Detailed information for compound 1560682

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 718.667 | Formula: C30H32F6N6O6S
  • H donors: 2 H acceptors: 6 LogP: 5.49 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(C1CN(CCN1S(=O)(=O)c1ccc(cc1)OC(F)(F)F)c1ccc(nn1)C(=O)NCC(C)(C)C)NCc1ccc(cc1)OC(F)(F)F
  • InChi: 1S/C30H32F6N6O6S/c1-28(2,3)18-38-26(43)23-12-13-25(40-39-23)41-14-15-42(49(45,46)22-10-8-21(9-11-22)48-30(34,35)36)24(17-41)27(44)37-16-19-4-6-20(7-5-19)47-29(31,32)33/h4-13,24H,14-18H2,1-3H3,(H,37,44)(H,38,43)
  • InChiKey: QPPMVDJEDQFPDJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi TAR-binding protein 0.0064 0.0898 0.0903
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0033 0.0326 0.0177
Schistosoma mansoni endoplasmin 0.0101 0.1589 0.1542
Toxoplasma gondii LsmAD domain-containing protein 0.0082 0.1242 0.1807
Brugia malayi Isocitrate dehydrogenase 0.0052 0.0673 0.0661
Echinococcus multilocularis heat shock protein 90 0.0101 0.1589 0.1459
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0037 0.0389 0.0000000002987
Echinococcus granulosus hexokinase 0.0175 0.2986 0.2879
Loa Loa (eye worm) helicase 0.0037 0.0389 0.0355
Schistosoma mansoni heat shock protein 0.0101 0.1589 0.1542
Trichomonas vaginalis conserved hypothetical protein 0.0089 0.1377 0.3242
Toxoplasma gondii NADPH-glutathione reductase 0.0033 0.0326 0.0475
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0116 0.1883 0.1759
Brugia malayi MH2 domain containing protein 0.0512 0.9347 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0037 0.0389 0.0241
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0033 0.0326 0.0475
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0094 0.1472 0.4309
Trichomonas vaginalis endoplasmin, putative 0.0073 0.1069 0.2428
Trypanosoma brucei heat shock protein, putative 0.0101 0.1589 0.4746
Echinococcus multilocularis isocitrate dehydrogenase 0.0052 0.0673 0.0529
Trypanosoma brucei heat shock protein, putative 0.0101 0.1589 0.4746
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.022 0.3846 0.8837
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0067 0.0953 0.0814
Trichomonas vaginalis heat shock protein, putative 0.0094 0.1472 0.3494
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0389 0.0628
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0037 0.0389 0.0241
Schistosoma mansoni heat shock protein 0.0101 0.1589 0.1542
Echinococcus granulosus chromobox protein 1 0.0225 0.3932 0.3839
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0294 0.0145
Echinococcus granulosus TGF beta signal transducer SmadC 0.0035 0.0353 0.0205
Plasmodium falciparum endoplasmin, putative 0.0073 0.1069 0.1437
Trichomonas vaginalis heat shock protein, putative 0.0058 0.0796 0.1705
Plasmodium vivax heterochromatin protein 1, putative 0.0037 0.0389 0.0561
Loa Loa (eye worm) hypothetical protein 0.0126 0.207 0.2165
Plasmodium vivax hexokinase, putative 0.0175 0.2986 0.4344
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0052 0.0673 0.1303
Trichomonas vaginalis conserved hypothetical protein 0.0089 0.1377 0.3242
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0037 0.0389 0.0241
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0389 0.0628
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0086 0.1315 0.1182
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0294 0.0145
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0037 0.0389 0.0355
Entamoeba histolytica hypothetical protein 0.0116 0.1883 0.5753
Leishmania major trypanothione reductase 0.0097 0.1515 0.447
Echinococcus multilocularis mothers against decapentaplegic 5 0.0035 0.0353 0.0205
Toxoplasma gondii isocitrate dehydrogenase 0.0052 0.0673 0.0979
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0898 0.0848
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0037 0.0389 0.0628
Trichomonas vaginalis chromobox protein, putative 0.0225 0.3932 1
Loa Loa (eye worm) transcription factor SMAD2 0.0512 0.9347 1
Plasmodium falciparum hexokinase 0.0175 0.2986 0.4267
Brugia malayi Protein cec-1. 0.0037 0.0389 0.0355
Echinococcus granulosus Chromo domain 0.0037 0.0389 0.0241
Schistosoma mansoni smad1 5 8 and 0.0035 0.0353 0.0299
