TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 439.401 | Formula: C19H13N5O6S
H donors: 2 H acceptors: 5 LogP: 1.67 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: N=C1NC(=O)/C(=C/c2cn(Cc3ccc(o3)c3ccccc3[N+](=O)[O-])c(=O)[nH]c2=O)/S1
InChi: 1S/C19H13N5O6S/c20-18-21-17(26)15(31-18)7-10-8-23(19(27)22-16(10)25)9-11-5-6-14(30-11)12-3-1-2-4-13(12)24(28)29/h1-8H,9H2,(H2,20,21,26)(H,22,25,27)/b15-7-
InChiKey: MPSMSGFGSFJFCW-CHHVJCJISA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Plasmodium falciparum	serine repeat antigen 2	0.0092	0.0906	0.0845
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0427	0.6585	1
Entamoeba histolytica	cysteine proteinase, putative	0.0228	0.3208	0.4556
Schistosoma mansoni	cathepsin F (C01 family)	0.0427	0.6585	0.6502
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0092	0.0906	0.0845
Echinococcus multilocularis	cathepsin b	0.0629	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0427	0.6585	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0427	0.6585	0.6449
Loa Loa (eye worm)	fibroinase	0.0427	0.6585	0.6585
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0427	0.6585	1
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0092	0.0906	0.0845
Entamoeba histolytica	hypothetical protein	0.0092	0.0906	0.0845
Plasmodium vivax	serine-repeat antigen 4 (SERA)	0.0092	0.0906	0.0845
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0092	0.0906	0.0906
Trypanosoma cruzi	cysteine proteinase, putative	0.0228	0.3208	0.2939
Giardia lamblia	Hypothetical protein	0.0092	0.0906	0.1571
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0427	0.6585	1
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0382	0.0382
Brugia malayi	Papain family cysteine protease containing protein	0.0228	0.3208	0.3044
Onchocerca volvulus	Cathepsin L homolog	0.0427	0.6585	1
Leishmania major	cathepsin L-like protease	0.0427	0.6585	1
Giardia lamblia	Cathepsin B precursor	0.0092	0.0906	0.1571
Trypanosoma cruzi	cysteine peptidase, putative	0.0427	0.6585	0.6449
Trypanosoma cruzi	major cysteine proteinase, putative	0.0092	0.0906	0.0545
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0228	0.3208	0.3044
Schistosoma mansoni	hypothetical protein	0.0061	0.0382	0.0149
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0055	0.0277	0.0042
Plasmodium falciparum	cysteine proteinase falcipain 1	0.0228	0.3208	0.4556
Loa Loa (eye worm)	hypothetical protein	0.0629	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0427	0.6585	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0629	1	1
Schistosoma mansoni	cathepsin s	0.0136	0.1642	0.1439
Plasmodium vivax	serine-repeat antigen 2 (SERA)	0.0092	0.0906	0.0845
Giardia lamblia	Cathepsin L precursor	0.0092	0.0906	0.1571
Entamoeba histolytica	cysteine proteinase 2	0.0228	0.3208	0.4556
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0906	0.0906
Plasmodium vivax	dipeptidyl aminopeptidase 3, putative	0.0092	0.0906	0.0845
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0427	0.6585	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0228	0.3208	0.2939
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0092	0.0906	0.1571
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0427	0.6585	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0427	0.6585	1
Plasmodium vivax	dipeptidyl aminopeptidase 2, putative	0.0092	0.0906	0.0845
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0092	0.0906	0.0845
Loa Loa (eye worm)	hypothetical protein	0.0292	0.4283	0.4283
Schistosoma mansoni	SmCB2 peptidase (C01 family)	0.0629	1	1
Plasmodium vivax	serine-repeat antigen (SERA)	0.0092	0.0906	0.0845
Schistosoma mansoni	hypothetical protein	0.0168	0.2185	0.1995
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0427	0.6585	1
Entamoeba histolytica	cysteine protease, putative	0.0228	0.3208	0.4556
Trypanosoma cruzi	cysteine peptidase (N-terminal), putative	0.0228	0.3208	0.2939
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0629	1	1
Giardia lamblia	Hypothetical protein	0.0092	0.0906	0.1571
Entamoeba histolytica	cysteine protease, putative	0.0427	0.6585	1
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0092	0.0906	0.0686
Onchocerca volvulus		0.0427	0.6585	1
Toxoplasma gondii	cathepsin CPC2	0.0092	0.0906	0.0845
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0427	0.6585	1
