Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | histamine receptor H4 | Starlite/ChEMBL | References |
Homo sapiens | histamine receptor H1 | Starlite/ChEMBL | References |
Cavia porcellus | Histamine H1 receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.032 | 0.2639 | 0.2639 |
Schistosoma mansoni | choline o-acyltransferase | 0.0153 | 0.1144 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.0191 | 0.0191 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.1144 | 0.1144 |
Leishmania major | carnitine/choline acetyltransferase, putative | 0.0153 | 0.1144 | 0.2185 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0153 | 0.1144 | 0.2185 |
Trypanosoma cruzi | carnitine/choline acetyltransferase, putative | 0.0153 | 0.1144 | 0.2185 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.032 | 0.2639 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0153 | 0.1144 | 0.2185 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0153 | 0.1144 | 0.2185 |
Onchocerca volvulus | 0.0153 | 0.1144 | 0.5 | |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.032 | 0.2639 | 0.2639 |
Trypanosoma brucei | carnitine O-palmitoyltransferase, putative | 0.0153 | 0.1144 | 0.4335 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0153 | 0.1144 | 0.2185 |
Schistosoma mansoni | choline o-acyltransferase | 0.0153 | 0.1144 | 1 |
Onchocerca volvulus | 0.0153 | 0.1144 | 0.5 | |
Leishmania major | carnitine palmitoyltransferase-like protein | 0.032 | 0.2639 | 0.5042 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.032 | 0.2639 | 0.4854 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0153 | 0.1144 | 0.4335 |
Brugia malayi | Choline O-acetyltransferase | 0.0153 | 0.1144 | 0.1144 |
Onchocerca volvulus | 0.0153 | 0.1144 | 0.5 | |
Echinococcus granulosus | choline O acetyltransferase | 0.0153 | 0.1144 | 0.189 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0608 | 0.5235 | 1 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.0608 | 0.5235 | 1 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.032 | 0.2639 | 0.4854 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0608 | 0.5235 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0153 | 0.1144 | 0.2185 |
Loa Loa (eye worm) | hypothetical protein | 0.1138 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0153 | 0.1144 | 0.2185 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0153 | 0.1144 | 0.4335 |
Onchocerca volvulus | 0.0153 | 0.1144 | 0.5 | |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0153 | 0.1144 | 0.1144 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.0191 | 0.0191 |
Loa Loa (eye worm) | carnitine O-palmitoyltransferase I isoform | 0.0153 | 0.1144 | 0.1144 |
Brugia malayi | Choline O-acetyltransferase | 0.0153 | 0.1144 | 0.1144 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.0608 | 0.5235 | 1 |
Trypanosoma brucei | carnitine O-acetyltransferase, putative | 0.0153 | 0.1144 | 0.4335 |
Trypanosoma cruzi | carnitine/choline acetyltransferase, putative | 0.0153 | 0.1144 | 0.2185 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0 | 0.5 |
Trypanosoma cruzi | carnitine O-acetyltransferase, putative | 0.0153 | 0.1144 | 0.2185 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.0608 | 0.5235 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0026 | 0 | 0.5 |
Trypanosoma cruzi | choline/carnitine O-acetyltransferase, putative | 0.0153 | 0.1144 | 0.2185 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0153 | 0.1144 | 0.1144 |
Echinococcus multilocularis | choline O acetyltransferase | 0.0153 | 0.1144 | 0.189 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0 | 0.5 |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.032 | 0.2639 | 0.5042 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | Partial agonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 mins | ChEMBL. | 21944853 | |
Kd (functional) | = 7.69 | Antagonist activity at H1R in guinea pig ileum assessed as inhibition of histamine-induced muscle contraction after 15 mins | ChEMBL. | 21944853 |
Ki (binding) | = 4.8 | Displacement of [3H]histamine from human H4R expressed in Sf9 cells co-expressing RGS19, Galphai2 and Gbeta1gamma2 after 60 mins by liquid scintillation counting | ChEMBL. | 21944853 |
Ki (binding) | = 6.11 | Displacement of [3H]mepyramine from human H1R expressed in Sf9 cells co-expressing RGS4 after 90 mins by liquid scintillation counting | ChEMBL. | 21944853 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.