Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | CD22 antigen | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0045 | 0.0055 | 1 |
Onchocerca volvulus | 0.0042 | 0.0018 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0197 | 0.2413 | 1 |
Mycobacterium leprae | Probable lipase LipE | 0.0042 | 0.0018 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0018 | 0.0408 |
Plasmodium vivax | ubiquitin-conjugating enzyme E2 N, putative | 0.0045 | 0.0055 | 0.0037 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0089 | 0.0746 | 1 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0687 | 1 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.027 | 0.3537 | 0.3525 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.0687 | 1 | 1 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0687 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0197 | 0.2413 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0042 | 0.0018 | 0.0169 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0045 | 0.0055 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0264 | 0.5899 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0018 | 0.0408 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.007 | 0.0448 | 1 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0089 | 0.0746 | 1 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0042 | 0.0015 | 0.0333 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0089 | 0.0746 | 1 |
Plasmodium falciparum | beta-ketoacyl-ACP synthase III | 0.0687 | 1 | 1 |
Schistosoma mansoni | jumonji domain containing protein | 0.0088 | 0.073 | 0.3024 |
Toxoplasma gondii | ubiquitin-conjugating enzyme subfamily protein | 0.0045 | 0.0055 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0042 | 0.0018 | 0.0169 |
Brugia malayi | Ubiquitin conjugating enzyme protein 13 | 0.0045 | 0.0055 | 0.0507 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0089 | 0.0746 | 1 |
Echinococcus multilocularis | geminin | 0.0197 | 0.2413 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0111 | 0.1083 | 1 |
Echinococcus granulosus | jumonji domain containing protein | 0.0047 | 0.0095 | 0.0394 |
Echinococcus granulosus | geminin | 0.0197 | 0.2413 | 1 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0687 | 1 | 1 |
Brugia malayi | ubiquitin conjugating enzyme protein 13 | 0.0045 | 0.0055 | 0.0507 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0042 | 0.0018 | 0.0408 |
Trypanosoma cruzi | ubiquitin-conjugating enzyme E2, putative | 0.0045 | 0.0055 | 1 |
Loa Loa (eye worm) | immunoglobulin I-set domain-containing protein | 0.0042 | 0.0015 | 0.0333 |
Brugia malayi | beta-lactamase | 0.0042 | 0.0018 | 0.0169 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0042 | 0.0018 | 0.0076 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.0687 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0018 | 0.0408 |
Schistosoma mansoni | ubiquitin conjugating enzyme 13 | 0.0045 | 0.0055 | 0.0228 |
Echinococcus multilocularis | ubiquitin conjugating enzyme E2 N | 0.0045 | 0.0055 | 0.0228 |
Mycobacterium leprae | conserved hypothetical protein | 0.0042 | 0.0018 | 0.5 |
Plasmodium vivax | beta-ketoacyl-acyl carrier protein synthase III precursor, putative | 0.0687 | 1 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0042 | 0.0015 | 0.0138 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0018 | 0.0408 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0042 | 0.0018 | 0.0076 |
Onchocerca volvulus | 0.0042 | 0.0018 | 0.5 | |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0042 | 0.0018 | 0.0076 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0045 | 0.0055 | 0.1226 |
Loa Loa (eye worm) | ubiquitin conjugating enzyme protein 13 | 0.0045 | 0.0055 | 0.1226 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0111 | 0.1083 | 0.4487 |
Brugia malayi | hypothetical protein | 0.0068 | 0.0425 | 0.3929 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0042 | 0.0018 | 0.0076 |
Trichomonas vaginalis | ubiquitin-conjugating enzyme E2, putative | 0.0045 | 0.0055 | 1 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0042 | 0.0015 | 0.0138 |
Leishmania major | ubiquitin-conjugating enzyme e2, putative | 0.0045 | 0.0055 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0018 | 0.0408 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0042 | 0.0018 | 0.0169 |
Entamoeba histolytica | fatty acid elongase, putative | 0.0089 | 0.0746 | 1 |
Onchocerca volvulus | 0.0042 | 0.0018 | 0.5 | |
Echinococcus multilocularis | jumonji domain containing protein | 0.0047 | 0.0095 | 0.0394 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0018 | 0.0408 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0111 | 0.1083 | 0.4487 |
Trypanosoma brucei | ubiquitin-protein ligase, putative | 0.0045 | 0.0055 | 1 |
Echinococcus granulosus | ubiquitin conjugating enzyme E2 N | 0.0045 | 0.0055 | 0.0228 |
Loa Loa (eye worm) | beta-lactamase | 0.0042 | 0.0018 | 0.0408 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.1 uM | Binding affinity to mouse CD22 after 1 hr by competition ELISA | ChEMBL. | 19720531 |
Ratio IC50 (binding) | = 38.4 | Ratio of 9-(40-hydroxy-4-biphenyl)acetamido-9-deoxy- Neu5Gca2-6GalOMP IC50 to compound IC50 for mouse CD22 after 1 hr by competition ELISA | ChEMBL. | 19720531 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.