TDR Targets

Basic information

Technical information

TDR Targets ID: 1539372
Name: 2-[1-(cyclohexylmethyl)-3-oxopiperazin-2-yl]- N-[2-(3,5-dimethylpyrazol-1-yl)ethyl]acetamid e
MW: 375.508 | Formula: C20H33N5O2
H donors: 2 H acceptors: 3 LogP: 1.78 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: O=C(CC1N(CCNC1=O)CC1CCCCC1)NCCn1nc(cc1C)C
InChi: 1S/C20H33N5O2/c1-15-12-16(2)25(23-15)11-9-21-19(26)13-18-20(27)22-8-10-24(18)14-17-6-4-3-5-7-17/h12,17-18H,3-11,13-14H2,1-2H3,(H,21,26)(H,22,27)
InChiKey: OTWHOJSEKJXWRQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-[1-(cyclohexylmethyl)-3-oxo-piperazin-2-yl]-N-[2-(3,5-dimethylpyrazol-1-yl)ethyl]acetamide
2-[1-(cyclohexylmethyl)-3-oxo-2-piperazinyl]-N-[2-(3,5-dimethyl-1-pyrazolyl)ethyl]acetamide
2-[1-(cyclohexylmethyl)-3-keto-piperazin-2-yl]-N-[2-(3,5-dimethylpyrazol-1-yl)ethyl]acetamide
2-[1-(cyclohexylmethyl)-3-oxo-piperazin-2-yl]-N-[2-(3,5-dimethylpyrazol-1-yl)ethyl]ethanamide
MLS000733766
SMR000316803
2-[1-(cyclohexylmethyl)-3-oxopiperazin-2-yl]-N-[2-(3,5-dimethyl-1H-pyrazol-1-yl)ethyl]acetamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	APEX nuclease (multifunctional DNA repair enzyme) 1	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	Get druggable targets OG5_126768	All targets in OG5_126768
Treponema pallidum	exodeoxyribonuclease (exoA)	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium parvum	conserved hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania donovani	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium berghei	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania infantum	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Candida albicans	similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium yoelii	putative AP endonuclease-related	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma congolense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Cryptosporidium hominis	dna-(apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Entamoeba histolytica	exodeoxyribonuclease III, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi	exonuclease III	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K10771 AP endonuclease 1, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium knowlesi	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	DNA-(apurinic or apyrimidinic site) lyase 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania braziliensis	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768
Toxoplasma gondii	exonuclease III APE	Get druggable targets OG5_126768	All targets in OG5_126768
Neospora caninum	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania mexicana	apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	Get druggable targets OG5_126768	All targets in OG5_126768
Theileria parva	hypothetical protein	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Brugia malayi	exodeoxyribonuclease III family protein	Get druggable targets OG5_126768	All targets in OG5_126768
Trypanosoma brucei gambiense	apurinic/apyrimidinic endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Trichomonas vaginalis	ap endonuclease, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma japonicum	ko:K10772 AP endonuclease 2, putative	Get druggable targets OG5_126768	All targets in OG5_126768
Schistosoma mansoni	ap endonuclease	Get druggable targets OG5_126768	All targets in OG5_126768
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	Get druggable targets OG5_126768	All targets in OG5_126768

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium vivax	pyruvate kinase, putative	0.0033	0.0126	0.0809
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0038	0.0187	0.0347
Mycobacterium leprae	Probable pyruvate kinase PykA	0.0033	0.0126	0.0411
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0044	0.0206
Echinococcus multilocularis	tumor protein p63	0.0672	0.7061	0.8326
Trichomonas vaginalis	D-aminoacylase, putative	0.0148	0.1371	1
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0148	0.1371	0.1357
Loa Loa (eye worm)	inositol-1	0.0036	0.0164	0.0304
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0053	0.0345	0.033
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0038	0.0187	0.022
