TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 363.41 | Formula: C21H21N3O3
H donors: 3 H acceptors: 3 LogP: 4.6 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1ccc(cc1)C(C)(C)C)NNC(=O)C(=O)c1c[nH]c2c1cccc2
InChi: 1S/C21H21N3O3/c1-21(2,3)14-10-8-13(9-11-14)19(26)23-24-20(27)18(25)16-12-22-17-7-5-4-6-15(16)17/h4-12,22H,1-3H3,(H,23,26)(H,24,27)
InChiKey: LHLIGXZPCUMSAG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	SRC proto-oncogene, non-receptor tyrosine kinase	Starlite/ChEMBL	References
Homo sapiens	insulin-like growth factor 1 receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_129857	All targets in OG5_129857
Schistosoma japonicum	IPR000494,EGF receptor, L domain,domain-containing	Get druggable targets OG5_129857	All targets in OG5_129857
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FYN, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K08892 fyn-related kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	insulin growth factor 1 receptor beta	Get druggable targets OG5_129857	All targets in OG5_129857
Brugia malayi	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	IPR008957,Fibronectin, type III-like fold,domain-containing	Get druggable targets OG5_129857	All targets in OG5_129857
Echinococcus granulosus	tyrosine protein kinase Lyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	insulin receptor	Get druggable targets OG5_129857	All targets in OG5_129857
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K08252 receptor protein-tyrosine kinase [EC2.7.10.1], putative	Get druggable targets OG5_129857	All targets in OG5_129857
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_129857	All targets in OG5_129857
Echinococcus multilocularis	tyrosine protein kinase Fgr	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Blk	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK/INSR protein kinase	Get druggable targets OG5_129857	All targets in OG5_129857
Schistosoma japonicum	Insulin-like peptide receptor precursor, putative	Get druggable targets OG5_129857	All targets in OG5_129857
Echinococcus granulosus	tyrosine protein kinase Src64B	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Loa Loa (eye worm)	TK protein kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus granulosus	tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Src42A	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase FGR, putative	Get druggable targets OG5_127750	All targets in OG5_127750
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_129857	All targets in OG5_129857
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_129857	All targets in OG5_129857
Echinococcus multilocularis	insulin receptor	Get druggable targets OG5_129857	All targets in OG5_129857
Loa Loa (eye worm)	SRC-1	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	Get druggable targets OG5_127750	All targets in OG5_127750
Brugia malayi	protein-tyrosine kinase	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	tyrosine protein kinase HCK	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Insulin-like peptide receptor precursor, putative	Get druggable targets OG5_129857	All targets in OG5_129857
Echinococcus multilocularis	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_129857	All targets in OG5_129857
Echinococcus granulosus	tyrosine protein kinase Fyn	Get druggable targets OG5_127750	All targets in OG5_127750
Echinococcus multilocularis	insulin growth factor 1 receptor beta	Get druggable targets OG5_129857	All targets in OG5_129857
Schistosoma japonicum	ko:K04527 insulin receptor, putative	Get druggable targets OG5_129857	All targets in OG5_129857
Echinococcus multilocularis	tyrosine protein kinase Srms	Get druggable targets OG5_127750	All targets in OG5_127750
Schistosoma japonicum	Proto-oncogene tyrosine-protein kinase Yrk, putative	Get druggable targets OG5_127750	All targets in OG5_127750

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0073	0.4141	0.4141