Echinococcus granulosus heat shock protein 0.0101 0.1589 0.1459
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0898 0.0758
Leishmania major heat shock protein 83-1 0.0101 0.1589 0.4746
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.1589 0.1647
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0037 0.0389 0.0000000002987
Leishmania major heat shock protein 83-1 0.0101 0.1589 0.4746
Loa Loa (eye worm) isocitrate dehydrogenase 0.0052 0.0673 0.0661
Plasmodium vivax ataxin-2 like protein, putative 0.0082 0.1242 0.1803
Loa Loa (eye worm) MH1 domain-containing protein 0.0035 0.0353 0.0316
Schistosoma mansoni hypothetical protein 0.0032 0.0294 0.024
Plasmodium vivax heat shock protein, putative 0.0381 0.687 1
Loa Loa (eye worm) glutathione reductase 0.0097 0.1515 0.1568
Entamoeba histolytica heat shock protein 90, putative 0.0101 0.1589 0.4619
Onchocerca volvulus 0.0175 0.2986 1
Brugia malayi Valyl-tRNA synthetase 0.0037 0.0389 0.0355
Giardia lamblia Heat shock protein HSP 90-alpha 0.0101 0.1589 1
Brugia malayi Heterochromatin protein 1 0.0225 0.3932 0.417
Trypanosoma brucei hexokinase, putative 0.0175 0.2986 1
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0898 0.0848
Trypanosoma brucei heat shock protein 90, putative 0.0101 0.1589 0.4746
Brugia malayi hypothetical protein 0.0082 0.1242 0.1273
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0052 0.0673 0.0529
Trypanosoma brucei heat shock protein, putative 0.0101 0.1589 0.4746
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0037 0.0389 0.0241
Echinococcus multilocularis hexokinase 0.0175 0.2986 0.2879
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0037 0.0389 0.0628
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.1589 0.1647
Onchocerca volvulus Hexokinase homolog 0.011 0.176 0.5279
Trichomonas vaginalis heat shock protein, putative 0.0101 0.1589 0.3801
Brugia malayi M-phase phosphoprotein, mpp8 0.0037 0.0389 0.0355
Plasmodium vivax heat shock protein 86, putative 0.0101 0.1589 0.2308
Trichomonas vaginalis chromobox protein, putative 0.0037 0.0389 0.0628
Plasmodium falciparum heat shock protein 90, putative 0.0381 0.687 1
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0033 0.0326 0.0469
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0389 0.0628
Brugia malayi Thioredoxin reductase 0.0097 0.1515 0.1568
Entamoeba histolytica hypothetical protein 0.0037 0.0389 0.0000000002987
Trichomonas vaginalis conserved hypothetical protein 0.0126 0.207 0.5076
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0052 0.0673 0.0974
Trichomonas vaginalis hypothetical protein 0.0037 0.0389 0.0628
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0294 0.0145
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0116 0.1883 0.1759
Echinococcus multilocularis chromobox protein 1 0.0225 0.3932 0.3839
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0052 0.0673 0.0529
Entamoeba histolytica hypothetical protein 0.0116 0.1883 0.5753
Schistosoma mansoni smad1 5 8 and 0.0035 0.0353 0.0299
Plasmodium falciparum thioredoxin reductase 0.0033 0.0326 0.034
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0052 0.0673 0.0529
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0037 0.0389 0.0566
Schistosoma mansoni Smad4 0.0035 0.0353 0.0299
Brugia malayi hypothetical protein 0.0116 0.1883 0.1964
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0025 0.0159 0.0107
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0037 0.0389 0.0432
Mycobacterium tuberculosis Probable oxidoreductase 0.0245 0.431 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.1242 0.1273
Leishmania major heat shock protein 83-1 0.0101 0.1589 0.4746
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0037 0.0389 0.0628
Brugia malayi RNA binding protein 0.0064 0.0898 0.0903
Leishmania major hexokinase, putative 0.0175 0.2986 1
Giardia lamblia Heat shock protein HSP 90-alpha 0.0086 0.1315 0.7834
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0037 0.0389 0.0628
Brugia malayi MH2 domain containing protein 0.0035 0.0353 0.0316
Toxoplasma gondii hexokinase 0.0175 0.2986 0.4347
Trichomonas vaginalis conserved hypothetical protein 0.0126 0.207 0.5076
Trypanosoma cruzi heat shock protein 90, putative 0.0101 0.1589 0.4746
