TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 448.556 | Formula: C30H28N2O2
H donors: 0 H acceptors: 1 LogP: 6.26 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)[C@@H]1[C@@H](C)N(c2ccccc2)c2c(C(=O)N1Cc1ccccc1)cccc2
InChi: 1S/C30H28N2O2/c1-22-29(24-17-19-26(34-2)20-18-24)31(21-23-11-5-3-6-12-23)30(33)27-15-9-10-16-28(27)32(22)25-13-7-4-8-14-25/h3-20,22,29H,21H2,1-2H3/t22-,29+/m1/s1
InChiKey: OAGQVGNMZNGNID-MNNSJKJDSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	cathepsin l1	0.0029	0.0272	0.042
Brugia malayi	Nuclear hormone receptor-like 1	0.0005	0.0009	0.001
Schistosoma mansoni	cathepsin s	0.0008	0.0033	0.0051
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0005	0.0003	0.0005
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0029	0.0272	0.1164
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0022	0.0188	0.0294
Brugia malayi	Cathepsin L-like precursor	0.0029	0.0272	0.042
Brugia malayi	Cathepsin L-like precursor	0.0029	0.0272	0.042
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0009	0.001
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0008	0.0033	0.0046
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0063	0.0094
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0061	0.0623	0.2257
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.0063	0.0099
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0029	0.0272	0.1164
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0005	0.0009	0.001
Loa Loa (eye worm)	hypothetical protein	0.001	0.0063	0.0094
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0022	0.0188	0.6499
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0029	0.0272	0.1164
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0581	0.6419	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.0619	0.096
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0019	0.0161	0.0158
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0063	0.0061
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0029	0.0272	1
Schistosoma mansoni	cpg binding protein	0.0034	0.0325	0.0507
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0029	0.0272	0.1164
Echinococcus multilocularis	cysteine protease	0.0029	0.0272	0.0269
Trypanosoma cruzi	cysteine peptidase, putative	0.0029	0.0272	0.0375
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0009	0.001
Giardia lamblia	Cathepsin B precursor	0.0195	0.2115	1
Echinococcus granulosus	cathepsin L cysteine protease	0.0029	0.0272	0.042
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0029	0.0272	0.0269
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0022	0.0188	0.0294
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0029	0.0272	0.0375
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0188	0.0762
Schistosoma mansoni	coup transcription factor	0.001	0.0063	0.0099
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0188	0.0762
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0188	0.0289
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0188	0.0289
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0063	0.0094
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.0063	0.0094
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0029	0.0272	0.1164
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0022	0.0188	0.0762
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0063	0.0094
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0188	0.0762
Brugia malayi	Cathepsin L-like precursor	0.0029	0.0272	0.042
Schistosoma mansoni	cathepsin C	0.0022	0.0188	0.0294
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0005	0.0009	0.0015
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0019	0.0161	0.0246
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0063	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0188	0.0289
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.0063	0.0094
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.0063	0.0099
Echinococcus multilocularis	GPCR, family 2	0.0019	0.0161	0.0158
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.001	0.0063	0.2004
Schistosoma mansoni	cpg binding protein	0.0032	0.0305	0.0475
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0063	0.0099
Brugia malayi	nuclear hormone receptor	0.001	0.0063	0.0094
Onchocerca volvulus	Protein ultraspiracle homolog	0.001	0.0063	0.2004
Plasmodium vivax	serine-repeat antigen (SERA)	0.0022	0.0188	0.6499
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0029	0.0272	0.0269
Entamoeba histolytica	cysteine protease, putative	0.0029	0.0272	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0022	0.0188	0.0294
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.0063	0.0099
Onchocerca volvulus		0.0029	0.0272	0.892
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0063	0.0094
Schistosoma mansoni	cpg binding protein	0.0034	0.0325	0.0507
Trypanosoma cruzi	cysteine peptidase, putative	0.0029	0.0272	0.0375
Brugia malayi	Papain family cysteine protease containing protein	0.0029	0.0272	0.042
