Detailed information for compound 155097

Basic information

Technical information
  • TDR Targets ID: 155097
  • Name: ethyl N-[2-[4-[[1-(5-acetamido-2-chlorophenyl )-3-butyl-5-oxo-1,2,4-triazol-4-yl]methyl]-3- fluorophenyl]-4-propylphenyl]sulfonylcarbamat e
  • MW: 686.193 | Formula: C33H37ClFN5O6S
  • H donors: 2 H acceptors: 5 LogP: 6.37 Rotable bonds: 16
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCCc1nn(c(=O)n1Cc1ccc(cc1F)c1cc(CCC)ccc1S(=O)(=O)NC(=O)OCC)c1cc(ccc1Cl)NC(=O)C
  • InChi: 1S/C33H37ClFN5O6S/c1-5-8-10-31-37-40(29-19-25(36-21(4)41)14-15-27(29)34)33(43)39(31)20-24-13-12-23(18-28(24)35)26-17-22(9-6-2)11-16-30(26)47(44,45)38-32(42)46-7-3/h11-19H,5-10,20H2,1-4H3,(H,36,41)(H,38,42)
  • InChiKey: AVPYNETYRCMACW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl N-[2-[4-[[1-(5-acetamido-2-chloro-phenyl)-3-butyl-5-oxo-1,2,4-triazol-4-yl]methyl]-3-fluoro-phenyl]-4-propyl-phenyl]sulfonylcarbamate
  • N-[2-[4-[[1-(5-acetamido-2-chlorophenyl)-3-butyl-5-oxo-1,2,4-triazol-4-yl]methyl]-3-fluorophenyl]-4-propylphenyl]sulfonylcarbamic acid ethyl ester
  • N-[2-[4-[[1-(5-acetamido-2-chloro-phenyl)-3-butyl-5-keto-1,2,4-triazol-4-yl]methyl]-3-fluoro-phenyl]-4-propyl-phenyl]sulfonylcarbamic acid ethyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens angiotensin II receptor, type 1 Starlite/ChEMBL No references
Homo sapiens angiotensin II receptor, type 2 Starlite/ChEMBL No references
Oryctolagus cuniculus Angiotensin II type 1a (AT-1a) receptor Starlite/ChEMBL No references
Rattus norvegicus Angiotensin II type 2 (AT-2) receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus growth hormone secretagogue receptor type 1 Angiotensin II type 1a (AT-1a) receptor   359 aa 342 aa 22.2 %
Onchocerca volvulus Angiotensin II type 1a (AT-1a) receptor   359 aa 399 aa 25.3 %
Loa Loa (eye worm) hypothetical protein Angiotensin II type 1a (AT-1a) receptor   359 aa 308 aa 27.3 %
Echinococcus multilocularis allatostatin A receptor Angiotensin II type 2 (AT-2) receptor   363 aa 342 aa 24.6 %
Echinococcus granulosus allatostatin A receptor Angiotensin II type 2 (AT-2) receptor   363 aa 340 aa 24.1 %
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily Angiotensin II type 1a (AT-1a) receptor   359 aa 306 aa 21.9 %
Brugia malayi GnHR receptor homolog Angiotensin II type 1a (AT-1a) receptor   359 aa 364 aa 20.3 %
Loa Loa (eye worm) hypothetical protein Angiotensin II type 1a (AT-1a) receptor   359 aa 335 aa 23.0 %
Onchocerca volvulus E3 ubiquitin-protein ligase rpm-1 homolog Angiotensin II type 1a (AT-1a) receptor   359 aa 328 aa 20.7 %
Brugia malayi ORL1-like opioid receptor Angiotensin II type 1a (AT-1a) receptor   359 aa 333 aa 21.3 %
Echinococcus multilocularis thyrotropin releasing hormone receptor Angiotensin II type 2 (AT-2) receptor   363 aa 308 aa 21.8 %
Schistosoma japonicum Rhodopsin, putative Angiotensin II type 2 (AT-2) receptor   363 aa 341 aa 22.0 %
Onchocerca volvulus Angiotensin II type 1a (AT-1a) receptor   359 aa 341 aa 23.2 %
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Angiotensin II type 1a (AT-1a) receptor   359 aa 325 aa 20.9 %
Echinococcus granulosus pyroglutamylated rfamide peptide receptor angiotensin II receptor, type 1 359 aa 403 aa 19.1 %
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor Angiotensin II type 2 (AT-2) receptor   363 aa 398 aa 18.1 %
Loa Loa (eye worm) neuropeptide F receptor Angiotensin II type 2 (AT-2) receptor   363 aa 356 aa 23.3 %
Echinococcus granulosus neuropeptide receptor Angiotensin II type 2 (AT-2) receptor   363 aa 306 aa 22.2 %
Echinococcus granulosus pyroglutamylated rfamide peptide receptor Angiotensin II type 2 (AT-2) receptor   363 aa 398 aa 18.3 %
Onchocerca volvulus Angiotensin II type 1a (AT-1a) receptor   359 aa 296 aa 23.0 %
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor Angiotensin II type 1a (AT-1a) receptor   359 aa 346 aa 18.2 %
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor Angiotensin II type 1a (AT-1a) receptor   359 aa 364 aa 23.1 %
Echinococcus multilocularis neuropeptide receptor Angiotensin II type 2 (AT-2) receptor   363 aa 308 aa 21.4 %
Onchocerca volvulus Angiotensin II type 2 (AT-2) receptor   363 aa 305 aa 21.6 %
Brugia malayi putative neuropeptide receptor NPR1 Angiotensin II type 1a (AT-1a) receptor   359 aa 295 aa 27.1 %
Onchocerca volvulus Angiotensin II type 2 (AT-2) receptor   363 aa 306 aa 22.5 %