Brugia malayi	Cathepsin L-like precursor	0.0427	0.6585	0.6502
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0427	0.6585	1
Plasmodium vivax	vivapain-1	0.0228	0.3208	0.4556
Brugia malayi	Cathepsin L-like precursor	0.0427	0.6585	0.6502
Trichomonas vaginalis	Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase	0.0092	0.0906	0.0845
Entamoeba histolytica	cysteine protease, putative	0.0092	0.0906	0.0845
Onchocerca volvulus		0.0427	0.6585	1
Trichomonas vaginalis	conserved hypothetical protein	0.0092	0.0906	0.0845
Giardia lamblia	Cysteine protease	0.0092	0.0906	0.1571
Echinococcus granulosus	cysteine protease	0.0228	0.3208	0.3015
Schistosoma mansoni	cathepsin F (C01 family)	0.0292	0.4283	0.4144
Plasmodium falciparum	dipeptidyl aminopeptidase 2	0.0092	0.0906	0.0845
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0427	0.6585	1
Entamoeba histolytica	cysteine proteinase 1, putative	0.0228	0.3208	0.4556
Leishmania major	cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like	0.0258	0.3719	0.5379
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0427	0.6585	1
Plasmodium falciparum	serine repeat antigen 8	0.0092	0.0906	0.0845
Plasmodium vivax	serine-repeat antigen 5 (SERA)	0.0092	0.0906	0.0845
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0906	0.0906
Loa Loa (eye worm)	cysteine protease	0.0427	0.6585	0.6585
Plasmodium vivax	dipeptidyl aminopeptidase 1, putative	0.0092	0.0906	0.0845
Brugia malayi	cathepsin F-like cysteine proteinase	0.0136	0.1642	0.1439
Entamoeba histolytica	cysteine proteinase, putative	0.0292	0.4283	0.6288
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0427	0.6585	1
Plasmodium falciparum	serine repeat antigen 9	0.0092	0.0906	0.0845
Plasmodium falciparum	dipeptidyl aminopeptidase 3	0.0092	0.0906	0.0845
Brugia malayi	cathepsin L-like precursor	0.0292	0.4283	0.4144
Schistosoma mansoni	cathepsin C	0.0092	0.0906	0.0686
Echinococcus multilocularis	cathepsin L	0.0228	0.3208	0.3208
Brugia malayi	Cathepsin L-like precursor	0.0136	0.1642	0.1439
Giardia lamblia	Cathepsin B precursor	0.0092	0.0906	0.1571
Onchocerca volvulus		0.0427	0.6585	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0427	0.6585	1
Leishmania major	cathepsin L-like protease	0.0427	0.6585	1
Plasmodium falciparum	serine repeat antigen 1	0.0092	0.0906	0.0845
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0092	0.0906	0.0686
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0228	0.3208	0.3044
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0602	0.9554	0.9554
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0427	0.6585	1
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0092	0.0906	0.0686
Leishmania major	cathepsin L-like protease	0.0427	0.6585	1
Loa Loa (eye worm)	hypothetical protein	0.0427	0.6585	0.6585
Trichomonas vaginalis	Clan CA, family C1, cathepsin H-like cysteine peptidase	0.0092	0.0906	0.0845
Loa Loa (eye worm)	calpain family protein 1	0.0053	0.0237	0.0237
Plasmodium vivax	vivapain-2	0.0427	0.6585	1
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0258	0.3719	0.3469
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0427	0.6585	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0228	0.3208	0.4556
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0228	0.3208	0.4556
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0092	0.0906	0.0845
Entamoeba histolytica	cysteine proteinase, putative	0.0228	0.3208	0.4556
Giardia lamblia	Cysteine protease	0.0092	0.0906	0.1571
Giardia lamblia	Cathepsin B precursor	0.0092	0.0906	0.1571
Giardia lamblia	Cathepsin L precursor	0.0092	0.0906	0.1571
Entamoeba histolytica	cysteine protease, putative	0.0228	0.3208	0.4556
Entamoeba histolytica	cysteine protease, putative	0.0228	0.3208	0.4556
Entamoeba histolytica	cysteine protease, putative	0.0228	0.3208	0.4556
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0228	0.3208	0.4556
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0092	0.0906	0.0845
Schistosoma mansoni	hypothetical protein	0.0168	0.2185	0.1995
Plasmodium vivax	unspecified product	0.0136	0.1642	0.2031
Brugia malayi	cathepsin L precursor	0.0092	0.0906	0.0686
Echinococcus multilocularis	cathepsin b	0.0629	1	1
Giardia lamblia	Cathepsin L precursor	0.0092	0.0906	0.1571
