TDR Targets

Basic information

Technical information

TDR Targets ID: 1551867
Name: 2-(3,5-dimethyl-1H-pyrazol-4-yl)ethanamine hy drochloride
MW: 175.659 | Formula: C7H14ClN3
H donors: 2 H acceptors: 1 LogP: 1.14 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: NCCc1c(C)n[nH]c1C.Cl
InChi: 1S/C7H13N3.ClH/c1-5-7(3-4-8)6(2)10-9-5;/h3-4,8H2,1-2H3,(H,9,10);1H
InChiKey: QLKMMTQYHWZUKR-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

2-(3,5-dimethyl-1H-pyrazol-4-yl)ethylamine hydrochloride
2-(3,5-Dimethyl-1H-pyrazol-4-yl)-ethylamine
MLS000026997
SMR000012682

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	cpg binding protein	0.0031	0.0338	0.1025
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0062	0.0717	0.2187
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0008	0.0062	0.5
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0008	0.0062	0.0011
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0062	0.0586
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0043	0.0411
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0271	0.3261	1
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0043	0.0411
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0008	0.0062	0.0586
Plasmodium vivax	vivapain-2	0.0008	0.0062	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0062	0.0586
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0008	0.0062	0.0189
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0008	0.0062	1
Echinococcus granulosus	cathepsin b	0.0271	0.3261	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0008	0.0062	0.0189
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0062	0.0586
Echinococcus granulosus	cathepsin b	0.0271	0.3261	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0062	0.0586
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0008	0.0062	0.0175
Trichomonas vaginalis	conserved hypothetical protein	0.0004	0.0006	0.0056
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0008	0.0062	0.0586
Brugia malayi	cathepsin B-like cysteine proteinase	0.0271	0.3261	1
Entamoeba histolytica	cysteine proteinase, putative	0.0008	0.0062	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0043	0.0411
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0062	0.0586
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0043	0.0411
Plasmodium falciparum	serine repeat antigen 4	0.0008	0.0062	1
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0043	0.0411
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0008	0.0062	0.0175
Trypanosoma cruzi	cysteine peptidase, putative	0.0008	0.0062	0.0189
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.0071	0.003
Giardia lamblia	Cathepsin B precursor	0.009	0.1051	1
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0008	0.0062	0.0175
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0062	1
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0062	0.0586
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0043	0.0411
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0008	0.0062	0.0586
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0008	0.0062	0.5
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0008	0.0062	1
Entamoeba histolytica	cysteine proteinase 2	0.0008	0.0062	1
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0062	1
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0008	0.0062	1
Echinococcus multilocularis	cathepsin L	0.0008	0.0062	0.0011
Echinococcus multilocularis	cathepsin L cysteine protease	0.0008	0.0062	0.0011
Entamoeba histolytica	cysteine proteinase, putative	0.0008	0.0062	1
Entamoeba histolytica	cysteine proteinase, putative	0.0008	0.0062	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0008	0.0062	0.0586
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0008	0.0062	0.0175
Entamoeba histolytica	cysteine proteinase, putative	0.0008	0.0062	1
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0008	0.0062	0.5
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.0529	0.1489
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0062	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0008	0.0062	0.0586
Echinococcus multilocularis	cathepsin b	0.0271	0.3261	0.3227
Entamoeba histolytica	cysteine proteinase, putative	0.0008	0.0062	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0062	0.0586
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0008	0.0062	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0062	0.0586
Echinococcus multilocularis	cysteine protease	0.0008	0.0062	0.0011
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0008	0.0062	0.0586
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0008	0.0062	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0008	0.0062	0.0586
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0062	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0008	0.0062	0.0175
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.009	0.1051	0.3223
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0008	0.0062	0.0175
Entamoeba histolytica	cysteine proteinase, putative	0.0008	0.0062	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.009	0.1051	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0062	0.0586
Echinococcus granulosus	cathepsin l1	0.0008	0.0062	0.0033
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0008	0.0062	0.0586
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0004	0.0014	0.0028
Plasmodium vivax	vivapain-3	0.0008	0.0062	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0008	0.0062	0.0586
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0062	0.0586