Echinococcus granulosus tm gpcr rhodopsin Angiotensin II type 1a (AT-1a) receptor   359 aa 306 aa 21.9 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Angiotensin II type 2 (AT-2) receptor   363 aa 310 aa 23.5 %
Onchocerca volvulus Angiotensin II type 1a (AT-1a) receptor   359 aa 313 aa 25.6 %
Echinococcus multilocularis G-protein coupled receptor, putative Angiotensin II type 1a (AT-1a) receptor   359 aa 307 aa 22.5 %
Echinococcus granulosus pyroglutamylated rfamide peptide receptor angiotensin II receptor, type 2 363 aa 398 aa 18.3 %
Schistosoma mansoni opsin-like receptor Angiotensin II type 1a (AT-1a) receptor   359 aa 299 aa 25.1 %
Onchocerca volvulus Angiotensin II type 2 (AT-2) receptor   363 aa 311 aa 23.8 %
Schistosoma mansoni adenoreceptor Angiotensin II type 2 (AT-2) receptor   363 aa 328 aa 22.0 %
Echinococcus granulosus thyrotropin releasing hormone receptor Angiotensin II type 2 (AT-2) receptor   363 aa 308 aa 22.1 %
Schistosoma mansoni peptide (allatostatin)-like receptor Angiotensin II type 2 (AT-2) receptor   363 aa 364 aa 20.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) neuropeptide F receptor 0.002 0.0119 0.0303
Brugia malayi Dopamine receptor protein 1 0.002 0.0119 0.0303
Echinococcus multilocularis neuropeptide Y receptor 0.002 0.0119 0.012
Echinococcus multilocularis allatostatin A receptor 0.002 0.0119 0.012
Mycobacterium tuberculosis Probable aminotransferase 0.0769 1 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0153 0.0075
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.002 0.0119 0.0303
Brugia malayi RNA recognition motif domain containing protein 0.0135 0.1643 0.4182
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.002 0.0119 0.0303
Echinococcus granulosus neuropeptide Y receptor 0.002 0.0119 0.0726
Treponema pallidum DNA ligase (lig) 0.0021 0.0132 0.5
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0066 0.0736 0.4477
Onchocerca volvulus 0.002 0.0119 0.0525
Schistosoma mansoni hypothetical protein 0.0144 0.1753 0.4462
Schistosoma mansoni amine GPCR 0.002 0.0119 0.0303
Brugia malayi Calcitonin receptor-like protein seb-1 0.021 0.263 0.6693
Trichomonas vaginalis CAMK family protein kinase 0.0089 0.1032 0.0912
Plasmodium falciparum ornithine aminotransferase 0.0109 0.1301 1
Schistosoma mansoni tar DNA-binding protein 0.0135 0.1643 0.4182
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0119 0.0303
Brugia malayi hypothetical protein 0.002 0.0119 0.0303
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0119 0.0726
Brugia malayi hypothetical protein 0.002 0.0119 0.0303
Onchocerca volvulus 0.002 0.0119 0.0525
Schistosoma mansoni biogenic amine receptor 0.002 0.0119 0.0303
Brugia malayi RE15519p 0.002 0.0119 0.0303
Brugia malayi G protein-coupled receptor F59B2.13 0.002 0.0119 0.0303
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0109 0.1301 0.1232
Echinococcus granulosus somatostatin receptor 0.002 0.0119 0.0726
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.002 0.0119 0.0303
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0066 0.0736 0.1872
Loa Loa (eye worm) hypothetical protein 0.021 0.263 0.6693
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0303
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.002 0.0119 0.0303
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0033 0.0297 0.1833
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0303
Brugia malayi hypothetical protein 0.0035 0.0319 0.0812
Plasmodium vivax replication factor C subunit 1, putative 0.0021 0.0132 0.0435
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0572 0.4034
Echinococcus multilocularis alpha 1A adrenergic receptor 0.002 0.0119 0.012
Echinococcus granulosus tm gpcr rhodopsin 0.002 0.0119 0.0726
Schistosoma mansoni glutaminase 0.0309 0.3929 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0119 0.012
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.002 0.0119 0.0726
Loa Loa (eye worm) nuclear hormone receptor 0.01 0.118 0.3002
Brugia malayi Dopamine receptor 0.002 0.0119 0.0303
Schistosoma mansoni biogenic amine (dopamine) receptor 0.002 0.0119 0.0303
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0119 0.0726
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0153 0.0075
Brugia malayi AKH receptor 0.002 0.0119 0.0303
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0769 1 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.002 0.0119 0.0303
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0066 0.0736 0.4477
Brugia malayi G-protein coupled receptor 0.002 0.0119 0.0303
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0303