Giardia lamblia	Pyruvate kinase	0.0033	0.0126	0.6411
Mycobacterium leprae	conserved hypothetical protein	0.0148	0.1371	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0271	0.0319
Brugia malayi	TAR-binding protein	0.0518	0.5387	1
Brugia malayi	beta-lactamase	0.0148	0.1371	0.2545
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0081	0.0648	0.4664
Loa Loa (eye worm)	pyruvate kinase	0.0033	0.0126	0.0233
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0044	0.0206
Loa Loa (eye worm)	pyruvate kinase-PB	0.0023	0.0018	0.0033
Mycobacterium ulcerans	esterase/lipase LipP	0.0148	0.1371	1
Echinococcus multilocularis	pyruvate kinase	0.0033	0.0126	0.0148
Trypanosoma brucei	unspecified product	0.0027	0.0057	0.0306
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0038	0.0187	0.1262
Schistosoma mansoni	hypothetical protein	0.0048	0.0296	0.0349
Trypanosoma brucei	DNA polymerase kappa, putative	0.0038	0.0187	0.1262
Schistosoma mansoni	tar DNA-binding protein	0.0518	0.5387	0.6352
Loa Loa (eye worm)	TAR-binding protein	0.0518	0.5387	1
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1371	0.2545
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0033	0.0122	0.0387
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0265	0.264	0.3113
Echinococcus multilocularis	microtubule associated protein 2	0.0803	0.8481	1
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0164	0.1091
Brugia malayi	RNA binding protein	0.0518	0.5387	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0296	0.0549
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0048	0.0296	0.0349
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0028	0.0072	0.0889
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0081	0.0648	1
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0081	0.0648	0.4664
Echinococcus multilocularis	GPCR, family 2	0.0048	0.0296	0.0349
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0265	0.264	0.3113
Schistosoma mansoni	cellular tumor antigen P53	0.0098	0.0837	0.0987
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0164	0.1091
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0837	0.1554
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0038	0.0187	0.1262
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0148	0.1371	1
Leishmania major	pyruvate kinase	0.0033	0.0126	0.0809
Schistosoma mansoni	pyruvate kinase	0.0033	0.0126	0.0148
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0038	0.0187	0.022
Schistosoma mansoni	DNA polymerase eta	0.0038	0.0187	0.022
Onchocerca volvulus	Pyruvate kinase homolog	0.0033	0.0126	0.0916
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0028	0.0072	0.0415
Echinococcus multilocularis	dna polymerase kappa	0.0038	0.0187	0.022
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0164	0.1091
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0048	0.0296	0.0349
Echinococcus granulosus	microtubule associated protein 2	0.0803	0.8481	1
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0081	0.0648	0.4433
Mycobacterium tuberculosis	Probable esterase LipL	0.0148	0.1371	0.1357
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0518	0.5387	1
Trypanosoma brucei	hypothetical protein, conserved	0.0148	0.1371	1
Schistosoma mansoni	hypothetical protein	0.0265	0.264	0.3113
Toxoplasma gondii	ABC1 family protein	0.0148	0.1371	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0271	0.0319
Trypanosoma brucei	unspecified product	0.0038	0.0187	0.1262
Brugia malayi	latrophilin 2 splice variant baaae	0.0105	0.0906	0.1682
Trypanosoma brucei	DNA polymerase kappa, putative	0.0038	0.0187	0.1262
Leishmania major	hypothetical protein, conserved	0.0025	0.0044	0.0206
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0271	0.0503
Brugia malayi	exodeoxyribonuclease III family protein	0.0023	0.0016	0.003
Trypanosoma brucei	unspecified product	0.0027	0.0057	0.0306
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0148	0.1371	0.1357
Loa Loa (eye worm)	hypothetical protein	0.0153	0.1432	0.2658
Schistosoma mansoni	tar DNA-binding protein	0.0518	0.5387	0.6352
Loa Loa (eye worm)	pyruvate kinase	0.0033	0.0126	0.0233
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0081	0.0648	0.0764