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0043	0.0411
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0062	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0043	0.0411
Echinococcus multilocularis	cathepsin L cysteine protease	0.0008	0.0062	0.0011
Trypanosoma cruzi	cysteine protease, putative	0.0008	0.0062	0.0189
Schistosoma mansoni	cathepsin F (C01 family)	0.0008	0.0062	0.0175
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0007	0.0043	0.0411
Entamoeba histolytica	cysteine proteinase 1, putative	0.0008	0.0062	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0008	0.0062	0.0586
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0008	0.0062	0.0189
Trypanosoma brucei	cysteine peptidase C (CPC)	0.009	0.1051	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0062	0.0586
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0008	0.0062	0.5
Echinococcus multilocularis	cathepsin L	0.0008	0.0062	0.0011
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0008	0.0062	0.0586
Plasmodium falciparum	serine repeat antigen 5	0.0008	0.0062	1
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0073	0.0034
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0062	0.0586
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0047	0.0529	0.146
Plasmodium vivax	serine-repeat antigen (SERA)	0.0008	0.0062	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0008	0.0062	0.0586
Echinococcus multilocularis	cathepsin b	0.0271	0.3261	0.3227
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0008	0.0062	0.0175
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0008	0.0062	0.0175
Trypanosoma cruzi	major cysteine proteinase, putative	0.0008	0.0062	0.0189
Trypanosoma cruzi	cruzipain precursor, putative	0.0008	0.0062	0.0189
Echinococcus multilocularis	cysteine protease	0.0008	0.0062	0.0011
Giardia lamblia	Cathepsin B precursor	0.009	0.1051	1
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0055	0.0636	0.5806
Plasmodium falciparum	serine repeat antigen 2	0.0008	0.0062	1
Trypanosoma cruzi	cysteine proteinase, putative	0.0008	0.0062	0.0189
Plasmodium vivax	vivapain-1	0.0008	0.0062	0.5
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0271	0.3261	1
Schistosoma mansoni	cpg binding protein	0.0031	0.0338	0.1025
Echinococcus granulosus	cpg binding protein	0.0031	0.0338	0.0895
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0062	0.0586
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0062	1
Schistosoma mansoni	cathepsin C	0.0008	0.0062	0.0175
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0008	0.0062	0.0175
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0008	0.0062	0.0586
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0043	0.0411
Schistosoma mansoni	cathepsin F (C01 family)	0.0008	0.0062	0.0175
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0008	0.0062	0.0586
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0008	0.0062	0.0011
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0008	0.0062	0.0586
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0008	0.0062	0.0586
Echinococcus granulosus	cathepsin l1	0.0008	0.0062	0.0033
Schistosoma mansoni	cathepsin F (C01 family)	0.0008	0.0062	0.0175
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0008	0.0062	0.0586
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0062	0.0586
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.009	0.1051	1
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0004	0.0006	0.0056
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0271	0.3261	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0008	0.0062	0.0175
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0047	0.0529	0.146
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0062	0.0586
Echinococcus granulosus	cathepsin L cysteine protease	0.0008	0.0062	0.0033
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0271	0.3261	1
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0008	0.0062	0.5
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0062	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0043	0.0411
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.0051	0.0142
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0271	0.3261	1
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0008	0.0062	0.5
Trypanosoma cruzi	major cysteine proteinase, putative	0.0008	0.0062	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0271	0.3261	1
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0008	0.0062	0.5
Plasmodium falciparum	serine repeat antigen 9	0.0008	0.0062	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0062	0.0586
Toxoplasma gondii	cathepsin B	0.009	0.1051	1
Echinococcus granulosus	cysteine protease	0.0008	0.0062	0.0033
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0062	0.0586
Onchocerca volvulus		0.0029	0.0318	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0008	0.0062	0.0189
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0008	0.0062	0.5
Plasmodium falciparum	serine repeat antigen 8	0.0008	0.0062	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0062	0.0586
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0047	0.0529	0.1489
Trypanosoma cruzi	cysteine peptidase, putative	0.0008	0.0062	0.0189
Plasmodium vivax	unspecified product	0.0008	0.0062	0.5
Plasmodium vivax	unspecified product	0.0008	0.0062	0.5
Entamoeba histolytica	cysteine proteinase, putative	0.0008	0.0062	1
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0008	0.0062	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0008	0.0062	0.0586
