Detailed information for compound 1557010

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 450.057 | Formula: C25H40ClN3O2
  • H donors: 2 H acceptors: 1 LogP: 6.2 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc(cc1)CCCCCCCOCC1CCCCC1)NC1(CC1)C(=N)N.Cl
  • InChi: 1S/C25H39N3O2.ClH/c26-24(27)25(16-17-25)28-23(29)22-14-12-20(13-15-22)9-5-2-1-3-8-18-30-19-21-10-6-4-7-11-21;/h12-15,21H,1-11,16-19H2,(H3,26,27)(H,28,29);1H
  • InChiKey: XANMGMLOABWIBD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus sphingosine kinase 2 Starlite/ChEMBL References
Homo sapiens sphingosine kinase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus sphingosine kinase 1 Get druggable targets OG5_128162 All targets in OG5_128162
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_128162 All targets in OG5_128162
Schistosoma mansoni sphingosine kinase A B Get druggable targets OG5_128162 All targets in OG5_128162
Schistosoma mansoni sphingoid long chain base kinase Get druggable targets OG5_128162 All targets in OG5_128162
Candida albicans similar to S. cerevisiae LCB4 (YOR171C) sphingoid long chain base (LCB) kinase Get druggable targets OG5_128162 All targets in OG5_128162
Echinococcus multilocularis sphingosine kinase 1 Get druggable targets OG5_128162 All targets in OG5_128162
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128162 All targets in OG5_128162
Schistosoma japonicum ko:K00901 diacylglycerol kinase [EC2.7.1.107], putative Get druggable targets OG5_128162 All targets in OG5_128162
Candida albicans similar to S. cerevisiae LCB4 (YOR171C) sphingoid long chain base (LCB) kinase Get druggable targets OG5_128162 All targets in OG5_128162
Entamoeba histolytica hypothetical protein, conserved Get druggable targets OG5_128162 All targets in OG5_128162
Mycobacterium tuberculosis Conserved protein Get druggable targets OG5_128162 All targets in OG5_128162
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0015 0.0043 0.0043
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0197 0.4608
Trichomonas vaginalis diacylglycerol kinase, putative 0.0014 0.0019 0.0287
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.065 1
Loa Loa (eye worm) hypothetical protein 0.0265 0.7068 0.7068
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0409 0.0409
Schistosoma mansoni protein phosphatase 2C 0.0015 0.004 0.0022
Loa Loa (eye worm) hypothetical protein 0.0014 0.0019 0.0019
Trichomonas vaginalis sphingosine kinase, putative 0.0014 0.0019 0.0287
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.065 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.065 1
Brugia malayi intermediate filament protein 0.0028 0.0409 0.0579
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0197 0.0197
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0025 0.032 0.5
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.1213 0.1196
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.004 0.0622
Entamoeba histolytica diacylglycerol kinase, putative 0.0014 0.0019 0.0019
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0043 0.0024
Schistosoma mansoni sphingoid long chain base kinase 0.0369 1 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.004 0.004
Entamoeba histolytica hypothetical protein 0.0023 0.0257 0.0257
Loa Loa (eye worm) hypothetical protein 0.0033 0.054 0.054
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0969 0.1371
Echinococcus granulosus GPCR family 2 0.0015 0.0043 0.0024
Schistosoma mansoni alpha glucosidase 0.0037 0.065 0.0633
Schistosoma mansoni hypothetical protein 0.0015 0.0043 0.0024
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.004 0.0622
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.065 0.065
Brugia malayi diacylglycerol kinase 0.0014 0.0019 0.0026
Plasmodium falciparum JmjC domain-containing protein, putative 0.0015 0.004 0.0561
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.1213 0.1196
Schistosoma mansoni alpha-glucosidase 0.0143 0.3633 0.3621
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0407 0.6146
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0015 0.004 0.0022
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0043 0.0043
Echinococcus multilocularis snurportin 1 0.0301 0.8075 0.8072
Echinococcus granulosus lysine specific demethylase 5A 0.0057 0.1213 0.1196
Schistosoma mansoni hypothetical protein 0.0015 0.0043 0.0024
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0043 0.0024
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0025 0.032 0.5
Leishmania major sphingosine kinase A, B, putative 0.0014 0.0019 0.0287