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.0063	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0033	0.0046
Entamoeba histolytica	cysteine proteinase, putative	0.0029	0.0272	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0581	0.6419	1
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0009	0.001
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0005	0.0009	0.001
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0033	0.0046
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0063	0.0099
Schistosoma mansoni	hypothetical protein	0.0019	0.0161	0.0251
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0055	0.0564	0.0874
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0022	0.0188	0.0762
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0059	0.0087
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0022	0.0188	0.6499
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0029	0.0272	0.1164
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0005	0.0009	0.0015
Loa Loa (eye worm)	hypothetical protein	0.001	0.0063	0.0094
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0063	0.0094
Schistosoma mansoni	cathepsin F (C01 family)	0.0029	0.0272	0.0424
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0564	0.0879
Entamoeba histolytica	cysteine protease, putative	0.0029	0.0272	1
Schistosoma mansoni	hypothetical protein	0.0019	0.0161	0.0251
Brugia malayi	Nuclear hormone receptor-like 1	0.0005	0.0009	0.001
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.0188	0.0762
Schistosoma mansoni	nuclear receptor	0.0005	0.0003	0.0005
Onchocerca volvulus	Cathepsin L homolog	0.0022	0.0188	0.6143
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0022	0.0188	0.0289
Brugia malayi	cathepsin L-like cysteine proteinase	0.0022	0.0188	0.0289
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0063	0.0094
Loa Loa (eye worm)	fibroinase	0.0029	0.0272	0.042
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0195	0.2115	0.3296
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0188	0.0762
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0029	0.0272	0.1164
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.0063	0.0099
Brugia malayi	Cathepsin L-like precursor	0.0008	0.0033	0.0046
Brugia malayi	Cathepsin L-like precursor	0.0022	0.0188	0.0289
Onchocerca volvulus	Cathepsin F homolog	0.0029	0.0272	0.892
Plasmodium vivax	vivapain-3	0.0029	0.0272	1
Entamoeba histolytica	cysteine protease, putative	0.0029	0.0272	1
Schistosoma mansoni	zinc finger protein	0.0005	0.0003	0.0005
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0008	0.0037	0.0034
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0564	0.0561
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0019	0.0161	0.0246
Brugia malayi	hypothetical protein	0.0005	0.0009	0.001
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0063	0.0094
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0022	0.0188	0.0294
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0009	0.001
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0063	0.0094
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0022	0.0188	0.0294
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.0619	0.096
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0029	0.0272	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0029	0.0272	0.1164
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0022	0.0188	0.0762
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.0063	0.0094
Schistosoma mansoni	nuclear receptor nhr-48	0.0005	0.0003	0.0005
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0407	0.063
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0063	0.0094
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0022	0.0188	0.0762
Echinococcus multilocularis	cathepsin L cysteine protease	0.0029	0.0272	0.0269
Loa Loa (eye worm)	hypothetical protein	0.001	0.0063	0.0094
Entamoeba histolytica	cysteine protease, putative	0.0029	0.0272	1
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0019	0.0161	0.0246
Entamoeba histolytica	cysteine protease, putative	0.0029	0.0272	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0029	0.0272	0.1164
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0063	0.0094
Onchocerca volvulus	Cathepsin L homolog	0.0029	0.0272	0.892
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0063	0.0094
Entamoeba histolytica	cysteine protease, putative	0.0029	0.0272	1
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0063	0.0061
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.0063	0.0094
Onchocerca volvulus		0.0032	0.0305	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0188	0.0762
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0029	0.0272	0.1164
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0188	0.0289
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0407	0.063
Plasmodium vivax	unspecified product	0.0029	0.0272	1
Brugia malayi	CXXC zinc finger family protein	0.0032	0.0305	0.0471