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.009	0.1051	0.3214
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0062	0.0586
Plasmodium falciparum	serine repeat antigen 3	0.0008	0.0062	1
Entamoeba histolytica	hypothetical protein	0.0008	0.0062	1
Plasmodium vivax	serine-repeat antigen (SERA)	0.0008	0.0062	0.5
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0062	0.0586
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0008	0.0062	0.5
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0008	0.0062	0.0586
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0043	0.0411
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0008	0.0062	0.0586
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0008	0.0062	0.0586
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0062	1
Plasmodium falciparum	serine repeat antigen 1	0.0008	0.0062	1
Schistosoma mansoni	cathepsin S (C01 family)	0.0008	0.0062	0.0175
Schistosoma mansoni	cpg binding protein	0.0029	0.0318	0.0963
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0008	0.0062	0.0586
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0529	0.161
Plasmodium falciparum	serine repeat antigen 6	0.0008	0.0062	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.0529	0.048
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0008	0.0062	0.0586
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0062	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0047	0.0529	0.048
Echinococcus granulosus	cathepsin L	0.0008	0.0062	0.0033
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0062	1
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0008	0.0062	0.5
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0008	0.0062	0.0175
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0043	0.0411
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0008	0.0062	0.0586
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0008	0.0062	0.0586
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0062	1
Trichomonas vaginalis	helicase, putative	0.0007	0.0043	0.0411
Trichomonas vaginalis	hypothetical protein	0.0004	0.0006	0.0056
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0008	0.0062	0.0586
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0529	0.161
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0008	0.0062	0.0586
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0062	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0062	0.0586
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0073	0.0068
Plasmodium falciparum	serine repeat antigen 7	0.0008	0.0062	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0062	0.0586
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0062	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0008	0.0062	0.0189
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0008	0.0062	0.0175
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0008	0.0062	1
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0062	1
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0062	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0008	0.0062	0.0586
Schistosoma mansoni	cathepsin B (C01 family)	0.0008	0.0062	0.0175
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0318	0.0802
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0008	0.0062	0.0586
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0318	0.0802
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0008	0.0062	0.0033
Giardia lamblia	Cathepsin B precursor	0.009	0.1051	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0008	0.0062	0.0586
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0043	0.0411
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0062	0.0586
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0043	0.0411
Trichomonas vaginalis	conserved hypothetical protein	0.0007	0.0043	0.0411
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0008	0.0062	0.0033
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0008	0.0062	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0008	0.0062	0.0586
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0062	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0008	0.0062	0.0586
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0008	0.0062	1
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0062	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0062	0.0586
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0062	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0047	0.0529	0.161
Loa Loa (eye worm)	cathepsin B	0.009	0.1051	0.3093
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0008	0.0062	0.0586
Echinococcus multilocularis	cpg binding protein	0.0031	0.0338	0.0289
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0062	0.0586
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0062	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0008	0.0062	0.0189
Echinococcus granulosus	cathepsin L	0.0008	0.0062	0.0033
Plasmodium vivax	vivapain-2	0.0008	0.0062	0.5
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0073	0.0022
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0008	0.0062	0.0586
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0008	0.0062	0.0586
Entamoeba histolytica	cysteine protease, putative	0.0008	0.0062	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0008	0.0062	0.0586
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0007	0.0043	0.0411

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	3.2944 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1902856

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1551867