Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.5122 | 0.5122 |
Brugia malayi | MH2 domain containing protein | 0.001 | 0.0316 | 0.0316 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.359 | 0.6812 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5122 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.359 | 0.6812 |
Brugia malayi | MH1 domain containing protein | 0.001 | 0.0316 | 0.0316 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5122 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.5122 | 1 |
Loa Loa (eye worm) | Smad1 | 0.001 | 0.0316 | 0.0316 |
Brugia malayi | RNA binding protein | 0.0076 | 0.5122 | 0.5122 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.001 | 0.0316 | 0.0316 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.5122 | 0.5122 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.359 | 0.359 |
Brugia malayi | Smad1 | 0.001 | 0.0316 | 0.0316 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5122 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.5122 | 0.5122 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.359 | 0.6812 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5122 | 1 |
Brugia malayi | MH2 domain containing protein | 0.001 | 0.0316 | 0.0316 |
Brugia malayi | MH1 domain containing protein | 0.001 | 0.0316 | 0.0316 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.5122 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.359 | 0.6812 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.5122 | 0.5122 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5122 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.001 | 0.0316 | 0.0316 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.5122 | 0.5122 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.359 | 0.359 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.359 | 0.6812 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.359 | 0.6812 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.359 | 0.6812 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.7079 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PubChem BioAssay. qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.