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0063	0.0061
Loa Loa (eye worm)	hypothetical protein	0.006	0.0619	0.096
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0063	0.0094
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0188	0.0762
Echinococcus multilocularis	cathepsin L cysteine protease	0.0029	0.0272	0.0269
Onchocerca volvulus	Cathepsin L homolog	0.0029	0.0272	0.892
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0195	0.2115	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.0063	0.0099
Brugia malayi	Latrophilin receptor protein 2	0.0019	0.0161	0.0246
Echinococcus granulosus	cathepsin b	0.0581	0.6419	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0029	0.0272	0.0375
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0063	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0581	0.6419	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0022	0.0188	0.0244
Brugia malayi	ecdysteroid receptor	0.001	0.0063	0.0094
Plasmodium vivax	vivapain-2	0.0029	0.0272	1
Onchocerca volvulus		0.0022	0.0188	0.6143
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.0619	0.096
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0022	0.0188	0.6499
Giardia lamblia	Cathepsin B precursor	0.0195	0.2115	1
Brugia malayi	nuclear receptor RXR	0.0005	0.0009	0.001
Brugia malayi	Cathepsin L-like precursor	0.0029	0.0272	0.042
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0022	0.0188	0.6499
Entamoeba histolytica	cysteine proteinase, putative	0.0029	0.0272	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0022	0.0188	0.0762
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0008	0.0037	0.0058
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0029	0.0272	0.1164
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0029	0.0272	0.1164
Loa Loa (eye worm)	hypothetical protein	0.001	0.0063	0.0094
Echinococcus granulosus	cathepsin l1	0.0022	0.0188	0.0289
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0029	0.0272	0.1164
Brugia malayi	cathepsin F-like cysteine proteinase	0.0022	0.0188	0.0289
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0029	0.0272	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	0.0564	0.0874
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0063	0.0061
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0564	0.0874
Echinococcus multilocularis	cathepsin b	0.0581	0.6419	0.6418
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0063	0.0061
Loa Loa (eye worm)	cathepsin B	0.0195	0.2115	0.3292
Plasmodium vivax	vivapain-2	0.0029	0.0272	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0029	0.0272	0.0375
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0029	0.0272	0.1164
Brugia malayi	Papain family cysteine protease containing protein	0.0022	0.0188	0.0289
Echinococcus multilocularis	cysteine protease	0.0029	0.0272	0.0269
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0059	0.0056
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0029	0.0272	0.0424
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0019	0.0161	0.0246
Onchocerca volvulus		0.0029	0.0272	0.892
Onchocerca volvulus	Bile acid receptor homolog	0.001	0.0063	0.2004
Trypanosoma cruzi	cysteine peptidase, putative	0.0029	0.0272	0.0375
Entamoeba histolytica	cysteine protease, putative	0.0029	0.0272	1
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0022	0.0188	0.6499
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0063	0.0061
Entamoeba histolytica	cysteine proteinase, putative	0.0029	0.0272	1
Brugia malayi	cathepsin L-like precursor	0.0022	0.0188	0.0289
Schistosoma mansoni	cathepsin B (C01 family)	0.0022	0.0188	0.0294
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0022	0.0188	0.0762
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0063	0.0094
Onchocerca volvulus		0.0029	0.0272	0.892
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.0063	0.0099
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0022	0.0188	0.0289
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0022	0.0188	0.0762
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0029	0.0272	0.1164
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0195	0.2115	1
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0195	0.2115	1
Entamoeba histolytica	cysteine protease, putative	0.0029	0.0272	1
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0022	0.0188	0.6499
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0063	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0188	0.0289
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0029	0.0272	0.1164
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.0058	0.0085
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0063	0.0094
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0029	0.0272	0.1164
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0063	0.0061
Echinococcus multilocularis	cathepsin b	0.0581	0.6419	0.6418
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0005	0.0003	0.0005
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0029	0.0272	0.042
