Detailed information for compound 1539875

Basic information

Technical information
  • TDR Targets ID: 1539875
  • Name: N-(2,4-dichlorophenyl)-1-ethylpyrazole-4-carb oxamide
  • MW: 284.141 | Formula: C12H11Cl2N3O
  • H donors: 1 H acceptors: 2 LogP: 2.62 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCn1ncc(c1)C(=O)Nc1ccc(cc1Cl)Cl
  • InChi: 1S/C12H11Cl2N3O/c1-2-17-7-8(6-15-17)12(18)16-11-4-3-9(13)5-10(11)14/h3-7H,2H2,1H3,(H,16,18)
  • InChiKey: FDKHKUMOTHCPKK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2,4-dichlorophenyl)-1-ethyl-pyrazole-4-carboxamide
  • N-(2,4-dichlorophenyl)-1-ethyl-4-pyrazolecarboxamide
  • N-(2,4-dichlorophenyl)-1-ethyl-1H-pyrazole-4-carboxamide
  • SMR000476800
  • ZINC00356085
  • MLS001178565

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum calcium-dependent protein kinase 4 0.0072 0.0597 0.0597
Loa Loa (eye worm) hypothetical protein 0.007 0.0582 0.2475
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0018 0.0048 0.0205
Echinococcus granulosus synaptic vesicle 2 protein 0.0033 0.0201 0.0248
Trypanosoma brucei sugar transporter, putative 0.0033 0.0201 0.2874
Loa Loa (eye worm) hypothetical protein 0.0033 0.0201 0.0857
Loa Loa (eye worm) hypothetical protein 0.0052 0.0399 0.1695
Trichomonas vaginalis glucose transporter, putative 0.0072 0.0606 0.225
Chlamydia trachomatis lysine--tRNA ligase 0.0052 0.0399 1
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0201 0.0747
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0072 0.0597 0.2538
Loa Loa (eye worm) latrophilin receptor protein 2 0.0018 0.0048 0.0205
Loa Loa (eye worm) hypothetical protein 0.0033 0.0201 0.0857
Loa Loa (eye worm) hypothetical protein 0.0035 0.0222 0.0945
Plasmodium vivax calcium-dependent protein kinase, putative 0.0072 0.0597 0.0597
Schistosoma mansoni hypothetical protein 0.0018 0.0048 0.0059
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0072 0.0597 0.2538
Plasmodium vivax lysine--tRNA ligase, putative 0.0052 0.0399 0.0399
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.007 0.0582 0.0718
Loa Loa (eye worm) sugar transporter 0.0033 0.0201 0.0857
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0033 0.0201 0.6328
Loa Loa (eye worm) sugar transporter 0.0234 0.2253 0.9584
Schistosoma mansoni sugar transporter 0.0033 0.0201 0.0248
Treponema pallidum prolyl-tRNA synthetase 0.0025 0.0119 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0201 0.0857
Trypanosoma brucei THT1 - hexose transporter, putative 0.0072 0.0606 0.8651
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0072 0.0597 0.0736
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0201 0.0747
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0222 0.0274
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0201 0.0747
Brugia malayi Sugar transporter family protein 0.0033 0.0201 0.0857
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0234 0.2253 0.278
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0052 0.0399 1
Plasmodium vivax sugar transporter, putative 0.0033 0.0201 0.0201
Plasmodium falciparum calcium-dependent protein kinase 1 0.0072 0.0597 0.0597
Echinococcus multilocularis solute carrier family 22 0.0033 0.0201 0.0248
Schistosoma mansoni hypothetical protein 0.0018 0.0048 0.0059
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.007 0.0582 0.0718
Leishmania major glucose transporter/membrane transporter D2, putative 0.0072 0.0606 0.8651
Trypanosoma brucei glucose transporter, putative 0.0072 0.0606 0.8651
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0201 0.0747
Trypanosoma cruzi hexose transporter, putative 0.0072 0.0606 0.8651
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0606 0.225
Brugia malayi Major Facilitator Superfamily protein 0.0033 0.0201 0.0857
Schistosoma mansoni protein kinase 0.0072 0.0597 0.0736
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0222 0.0274
Leishmania major glucose transporter, lmgt2 0.0072 0.0606 0.8651
Trypanosoma cruzi sugar transporter, putative 0.0033 0.0201 0.2874
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0201 0.0747
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0234 0.2253 0.278
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0222 0.0274
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.026 0.1106
Loa Loa (eye worm) hypothetical protein 0.0033 0.0201 0.0857
Toxoplasma gondii sugar transporter ST3 0.0033 0.0201 0.0305
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0033 0.0201 0.0248
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0052 0.0399 1
Echinococcus granulosus solute carrier family 22 0.0033 0.0201 0.0248
Plasmodium falciparum protein kinase 7 0.066 0.6612 0.6612
Brugia malayi hypothetical protein 0.0033 0.0201 0.0857
Trichomonas vaginalis sugar transport protein, putative 0.0033 0.0201 0.0747
Loa Loa (eye worm) hypothetical protein 0.0033 0.0201 0.0857
Brugia malayi Sugar transporter family protein 0.0033 0.0201 0.0857
Trichomonas vaginalis myo-inositol transporter, putative 0.0033 0.0201 0.0747
Trichomonas vaginalis set domain proteins, putative 0.0277 0.2695 1
Giardia lamblia Lysyl-tRNA synthetase 0.0052 0.0399 0.6849
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.007 0.0582 0.0718
Loa Loa (eye worm) hypothetical protein 0.0033 0.0201 0.0857