Loa Loa (eye worm) hypothetical protein 0.0056 0.0742 0.0735
Toxoplasma gondii heat shock protein HSP90 0.0101 0.1589 0.2312
Brugia malayi hexokinase type II 0.0056 0.0742 0.0735
Leishmania major heat shock protein 83-1 0.0101 0.1589 0.4746
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0033 0.0326 0.5
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0037 0.0389 0.0628
Brugia malayi isocitrate dehydrogenase 0.0052 0.0673 0.0661
Trichomonas vaginalis chromobox protein, putative 0.0136 0.2251 0.5553
Loa Loa (eye worm) hypothetical protein 0.0037 0.0389 0.0355
Schistosoma mansoni chromobox protein 0.0037 0.0389 0.0335
Echinococcus multilocularis Smad4 0.0035 0.0353 0.0205
Mycobacterium ulcerans heat shock protein 90 0.0094 0.1472 1
Plasmodium vivax heat shock protein 90, putative 0.0067 0.0953 0.1383
Brugia malayi MH1 domain containing protein 0.0035 0.0353 0.0316
Brugia malayi Associated with TFs and helicases family protein 0.0037 0.0389 0.0355
Leishmania major heat shock protein 83-1 0.0101 0.1589 0.4746
Leishmania major heat shock protein, putative 0.0067 0.0953 0.2357
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0052 0.0673 0.0529
Loa Loa (eye worm) thioredoxin reductase 0.0097 0.1515 0.1568
Mycobacterium tuberculosis Probable dehydrogenase 0.022 0.3846 0.8837
Brugia malayi Hexokinase family protein 0.011 0.176 0.1831
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0037 0.0389 0.0432
Schistosoma mansoni chromobox protein 0.0037 0.0389 0.0335
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0037 0.0389 0.0628
Schistosoma mansoni endoplasmin 0.0101 0.1589 0.1542
Onchocerca volvulus 0.0175 0.2986 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0037 0.0389 0.0628
Loa Loa (eye worm) endoplasmin 0.0101 0.1589 0.1647
Echinococcus multilocularis endoplasmin 0.0094 0.1472 0.1341
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0067 0.0953 0.2172
Schistosoma mansoni hexokinase 0.0175 0.2986 0.2947
Trypanosoma brucei heat shock protein 90, putative 0.0101 0.1589 0.4746
Trichomonas vaginalis chromobox protein, putative 0.0037 0.0389 0.0628
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0094 0.1472 1
Trichomonas vaginalis heat shock protein, putative 0.0086 0.1315 0.3078
Trypanosoma brucei trypanothione reductase 0.0097 0.1515 0.447
Loa Loa (eye worm) hypothetical protein 0.0037 0.0389 0.0355
Entamoeba histolytica hexokinase 1 0.0175 0.2986 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0294 0.0145
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0037 0.0389 0.0335
Echinococcus granulosus thioredoxin glutathione reductase 0.0097 0.1515 0.1385
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0389 0.0628
Echinococcus multilocularis hexokinase 0.0175 0.2986 0.2879
Onchocerca volvulus 0.0099 0.1557 0.4498
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0052 0.0673 0.0621
Schistosoma mansoni smad1 5 8 and 0.0035 0.0353 0.0299
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0037 0.0389 0.0628
Trypanosoma brucei hexokinase 0.0175 0.2986 1
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0898 0.0848
Brugia malayi chromobox protein homolog 3 0.0126 0.207 0.2165
Leishmania major heat shock protein 83-1 0.0101 0.1589 0.4746
Onchocerca volvulus 0.011 0.176 0.5279
Trypanosoma brucei heat shock protein 84, putative 0.0067 0.0953 0.2357
Loa Loa (eye worm) hypothetical protein 0.0037 0.0389 0.0355
Echinococcus multilocularis heat shock protein 90 0.0086 0.1315 0.1182
Echinococcus multilocularis Chromo domain 0.0037 0.0389 0.0241
Brugia malayi SET domain containing protein 0.0037 0.0389 0.0355
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0898 0.0848
Schistosoma mansoni chromobox protein 0.0225 0.3932 0.3898
Schistosoma mansoni heat shock protein 0.0067 0.0953 0.0903
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0037 0.0389 0.0628
Echinococcus granulosus smad 0.0035 0.0353 0.0205
Treponema pallidum hexokinase (hxk) 0.0175 0.2986 1
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0151 0.0099
Echinococcus granulosus mothers against decapentaplegic 5 0.0035 0.0353 0.0205
Loa Loa (eye worm) heat shock protein 75 0.0067 0.0953 0.0963
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0037 0.0389 0.0241