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0047	0.2342	0.1819
Trichomonas vaginalis	tubulin beta chain, putative	0.0022	0.064	0.2166
Plasmodium falciparum	tubulin beta chain	0.0056	0.2955	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0056	0.2955	0.253
Leishmania major	beta tubulin	0.0056	0.2955	1
Leishmania major	beta tubulin	0.0056	0.2955	1
Leishmania major	beta tubulin	0.0056	0.2955	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.064	0.064
Echinococcus multilocularis	tubulin alpha chain	0.0022	0.064	0.0074
Echinococcus multilocularis	tubulin alpha chain	0.0022	0.064	0.0074
Leishmania major	beta tubulin	0.0056	0.2955	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0022	0.064	0.2166
Brugia malayi	protein-tyrosine kinase	0.0042	0.2041	0.2041
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0042	0.2041	0.156
Echinococcus multilocularis	Tubulin beta 2C chain	0.0056	0.2955	0.253
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0047	0.2342	0.1819
Leishmania major	beta tubulin	0.0056	0.2955	1
Echinococcus multilocularis	tubulin epsilon chain	0.0022	0.064	0.0074
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0159	1	1
Plasmodium vivax	tubulin beta chain, putative	0.0056	0.2955	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0047	0.2342	0.1819
Leishmania major	beta tubulin	0.0056	0.2955	1
Echinococcus granulosus	tyrosine protein kinase HCK	0.0038	0.1732	0.1167
Trichomonas vaginalis	tubulin beta chain, putative	0.0022	0.064	0.2166
Loa Loa (eye worm)	BEN-1 protein	0.0056	0.2955	0.2955
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0047	0.2342	0.1819
Leishmania major	beta tubulin	0.0056	0.2955	1
Echinococcus granulosus	epidermal growth factor receptor	0.0073	0.4141	0.3741
Echinococcus multilocularis	epidermal growth factor receptor	0.0073	0.4141	0.3787
Echinococcus multilocularis	tubulin gamma 1 chain	0.0022	0.064	0.0074
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0047	0.2342	0.1819
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0047	0.2342	0.188
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0047	0.2342	0.1819
Loa Loa (eye worm)	SRC-1	0.0047	0.2342	0.2342
Echinococcus granulosus	tyrosine kinase	0.0042	0.2041	0.1497
Echinococcus granulosus	epidermal growth factor receptor	0.0073	0.4141	0.3741
Echinococcus multilocularis	Tubulin beta 2C chain	0.0056	0.2955	0.253
Brugia malayi	alpha-tubulin	0.0022	0.064	0.064
Schistosoma mansoni	tubulin subunit beta	0.0056	0.2955	0.2474
Trypanosoma brucei	epsilon tubulin	0.0022	0.064	0.2166
Brugia malayi	Tubulin beta-1 chain	0.0056	0.2955	0.2955
Schistosoma mansoni	tubulin subunit beta	0.0056	0.2955	0.2474
Echinococcus multilocularis	beta tubulin	0.0056	0.2955	0.253
Giardia lamblia	Beta tubulin	0.0056	0.2955	1
Leishmania major	beta tubulin	0.0056	0.2955	1
Leishmania major	beta tubulin	0.0056	0.2955	1
Loa Loa (eye worm)	TK protein kinase	0.0042	0.2041	0.2041
Echinococcus granulosus	beta tubulin	0.0056	0.2955	0.2474
Echinococcus granulosus	Tubulin beta 2C chain	0.0056	0.2955	0.2474
Echinococcus multilocularis	epidermal growth factor receptor	0.0073	0.4141	0.3787
Trypanosoma brucei	beta tubulin	0.0056	0.2955	1
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0042	0.2041	0.1497
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0022	0.064	0.2166
Leishmania major	beta tubulin	0.0056	0.2955	1
Trypanosoma brucei	alpha tubulin	0.0022	0.064	0.2166
Schistosoma mansoni	tubulin subunit beta	0.0056	0.2955	0.2474
Trypanosoma brucei	beta tubulin	0.0056	0.2955	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0056	0.2955	1
Leishmania major	beta tubulin	0.0056	0.2955	1
Loa Loa (eye worm)	tubulin beta-4 chain	0.0056	0.2955	0.2955
Echinococcus granulosus	Tubulin beta 2C chain	0.0056	0.2955	0.2474
Giardia lamblia	Beta tubulin	0.0056	0.2955	1
Schistosoma mansoni	tyrosine kinase	0.0073	0.4141	0.3741
Echinococcus granulosus	insulin receptor	0.0159	1	1
Trichomonas vaginalis	tubulin gamma chain, putative	0.0056	0.2955	1
Echinococcus multilocularis	beta tubulin	0.0056	0.2955	0.253
