TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 461.813 | Formula: C20H27Cl3N4O2
H donors: 1 H acceptors: 2 LogP: 3.96 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CC(c1noc(c1)CNCCN1CCN(CC1)C(=O)c1ccc(c(c1)Cl)Cl)C.Cl
InChi: 1S/C20H26Cl2N4O2.ClH/c1-14(2)19-12-16(28-24-19)13-23-5-6-25-7-9-26(10-8-25)20(27)15-3-4-17(21)18(22)11-15;/h3-4,11-12,14,23H,5-10,13H2,1-2H3;1H
InChiKey: QXFGIGPHXNCGQI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0111	0.0389
Onchocerca volvulus		0.004	0.0294	0.1042
Echinococcus granulosus	single minded 2	0.004	0.0294	0.0348
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0015	0.001	0.001
Echinococcus multilocularis	musashi	0.003	0.0181	0.0179
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0176	0.0622
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0025	0.0128	0.014
Schistosoma mansoni	RAR-like nuclear receptor	0.0025	0.0128	0.014
Loa Loa (eye worm)	phosphatidylinositol 3	0.0044	0.034	0.0404
Brugia malayi	Nuclear hormone receptor-like 1	0.0025	0.0128	0.014
Brugia malayi	hypoxia-induced factor 1	0.0166	0.1729	0.2039
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0025	0.0128	0.014
Brugia malayi	RNA binding protein	0.0062	0.0543	0.0632
Brugia malayi	nuclear receptor NHR-88	0.0025	0.0128	0.014
Echinococcus granulosus	lamin	0.003	0.0181	0.0213
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0025	0.0128	0.014
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0025	0.0128	0.0126
Onchocerca volvulus	Protein ultraspiracle homolog	0.0025	0.0128	0.045
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0015	0.001	0.0034
Loa Loa (eye worm)	intermediate filament protein	0.003	0.0181	0.0215
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0025	0.0128	0.015
Schistosoma mansoni	aryl hydrocarbon receptor	0.0054	0.0452	0.0525
Brugia malayi	isocitrate dehydrogenase	0.0017	0.0041	0.0037
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0238	0.0842
Toxoplasma gondii	aldehyde dehydrogenase	0.0067	0.0604	1
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0017	0.0041	0.0166
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0128	0.0152
Loa Loa (eye worm)	RNA binding protein	0.0062	0.0543	0.0646
Loa Loa (eye worm)	transcription factor SMAD2	0.0132	0.1339	0.1591
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0033	0.0217	0.3128
Trypanosoma cruzi	target of rapamycin kinase 3	0.0035	0.0239	0.0998
Echinococcus granulosus	GTPase activating Rap:RanGAP domain 3	0.0224	0.2377	0.2825
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0025	0.0128	0.014
Schistosoma mansoni	coup transcription factor	0.0025	0.0128	0.014
Schistosoma mansoni	mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3	0.0224	0.2377	0.2807
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0238	0.0842
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0044	0.034	0.5616
Trichomonas vaginalis	set domain proteins, putative	0.0262	0.281	1
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0226	0.2408	0.2862
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.034	0.1204
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0025	0.0128	0.0126
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0128	0.0152
Echinococcus granulosus	tumor protein p63	0.0329	0.3576	0.4251
Schistosoma mansoni	aldehyde dehydrogenase	0.0067	0.0604	0.0704
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0017	0.0041	0.5
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0035	0.0239	0.3935
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0128	0.0152
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0017	0.0041	0.0047
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0128	0.0152
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0025	0.0128	0.014
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0025	0.0128	0.014
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0067	0.0604	1
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0033	0.0217	0.0246
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0025	0.0128	0.0152
Schistosoma mansoni	protein kinase	0.0535	0.5909	0.6995
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0212	0.0751
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0015	0.001	0.0029
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0017	0.0041	0.0657
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.014	0.0493
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0217	0.0246
Schistosoma mansoni	vam6/vps39 related	0.0224	0.2377	0.2807
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0238	0.0842
Echinococcus multilocularis	lamin dm0	0.003	0.0181	0.0179
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0025	0.0128	0.0126
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0033	0.0212	0.3046
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0014	0.0006	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0128	0.0152
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0212	0.0751