Brugia malayi Sugar transporter family protein 0.0234 0.2253 0.9584
Schistosoma mansoni glucose transporter 0.0033 0.0201 0.0248
Echinococcus multilocularis solute carrier family 22 0.0033 0.0201 0.0248
Plasmodium vivax CDK-related protein kinase 6, putative 0.0992 1 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0048 0.0205
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0033 0.0201 0.2874
Brugia malayi hypothetical protein 0.0033 0.0201 0.0857
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0243 0.2351 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0201 0.0857
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0234 0.2253 0.278
Trypanosoma brucei glucose transporter, putative 0.0072 0.0606 0.8651
Toxoplasma gondii transporter, major facilitator family protein 0.0033 0.0201 0.0305
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0222 0.0274
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0222 0.0274
Trypanosoma cruzi hexose transporter, putative 0.0072 0.0606 0.8651
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0201 0.0747
Echinococcus granulosus General substrate transporter 0.0201 0.1918 0.2366
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0029 0.016 0.0679
Entamoeba histolytica hypothetical protein 0.0052 0.0399 0.6679
Loa Loa (eye worm) hypothetical protein 0.0056 0.0443 0.1882
Plasmodium falciparum proline--tRNA ligase 0.0082 0.0701 0.0701
Schistosoma mansoni protein kinase 0.0072 0.0597 0.0736
Schistosoma mansoni hypothetical protein 0.0018 0.0048 0.0059
Leishmania major lysyl-tRNA synthetase, putative 0.0052 0.0399 0.5689
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0082 0.0701 1
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0201 0.0747
Trichomonas vaginalis conserved hypothetical protein 0.0234 0.2253 0.8363
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0052 0.0399 0.5689
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0201 0.0747
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0201 0.0747
Schistosoma mansoni sugar transporter 0.0033 0.0201 0.0248
Trypanosoma brucei THT1 - hexose transporter, putative 0.0072 0.0606 0.8651
Echinococcus multilocularis lysyl tRNA synthetase 0.0052 0.0399 0.0492
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0201 0.0747
Trichomonas vaginalis conserved hypothetical protein 0.0072 0.0606 0.225
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0034 0.0209 0.0258
Echinococcus multilocularis microtubule associated protein 2 0.0807 0.8107 1
Trypanosoma cruzi hexose transporter, putative 0.0072 0.0606 0.8651
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0082 0.0701 1
Trypanosoma brucei glucose transporter 2A 0.0072 0.0606 0.8651
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0033 0.0201 0.0201
Echinococcus multilocularis solute carrier family 22 0.0033 0.0201 0.0248
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0201 0.0747
Trypanosoma brucei glucose transporter, putative 0.0072 0.0606 0.8651
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0082 0.0701 1
Brugia malayi Major Facilitator Superfamily protein 0.0033 0.0201 0.0857
Schistosoma mansoni lysyl-tRNA synthetase 0.0052 0.0399 0.0492
Loa Loa (eye worm) major facilitator superfamily transporter 0.0033 0.0201 0.0857
Echinococcus granulosus microtubule associated protein 2 0.0807 0.8107 1
Trypanosoma cruzi hexose transporter 0.0072 0.0606 0.8651
Echinococcus multilocularis GPCR, family 2 0.0018 0.0048 0.0059
Trypanosoma brucei glucose transporter, putative 0.0072 0.0606 0.8651
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0234 0.2253 0.278
Toxoplasma gondii protein kinase, putative 0.066 0.6612 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0072 0.0597 0.0736
Echinococcus multilocularis solute carrier family 22 0.0033 0.0201 0.0248
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0201 0.0747
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0222 0.0274
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0044 0.0318 1
Schistosoma mansoni hypothetical protein 0.0234 0.2253 0.278
Mycobacterium ulcerans integral membrane transport protein 0.0033 0.0201 0.5052
Onchocerca volvulus 0.0277 0.2695 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0395 0.0487
Trypanosoma cruzi hexose transporter, putative 0.004 0.027 0.386
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0033 0.0201 0.5052
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0052 0.0399 0.5689
Schistosoma mansoni lysyl-tRNA synthetase 0.0052 0.0399 0.0492
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0234 0.2253 0.278
Loa Loa (eye worm) hypothetical protein 0.0033 0.0201 0.0857
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0018 0.0048 0.0059
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0201 0.0747
Leishmania major myo-inositol/proton symporter (MIT) 0.0033 0.0201 0.2874
Brugia malayi Pre-SET motif family protein 0.0035 0.0222 0.0945
Trichomonas vaginalis sugar transporter, putative 0.0072 0.0606 0.225
Plasmodium vivax hexose transporter 0.0234 0.2253 0.2253
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0072 0.0597 0.0736
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.007 0.0582 0.2475