Loa Loa (eye worm) RNA binding protein 0.0064 0.0898 0.0903
Trypanosoma cruzi heat shock protein 85, putative 0.0101 0.1589 0.4746
Schistosoma mansoni chromobox protein 0.0225 0.3932 0.3898
Echinococcus granulosus GPCR family 2 0.0032 0.0294 0.0145
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0025 0.0159 0.0107
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0052 0.0673 0.1303
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0052 0.0673 0.087
Echinococcus granulosus tar DNA binding protein 0.0064 0.0898 0.0758
Brugia malayi heat shock protein 90 0.0101 0.1589 0.1647
Loa Loa (eye worm) hypothetical protein 0.0119 0.194 0.2025
Entamoeba histolytica hypothetical protein 0.0116 0.1883 0.5753
Schistosoma mansoni hypothetical protein 0.0547 1 1
Schistosoma mansoni hypothetical protein 0.0037 0.0389 0.0336
Loa Loa (eye worm) hexokinase 0.0175 0.2986 0.3152
Loa Loa (eye worm) hexokinase 0.0054 0.0714 0.0705
Toxoplasma gondii heat shock protein 75, putative 0.0067 0.0953 0.1387
Loa Loa (eye worm) hypothetical protein 0.0037 0.0389 0.0355
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0389 0.0628
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0052 0.0673 0.0851
Trypanosoma cruzi heat shock protein, putative 0.0067 0.0953 0.2357
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0067 0.0953 0.0814
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0033 0.0326 0.0287
Giardia lamblia Grp94/Hsp90 0.0094 0.1472 0.9079
Leishmania major hypothetical protein, conserved 0.0082 0.1242 0.3442
Brugia malayi Hsp90 protein 0.0067 0.0953 0.0963
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0037 0.0389 0.0241
Loa Loa (eye worm) hypothetical protein 0.0056 0.0742 0.0735
Echinococcus granulosus chromobox protein 2 0.0037 0.0389 0.0241
Schistosoma mansoni hypothetical protein 0.0032 0.0294 0.024
Echinococcus multilocularis hexokinase 0.0175 0.2986 0.2879
Trypanosoma cruzi PAB1-binding protein , putative 0.0082 0.1242 0.3442
Brugia malayi MH2 domain containing protein 0.0035 0.0353 0.0316
Onchocerca volvulus 0.0175 0.2986 1
Plasmodium falciparum heat shock protein 90 0.0101 0.1589 0.2203
Leishmania major heat shock protein 83-1 0.0101 0.1589 0.4746
Entamoeba histolytica hexokinase 2 0.0175 0.2986 1
Brugia malayi hypothetical protein 0.0037 0.0389 0.0355
Toxoplasma gondii isocitrate dehydrogenase 0.0052 0.0673 0.0979
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0294 0.0253
Leishmania major heat shock protein 83-1 0.0101 0.1589 0.4746
Leishmania major heat shock protein 83-1 0.0101 0.1589 0.4746
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0389 0.0561
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0037 0.0389 0.0335
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0052 0.0673 0.0529
Trypanosoma cruzi heat shock protein 90, putative 0.0086 0.1315 0.3718
Loa Loa (eye worm) MH2 domain-containing protein 0.0035 0.0353 0.0316
Brugia malayi MH1 domain containing protein 0.0035 0.0353 0.0316
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0294 0.0253
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0037 0.0389 0.0628
Echinococcus multilocularis chromobox protein 1 0.0225 0.3932 0.3839
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0037 0.0389 0.0335
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0136 0.2251 0.7168
Loa Loa (eye worm) hypothetical protein 0.0099 0.1557 0.1613
Toxoplasma gondii thioredoxin reductase 0.0097 0.1515 0.2205
Schistosoma mansoni hypothetical protein 0.0032 0.0294 0.024
Plasmodium falciparum heat shock protein 90, putative 0.0058 0.0796 0.1033
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0097 0.1515 0.2985
Leishmania major heat shock protein 83-1 0.0101 0.1589 0.4746
Leishmania major heat shock protein 83-1 0.0101 0.1589 0.4746
Trypanosoma cruzi Heat shock protein 83, putative 0.0101 0.1589 0.4746
Trypanosoma brucei PAB1-binding protein , putative 0.0082 0.1242 0.3442
Loa Loa (eye worm) hypothetical protein 0.0037 0.0389 0.0355
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0245 0.431 1
Echinococcus granulosus heat shock protein 90 0.0086 0.1315 0.1182
Loa Loa (eye worm) CHromoDomain protein family member 0.0037 0.0389 0.0355