Schistosoma mansoni lamin 0.0028 0.0409 0.0391
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0025 0.032 0.0302
Entamoeba histolytica diacylglycerol kinase, putative 0.0014 0.0019 0.0019
Entamoeba histolytica diacylglycerol kinase, putative 0.0014 0.0019 0.0019
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.065 0.092
Trichomonas vaginalis ran, putative 0.0021 0.0197 0.3038
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0409 0.0579
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.3599 0.3587
Onchocerca volvulus 0.0028 0.0409 0.0807
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0197 0.0279
Trypanosoma cruzi Sphingosine kinase 0.0014 0.0019 0.0287
Echinococcus granulosus jumonji domain containing 1A 0.0015 0.004 0.0022
Trypanosoma brucei Diacylglycerol kinase catalytic domain containing protein, putative 0.0014 0.0019 0.0287
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0142 0.3599 0.3587
Onchocerca volvulus Ceramide kinase 1 homolog 0.0014 0.0019 0.0037
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0443 0.0443
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.3599 0.3587
Trypanosoma brucei hypothetical protein, conserved 0.0014 0.0019 0.0287
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.3599 0.3587
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0015 0.004 0.0022
Trichomonas vaginalis bmru protein, putative 0.0014 0.0019 0.0287
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0194 0.5067 1
Onchocerca volvulus 0.0028 0.0409 0.0807
Trypanosoma brucei glucosidase, putative 0.0037 0.065 1
Schistosoma mansoni lamin 0.0028 0.0409 0.0391
Schistosoma mansoni phd/f-box containing protein 0.0015 0.004 0.0022
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0015 0.004 0.0345
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0043 0.0061
Loa Loa (eye worm) hypothetical protein 0.0028 0.0407 0.0407
Loa Loa (eye worm) diacylglycerol kinase 2 0.0014 0.0019 0.0019
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.065 1
Schistosoma mansoni hypothetical protein 0.0301 0.8075 0.8072
Echinococcus multilocularis survival motor neuron protein 1 0.0265 0.7068 0.7063
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0301 0.8075 0.8075
Trypanosoma brucei hypothetical protein, conserved 0.0025 0.032 0.4928
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.0014 0.0019 0.0287
Echinococcus multilocularis phd:f box containing protein 0.0015 0.004 0.0022
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0025 0.032 0.4778
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0043 0.0024
Trypanosoma brucei diacylglycerol kinase, putative 0.0014 0.0019 0.0287
Brugia malayi Eye-specific diacylglycerol kinase 0.0014 0.0019 0.0026
Echinococcus multilocularis lamin dm0 0.0028 0.0409 0.0391
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0407 0.6256
Echinococcus granulosus JmjC domain containing protein 4 0.0015 0.004 0.0022
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.065 1
Echinococcus granulosus phd:f box containing protein 0.0015 0.004 0.0022
Loa Loa (eye worm) hypothetical protein 0.0028 0.0409 0.0409
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.065 1
Echinococcus granulosus snurportin 1 0.0301 0.8075 0.8072
Echinococcus granulosus lysosomal alpha glucosidase 0.0166 0.4283 0.4272
Trichomonas vaginalis bmru protein, putative 0.0014 0.0019 0.0287
Brugia malayi Diacylglycerol kinase protein 2 0.0014 0.0019 0.0026
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0142 0.3599 0.3599
Brugia malayi jmjC domain containing protein 0.0015 0.004 0.0057
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.1213 0.1196
Onchocerca volvulus 0.0014 0.0019 0.0037
Onchocerca volvulus 0.0089 0.2125 0.4195
Echinococcus multilocularis lysine specific demethylase 6a 0.0015 0.004 0.0022
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.3599 0.3587
Schistosoma mansoni intermediate filament proteins 0.0028 0.0409 0.0391
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0142 0.3599 0.3587
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0043 0.0024
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0197 0.3038
Loa Loa (eye worm) jmjC domain-containing protein 0.0057 0.1213 0.1213
Brugia malayi hypothetical protein 0.0265 0.7068 1
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0197 0.5
Schistosoma mansoni hypothetical protein 0.0015 0.0043 0.0024
Loa Loa (eye worm) hypothetical protein 0.0015 0.004 0.004
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0197 0.4608