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0018 0.0048 0.0059
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0201 0.0747
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0395 0.0487
Echinococcus granulosus Sugar transporter ERD6 protein 0.0033 0.0201 0.0248
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.0395 0.168
Loa Loa (eye worm) hypothetical protein 0.0033 0.0201 0.0857
Schistosoma mansoni sugar transporter 0.0033 0.0201 0.0248
Loa Loa (eye worm) hypothetical protein 0.0033 0.0201 0.0857
Leishmania major glucose transporter, lmgt3 0.0072 0.0606 0.8651
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0201 0.0747
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0201 0.0747
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0072 0.0597 0.0736
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0044 0.0318 0.5469
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0201 0.0747
Plasmodium falciparum calcium-dependent protein kinase 2 0.0072 0.0597 0.0597
Plasmodium vivax SET domain protein, putative 0.0035 0.0222 0.0222
Brugia malayi lysyl-tRNA synthetase 0.0052 0.0399 0.1695
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0201 0.0747
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.007 0.0582 0.216
Echinococcus granulosus solute carrier family 22 0.0033 0.0201 0.0248
Toxoplasma gondii lysine-tRNA ligase 0.0052 0.0399 0.0603
Echinococcus granulosus lysyl tRNA synthetase 0.0052 0.0399 0.0492
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0201 0.0747
Plasmodium falciparum calcium-dependent protein kinase 5 0.0072 0.0597 0.0597
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0018 0.0048 0.0059
Giardia lamblia Prolyl-tRNA synthetase 0.007 0.0582 1
Loa Loa (eye worm) hypothetical protein 0.007 0.0582 0.2475
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0395 0.0487
Trypanosoma brucei glucose transporter, putative 0.0072 0.0606 0.8651
Toxoplasma gondii facilitative glucose transporter GT1 0.0234 0.2253 0.3408
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0201 0.0747
Entamoeba histolytica protein kinase, putative 0.0072 0.0597 1
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.007 0.0582 0.2475
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0072 0.0597 0.0736
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0033 0.0201 0.5052
Onchocerca volvulus 0.0035 0.0222 0.0083
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0222 0.0274
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0201 0.0747
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0395 0.0487
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0046 0.0333 0.1236
Echinococcus granulosus solute carrier family 22 0.0033 0.0201 0.0248
Plasmodium falciparum calcium-dependent protein kinase 3 0.0072 0.0597 0.0597
Trichomonas vaginalis glucose transporter, putative 0.0033 0.0201 0.0747
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0052 0.0399 0.1479
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0201 0.0747
Echinococcus multilocularis synaptic vesicle 2 protein 0.0033 0.0201 0.0248
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0201 0.0747
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0072 0.0597 0.0736
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0201 0.0747
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0201 0.0747
Leishmania major hypothetical protein, conserved 0.0033 0.0201 0.2874
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0072 0.0597 0.0597
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0201 0.0747
Loa Loa (eye worm) hypothetical protein 0.0033 0.0201 0.0857
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0018 0.0048 0.0059
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0201 0.0747
Schistosoma mansoni sugar transporter 0.0033 0.0201 0.0248
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0082 0.0701 0.106
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0395 0.0487
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0201 0.0747
Schistosoma mansoni hypothetical protein 0.0018 0.0048 0.0059
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.0395 0.168
Echinococcus granulosus calcium dependent protein kinase 0.0067 0.0552 0.068
Trichomonas vaginalis glucose transporter, putative 0.0072 0.0606 0.225
Trypanosoma brucei glucose transporter, putative 0.0072 0.0606 0.8651
Loa Loa (eye worm) hypothetical protein 0.0033 0.0201 0.0857
Echinococcus granulosus solute carrier family 22 0.0033 0.0201 0.0248
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0072 0.0597 0.0597
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0443 0.1882
Loa Loa (eye worm) hypothetical protein 0.0033 0.0201 0.0857
Loa Loa (eye worm) major facilitator superfamily transporter 0.0033 0.0201 0.0857
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0201 0.0747
Brugia malayi major facilitator superfamily protein 0.0033 0.0201 0.0857
Trypanosoma brucei glucose transporter, putative 0.0072 0.0606 0.8651
Plasmodium falciparum hexose transporter 0.0234 0.2253 0.2253
Leishmania major protein kinase, putative 0.0072 0.0597 0.8517
Leishmania major glucose transporter, lmgt1 0.0072 0.0606 0.8651
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0025 0.0119 0.2978