Echinococcus granulosus GPCR family 2 0.0066 0.0736 0.4477
Giardia lamblia Kinase, PLK 0.0089 0.1032 1
Trichomonas vaginalis CAMK family protein kinase 0.0089 0.1032 0.0912
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0303
Schistosoma mansoni neuropeptide receptor 0.002 0.0119 0.0303
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0303
Schistosoma mansoni kinase 0.0045 0.0455 0.1158
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0022 0.0153 0.0075
Brugia malayi Pax transcription activation domain interacting protein 0.0021 0.0132 0.0336
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.002 0.0119 0.0303
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0135 0.1643 0.4182
Mycobacterium ulcerans L-lysine aminotransferase 0.0109 0.1301 0.1232
Schistosoma mansoni biogenic amine (5HT) receptor 0.002 0.0119 0.0303
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0303
Echinococcus granulosus thyrotropin releasing hormone receptor 0.002 0.0119 0.0726
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0119 0.0726
Schistosoma mansoni hypothetical protein 0.0066 0.0736 0.1872
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.002 0.0119 0.012
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0303
Echinococcus multilocularis fmrfamide receptor 0.002 0.0119 0.012
Brugia malayi Serotonin/octopamine receptor family protein 7 0.002 0.0119 0.0303
Schistosoma mansoni tar DNA-binding protein 0.0135 0.1643 0.4182
Echinococcus granulosus tachykinin peptides receptor 99D 0.002 0.0119 0.0726
Schistosoma mansoni opsin-like receptor 0.002 0.0119 0.0303
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0297 0.0299
Brugia malayi hypothetical protein 0.002 0.0119 0.0303
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.002 0.0119 0.012
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0033 0.0297 0.1807
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0109 0.1301 0.1232
Brugia malayi hypothetical protein 0.002 0.0119 0.0303
Entamoeba histolytica serine/threonine protein kinase, putative 0.0089 0.1032 1
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0153 0.039
Brugia malayi follicle stimulating hormone receptor 0.002 0.0119 0.0303
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0303
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0109 0.1301 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0106 0.1254 0.7632
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0119 0.0726
Trichomonas vaginalis glutaminase, putative 0.0309 0.3929 0.3848
Echinococcus multilocularis neuropeptide receptor 0.002 0.0119 0.012
Onchocerca volvulus 0.002 0.0119 0.0525
Echinococcus multilocularis neuropeptide receptor 0.002 0.0119 0.012
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0303
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0022 0.0153 0.0075
Onchocerca volvulus 0.002 0.0119 0.0525
Schistosoma mansoni biogenic amine receptor 0.002 0.0119 0.0303
Brugia malayi RNA binding protein 0.0135 0.1643 0.4182
Loa Loa (eye worm) glutaminase 0.0309 0.3929 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0079 0.0201
Echinococcus granulosus neuropeptides capa receptor 0.002 0.0119 0.0726
Brugia malayi latrophilin 2 splice variant baaae 0.0144 0.1753 0.4462
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0572 0.4889
Echinococcus granulosus tm gpcr rhodopsin 0.002 0.0119 0.0726
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0303
Echinococcus granulosus nibrin 0.0021 0.0132 0.0804
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0109 0.1301 0.1232
Brugia malayi sulfakinin receptor protein 0.002 0.0119 0.0303
Echinococcus granulosus ornithine aminotransferase 0.0109 0.1301 0.7916
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.002 0.0119 0.0303
Brugia malayi Dopamine receptor protein 2 0.002 0.0119 0.0303
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0303
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0022 0.0153 0.0022
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0303
Schistosoma mansoni DNA ligase IV 0.0021 0.0132 0.0336
Echinococcus multilocularis neuropeptide FF receptor 2 0.002 0.0119 0.012
Onchocerca volvulus Serine\/threonine kinase homolog 0.0089 0.1032 0.4541
Loa Loa (eye worm) RNA binding protein 0.0135 0.1643 0.4182
Schistosoma mansoni hypothetical protein 0.0066 0.0736 0.1872
Loa Loa (eye worm) TYRA-2 protein 0.002 0.0119 0.0303
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0763 0.9925 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0303