Brugia malayi jmjC domain containing protein 0.0015 0.004 0.0057
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.054 0.0765
Schistosoma mansoni hypothetical protein 0.0054 0.1134 0.1118
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0015 0.004 0.0345
Brugia malayi hypothetical protein 0.0014 0.0019 0.0026
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.004 0.004
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.065 0.065
Schistosoma mansoni alpha-glucosidase 0.0143 0.3633 0.3621
Mycobacterium tuberculosis Conserved protein 0.0369 1 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.065 0.065
Brugia malayi jmjC domain containing protein 0.0057 0.1213 0.1716
Brugia malayi Importin beta-1 subunit 0.0028 0.0407 0.0575
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0197 0.2832
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0014 0.0019 0.0287
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0025 0.032 0.7775
Schistosoma mansoni survival motor neuron protein 0.0054 0.1134 0.1118
Schistosoma mansoni phosphatidylserine receptor 0.0015 0.004 0.0022
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.065 1
Loa Loa (eye worm) ceramide kinase 0.0014 0.0019 0.0019
Schistosoma mansoni sphingosine kinase A B 0.0369 1 1
Trypanosoma cruzi Diacylglycerol kinase catalytic domain containing protein, putative 0.0014 0.0019 0.0287
Leishmania major phosphopantetheinyl transferase-like protein 0.0025 0.032 0.4928
Leishmania major diacylglycerol kinase-like protein 0.0014 0.0019 0.0287
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0015 0.004 0.0022
Loa Loa (eye worm) hypothetical protein 0.0014 0.0019 0.0019
Mycobacterium leprae conserved hypothetical protein 0.0025 0.032 0.5
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0257 0.3951
Loa Loa (eye worm) hypothetical protein 0.0194 0.5067 0.5067
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0025 0.032 0.7775
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.065 1
Echinococcus multilocularis L aminoadipate semialdehyde 0.0089 0.2125 0.211
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.065 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0054 0.1134 0.1605
Leishmania major hypothetical protein, conserved 0.0014 0.0019 0.0287
Brugia malayi Ceramide kinase 0.0014 0.0019 0.0026
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.1213 0.1196
Plasmodium vivax importin-beta 2, putative 0.0028 0.0407 1
Entamoeba histolytica hypothetical protein 0.0025 0.032 0.032
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0019 0.0287
Schistosoma mansoni jumonji domain containing protein 0.0057 0.1213 0.1196
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0019 0.0287
Leishmania major hypothetical protein, conserved 0.0014 0.0019 0.0287
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0089 0.2125 0.211
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0015 0.004 0.0622
Trichomonas vaginalis diacylglycerol kinase, putative 0.0014 0.0019 0.0287
Plasmodium vivax JmjC domain containing protein 0.0015 0.004 0.0561
Leishmania major importin beta-1 subunit, putative 0.0023 0.0257 0.3951
Echinococcus multilocularis lamin 0.0028 0.0409 0.0391
Echinococcus multilocularis lysosomal alpha glucosidase 0.0166 0.4283 0.4272
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.004 0.004
Plasmodium falciparum importin beta, putative 0.0028 0.0407 1
Schistosoma mansoni ran 0.0021 0.0197 0.0179
Echinococcus granulosus intermediate filament protein 0.0028 0.0409 0.0391
Echinococcus granulosus L aminoadipate semialdehyde 0.0089 0.2125 0.211
Echinococcus multilocularis lysosomal alpha glucosidase 0.0166 0.4283 0.4272
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0014 0.0019 0.0287
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.004 0.0057
Brugia malayi diacylglycerol kinase 0.0014 0.0019 0.0026
Loa Loa (eye worm) hypothetical protein 0.0028 0.0394 0.0394
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0025 0.032 0.0302
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0407 0.6256
Brugia malayi jmjC domain containing protein 0.0015 0.004 0.0057
Schistosoma mansoni hypothetical protein 0.0033 0.054 0.0523
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0043 0.0061
Trypanosoma cruzi Sphingosine kinase 0.0014 0.0019 0.0287
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0409 0.0409
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0142 0.3599 0.5092
Loa Loa (eye worm) hypothetical protein 0.0014 0.0019 0.0019
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0014 0.0019 0.0287
