | 0.2268 | 0.1789 |
Onchocerca volvulus | 0.0294 | 0.2268 | 1 | |
Plasmodium vivax | vivapain-2 | 0.0294 | 0.2268 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0294 | 0.2268 | 0.2268 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0294 | 0.2268 | 0.2268 |
Entamoeba histolytica | cysteine protease, putative | 0.0164 | 0.0694 | 0.0651 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0164 | 0.0694 | 0.0694 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0294 | 0.2268 | 0.7498 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0164 | 0.0694 | 0.0651 |
Leishmania major | cathepsin L-like protease | 0.0294 | 0.2268 | 0.7498 |
Echinococcus multilocularis | cysteine protease | 0.0294 | 0.2268 | 0.2223 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.0534 | 0.0534 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0151 | 0.0534 | 0.0534 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0294 | 0.2268 | 0.7498 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0205 | 0.1195 | 0.1195 |
Echinococcus granulosus | cathepsin L | 0.0164 | 0.0694 | 0.0639 |
Echinococcus granulosus | cathepsin L cysteine protease | 0.0164 | 0.0694 | 0.0639 |
Brugia malayi | Cathepsin L-like precursor | 0.0294 | 0.2268 | 0.2268 |
Entamoeba histolytica | cysteine protease, putative | 0.0164 | 0.0694 | 0.0651 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.034 | 0.283 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0205 | 0.1195 | 0.3626 |
Loa Loa (eye worm) | hypothetical protein | 0.093 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase 2 | 0.0164 | 0.0694 | 0.0651 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0164 | 0.0694 | 0.0694 |
Echinococcus granulosus | cathepsin b | 0.093 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0294 | 0.2268 | 0.7498 |
Loa Loa (eye worm) | hypothetical protein | 0.0205 | 0.1195 | 0.1195 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0294 | 0.2268 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0294 | 0.2268 | 0.2223 |
Echinococcus multilocularis | cathepsin L | 0.0164 | 0.0694 | 0.0639 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0294 | 0.2268 | 0.7498 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.0534 | 0.0534 |
Loa Loa (eye worm) | hypothetical protein | 0.0293 | 0.2256 | 0.2256 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0294 | 0.2268 | 0.7498 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.034 | 0.283 | 0.283 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0164 | 0.0694 | 0.0488 |
Trypanosoma cruzi | cysteine protease, putative | 0.0164 | 0.0694 | 0.0116 |
Giardia lamblia | Cathepsin B precursor | 0.034 | 0.283 | 1 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0155 | 0.0584 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0205 | 0.1195 | 0.2719 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0155 | 0.0584 | 0.0584 |
Echinococcus multilocularis | cathepsin b | 0.093 | 1 | 1 |
Echinococcus granulosus | cysteine protease | 0.0164 | 0.0694 | 0.0639 |
Brugia malayi | Cathepsin L-like precursor | 0.0294 | 0.2268 | 0.2268 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0294 | 0.2268 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0294 | 0.2268 | 0.7498 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.093 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 21.4 % | Tested for the antagonistic activity against 5-hydroxytryptamine 3 receptor from guinea pig ileum | ChEMBL. | 8410988 |
Inhibition (functional) | = 21.4 % | Tested for the antagonistic activity against 5-hydroxytryptamine 3 receptor from guinea pig ileum | ChEMBL. | 8410988 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.