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0028	0.0072	0.0889
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0081	0.0648	1
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0081	0.0648	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0075	0.0579	0.0682
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0048	0.0296	0.0349
Trichomonas vaginalis	D-aminoacylase, putative	0.0148	0.1371	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0027	0.0057	0.0306
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0164	0.1091
Brugia malayi	Pyruvate kinase, M2 isozyme	0.0033	0.0126	0.0233
Trypanosoma brucei	DNA polymerase kappa, putative	0.0038	0.0187	0.1262
Entamoeba histolytica	hypothetical protein	0.0075	0.0579	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0027	0.0057	0.0306
Trypanosoma brucei	pyruvate kinase 1	0.0033	0.0126	0.0809
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0038	0.0187	0.1262
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0036	0.0164	0.1091
Schistosoma mansoni	hypothetical protein	0.0105	0.0906	0.1068
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0038	0.0187	0.0171
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0038	0.0187	0.022
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0048	0.0296	0.0549
Loa Loa (eye worm)	MH2 domain-containing protein	0.0133	0.121	0.2246
Mycobacterium tuberculosis	Probable pyruvate kinase PykA	0.0033	0.0126	0.011
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.0164	0.1091
Echinococcus multilocularis	pyruvate kinase	0.0026	0.0051	0.006
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0038	0.0187	0.1262
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0126	0.0233
Schistosoma mansoni	tar DNA-binding protein	0.0518	0.5387	0.6352
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0033	0.0126	0.0809
Mycobacterium ulcerans	beta-lactamase	0.0148	0.1371	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0038	0.0187	0.1262
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0048	0.0296	0.0549
Mycobacterium ulcerans	DNA polymerase IV	0.0038	0.0187	0.1262
Trypanosoma brucei	DNA polymerase kappa, putative	0.0038	0.0187	0.1262
Entamoeba histolytica	hypothetical protein	0.0075	0.0579	1
Mycobacterium tuberculosis	Probable lipase LipE	0.0148	0.1371	0.1357
Brugia malayi	Latrophilin receptor protein 2	0.0048	0.0296	0.0549
Trichomonas vaginalis	pyruvate kinase, putative	0.0033	0.0126	0.0809
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0148	0.1371	0.1616
Trypanosoma cruzi	hypothetical protein, conserved	0.0148	0.1371	1
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0081	0.0648	1
Toxoplasma gondii	pyruvate kinase PyK1	0.0033	0.0126	0.0809
Loa Loa (eye worm)	transcription factor SMAD2	0.0133	0.121	0.2246
Onchocerca volvulus	Pyruvate kinase homolog	0.0033	0.0126	0.0916
Mycobacterium ulcerans	lipase LipD	0.0148	0.1371	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0027	0.0057	0.0306
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0053	0.0345	0.033
Schistosoma mansoni	hypothetical protein	0.0075	0.0579	0.0682
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1371	0.2545
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1371	0.2545
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0038	0.0187	0.1262
Plasmodium vivax	hypothetical protein, conserved	0.0148	0.1371	1
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0038	0.0187	0.0171
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0048	0.0296	0.0349
Trichomonas vaginalis	inositol monophosphatase, putative	0.0036	0.0164	0.1091
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0148	0.1371	0.1357
Echinococcus granulosus	peptidase Clp S14 family	0.0053	0.0345	0.0407
Trypanosoma brucei	DNA polymerase kappa, putative	0.0038	0.0187	0.1262
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0081	0.0648	0.4664
Onchocerca volvulus		0.0148	0.1371	1
Echinococcus granulosus	dna polymerase eta	0.0038	0.0187	0.022
Trypanosoma brucei	DNA polymerase kappa, putative	0.0038	0.0187	0.1262
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0148	0.1371	0.1616
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0153	0.1432	0.2658