Echinococcus multilocularis General substrate transporter 0.0201 0.1918 0.2366
Toxoplasma gondii sugar transporter ST2 0.0033 0.0201 0.0305
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0395 0.0487
Trypanosoma cruzi hexose transporter, putative 0.0033 0.0201 0.2874
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0201 0.0747
Echinococcus multilocularis calcium dependent protein kinase 0.0067 0.0552 0.068
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0072 0.0597 0.0903
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0072 0.0597 0.0736
Loa Loa (eye worm) hypothetical protein 0.0072 0.0597 0.2538
Schistosoma mansoni glucose transport protein 0.0234 0.2253 0.278
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.007 0.0582 1
Trichomonas vaginalis sugar transporter, putative 0.0072 0.0606 0.225
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0072 0.0597 0.0903
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0378 0.3724 0.3724
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0072 0.0597 0.0736
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0072 0.0597 0.2538
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0201 0.0747
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0201 0.0747
Brugia malayi hypothetical protein 0.0033 0.0201 0.0857
Giardia lamblia Hexose transporter 0.0033 0.0201 0.346
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.007 0.0582 0.9752
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0443 0.1882
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0201 0.0747
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0201 0.0747
Brugia malayi major facilitator superfamily protein 0.0033 0.0201 0.0857
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0234 0.2253 0.278
Chlamydia trachomatis proline--tRNA ligase 0.0025 0.0119 0.2978
Brugia malayi Latrophilin receptor protein 2 0.0018 0.0048 0.0205
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0234 0.2253 0.278
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0222 0.0336
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0072 0.0597 0.0903
Loa Loa (eye worm) hypothetical protein 0.0057 0.0448 0.1904
Trichomonas vaginalis sugar transporter, putative 0.0072 0.0606 0.225
Brugia malayi Cam kinase protein 1 0.0072 0.0597 0.2538
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0201 0.0747
Schistosoma mansoni hypothetical protein 0.0039 0.026 0.0321
Schistosoma mansoni glucose transport protein 0.0234 0.2253 0.278
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0052 0.0399 0.6849
Plasmodium falciparum lysine--tRNA ligase 0.0052 0.0399 0.0399
Trypanosoma brucei glucose transporter 1E 0.0072 0.0606 0.8651
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0033 0.0201 0.6328
Loa Loa (eye worm) hypothetical protein 0.0033 0.0201 0.0857
Echinococcus granulosus GPCR family 2 0.0018 0.0048 0.0059
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0072 0.0597 0.8517
Toxoplasma gondii sugar transporter ST1 0.0033 0.0201 0.0305
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0044 0.0318 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.026 0.1106
Brugia malayi Major Facilitator Superfamily protein 0.0033 0.0201 0.0857
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0033 0.0201 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0443 0.1882
Schistosoma mansoni serine/threonine protein kinase 0.0072 0.0597 0.0736
Trypanosoma brucei glucose transporter, putative 0.0072 0.0606 0.8651
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0234 0.2253 0.278
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0033 0.0201 0.0248
Mycobacterium ulcerans sugar transporter 0.0033 0.0201 0.5052
Plasmodium falciparum mitogen-activated protein kinase 2 0.0378 0.3724 0.3724
Schistosoma mansoni microtubule-associated protein tau 0.0807 0.8107 1
Trichomonas vaginalis CAMK family protein kinase 0.0072 0.0597 0.2215
Entamoeba histolytica protein kinase, putative 0.0072 0.0597 1
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0072 0.0597 0.0597
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0201 0.0747
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0082 0.0701 1
Trypanosoma brucei THT1 - hexose transporter, putative 0.0072 0.0606 0.8651
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0378 0.3724 0.5632
Schistosoma mansoni glucose transport protein 0.0234 0.2253 0.278
Loa Loa (eye worm) hypothetical protein 0.0033 0.0201 0.0857
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0082 0.0701 1
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0201 0.0747
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0201 0.0747
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0201 0.0747
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0395 0.0487
Plasmodium vivax proline--tRNA ligase, putative 0.0082 0.0701 0.0701
Trypanosoma cruzi glucose transporter, putative 0.0033 0.0201 0.2874
Giardia lamblia Sugar-proton symporter 0.0033 0.0201 0.346
Trichomonas vaginalis sugar transporter, putative 0.0033 0.0201 0.0747
Schistosoma mansoni protein kinase 0.0072 0.0597 0.0736
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.007 0.0582 0.0718
Brugia malayi Pre-SET motif family protein 0.0243 0.2351 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.