Onchocerca volvulus		0.0029	0.0272	0.892
Loa Loa (eye worm)	hypothetical protein	0.001	0.0063	0.0094
Toxoplasma gondii	cathepsin CPL	0.0029	0.0272	0.0435
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.0564	0.0561
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0022	0.0188	0.6499
Loa Loa (eye worm)	histone methyltransferase	0.001	0.0059	0.0087
Entamoeba histolytica	cysteine proteinase, putative	0.0029	0.0272	1
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0008	0.0037	0.0034
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0029	0.0272	0.042
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0019	0.0161	0.0158
Entamoeba histolytica	cysteine protease, putative	0.0029	0.0272	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0188	0.0762
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0029	0.0272	0.1164
Brugia malayi	Cathepsin L-like precursor	0.0029	0.0272	0.042
Brugia malayi	Papain family cysteine protease containing protein	0.0022	0.0188	0.0289
Schistosoma mansoni	hypothetical protein	0.0019	0.0161	0.0251
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0029	0.0272	0.1164
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0063	0.0099
Toxoplasma gondii	cathepsin B	0.0195	0.2115	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0022	0.0188	0.0289
Echinococcus granulosus	cathepsin L	0.0022	0.0188	0.0289
Echinococcus multilocularis	cathepsin L	0.0022	0.0188	0.0186
Brugia malayi	cathepsin F-like cysteine proteinase	0.0008	0.0033	0.0046
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0029	0.0272	0.1164
Brugia malayi	Papain family cysteine protease containing protein	0.0022	0.0188	0.0289
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0581	0.6419	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0188	0.0289
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0022	0.0188	0.0244
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0022	0.0188	0.0289
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0063	0.0094
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0022	0.0188	0.0762
Brugia malayi	fibroinase precursor	0.0022	0.0188	0.0289
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.0063	0.0099
Trypanosoma cruzi	cysteine peptidase, putative	0.0029	0.0272	0.0375
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0581	0.6419	1
Echinococcus granulosus	cysteine protease	0.0029	0.0272	0.042
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.0063	0.0094
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0029	0.0272	0.042
Loa Loa (eye worm)	hypothetical protein	0.001	0.0063	0.0094
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.0063	0.0099
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0029	0.0272	0.1164
Trypanosoma cruzi	cysteine protease, putative	0.0029	0.0272	0.0375
Plasmodium vivax	vivapain-1	0.0029	0.0272	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0188	0.0289
Plasmodium vivax	unspecified product	0.0022	0.0188	0.6499
Brugia malayi	cathepsin B-like cysteine proteinase	0.0581	0.6419	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0022	0.0188	0.0244
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0063	0.0094
Loa Loa (eye worm)	ctsf protein	0.0029	0.0272	0.042
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0063	0.0094
Schistosoma mansoni	hypothetical protein	0.0019	0.0161	0.0251
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0272	0.042
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0029	0.0272	0.1164
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0068	0.0704	0.1097
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0063	0.0094
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0022	0.0188	0.6499
Loa Loa (eye worm)	hypothetical protein	0.0005	0.0009	0.001
Echinococcus granulosus	cpg binding protein	0.0034	0.0325	0.0502
Echinococcus multilocularis	cathepsin L	0.0029	0.0272	0.0269
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0022	0.0188	0.0294
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0188	0.0762
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0029	0.0272	1
Onchocerca volvulus		0.0029	0.0272	0.892
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.0063	0.0094
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0029	0.0272	0.1164
Giardia lamblia	Cathepsin B precursor	0.0195	0.2115	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0564	0.0879
Onchocerca volvulus		0.0029	0.0272	0.892
Schistosoma mansoni	cathepsin F (C01 family)	0.0029	0.0272	0.0424
Schistosoma mansoni	nuclear hormone receptor	0.0005	0.0003	0.0005
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0008	0.0037	0.0054
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0029	0.0272	0.1164
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0188	0.0762
Onchocerca volvulus		0.0022	0.0188	0.6143
Schistosoma mansoni	cathepsin S (C01 family)	0.0022	0.0188	0.0294
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0022	0.0188	0.6499