Onchocerca volvulus 0.002 0.0119 0.0525
Echinococcus granulosus G protein coupled receptor 139 0.002 0.0119 0.0726
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0109 0.1301 0.1242
Loa Loa (eye worm) pigment dispersing factor receptor c 0.021 0.263 0.6693
Loa Loa (eye worm) glutaminase 2 0.0309 0.3929 1
Echinococcus multilocularis neuropeptide s receptor 0.002 0.0119 0.012
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0153 0.0087
Loa Loa (eye worm) hypothetical protein 0.0066 0.0736 0.1872
Trichomonas vaginalis CAMK family protein kinase 0.0089 0.1032 0.0912
Onchocerca volvulus 0.002 0.0119 0.0525
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0021 0.0132 0.0336
Echinococcus multilocularis isocitrate dehydrogenase 0.0033 0.0297 0.0299
Echinococcus multilocularis g protein coupled receptor 0.002 0.0119 0.012
Loa Loa (eye worm) hypothetical protein 0.0144 0.1753 0.4462
Trichomonas vaginalis CAMK family protein kinase 0.0089 0.1032 0.0912
Echinococcus multilocularis ornithine aminotransferase 0.0109 0.1301 0.1311
Echinococcus granulosus tm gpcr rhodopsin 0.002 0.0119 0.0726
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0303
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0297 0.1833
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0033 0.0297 0.0232
Brugia malayi neuropeptide F receptor 0.002 0.0119 0.0303
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0303
Onchocerca volvulus 0.002 0.0119 0.0525
Brugia malayi Melatonin receptor type 1A 0.002 0.0119 0.0303
Schistosoma mansoni adenoreceptor 0.002 0.0119 0.0303
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.002 0.0119 0.0303
Echinococcus granulosus neuropeptide receptor A26 0.002 0.0119 0.0726
Echinococcus multilocularis g protein coupled receptor 0.002 0.0119 0.012
Brugia malayi Serotonin receptor 0.002 0.0119 0.0303
Echinococcus multilocularis serotonin receptor 0.002 0.0119 0.012
Trypanosoma cruzi polo-like protein kinase, putative 0.0089 0.1032 1
Schistosoma mansoni tar DNA-binding protein 0.0135 0.1643 0.4182
Onchocerca volvulus 0.002 0.0119 0.0525
Schistosoma mansoni amine GPCR 0.002 0.0119 0.0303
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0089 0.1032 0.2625
Onchocerca volvulus 0.002 0.0119 0.0525
Brugia malayi Serotonin receptor 0.002 0.0119 0.0303
Brugia malayi hypothetical protein 0.002 0.0119 0.0303
Brugia malayi topoisomerase 0.0021 0.0132 0.0336
Echinococcus multilocularis tachykinin peptides receptor 99D 0.002 0.0119 0.012
Brugia malayi DKFZp564C0469 protein 0.0021 0.0132 0.0336
Toxoplasma gondii ATPase, AAA family protein 0.0021 0.0132 0.000002953
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0109 0.1301 0.1232
Echinococcus granulosus replication factor c subunit 1 0.0021 0.0132 0.0804
Echinococcus multilocularis g protein coupled receptor 0.002 0.0119 0.012
Plasmodium vivax ornithine aminotransferase, putative 0.0109 0.1301 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.002 0.0119 0.0525
Brugia malayi hypothetical protein 0.002 0.0119 0.0303
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0572 0.4034
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0303
Schistosoma mansoni growth hormone secretagogue receptor 0.002 0.0119 0.0303
Schistosoma mansoni histamine h1 receptor 0.002 0.0119 0.0303
Loa Loa (eye worm) G-protein coupled receptor 0.002 0.0119 0.0303
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0183 0.2272 1
Brugia malayi TAR-binding protein 0.0135 0.1643 0.4182
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.002 0.0119 0.0303
Schistosoma mansoni opsin-like receptor 0.002 0.0119 0.0303
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0303
Schistosoma mansoni tar DNA-binding protein 0.0135 0.1643 0.4182
Schistosoma mansoni serine/threonine protein kinase 0.0089 0.1032 0.2625
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0303
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0066 0.0736 0.0741
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0303
Mycobacterium ulcerans hypothetical protein 0.0022 0.0153 0.0075
Onchocerca volvulus 0.002 0.0119 0.0525
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0303
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0119 0.0303
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.002 0.0119 0.012
Schistosoma mansoni opsin-like receptor 0.002 0.0119 0.0303
Loa Loa (eye worm) hypothetical protein 0.0183 0.2272 0.5782
Schistosoma mansoni hypothetical protein 0.0024 0.0179 0.0455