Brugia malayi	cathepsin Z-like cysteine proteinase	0.0092	0.0906	0.0686
Trypanosoma cruzi	cysteine peptidase C (CPC), putative	0.0629	1	1
Leishmania major	cathepsin L-like protease	0.0427	0.6585	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0427	0.6585	0.6449
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0292	0.4283	0.4144
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0427	0.6585	1
Loa Loa (eye worm)	ctsf protein	0.0427	0.6585	0.6585
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0427	0.6585	1
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0427	0.6585	0.6488
Loa Loa (eye worm)	hypothetical protein	0.0136	0.1642	0.1642
Plasmodium falciparum	serine repeat antigen 6	0.0092	0.0906	0.0845
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0258	0.3719	0.3566
Entamoeba histolytica	cysteine protease, putative	0.0228	0.3208	0.4556
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0092	0.0906	0.0686
Entamoeba histolytica	cysteine protease, putative	0.0092	0.0906	0.0845
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0092	0.0906	0.0686
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0427	0.6585	0.6585
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0292	0.4283	0.6288
Entamoeba histolytica	cysteine protease, putative	0.0092	0.0906	0.0845
Brugia malayi	Papain family cysteine protease containing protein	0.0092	0.0906	0.0686
Echinococcus multilocularis	cathepsin L	0.0092	0.0906	0.0906
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0427	0.6585	1
Schistosoma mansoni	SmCL2-like peptidase (C01 family)	0.0228	0.3208	0.3044
Entamoeba histolytica	cysteine protease, putative	0.0228	0.3208	0.4556
Leishmania major	cathepsin L-like protease	0.0427	0.6585	1
Brugia malayi	Cathepsin L-like precursor	0.0427	0.6585	0.6502
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0427	0.6585	0.6585
Toxoplasma gondii	cathepsin CPC1	0.0092	0.0906	0.0845
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0092	0.0906	0.0845
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0427	0.6585	1
Brugia malayi	Cathepsin L-like precursor	0.0427	0.6585	0.6502
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0427	0.6585	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0092	0.0906	0.0845
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0427	0.6585	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0427	0.6585	0.6585
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0092	0.0906	0.0845
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0427	0.6585	1
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0906	0.0906
Onchocerca volvulus		0.0427	0.6585	1
Schistosoma mansoni	cathepsin B (C01 family)	0.0092	0.0906	0.0686
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0427	0.6585	0.6585
Giardia lamblia	Cysteine protease	0.0092	0.0906	0.1571
Plasmodium falciparum	serine repeat antigen 5	0.0092	0.0906	0.0845
Brugia malayi	fibroinase precursor	0.0092	0.0906	0.0686
Schistosoma mansoni	cathepsin F (C01 family)	0.0427	0.6585	0.6502
Loa Loa (eye worm)	hypothetical protein	0.0136	0.1642	0.1642
Giardia lamblia	Cathepsin L-like protease	0.0092	0.0906	0.1571
Echinococcus multilocularis	prefoldin subunit 6	0.0061	0.0382	0.0382
Trypanosoma brucei	cysteine peptidase C (CPC)	0.0258	0.3719	0.5379
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0092	0.0906	0.0686
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0258	0.3719	0.5379
Plasmodium falciparum	serine repeat antigen 7	0.0092	0.0906	0.0845
Leishmania major	cathepsin L-like protease	0.0427	0.6585	1
Entamoeba histolytica	cysteine protease, putative	0.0092	0.0906	0.0845
Trypanosoma cruzi	cysteine peptidase, putative	0.0427	0.6585	0.6449
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0906	0.0906
Brugia malayi	Papain family cysteine protease containing protein	0.0092	0.0906	0.0686
Echinococcus multilocularis	family C2 unassigned peptidase (C02 family)	0.0055	0.0277	0.0277
Schistosoma mansoni	subfamily C1A non-peptidase homologue (C01 family)	0.0092	0.0906	0.0686
Entamoeba histolytica	cysteine protease, putative	0.0092	0.0906	0.0845
Giardia lamblia	Cathepsin B-like cysteine proteinase 3 precursor	0.0092	0.0906	0.1571
Plasmodium vivax	serine-repeat antigen 3 (SERA)	0.0092	0.0906	0.0845
Entamoeba histolytica	cysteine protease, putative	0.0228	0.3208	0.4556