Echinococcus granulosus	dna polymerase kappa	0.0038	0.0187	0.022
Echinococcus granulosus	tumor protein p63	0.0672	0.7061	0.8326
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0906	0.1682
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0044	0.0206
Brugia malayi	hypothetical protein	0.0075	0.0579	0.1074
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1371	0.2545
Trypanosoma brucei	DNA polymerase eta, putative	0.0038	0.0187	0.1262
Brugia malayi	Inositol-1	0.0036	0.0164	0.0304
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0038	0.0187	0.022
Entamoeba histolytica	hypothetical protein	0.0075	0.0579	1
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1371	0.2545
Trypanosoma brucei	DNA polymerase kappa, putative	0.0038	0.0187	0.1262
Schistosoma mansoni	ap endonuclease	0.0023	0.0016	0.0019
Mycobacterium tuberculosis	Conserved protein	0.0148	0.1371	0.1357
Echinococcus granulosus	inositol monophosphatase 1	0.0036	0.0164	0.0193
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0023	0.0016	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0018	0.0033
Brugia malayi	ImpB/MucB/SamB family protein	0.0038	0.0187	0.0347
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0271	0.0319
Echinococcus multilocularis	pyruvate kinase	0.0033	0.0126	0.0148
Mycobacterium tuberculosis	Probable hydrolase	0.0148	0.1371	0.1357
Brugia malayi	Probable ClpP-like protease	0.0081	0.0648	0.1203
Echinococcus granulosus	pyruvate kinase	0.0033	0.0126	0.0148
Leishmania major	hypothetical protein, conserved	0.0148	0.1371	1
Onchocerca volvulus	Pyruvate kinase homolog	0.0033	0.0126	0.0916
Leishmania major	DNA polymerase eta, putative	0.0038	0.0187	0.1262
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0153	0.1432	0.2658
Schistosoma mansoni	thyroid hormone receptor	0.0286	0.287	0.3384
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0148	0.1371	0.2545
Trichomonas vaginalis	esterase, putative	0.0148	0.1371	1
Schistosoma mansoni	hypothetical protein	0.0048	0.0296	0.0349
Brugia malayi	beta-lactamase family protein	0.0148	0.1371	0.2545
Schistosoma mansoni	tar DNA-binding protein	0.0518	0.5387	0.6352
Onchocerca volvulus		0.0148	0.1371	1
Onchocerca volvulus		0.0148	0.1371	1
Echinococcus granulosus	GPCR family 2	0.0048	0.0296	0.0349
Trypanosoma brucei	DNA polymerase IV, putative	0.0038	0.0187	0.1262
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0081	0.0648	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0187	0.0347
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0271	0.0503
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0286	0.287	0.3384
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0075	0.0579	0.0682
Trypanosoma cruzi	hypothetical protein, conserved	0.0148	0.1371	1
Echinococcus granulosus	tar DNA binding protein	0.0518	0.5387	0.6352
Mycobacterium ulcerans	hypothetical protein	0.0148	0.1371	1
Loa Loa (eye worm)	RNA binding protein	0.0518	0.5387	1
Mycobacterium ulcerans	pyruvate kinase	0.0033	0.0126	0.0809
Leishmania major	DNA polymerase kappa, putative	0.0038	0.0187	0.1262
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0038	0.0187	0.1262
Trichomonas vaginalis	DNA polymerase eta, putative	0.0038	0.0187	0.1262
Giardia lamblia	DINP protein human, muc B family	0.0038	0.0187	1
Entamoeba histolytica	pyruvate kinase, putative	0.0023	0.0018	0.0033
Trichomonas vaginalis	penicillin-binding protein, putative	0.0148	0.1371	1
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0164	0.0193
Schistosoma mansoni	tar DNA-binding protein	0.0518	0.5387	0.6352
Trypanosoma brucei	DNA polymerase kappa, putative	0.0038	0.0187	0.1262
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0053	0.0345	0.0407
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0023	0.0016	0.003
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0036	0.0164	0.1091
Brugia malayi	Pyruvate kinase, muscle isozyme	0.0033	0.0126	0.0233
Schistosoma mansoni	peptidase Clp (S14 family)	0.0081	0.0648	0.0764
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0044	0.0206
Echinococcus granulosus	beta LACTamase domain containing family member	0.0148	0.1371	0.1616
Brugia malayi	beta-lactamase family protein	0.0148	0.1371	0.2545