Echinococcus granulosus neuropeptide receptor 0.002 0.0119 0.0726
Brugia malayi gonadotropin-releasing hormone receptor 2 0.002 0.0119 0.0303
Echinococcus multilocularis orexin receptor type 2 0.002 0.0119 0.012
Echinococcus granulosus biogenic amine 5HT receptor 0.002 0.0119 0.0726
Brugia malayi hypothetical protein 0.002 0.0119 0.0303
Brugia malayi Steroid receptor seven-up type 2 0.0106 0.1254 0.3192
Echinococcus granulosus dro:myosuppressin receptor 0.002 0.0119 0.0726
Echinococcus multilocularis neuropeptide receptor A26 0.002 0.0119 0.012
Trichomonas vaginalis CAMK family protein kinase 0.0044 0.0439 0.0311
Schistosoma mansoni amine GPCR 0.002 0.0119 0.0303
Schistosoma mansoni biogenic amine (5HT) receptor 0.002 0.0119 0.0303
Schistosoma mansoni amine GPCR 0.002 0.0119 0.0303
Schistosoma mansoni neuropeptide f receptor 76f 0.002 0.0119 0.0303
Brugia malayi hypothetical protein 0.0021 0.0132 0.0336
Echinococcus multilocularis sex peptide receptor 0.002 0.0119 0.012
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0303
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0066 0.0736 0.0741
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0119 0.0303
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0119 0.012
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0303
Mycobacterium ulcerans glutaminase 0.0309 0.3929 0.3881
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0297 0.0299
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0119 0.0726
Schistosoma mansoni chromosome transmission fidelity factor 0.0021 0.0132 0.0336
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0303
Brugia malayi larval opioid receptor 0.002 0.0119 0.0303
Schistosoma mansoni topbp1 0.0021 0.0132 0.0336
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0022 0.0153 0.0075
Loa Loa (eye worm) hypothetical protein 0.0017 0.0079 0.0201
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.002 0.0119 0.0303
Trichomonas vaginalis CAMK family protein kinase 0.0044 0.0439 0.0311
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0079 0.0012
Schistosoma mansoni hypothetical protein 0.002 0.0119 0.0303
Loa Loa (eye worm) hypothetical protein 0.0054 0.0572 0.1455
Schistosoma mansoni hypothetical protein 0.0066 0.0736 0.1872
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0297 0.1411
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0303
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.002 0.0119 0.0303
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0021 0.0132 0.00000034971
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0022 0.0153 0.0075
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0119 0.0726
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0119 0.012
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0021 0.0132 0.00000034971
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0119 0.0303
Echinococcus multilocularis g-protein coupled receptor 0.002 0.0119 0.012
Loa Loa (eye worm) hypothetical protein 0.0021 0.0132 0.0336
Echinococcus granulosus peptide allatostatin:somatostatin 0.002 0.0119 0.0726
Brugia malayi G-protein coupled receptor 0.002 0.0119 0.0303
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0109 0.1301 0.1184
Onchocerca volvulus 0.002 0.0119 0.0525
Plasmodium vivax ataxin-2 like protein, putative 0.0054 0.0572 0.4034
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0303
Onchocerca volvulus 0.002 0.0119 0.0525
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0109 0.1301 0.331
Echinococcus granulosus neuropeptides capa receptor 0.002 0.0119 0.0726
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0089 0.1032 0.1039
Entamoeba histolytica acyl-coA synthetase, putative 0.0022 0.0153 0.0236
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0303
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0303
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0119 0.012
Brugia malayi hypothetical protein 0.002 0.0119 0.0303
Mycobacterium ulcerans hypothetical protein 0.0769 1 1
Brugia malayi G protein-coupled receptor 0.002 0.0119 0.0303
Echinococcus multilocularis replication factor c subunit 1 0.0021 0.0132 0.0133
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.002 0.0119 0.0303
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0769 1 1
Leishmania major hypothetical protein, conserved 0.0054 0.0572 0.4766
Echinococcus granulosus Aminotransferase class III 0.0109 0.1301 0.7916
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0303