Echinococcus granulosus survival motor neuron protein 1 0.0265 0.7068 0.7063
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0197 0.3038
Trypanosoma cruzi diacylglycerol kinase, putative 0.0014 0.0019 0.0287
Brugia malayi RNA, U transporter 1 0.008 0.1868 0.2643
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0407 0.0389
Brugia malayi Cytochrome P450 family protein 0.0029 0.0443 0.0626
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0197 0.3038
Echinococcus multilocularis JmjC domain containing protein 4 0.0015 0.004 0.0022
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0257 0.3951
Loa Loa (eye worm) hypothetical protein 0.0369 1 1
Echinococcus granulosus lamin 0.0028 0.0409 0.0391
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0142 0.3599 0.3587
Loa Loa (eye worm) hypothetical protein 0.0089 0.2125 0.2125
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.004 0.004
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.065 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.065 1
Schistosoma mansoni jumonji domain containing protein 0.0015 0.004 0.0022
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.004 0.004
Brugia malayi Glycosyl hydrolases family 31 protein 0.0166 0.4283 0.6059
Brugia malayi jmjC domain containing protein 0.0057 0.1213 0.1716
Schistosoma mansoni importin beta-1 0.0028 0.0407 0.0389
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0257 0.3951
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0014 0.0019 0.0287
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.065 0.0633
Leishmania major hypothetical protein, conserved 0.0015 0.004 0.0622
Loa Loa (eye worm) hypothetical protein 0.0048 0.0969 0.0969
Echinococcus granulosus lysine specific demethylase 6a 0.0015 0.004 0.0022
Trichomonas vaginalis sphingosine kinase, putative 0.0014 0.0019 0.0287
Schistosoma mansoni ran 0.0021 0.0197 0.0179
Loa Loa (eye worm) hypothetical protein 0.0015 0.004 0.004
Brugia malayi N-terminal motif family protein 0.0194 0.5067 0.7168
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0969 0.0969
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0197 0.0179
Echinococcus multilocularis sphingosine kinase 1 0.0369 1 1
Leishmania major GTP-binding protein, putative 0.0021 0.0197 0.3038
Schistosoma mansoni hypothetical protein 0.0015 0.0043 0.0024
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0025 0.032 0.4778
Echinococcus granulosus importin subunit beta 1 0.0028 0.0407 0.0389
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0166 0.4283 0.4283
Echinococcus multilocularis GPCR, family 2 0.0015 0.0043 0.0024
Entamoeba histolytica Ran family GTPase 0.0021 0.0197 0.0197
Schistosoma mansoni jumonji/arid domain-containing protein 0.0057 0.1213 0.1196
Mycobacterium ulcerans hypothetical protein 0.0369 1 1
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.065 0.0633
Onchocerca volvulus 0.0054 0.1134 0.2239
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0025 0.032 0.0302
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0257 0.3951
Entamoeba histolytica hypothetical protein, conserved 0.0369 1 1
Entamoeba histolytica diacylglycerol kinase, putative 0.0014 0.0019 0.0019
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0089 0.2125 0.3007
Trypanosoma brucei Sphingosine kinase 0.0014 0.0019 0.0287
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.065 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0197 0.0179
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0025 0.032 0.5
Leishmania major diacylglycerol kinase, putative 0.0014 0.0019 0.0287
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0969 0.1371
Echinococcus granulosus lamin dm0 0.0028 0.0409 0.0391
Brugia malayi jmjC domain containing protein 0.0015 0.004 0.0057
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.0014 0.0019 0.0019
Echinococcus multilocularis jumonji domain containing 1A 0.0015 0.004 0.0022
Trypanosoma cruzi diacylglycerol kinase, putative 0.0014 0.0019 0.0287
Echinococcus multilocularis musashi 0.0028 0.0409 0.0391
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.065 1
Onchocerca volvulus 0.0096 0.2314 0.4568

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.13 uM Inhibition of human recombinant SPHK1 expressed in baculovirus-infected Sf9 cells ChEMBL. 21495716
Ki (binding) = 15 uM Inhibition of mouse recombinant SPHK2 expressed in baculovirus-infected Sf9 cells ChEMBL. 21495716

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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