Echinococcus multilocularis	tumor protein p63	0.0329	0.3576	0.3575
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0025	0.0128	0.0126
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0025	0.0128	0.0152
Trypanosoma brucei	Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative	0.0224	0.2377	1
Brugia malayi	MH2 domain containing protein	0.0132	0.1339	0.1576
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0025	0.0128	0.014
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0025	0.0128	0.0126
Echinococcus multilocularis	FTZ F1 alpha	0.0025	0.0128	0.0126
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.0226	0.2408	0.2862
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0025	0.0128	0.0126
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.034	0.1204
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0006	0.0007
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0025	0.0128	0.015
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0025	0.0128	0.014
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0025	0.0128	0.0152
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0015	0.001	0.0008
Schistosoma mansoni	serine/threonine protein kinase	0.0226	0.2408	0.2844
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0166	0.1729	0.2056
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0032	0.0203	0.024
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.003	0.0181	0.0215
Schistosoma mansoni	thyroid hormone receptor	0.0025	0.0128	0.014
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0021	0.0078	0.0289
Echinococcus granulosus	protein kinase	0.0535	0.5909	0.7024
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0226	0.2408	0.2407
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0025	0.0128	0.0152
Echinococcus multilocularis	transfer RNA-Lys	0.004	0.0294	0.0293
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0543	0.0632
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0067	0.0604	1
Loa Loa (eye worm)	steroid hormone receptor	0.0025	0.0128	0.0152
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0044	0.034	0.0402
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0044	0.034	0.5
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0017	0.0033	0.0131
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0025	0.0128	0.0152
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0025	0.0128	0.015
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0137	0.0482
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0212	0.0751
Brugia malayi	Pre-SET motif family protein	0.0033	0.0217	0.0246
Brugia malayi	steroid hormone receptor	0.0025	0.0128	0.014
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0002	0.0002
Loa Loa (eye worm)	aryl Hydrocarbon receptor Associated protein family member	0.0014	0.0002	0.0002
Schistosoma mansoni	single-minded	0.0054	0.0452	0.0525
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0111	0.0391
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0543	0.0632
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0017	0.0041	0.0133
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0217	0.0258
Onchocerca volvulus		0.0025	0.0128	0.045
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0025	0.0128	0.014
Schistosoma mansoni	retinoic acid receptor RXR	0.0025	0.0128	0.014
Echinococcus granulosus	histone lysine methyltransferase setb	0.0033	0.0217	0.0256
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0212	0.0751
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0212	0.0751
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0111	0.0389
Plasmodium vivax	SET domain protein, putative	0.0033	0.0217	1
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0044	0.034	0.1394
Brugia malayi	Temporarily assigned gene name protein 59	0.0224	0.2377	0.2807
Brugia malayi	TAR-binding protein	0.0062	0.0543	0.0632
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0025	0.0128	0.014
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0111	0.0389
Mycobacterium leprae	Possible regulatory protein	0.0014	0.0002	0.5
Loa Loa (eye worm)	hypothetical protein	0.018	0.1887	0.2244
Brugia malayi	Protein kinase domain containing protein	0.0226	0.2408	0.2844
Echinococcus granulosus	tar DNA binding protein	0.0062	0.0543	0.0644
Brugia malayi	Isocitrate dehydrogenase	0.0017	0.0041	0.0037
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.014	0.0493
Schistosoma mansoni	protein kinase	0.0759	0.8443	1
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0025	0.0128	0.014
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0015	0.001	0.0135
Schistosoma mansoni	serine/threonine protein kinase	0.0226	0.2408	0.2844
Onchocerca volvulus		0.003	0.0181	0.0639
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0217	0.0246
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.014	0.0493
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0025	0.0128	0.014
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0543	0.0632