Trichomonas vaginalis CAMK family protein kinase 0.0089 0.1032 0.0912
Echinococcus multilocularis dro:myosuppressin receptor 0.002 0.0119 0.012
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0303
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0109 0.1301 0.1184
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0109 0.1301 1
Echinococcus granulosus orexin receptor type 2 0.002 0.0119 0.0726
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0179 0.018
Plasmodium falciparum replication factor C subunit 1, putative 0.0021 0.0132 0.0435
Loa Loa (eye worm) hypothetical protein 0.0021 0.0132 0.0336
Entamoeba histolytica acyl-CoA synthetase, putative 0.0022 0.0153 0.0236
Schistosoma mansoni biogenic amine (dopamine) receptor 0.002 0.0119 0.0303
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0303
Loa Loa (eye worm) melatonin receptor type 1A 0.002 0.0119 0.0303
Brugia malayi hypothetical protein 0.002 0.0119 0.0303
Brugia malayi hypothetical protein 0.0021 0.0132 0.0336
Echinococcus granulosus rhodopsin orphan GPCR 0.002 0.0119 0.0726
Toxoplasma gondii LsmAD domain-containing protein 0.0054 0.0572 0.3763
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.002 0.0119 0.0726
Brugia malayi serine/threonine-protein kinase plk-2 0.0089 0.1032 0.2625
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.002 0.0119 0.0726
Echinococcus granulosus neuropeptide FF receptor 2 0.002 0.0119 0.0726
Loa Loa (eye worm) hypothetical protein 0.0017 0.0079 0.0201
Onchocerca volvulus 0.002 0.0119 0.0525
Echinococcus granulosus fmrfamide receptor 0.002 0.0119 0.0726
Schistosoma mansoni neuropeptide receptor 0.002 0.0119 0.0303
Echinococcus granulosus g protein coupled receptor 0.002 0.0119 0.0726
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0089 0.1032 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0303
Echinococcus granulosus neuropeptide s receptor 0.002 0.0119 0.0726
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0089 0.1032 0.6278
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0119 0.0303
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0769 1 1
Loa Loa (eye worm) TAR-binding protein 0.0135 0.1643 0.4182
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.002 0.0119 0.012
Loa Loa (eye worm) hypothetical protein 0.0017 0.0079 0.0201
Loa Loa (eye worm) hypothetical protein 0.0021 0.0132 0.0336
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0119 0.0303
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.002 0.0119 0.0726
Schistosoma mansoni myosin xvIII 0.002 0.0119 0.0303
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0303
Onchocerca volvulus Neuropeptide F receptor homolog 0.002 0.0119 0.0525
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0303
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0109 0.1301 1
Echinococcus multilocularis neuropeptide Y receptor 0.002 0.0119 0.012
Brugia malayi putative neuropeptide receptor 0.002 0.0119 0.0303
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0153 0.039
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0572 0.4889
Chlamydia trachomatis DNA ligase 0.0021 0.0132 0.0435
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0303
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.002 0.0119 0.012
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0119 0.0303
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.002 0.0119 0.0303
Echinococcus multilocularis biogenic amine (5HT) receptor 0.002 0.0119 0.012
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0303
Schistosoma mansoni hypothetical protein 0.002 0.0119 0.0303
Loa Loa (eye worm) hypothetical protein 0.0021 0.0132 0.0336
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0119 0.012
Echinococcus multilocularis G protein coupled receptor 139 0.002 0.0119 0.012
Brugia malayi glutaminase DH11.1 0.0309 0.3929 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0033 0.0297 0.0756
Schistosoma mansoni hypothetical protein 0.002 0.0119 0.0303
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0297 0.1411
Loa Loa (eye worm) hypothetical protein 0.0021 0.0132 0.0336
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.002 0.0119 0.0303
Loa Loa (eye worm) hypothetical protein 0.0022 0.0153 0.039
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0033 0.0297 0.1833
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0033 0.0297 0.1784
Echinococcus multilocularis somatostatin receptor 0.002 0.0119 0.012