Schistosoma mansoni hypothetical protein 0.0547 1 1
Echinococcus granulosus Chromobox protein 3 0.0037 0.0389 0.0241
Echinococcus granulosus endoplasmin 0.0094 0.1472 0.1341
Loa Loa (eye worm) hypothetical protein 0.0037 0.0389 0.0355
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.022 0.3846 0.8837
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0245 0.431 1
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0037 0.0389 0.0335
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0052 0.0673 0.1303
Brugia malayi CHD4 protein 0.0037 0.0389 0.0355
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0052 0.0673 0.1303
Brugia malayi Hexokinase family protein 0.0175 0.2986 0.3152
Trypanosoma cruzi heat shock protein 85, putative 0.0086 0.1315 0.3718
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0898 0.0848
Echinococcus multilocularis hexokinase type 2 0.0175 0.2986 0.2879
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.1589 0.1647
Schistosoma mansoni hypothetical protein 0.0069 0.099 0.0939
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0033 0.0326 0.0177
Leishmania major hexokinase, putative 0.0175 0.2986 1
Trypanosoma cruzi heat shock protein 85, putative 0.0101 0.1589 0.4746
Brugia malayi glutathione reductase 0.0097 0.1515 0.1568
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0094 0.1472 0.2877
Loa Loa (eye worm) hypothetical protein 0.0069 0.099 0.1002
Treponema pallidum heat shock protein 90 0.0094 0.1472 0.4309
Echinococcus granulosus hexokinase 0.0175 0.2986 0.2879
Brugia malayi Endoplasmin precursor 0.0101 0.1589 0.1647
Trichomonas vaginalis chromobox protein, putative 0.0225 0.3932 1
Echinococcus multilocularis heat shock protein 0.0101 0.1589 0.1459
Echinococcus granulosus hexokinase type 2 0.0175 0.2986 0.2879
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0389 0.0561
Toxoplasma gondii Hsp90 domain-containing protein 0.0381 0.687 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.0389 0.0335
Plasmodium falciparum glutathione reductase 0.0097 0.1515 0.2095
Brugia malayi Smad1 0.0035 0.0353 0.0316
Loa Loa (eye worm) RecQ helicase 0.0024 0.0151 0.0099
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.099 0.1002
Echinococcus granulosus hexokinase 0.0175 0.2986 0.2879
Echinococcus multilocularis geminin 0.0547 1 1
Trypanosoma brucei heat shock protein, putative 0.0101 0.1589 0.4746
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0126 0.207 0.6474
Echinococcus multilocularis GPCR, family 2 0.0032 0.0294 0.0145
Echinococcus multilocularis chromobox protein 2 0.0037 0.0389 0.0241
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0037 0.0389 0.0628
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0067 0.0953 0.2172
Brugia malayi Hexokinase family protein 0.0054 0.0714 0.0705
Leishmania major heat shock protein 83-1 0.0101 0.1589 0.4746
Loa Loa (eye worm) hexokinase type II 0.0175 0.2986 0.3152
Trichomonas vaginalis chromobox protein, putative 0.0037 0.0389 0.0628
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0389 0.0628
Entamoeba histolytica hypothetical protein 0.0116 0.1883 0.5753
Trypanosoma brucei heat shock protein, putative 0.0101 0.1589 0.4746
Loa Loa (eye worm) hypothetical protein 0.0037 0.0389 0.0355
Leishmania major heat shock protein 83-1 0.0101 0.1589 0.4746
Trichomonas vaginalis Heterochromatin protein, putative 0.0037 0.0389 0.0628
Trypanosoma brucei heat shock protein, putative 0.0101 0.1589 0.4746
Loa Loa (eye worm) MH2 domain-containing protein 0.0512 0.9347 1
Entamoeba histolytica heat shock protein 90, putative 0.0101 0.1589 0.4619
Toxoplasma gondii heat shock protein 90, putative 0.0101 0.1589 0.2312
Echinococcus granulosus heat shock protein 90 0.0101 0.1589 0.1459
Trichomonas vaginalis chromobox protein, putative 0.0136 0.2251 0.5553
Plasmodium vivax glutathione reductase, putative 0.0097 0.1515 0.2201
Trypanosoma cruzi hexokinase, putative 0.0175 0.2986 1
Schistosoma mansoni hypothetical protein 0.0037 0.0389 0.0335
Echinococcus granulosus Smad4 0.0035 0.0353 0.0205
Plasmodium falciparum ataxin-2 like protein, putative 0.0082 0.1242 0.1692
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0035 0.0353 0.0299
Brugia malayi hypothetical protein 0.0053 0.0694 0.0683