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0025	0.0128	0.015
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.023	0.245	0.2913
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0025	0.0128	0.015
Brugia malayi	Steroid receptor seven-up type 2	0.0025	0.0128	0.014
Echinococcus granulosus	microtubule associated protein 2	0.0673	0.7468	0.8878
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0025	0.0128	0.0152
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0025	0.0128	0.014
Loa Loa (eye worm)	MH2 domain-containing protein	0.0132	0.1339	0.1591
Echinococcus granulosus	FTZ F1 alpha	0.0025	0.0128	0.015
Loa Loa (eye worm)	hypothetical protein	0.0224	0.2377	0.2826
Leishmania major	protein kinase, putative	0.0017	0.0033	0.0515
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0015	0.001	0.0029
Onchocerca volvulus		0.003	0.0181	0.0639
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0035	0.0239	0.0967
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0067	0.0604	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0062	0.0543	0.0646
Trypanosoma cruzi	STE group serine/threonine-protein kinase, putative	0.0017	0.0033	0.0131
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0015	0.001	0.0029
Echinococcus multilocularis	GTPase activating Rap:RanGAP domain 3	0.0224	0.2377	0.2376
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0238	0.0842
Loa Loa (eye worm)	hypothetical protein	0.0048	0.039	0.0463
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0044	0.034	0.1424
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0175	0.0208
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0044	0.034	0.1424
Brugia malayi	hypothetical protein	0.0224	0.2377	0.2807
Brugia malayi	RNA recognition motif domain containing protein	0.0062	0.0543	0.0632
Onchocerca volvulus		0.0033	0.0217	0.0767
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0017	0.0041	0.0049
Schistosoma mansoni	lamin	0.003	0.0181	0.0203
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0128	0.0152
Brugia malayi	intermediate filament protein	0.003	0.0181	0.0203
Loa Loa (eye worm)	hypothetical protein	0.003	0.0181	0.0215
Onchocerca volvulus		0.0262	0.281	1
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0025	0.0128	0.0126
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0025	0.0128	0.015
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0217	0.0246
Schistosoma mansoni	cellular tumor antigen P53	0.0048	0.039	0.0451
Leishmania major	protein kinase, putative	0.0017	0.0033	0.0515
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0044	0.034	0.5
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0044	0.034	0.0391
Echinococcus multilocularis	lamin	0.003	0.0181	0.0179
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0025	0.0128	0.014
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0016	0.0024	0.0029
Trypanosoma cruzi	STE group serine/threonine-protein kinase, putative	0.0017	0.0033	0.0131
Brugia malayi	ecdysteroid receptor	0.0025	0.0128	0.014
Loa Loa (eye worm)	TAR-binding protein	0.0062	0.0543	0.0646
Brugia malayi	Intermediate filament tail domain containing protein	0.003	0.0181	0.0203
Schistosoma mansoni	nuclear hormone receptor	0.0025	0.0128	0.014
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0035	0.0238	0.0842
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0212	0.0751
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0028	0.0165	0.0584
Schistosoma mansoni	intermediate filament proteins	0.003	0.0181	0.0203
Echinococcus granulosus	ecdysone induced protein 78C	0.0025	0.0128	0.015
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0044	0.034	0.0338
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0067	0.0604	1
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0226	0.2408	0.2862
Brugia malayi	PAS domain containing protein	0.0054	0.0452	0.0525
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0044	0.034	0.1394
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0111	0.0391
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0044	0.034	0.1204
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0017	0.0041	0.0133
Echinococcus multilocularis	ecdysone induced protein 78C	0.0025	0.0128	0.0126
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0017	0.0041	0.004
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0025	0.0128	0.014
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0111	0.0391
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0015	0.001	0.0029
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0015	0.001	0.0029
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0033	0.0217	0.0216
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0128	0.0152
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0033	0.0217	0.0216
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0025	0.0128	0.014
Giardia lamblia	GTOR	0.0044	0.034	0.5