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.002 0.0119 0.012
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0179 0.1088
Echinococcus granulosus hypothetical protein 0.002 0.0119 0.0726
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0119 0.0303
Loa Loa (eye worm) hypothetical protein 0.0022 0.0153 0.039
Echinococcus granulosus neuropeptide Y receptor 0.002 0.0119 0.0726
Schistosoma mansoni topbp1 0.0021 0.0132 0.0336
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.002 0.0119 0.012
Loa Loa (eye worm) hypothetical protein 0.0017 0.0079 0.0201
Trypanosoma brucei PAB1-binding protein , putative 0.0054 0.0572 0.4889
Echinococcus multilocularis nibrin 0.0021 0.0132 0.0133
Echinococcus multilocularis Aminotransferase class III 0.0109 0.1301 0.1311
Onchocerca volvulus 0.0021 0.0132 0.0581
Echinococcus multilocularis fmrfamide receptor 0.002 0.0119 0.012
Echinococcus multilocularis G-protein coupled receptor, putative 0.002 0.0119 0.012
Echinococcus granulosus serotonin receptor 0.002 0.0119 0.0726
Trichomonas vaginalis CAMK family protein kinase 0.0089 0.1032 0.0912
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0153 0.039
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0303
Loa Loa (eye worm) hypothetical protein 0.0021 0.0132 0.0336
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0303
Echinococcus multilocularis ornithine aminotransferase 0.0109 0.1301 0.1311
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0021 0.0132 0.0054
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0033 0.0297 0.0299
Schistosoma mansoni hypothetical protein 0.002 0.0119 0.0303
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0021 0.0132 0.0000038366
Echinococcus granulosus 7TM GPCR rhodopsin 0.002 0.0119 0.0726
Schistosoma mansoni alpha-1 adrenergic receptor 0.002 0.0119 0.0303
Brugia malayi ORL1-like opioid receptor 0.002 0.0119 0.0303
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0303
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0033 0.0297 0.1784
Loa Loa (eye worm) neuropeptide F receptor 0.002 0.0119 0.0303
Brugia malayi GnHR receptor homolog 0.002 0.0119 0.0303
Echinococcus granulosus g-protein coupled receptor 0.002 0.0119 0.0726
Brugia malayi Tachykinin-like peptides receptor 99D 0.002 0.0119 0.0303
Echinococcus granulosus alpha 1A adrenergic receptor 0.002 0.0119 0.0726
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0109 0.1301 0.331
Brugia malayi isocitrate dehydrogenase 0.0033 0.0297 0.0756
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0153 0.0075
Onchocerca volvulus 0.002 0.0119 0.0525
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0303
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0303
Echinococcus granulosus 7tm_1 domain containing protein 0.002 0.0119 0.0726
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0119 0.012
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0106 0.1254 0.1263
Echinococcus granulosus tar DNA binding protein 0.0135 0.1643 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0303
Echinococcus granulosus g protein coupled receptor 0.002 0.0119 0.0726
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.002 0.0119 0.012
Brugia malayi putative neuropeptide receptor NPR1 0.002 0.0119 0.0303
Loa Loa (eye worm) isocitrate dehydrogenase 0.0033 0.0297 0.0756
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0297 0.0299
Loa Loa (eye worm) hypothetical protein 0.0101 0.1187 0.3022
Brugia malayi N-terminal motif family protein 0.0183 0.2272 0.5782
Brugia malayi neuropeptide F receptor 0.002 0.0119 0.0303
Trypanosoma brucei polo-like protein kinase 0.0089 0.1032 1
Schistosoma mansoni amine GPCR 0.002 0.0119 0.0303
Trichomonas vaginalis replication factor C large subunit, putative 0.0021 0.0132 0.00000034971
Echinococcus multilocularis neuropeptides capa receptor 0.002 0.0119 0.012
Brugia malayi Latrophilin receptor protein 2 0.0066 0.0736 0.1872
Entamoeba histolytica acyl-CoA synthetase, putative 0.0022 0.0153 0.0236
Brugia malayi Isocitrate dehydrogenase 0.0033 0.0297 0.0756
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0303
Echinococcus multilocularis GPCR, family 2 0.0066 0.0736 0.0741
Schistosoma mansoni neuropeptide receptor 0.002 0.0119 0.0303
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.002 0.0119 0.0726
Schistosoma mansoni hypothetical protein 0.0066 0.0736 0.1872
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0119 0.012
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0297 0.1833