Echinococcus multilocularis	cysteine protease	0.0427	0.6585	0.6585
Onchocerca volvulus	Cathepsin F homolog	0.0427	0.6585	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0292	0.4283	0.6288
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0092	0.0906	0.0845
Echinococcus granulosus	prefoldin subunit 6	0.0061	0.0382	0.0108
Brugia malayi	Cathepsin L-like precursor	0.0292	0.4283	0.4144
Schistosoma mansoni	cathepsin S (C01 family)	0.0092	0.0906	0.0686
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0092	0.0906	0.0845
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0092	0.0906	0.1571
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0092	0.0906	0.0845
Onchocerca volvulus		0.0427	0.6585	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0092	0.0906	0.0845
Giardia lamblia	Cathepsin L-like protease	0.0092	0.0906	0.1571
Echinococcus granulosus	cathepsin b	0.0629	1	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0427	0.6585	1
Brugia malayi	Papain family cysteine protease containing protein	0.0228	0.3208	0.3044
Giardia lamblia	Cathepsin B precursor	0.0092	0.0906	0.1571
Entamoeba histolytica	cysteine proteinase, putative	0.0427	0.6585	1
Entamoeba histolytica	cysteine protease, putative	0.0228	0.3208	0.4556
Entamoeba histolytica	cysteine protease, putative	0.0228	0.3208	0.4556
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0427	0.6585	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0092	0.0906	0.0845
Leishmania major	cysteine peptidase A (CPA)	0.0427	0.6585	1
Echinococcus multilocularis	cysteine protease	0.0427	0.6585	0.6585
Onchocerca volvulus		0.0427	0.6585	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0292	0.4283	0.4056
Leishmania major	cathepsin L-like protease	0.0427	0.6585	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0602	0.9554	0.9542
Giardia lamblia	Cathepsin B precursor	0.0092	0.0906	0.1571
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0427	0.6585	1
Loa Loa (eye worm)	cathepsin B	0.0258	0.3719	0.3719
Giardia lamblia	Dipeptidyl-peptidase I precursor	0.0092	0.0906	0.1571
Entamoeba histolytica	cysteine protease, putative	0.0228	0.3208	0.4556
Entamoeba histolytica	papain family cysteine protease domain containing protein	0.0092	0.0906	0.0845
Plasmodium falciparum	serine repeat antigen 4	0.0092	0.0906	0.0845
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0427	0.6585	1
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0092	0.0906	0.0686
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0136	0.1642	0.1642
Trypanosoma cruzi	cysteine peptidase, putative	0.0427	0.6585	0.6449
Brugia malayi	Cathepsin L-like precursor	0.0292	0.4283	0.4144
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0906	0.0906
Entamoeba histolytica	cysteine protease, putative	0.0228	0.3208	0.4556
Entamoeba histolytica	cysteine proteinase, putative	0.0228	0.3208	0.4556
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0427	0.6585	1
Echinococcus granulosus	cathepsin L	0.0228	0.3208	0.3015
Onchocerca volvulus		0.0292	0.4283	0.5946
Brugia malayi	Papain family cysteine protease containing protein	0.0092	0.0906	0.0686
Echinococcus multilocularis	geminin	0.0168	0.2185	0.2185
Entamoeba histolytica	cysteine protease, putative	0.0228	0.3208	0.4556
Trichomonas vaginalis	conserved hypothetical protein	0.0092	0.0906	0.0845
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0092	0.0906	0.0906
Echinococcus granulosus	cathepsin L	0.0092	0.0906	0.0647
Loa Loa (eye worm)	hypothetical protein	0.0136	0.1642	0.1642
Trichomonas vaginalis	Clan CA, family C1, cathepsin B-like cysteine peptidase	0.0092	0.0906	0.0845
Leishmania major	cathepsin L-like protease	0.0427	0.6585	1
Giardia lamblia	Encystation-specific protease	0.0092	0.0906	0.1571
Echinococcus granulosus	cathepsin l1	0.0292	0.4283	0.412
Toxoplasma gondii	preprocathepsin c precursor, putative	0.0092	0.0906	0.0845
Entamoeba histolytica	cysteine proteinase, putative	0.0427	0.6585	1
Echinococcus multilocularis	calpain A	0.0055	0.0277	0.0277
Echinococcus granulosus	cathepsin L cysteine protease	0.0228	0.3208	0.3015
Trypanosoma cruzi	cysteine proteinase, putative	0.0228	0.3208	0.2939
Entamoeba histolytica	cysteine protease, putative	0.0228	0.3208	0.4556
Trypanosoma cruzi	cruzipain precursor, putative	0.0136	0.1642	0.131