Loa Loa (eye worm)	tubulin beta-2A chain	0.0056	0.2955	0.2955
Leishmania major	beta tubulin	0.0056	0.2955	1
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0047	0.2342	0.188
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0038	0.1732	0.1233
Loa Loa (eye worm)	TK protein kinase	0.0038	0.1732	0.1732
Trichomonas vaginalis	tubulin beta chain, putative	0.0022	0.064	0.2166
Echinococcus multilocularis	tubulin subunit beta	0.0056	0.2955	0.253
Entamoeba histolytica	tubulin family protein	0.0056	0.2955	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0056	0.2955	0.2474
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0159	1	1
Loa Loa (eye worm)	alpha-tubulin	0.0022	0.064	0.064
Onchocerca volvulus		0.0012	0	0.5
Leishmania major	beta tubulin	0.0056	0.2955	1
Entamoeba histolytica	protein kinase, putative	0.0038	0.1732	0.4717
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0047	0.2342	0.188
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0022	0.064	0.0074
Trypanosoma brucei	alpha tubulin	0.0022	0.064	0.2166
Trypanosoma brucei	epsilon tubulin	0.0022	0.064	0.2166
Loa Loa (eye worm)	tubulin beta chain	0.0056	0.2955	0.2955
Echinococcus multilocularis	tubulin alpha chain	0.0022	0.064	0.0074
Schistosoma mansoni	tyrosine kinase	0.0047	0.2342	0.1819
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0047	0.2342	0.188
Echinococcus granulosus	tubulin beta 4A class IVa	0.0056	0.2955	0.2474
Loa Loa (eye worm)	BEN-1 protein	0.0056	0.2955	0.2955
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0022	0.064	0.0074
Echinococcus multilocularis	tubulin alpha 3 chain	0.0022	0.064	0.0074
Trichomonas vaginalis	tubulin beta chain, putative	0.0022	0.064	0.2166
Schistosoma mansoni	tubulin subunit beta	0.0056	0.2955	0.2474
Echinococcus multilocularis	insulin receptor	0.0159	1	1
Schistosoma mansoni	tyrosine kinase	0.0159	1	1
Echinococcus granulosus	tubulin beta 1 chain	0.0056	0.2955	0.2474
Leishmania major	beta tubulin	0.0056	0.2955	1
Brugia malayi	Tubulin alpha chain	0.0022	0.064	0.064
Echinococcus multilocularis	Tubulin beta 2C chain	0.0056	0.2955	0.253
Schistosoma mansoni	tubulin subunit beta	0.0056	0.2955	0.2474
Schistosoma mansoni	tyrosine kinase	0.0071	0.3968	0.3555
Echinococcus multilocularis	hypothetical protein	0.0022	0.064	0.0074
Trypanosoma brucei	beta tubulin	0.0022	0.064	0.2166
Trichomonas vaginalis	tubulin alpha chain, putative	0.0022	0.064	0.2166
Echinococcus granulosus	Tubulin beta 2C chain	0.0056	0.2955	0.2474
Trypanosoma brucei	beta tubulin	0.0056	0.2955	1
Brugia malayi	Tubulin alpha-2 chain	0.0022	0.064	0.064
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0056	0.2955	0.253
Brugia malayi	Tubulin gamma chain	0.0022	0.064	0.064
Leishmania major	beta tubulin	0.0056	0.2955	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0056	0.2955	0.2474
Brugia malayi	tubulin alpha-2 chain	0.0022	0.064	0.064
Echinococcus granulosus	beta tubulin	0.0056	0.2955	0.2474
Schistosoma mansoni	tyrosine kinase	0.0047	0.2342	0.1819
Trypanosoma brucei	epsilon tubulin	0.0022	0.064	0.2166
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.004	0.1868	0.1376
Echinococcus granulosus	tyrosine protein kinase Src42A	0.004	0.1868	0.1312
Toxoplasma gondii	beta-tubulin, putative	0.0056	0.2955	1
Loa Loa (eye worm)	tubulin alpha chain	0.0022	0.064	0.064
Echinococcus multilocularis	Tubulin beta 2C chain	0.0056	0.2955	0.253
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0042	0.2041	0.156
Echinococcus multilocularis	tubulin alpha	0.0022	0.064	0.0074
Schistosoma mansoni	tyrosine kinase	0.0071	0.3968	0.3555
Loa Loa (eye worm)	beta-tubulin	0.0056	0.2955	0.2955
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0047	0.2342	0.1819
Brugia malayi	Tubulin alpha-2 chain	0.0022	0.064	0.064
Entamoeba histolytica	tubulin family protein	0.0056	0.2955	1
Trypanosoma brucei	tubulin gamma chain	0.0022	0.064	0.2166
Leishmania major	beta tubulin	0.0056	0.2955	1
Brugia malayi	Protein kinase domain containing protein	0.0089	0.5198	0.5198