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0303
Brugia malayi hypothetical protein 0.002 0.0119 0.0303
Schistosoma mansoni neuropeptide receptor 0.002 0.0119 0.0303
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0109 0.1301 0.1242
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0303
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0109 0.1301 0.1242
Schistosoma mansoni neuropeptide F-like receptor 0.002 0.0119 0.0303
Echinococcus multilocularis neuropeptides capa receptor 0.002 0.0119 0.012
Onchocerca volvulus 0.002 0.0119 0.0525
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0109 0.1301 0.1184
Trichomonas vaginalis CAMK family protein kinase 0.0089 0.1032 0.0912
Echinococcus granulosus sex peptide receptor 0.002 0.0119 0.0726
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.002 0.0119 0.012
Echinococcus multilocularis tar DNA binding protein 0.0135 0.1643 0.1656
Loa Loa (eye worm) G-protein coupled receptor 0.002 0.0119 0.0303
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.021 0.263 0.6693
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.002 0.0119 0.0303
Schistosoma mansoni peptide (allatostatin)-like receptor 0.002 0.0119 0.0303
Brugia malayi hypothetical protein 0.0054 0.0572 0.1455
Onchocerca volvulus 0.002 0.0119 0.0525
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0022 0.0153 0.0087
Echinococcus multilocularis rhodopsin orphan GPCR 0.002 0.0119 0.012
Echinococcus granulosus g protein coupled receptor 0.002 0.0119 0.0726
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0109 0.1301 0.1242
Echinococcus granulosus neuropeptide receptor 0.002 0.0119 0.0726
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0297 0.1635
Schistosoma mansoni tar DNA-binding protein 0.0135 0.1643 0.4182
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0022 0.0153 0.0022
Trypanosoma cruzi polo-like protein kinase, putative 0.0089 0.1032 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.002 0.0119 0.0303
Mycobacterium ulcerans acetylornithine aminotransferase 0.0109 0.1301 0.1232
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.002 0.0119 0.012
Schistosoma mansoni biogenic amine receptor 0.002 0.0119 0.0303
Onchocerca volvulus 0.002 0.0119 0.0525
Schistosoma mansoni rhodopsin-like orphan GPCR 0.002 0.0119 0.0303
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.002 0.0119 0.012
Loa Loa (eye worm) latrophilin receptor protein 2 0.0066 0.0736 0.1872
Loa Loa (eye worm) hypothetical protein 0.002 0.0119 0.0303
Loa Loa (eye worm) hypothetical protein 0.0022 0.0153 0.039
Echinococcus granulosus biogenic amine 5HT receptor 0.002 0.0119 0.0726
Onchocerca volvulus 0.0022 0.0153 0.0675
Echinococcus granulosus allatostatin A receptor 0.002 0.0119 0.0726
Echinococcus multilocularis serotonin receptor 0.002 0.0119 0.012
Schistosoma mansoni neuropeptide F-like receptor 0.002 0.0119 0.0303
Loa Loa (eye worm) follicle stimulating hormone receptor 0.002 0.0119 0.0303
Schistosoma mansoni biogenic amine (dopamine) receptor 0.002 0.0119 0.0303

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.1 nM In vitro ability of the compound to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain ChEMBL. No reference
IC50 (binding) = 0.1 nM In vitro ability of the compound to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT2 receptor from rat midbrain ChEMBL. No reference
IC50 (binding) = 1.4 nM In vitro ability of the compound to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta ChEMBL. No reference
IC50 (binding) = 1.4 nM In vitro ability of the compound to inhibit the binding of radioligand 125I[Sar1,IIe8]AII to AT1 receptor from rabbit aorta ChEMBL. No reference
IC50 (binding) = 2.6 nM In vitro inhibitory concentration of the compound against AT2 receptor from human adrenal tissues. ChEMBL. No reference
IC50 (binding) = 2.6 nM In vitro inhibitory concentration of the compound against AT2 receptor from human adrenal tissues. ChEMBL. No reference
IC50 (binding) = 15 nM In vitro inhibitory concentration of the compound against AT1 receptor from human adrenal tissues. ChEMBL. No reference
IC50 (binding) = 15 nM In vitro inhibitory concentration of the compound against AT1 receptor from human adrenal tissues. ChEMBL. No reference
Ratio (binding) = 0.07 AT2/AT1 receptor IC50 ratio of the compound ChEMBL. No reference
Ratio (binding) = 0.2 AT2/AT1 receptor IC50 ratio of the compound ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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