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0025	0.0128	0.045
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0017	0.0041	0.004
Onchocerca volvulus		0.0048	0.039	0.1382
Loa Loa (eye worm)	phosphatidylinositol 3	0.0015	0.001	0.0012
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.0226	0.2408	0.2407
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0025	0.0128	0.014
Echinococcus multilocularis	isocitrate dehydrogenase	0.0017	0.0041	0.004
Schistosoma mansoni	hypothetical protein	0.0224	0.2377	0.2807
Trypanosoma cruzi	Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative	0.0224	0.2377	1
Echinococcus multilocularis	microtubule associated protein 2	0.0673	0.7468	0.7467
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0044	0.034	0.0391
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0024	0.0111	0.0391
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0025	0.0128	0.014
Loa Loa (eye worm)	hypothetical protein	0.0224	0.2377	0.2826
Echinococcus granulosus	serine:threonine protein kinase mig 15	0.0756	0.8411	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0226	0.2408	0.2407
Schistosoma mansoni	mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3	0.0224	0.2377	0.2807
Onchocerca volvulus		0.0224	0.2377	0.8458
Loa Loa (eye worm)	STE/STE20/MSN protein kinase	0.0535	0.5909	0.7024
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0017	0.0041	0.0166
Brugia malayi	probable protein kinase	0.0759	0.8443	1
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0067	0.0604	0.0716
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0015	0.001	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0756	0.8411	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0025	0.0128	0.015
Chlamydia trachomatis	two component regulatory system sensor histidine kinase	0.0014	0.0002	0.5
Echinococcus granulosus	lamin dm0	0.003	0.0181	0.0213
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0017	0.0041	0.0037
Echinococcus multilocularis		0.0535	0.5909	0.5908
Brugia malayi	bHLH-PAS transcription factor	0.004	0.0294	0.0337
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0017	0.0041	0.004
Brugia malayi	photoreceptor-specific nuclear receptor	0.0025	0.0128	0.014
Brugia malayi	Pre-SET motif family protein	0.023	0.245	0.2894
Schistosoma mansoni	thyroid hormone receptor	0.0025	0.0128	0.014
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0017	0.0033	0.0131
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0037	0.0267	0.0946
Schistosoma mansoni	rap gtpase-activating protein	0.0224	0.2377	0.2807
Brugia malayi	cytoplasmic intermediate filament protein	0.0016	0.0024	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0128	0.0152
Loa Loa (eye worm)	hypothetical protein	0.0224	0.2377	0.2826
Onchocerca volvulus	Bile acid receptor homolog	0.0025	0.0128	0.045
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0044	0.034	0.5616
Brugia malayi	nuclear hormone receptor	0.0025	0.0128	0.014
Echinococcus multilocularis	tar DNA binding protein	0.0062	0.0543	0.0542
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0025	0.0128	0.0152
Brugia malayi	hypothetical protein	0.018	0.1887	0.2227
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0015	0.001	0.0135
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0026	0.0137	0.0482
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0025	0.0128	0.014
Loa Loa (eye worm)	STE/STE20/KHS protein kinase	0.0226	0.2408	0.2863
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0014	0.0006	0.0006
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0067	0.0604	0.0602
Echinococcus granulosus	Vam6:Vps39 protein	0.0224	0.2377	0.2825
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0543	0.0632
Trypanosoma cruzi	Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative	0.0224	0.2377	1
Schistosoma mansoni	lamin	0.003	0.0181	0.0203
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0025	0.0128	0.014
Schistosoma mansoni	protein kinase	0.0226	0.2408	0.2844
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0018	0.0049	0.0168
Schistosoma mansoni	microtubule-associated protein tau	0.0673	0.7468	0.8844
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0017	0.0041	0.004
Echinococcus granulosus	intermediate filament protein	0.003	0.0181	0.0213
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0033	0.0212	0.0751
Schistosoma mansoni	aldehyde dehydrogenase	0.0067	0.0604	0.0704
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0543	0.0632
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0067	0.0604	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)	= 16.1 %	Displacement of [3H]8-OH-DPAT from human 5-HT7 receptor expressed in HEK293 cells at 10 uM	ChEMBL.	22196512
Inhibition (binding)	= 76.4 %	Displacement of [3H]LSD from human 5-HT1A receptor expressed in CHO-K1 cells at 10 uM	ChEMBL.	22196512

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1929178

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1562477