Brugia malayi	beta-tubulin, identical	0.0056	0.2955	0.2955
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0022	0.064	0.064
Loa Loa (eye worm)	TK/INSR protein kinase	0.0159	1	1
Echinococcus multilocularis	tubulin beta 1 chain	0.0056	0.2955	0.253
Schistosoma mansoni	tyrosine kinase	0.0159	1	1
Echinococcus multilocularis	tubulin alpha chain	0.0022	0.064	0.0074
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0047	0.2342	0.1819
Trichomonas vaginalis	tubulin gamma chain, putative	0.0022	0.064	0.2166
Schistosoma mansoni	tyrosine kinase	0.0071	0.3968	0.3555
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0042	0.2041	0.156
Trichomonas vaginalis	tubulin beta chain, putative	0.0022	0.064	0.2166
Trichomonas vaginalis	tubulin beta chain, putative	0.0022	0.064	0.2166
Trichomonas vaginalis	tubulin, putative	0.0056	0.2955	1
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0073	0.4141	0.3741
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0056	0.2955	1
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0022	0.064	0.0074
Trypanosoma brucei	alpha tubulin	0.0022	0.064	0.2166
Leishmania major	beta tubulin	0.0056	0.2955	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0047	0.2342	0.188
Loa Loa (eye worm)	tubulin beta-1 chain	0.0056	0.2955	0.2955
Echinococcus granulosus	tubulin subunit beta	0.0056	0.2955	0.2474
Trichomonas vaginalis	tubulin beta chain, putative	0.0056	0.2955	1
Loa Loa (eye worm)	hypothetical protein	0.0086	0.5024	0.5024
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0047	0.2342	0.188
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0047	0.2342	0.188
Brugia malayi	SRC-1	0.0047	0.2342	0.2342
Toxoplasma gondii	beta-1 tubulin, putative	0.0056	0.2955	1
Echinococcus multilocularis	tubulin alpha 1C chain	0.0022	0.064	0.0074
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0056	0.2955	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0022	0.064	0.2166
Echinococcus multilocularis	tubulin alpha 3 chain	0.0022	0.064	0.0074
Giardia lamblia	Beta tubulin	0.0056	0.2955	1
Echinococcus multilocularis	tubulin alpha chain	0.0022	0.064	0.0074
Echinococcus multilocularis	tubulin alpha 1C chain	0.0022	0.064	0.0074
Trichomonas vaginalis	tubulin gamma chain, putative	0.0022	0.064	0.2166
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0047	0.2342	0.188
Brugia malayi	tubulin alpha chain - mouse	0.0022	0.064	0.064
Loa Loa (eye worm)	tubulin alpha chain	0.0022	0.064	0.064
Trypanosoma cruzi	beta tubulin, putative	0.0056	0.2955	1
Trypanosoma brucei	beta tubulin	0.0056	0.2955	1
Brugia malayi	Furin-like cysteine rich region family protein	0.0073	0.4141	0.4141
Leishmania major	beta tubulin	0.0056	0.2955	1
Trypanosoma brucei	alpha tubulin	0.0022	0.064	0.2166
Schistosoma mansoni	tyrosine kinase	0.0073	0.4141	0.3741
Echinococcus multilocularis	tubulin subunit TubB	0.0022	0.064	0.0074
Echinococcus granulosus	tyrosine protein kinase Blk	0.0042	0.2041	0.1497
Echinococcus multilocularis	peroxisome assembly protein 26	0.0022	0.064	0.0074
Loa Loa (eye worm)	alpha-tubulin	0.0022	0.064	0.064
Toxoplasma gondii	beta tubulin	0.0056	0.2955	1
Schistosoma mansoni	tyrosine kinase	0.0073	0.4141	0.3741
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0047	0.2342	0.188
Loa Loa (eye worm)	tubulin gamma chain	0.0022	0.064	0.064
Schistosoma mansoni	tubulin subunit beta	0.0056	0.2955	0.2474

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 4.4 uM	Inhibition of IGF-1R assessed as incorporation of p33 using [gammaP33]-ATP by microplate scintillation counting	ChEMBL.	21524503
IC50 (binding)	= 5.9 uM	Inhibition of SRC assessed as incorporation of p33 using [gammaP33]-ATP by microplate scintillation counting	ChEMBL.	21524503
IC50 (binding)	= 36 uM	Inhibition of c-MET assessed as incorporation of p33 using [gammaP33]-ATP by microplate scintillation counting	ChEMBL.	21524503

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1796180

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1578966