Brugia malayi	steroid hormone receptor	0.001	0.0063	0.0094
Echinococcus multilocularis	cpg binding protein	0.0034	0.0325	0.0322
Loa Loa (eye worm)	hypothetical protein	0.001	0.0063	0.0094
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0188	0.0289
Schistosoma mansoni	hypothetical protein	0.0041	0.0407	0.0634
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0029	0.0272	0.0424
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0022	0.0188	0.6499
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0029	0.0272	0.0424
Schistosoma mansoni	cathepsin F (C01 family)	0.0022	0.0188	0.0294
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0029	0.0272	0.1164
Onchocerca volvulus		0.001	0.0063	0.2004
Entamoeba histolytica	cysteine protease, putative	0.0029	0.0272	1
Entamoeba histolytica	cysteine protease, putative	0.0029	0.0272	1
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0032	0.0305	0.0471
Echinococcus granulosus	cathepsin L	0.0029	0.0272	0.042
Entamoeba histolytica	cysteine protease, putative	0.0029	0.0272	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0029	0.0272	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0022	0.0188	0.0289
Brugia malayi	hypothetical protein	0.0005	0.0009	0.001
Brugia malayi	Cathepsin L-like precursor	0.0022	0.0188	0.0289
Entamoeba histolytica	cysteine proteinase, putative	0.0029	0.0272	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0063	0.0061
Brugia malayi	Cathepsin L-like precursor	0.0029	0.0272	0.042
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0029	0.0272	0.1164
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0005	0.0009	0.0006
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0022	0.0188	0.0294
Plasmodium vivax	serine-repeat antigen (SERA)	0.0022	0.0188	0.6499
Schistosoma mansoni	nuclear receptor	0.0005	0.0003	0.0005
Loa Loa (eye worm)	hypothetical protein	0.001	0.0063	0.0094
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	0.0564	0.0874
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.0188	0.0762
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.0063	0.0094
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0063	0.0094
Schistosoma mansoni	nuclear hormone receptor	0.0005	0.0003	0.0005
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0063	0.0099
Entamoeba histolytica	cysteine proteinase 2	0.0029	0.0272	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0161	0.0246
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	0.0564	0.0879
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0063	0.0094
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0022	0.0188	0.0294
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0008	0.0033	0.0046
Entamoeba histolytica	cysteine protease, putative	0.0029	0.0272	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0029	0.0272	0.1164
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0022	0.0188	0.0294
Trypanosoma cruzi	cysteine peptidase, putative	0.0029	0.0272	0.0375
Brugia malayi	Papain family cysteine protease containing protein	0.0029	0.0272	0.042
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0022	0.0188	0.0289
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0195	0.2115	0.3261
Onchocerca volvulus		0.0029	0.0272	0.892
Trypanosoma cruzi	cysteine proteinase, putative	0.0029	0.0272	0.0375
Loa Loa (eye worm)	cysteine protease	0.0029	0.0272	0.042
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.0063	0.0061
Echinococcus granulosus	GPCR family 2	0.0019	0.0161	0.0246
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0063	0.0094
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0022	0.0188	0.0762
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0029	0.0272	0.042
Loa Loa (eye worm)	hypothetical protein	0.0008	0.0033	0.0046
Brugia malayi	Papain family cysteine protease containing protein	0.0029	0.0272	0.042
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.0063	0.0094
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0022	0.0188	0.0289
Echinococcus granulosus	cathepsin b	0.0581	0.6419	1
Entamoeba histolytica	cysteine protease, putative	0.0029	0.0272	1
Entamoeba histolytica	cysteine proteinase, putative	0.0029	0.0272	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0581	0.6419	1
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0008	0.0037	0.0054
Brugia malayi	nuclear receptor NHR-88	0.001	0.0063	0.0094
Brugia malayi	cathepsin L precursor	0.0022	0.0188	0.0289
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0022	0.0188	0.0762
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0188	0.0289

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.8913 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	7.9433 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	20.5962 uM	PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	22.3872 uM	PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	28.1838 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1900827

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1551863