Loa Loa (eye worm) hexokinase 0.0175 0.2986 0.3152
Trypanosoma brucei heat shock protein, putative 0.0101 0.1589 0.4746
Plasmodium falciparum ataxin-2 like protein, putative 0.0082 0.1242 0.1692
Trypanosoma cruzi heat shock protein 85, putative 0.0101 0.1589 0.4746
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0052 0.0673 0.1303
Leishmania major heat shock protein 83-1 0.0101 0.1589 0.4746
Trypanosoma cruzi trypanothione reductase, putative 0.0097 0.1515 0.447
Loa Loa (eye worm) heat shock protein 90 0.0101 0.1589 0.1647
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0033 0.0326 0.0272
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0037 0.0389 0.0628
Loa Loa (eye worm) heterochromatin protein 1 0.0225 0.3932 0.417
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0037 0.0389 0.0000000002987
Loa Loa (eye worm) Smad1 0.0035 0.0353 0.0316
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.022 0.3846 0.8367
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0898 0.0903
Trichomonas vaginalis mercuric reductase, putative 0.0033 0.0326 0.0462
Echinococcus multilocularis smad 0.0035 0.0353 0.0205
Schistosoma mansoni hypothetical protein 0.0116 0.1883 0.1838
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0898 0.0903
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0033 0.0326 0.0469
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0037 0.0389 0.0566
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0389 0.0628
Plasmodium falciparum glutathione reductase 0.0033 0.0326 0.034
Trypanosoma cruzi heat shock protein 90, putative 0.0042 0.0488 0.0609
Leishmania major heat shock protein 83-1 0.0101 0.1589 0.4746
Trichomonas vaginalis heat shock protein, putative 0.0094 0.1472 0.3494
Trypanosoma cruzi hexokinase, putative 0.0175 0.2986 1
Leishmania major heat shock protein 83-1 0.0101 0.1589 0.4746
Brugia malayi hexokinase 0.0175 0.2986 0.3152
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0294 0.0253
Echinococcus multilocularis Chromobox protein 3 0.0037 0.0389 0.0241
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0033 0.0326 0.034
Trypanosoma brucei Heat shock protein 83, putative 0.0101 0.1589 0.4746
Plasmodium vivax thioredoxin reductase, putative 0.0097 0.1515 0.2201
Trypanosoma cruzi PAB1-binding protein , putative 0.0082 0.1242 0.3442
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0389 0.0628
Loa Loa (eye worm) hexokinase 0.011 0.176 0.1831
Plasmodium vivax endoplasmin, putative 0.0101 0.1589 0.2308
Plasmodium falciparum heterochromatin protein 1 0.0037 0.0389 0.0432
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0389 0.0628
Echinococcus granulosus chromobox protein 1 0.0225 0.3932 0.3839
Trichomonas vaginalis glutathione reductase, putative 0.0033 0.0326 0.0462
Loa Loa (eye worm) hypothetical protein 0.0101 0.1589 0.1647
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0898 0.0903
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0037 0.0389 0.0566
Schistosoma mansoni transcription factor LCR-F1 0.0116 0.1883 0.1838
Loa Loa (eye worm) hypothetical protein 0.0032 0.0294 0.0253
Trypanosoma brucei hexokinase 0.0175 0.2986 1
Schistosoma mansoni smad 0.0035 0.0353 0.0299
Echinococcus multilocularis thioredoxin glutathione reductase 0.0097 0.1515 0.1385
Mycobacterium tuberculosis Putative ferredoxin reductase 0.022 0.3846 0.8837
Loa Loa (eye worm) hypothetical protein 0.0122 0.199 0.2079
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.022 0.3846 0.8837
Trypanosoma brucei heat shock protein, putative 0.0101 0.1589 0.4746
Leishmania major heat shock protein 83-1 0.0101 0.1589 0.4746
Trichomonas vaginalis heat shock protein, putative 0.0073 0.1069 0.2428
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0035 0.0353 0.0205
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0245 0.431 1
Plasmodium falciparum thioredoxin reductase 0.0097 0.1515 0.2095
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0037 0.0389 0.0628
Schistosoma mansoni hypothetical protein 0.0032 0.0294 0.024
Mycobacterium tuberculosis Probable reductase 0.022 0.3846 0.8837
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0033 0.0326 0.034

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.