Trypanosoma brucei	DNA polymerase IV, putative	0.0038	0.0187	0.1262
Leishmania major	pyruvate kinase	0.0033	0.0126	0.0809
Brugia malayi	hypothetical protein	0.0025	0.0044	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0148	0.1371	0.2545
Schistosoma mansoni	microtubule-associated protein tau	0.0803	0.8481	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0148	0.1371	1
Entamoeba histolytica	hypothetical protein	0.0075	0.0579	1
Trypanosoma cruzi	DNA polymerase eta, putative	0.0038	0.0187	0.1262
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0271	0.0319
Loa Loa (eye worm)	pyruvate kinase	0.0033	0.0126	0.0233
Mycobacterium tuberculosis	Conserved protein	0.0148	0.1371	0.1357
Schistosoma mansoni	hypothetical protein	0.0048	0.0296	0.0349
Brugia malayi	ImpB/MucB/SamB family protein	0.0038	0.0187	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0044	0.0082
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0053	0.0345	0.2103
Schistosoma mansoni	ap endonuclease	0.0023	0.0016	0.0019
Echinococcus multilocularis	inositol monophosphatase 1	0.0036	0.0164	0.0193
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0038	0.0187	0.3039
Schistosoma mansoni	pyruvate kinase	0.0033	0.0126	0.0148
Trypanosoma cruzi	pyruvate kinase 2, putative	0.0033	0.0126	0.0809
Trypanosoma brucei	DNA polymerase kappa, putative	0.0038	0.0187	0.1262
Echinococcus granulosus	pyruvate kinase	0.0033	0.0126	0.0148
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0081	0.0648	0.4664
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0148	0.1371	0.2545
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0036	0.0164	0.2627
Echinococcus multilocularis	tar DNA binding protein	0.0518	0.5387	0.6352
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0153	0.1432	0.2658
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0081	0.0648	0.4664
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0044	0.0442
Trypanosoma brucei	pyruvate kinase 1, putative	0.0033	0.0126	0.0809
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0044	0.0206
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0023	0.0016	0.0019
Mycobacterium ulcerans	DNA polymerase IV	0.0038	0.0187	0.1262
Mycobacterium leprae	Probable lipase LipE	0.0148	0.1371	1
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.0164	0.1091
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0036	0.0164	0.2339
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0044	0.0442
Trichomonas vaginalis	penicillin-binding protein, putative	0.0148	0.1371	1
Plasmodium falciparum	pyruvate kinase	0.0033	0.0126	0.1735
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0271	0.0319
Schistosoma mansoni	transcription factor LCR-F1	0.0075	0.0579	0.0682
Schistosoma mansoni	thyroid hormone receptor	0.0286	0.287	0.3384
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0148	0.1371	0.1616
Echinococcus multilocularis	dna polymerase eta	0.0038	0.0187	0.022
Trichomonas vaginalis	pyruvate kinase, putative	0.0033	0.0126	0.0809
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0081	0.0648	0.0764
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0648	0.1203
Loa Loa (eye worm)	beta-lactamase	0.0148	0.1371	0.2545
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0271	0.0319
Schistosoma mansoni	hypothetical protein	0.0048	0.0296	0.0349
Onchocerca volvulus		0.0098	0.0837	0.6105
Mycobacterium tuberculosis	Conserved protein	0.0148	0.1371	0.1357
Schistosoma mansoni	inositol monophosphatase	0.0036	0.0164	0.0193
Brugia malayi	RNA recognition motif domain containing protein	0.0518	0.5387	1
Brugia malayi	MH2 domain containing protein	0.0133	0.121	0.2246
Mycobacterium tuberculosis	Probable lipase LipD	0.0148	0.1371	0.1357
Trypanosoma brucei	DNA polymerase kappa, putative	0.0038	0.0187	0.1262
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0033	0.0122	0.0107
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0271	0.0319
Toxoplasma gondii	hypothetical protein	0.0028	0.0072	0.0415

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	3.1623 uM	PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	39.8107 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1900242

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1539372