Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0016 | 0.0025 | 0.0051 |
Onchocerca volvulus | 0.0041 | 0.0344 | 1 | |
Trypanosoma brucei | hypothetical protein, conserved | 0.0041 | 0.0344 | 1 |
Echinococcus multilocularis | musashi | 0.0031 | 0.0213 | 0.0206 |
Schistosoma mansoni | choline o-acyltransferase | 0.0041 | 0.0344 | 0.032 |
Leishmania major | carnitine palmitoyltransferase-like protein | 0.0041 | 0.0344 | 0.1193 |
Onchocerca volvulus | 0.0041 | 0.0344 | 1 | |
Onchocerca volvulus | 0.0041 | 0.0344 | 1 | |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.0213 | 0.0436 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0041 | 0.0344 | 0.0656 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.0221 | 0.2699 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0031 | 0.0213 | 0.0189 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0.0344 | 0.1193 |
Schistosoma mansoni | lamin | 0.0031 | 0.0213 | 0.0189 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0025 | 0.0018 |
Echinococcus multilocularis | lamin dm0 | 0.0031 | 0.0213 | 0.0206 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.0221 | 0.2699 | 0.2693 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.0213 | 0.0387 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0782 | 1 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0016 | 0.0025 | 0.0018 |
Loa Loa (eye worm) | hypothetical protein | 0.039 | 0.4893 | 1 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0025 | 0.0018 |
Echinococcus multilocularis | lamin | 0.0031 | 0.0213 | 0.0206 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.0041 | 0.0344 | 0.0703 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0221 | 0.2699 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0344 | 0.0703 |
Trypanosoma cruzi | carnitine/choline acetyltransferase, putative | 0.0041 | 0.0344 | 0.1193 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0221 | 0.2699 | 1 |
Trypanosoma brucei | carnitine O-palmitoyltransferase, putative | 0.0041 | 0.0344 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0.0344 | 0.1193 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0016 | 0.0025 | 0.5 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0041 | 0.0344 | 0.0656 |
Echinococcus granulosus | lamin dm0 | 0.0031 | 0.0213 | 0.0206 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0016 | 0.0025 | 0.5 |
Leishmania major | carnitine/choline acetyltransferase, putative | 0.0041 | 0.0344 | 0.1193 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.039 | 0.4893 | 1 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0041 | 0.0344 | 0.0703 |
Trypanosoma cruzi | choline/carnitine O-acetyltransferase, putative | 0.0041 | 0.0344 | 0.1193 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0.0344 | 0.1193 |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.0041 | 0.0344 | 0.1193 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0016 | 0.0025 | 0.0018 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0041 | 0.0344 | 0.1193 |
Echinococcus granulosus | lamin | 0.0031 | 0.0213 | 0.0206 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0007 | 0.0015 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0025 | 0.0018 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0.0344 | 0.1193 |
Echinococcus granulosus | choline O acetyltransferase | 0.0041 | 0.0344 | 0.0337 |
Brugia malayi | Choline O-acetyltransferase | 0.0041 | 0.0344 | 0.0656 |
Schistosoma mansoni | choline o-acyltransferase | 0.0041 | 0.0344 | 0.032 |
Trypanosoma cruzi | carnitine/choline acetyltransferase, putative | 0.0041 | 0.0344 | 0.1193 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0206 | 0.0421 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.0221 | 0.2699 | 0.2693 |
Brugia malayi | Choline O-acetyltransferase | 0.0041 | 0.0344 | 0.0656 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0016 | 0.0028 | 0.0058 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0016 | 0.0025 | 0.5 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0016 | 0.0028 | 0.0007 |
Echinococcus granulosus | intermediate filament protein | 0.0031 | 0.0213 | 0.0206 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0041 | 0.0344 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0025 | 0.0018 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.0041 | 0.0344 | 0.0337 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0213 | 0.0436 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0016 | 0.0025 | 0.5 |
Loa Loa (eye worm) | carnitine O-palmitoyltransferase I isoform | 0.0041 | 0.0344 | 0.0703 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.0213 | 0.0436 |
Onchocerca volvulus | 0.0041 | 0.0344 | 1 | |
Brugia malayi | intermediate filament protein | 0.0031 | 0.0213 | 0.0387 |
Trypanosoma brucei | carnitine O-acetyltransferase, putative | 0.0041 | 0.0344 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0782 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0.0344 | 0.1193 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0016 | 0.0025 | 0.5 |
Schistosoma mansoni | lamin | 0.0031 | 0.0213 | 0.0189 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0041 | 0.0344 | 1 |
Echinococcus multilocularis | choline O acetyltransferase | 0.0041 | 0.0344 | 0.0337 |
Trypanosoma cruzi | carnitine O-acetyltransferase, putative | 0.0041 | 0.0344 | 0.1193 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.0041 | 0.0344 | 0.0337 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.