Brugia malayi	cathepsin L-like cysteine proteinase, identical	0.0136	0.1642	0.1439
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0427	0.6585	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0427	0.6585	1
Giardia lamblia	Cathepsin L precursor	0.0092	0.0906	0.1571
Onchocerca volvulus		0.0427	0.6585	1
Giardia lamblia	Cathepsin B precursor	0.0258	0.3719	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0135	0.0135
Brugia malayi	Cathepsin L-like precursor	0.0427	0.6585	0.6502
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0228	0.3208	0.4556
Schistosoma mansoni	cathepsin B-like peptidase (C01 family)	0.0629	1	1
Echinococcus granulosus	cathepsin b	0.0629	1	1
Plasmodium vivax	unspecified product	0.0092	0.0906	0.0845
Entamoeba histolytica	cysteine proteinase, putative	0.0228	0.3208	0.4556
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0427	0.6585	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0427	0.6585	1
Brugia malayi	Papain family cysteine protease containing protein	0.0427	0.6585	0.6502
Giardia lamblia	Cysteine protease	0.0092	0.0906	0.1571
Echinococcus multilocularis	cathepsin L cysteine protease	0.0427	0.6585	0.6585
Toxoplasma gondii	cathepsin CPL	0.0427	0.6585	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0427	0.6585	1
Brugia malayi	cathepsin F-like cysteine proteinase	0.0092	0.0906	0.0686
Trypanosoma cruzi	cysteine peptidase, putative	0.0136	0.1642	0.131
Loa Loa (eye worm)	hypothetical protein	0.0292	0.4283	0.4283
Plasmodium falciparum	serine repeat antigen 3	0.0092	0.0906	0.0845
Giardia lamblia	Cathepsin B precursor	0.0258	0.3719	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0427	0.6585	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0427	0.6585	1
Plasmodium vivax	serine-repeat antigen (SERA), putative	0.0092	0.0906	0.0845
Plasmodium vivax	serine-repeat antigen 4 (SERA), putative	0.0092	0.0906	0.0845
Trypanosoma cruzi	cysteine protease, putative	0.0228	0.3208	0.2939
Plasmodium vivax	serine-repeat antigen (SERA)	0.0092	0.0906	0.0845
Brugia malayi	cahepsin L-like non-peptiedase homolog	0.0092	0.0906	0.0686
Echinococcus granulosus	cathepsin l1	0.0427	0.6585	0.6488
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0427	0.6585	0.6585
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0427	0.6585	1
Entamoeba histolytica	cysteine protease, putative	0.0092	0.0906	0.0845
Echinococcus granulosus	geminin	0.0168	0.2185	0.1962
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or H-like cysteine peptidase	0.0092	0.0906	0.0845
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0906	0.0906
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0427	0.6585	1
Plasmodium falciparum	dipeptidyl aminopeptidase 1	0.0092	0.0906	0.0845
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0237	0.0237
Loa Loa (eye worm)	hypothetical protein	0.0292	0.4283	0.4283
Trichomonas vaginalis	Clan CA, family C1, cathepsin F-like cysteine peptidase	0.0092	0.0906	0.0845
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0427	0.6585	1
Onchocerca volvulus	Cathepsin L homolog	0.0427	0.6585	1
Loa Loa (eye worm)	cysteine proteinase cathepsin Z	0.0092	0.0906	0.0906
Schistosoma mansoni	subfamily C1A unassigned peptidase (C01 family)	0.0092	0.0906	0.0686
Giardia lamblia	Cathepsin L precursor	0.0092	0.0906	0.1571
Plasmodium vivax	vivapain-3	0.0228	0.3208	0.4556
Plasmodium vivax	unspecified product	0.0228	0.3208	0.4556
Brugia malayi	Cathepsin L-like precursor	0.0427	0.6585	0.6502
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0092	0.0906	0.0845
Giardia lamblia	Cathepsin B precursor	0.0258	0.3719	1
Brugia malayi	KE2 family protein	0.0061	0.0382	0.0149
Plasmodium vivax	vivapain-2	0.0427	0.6585	1
Toxoplasma gondii	cathepsin B	0.0258	0.3719	0.5379
Schistosoma mansoni	dipeptidyl-peptidase I (C01 family)	0.0092	0.0906	0.0686
Schistosoma mansoni	family C2 unassigned peptidase (C02 family)	0.0055	0.0277	0.0042
Trypanosoma cruzi	major cysteine proteinase, putative	0.0092	0.0906	0.0545
Brugia malayi	cathepsin L-like cysteine proteinase	0.0092	0.0906	0.0686
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0427	0.6585	0.6488
Giardia lamblia	Cathepsin L precursor	0.0092	0.0906	0.1571

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1917172

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1566516