Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0371 | 0.0462 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.0192 | 0.2513 | 0.2398 |
Onchocerca volvulus | 0.0035 | 0.0151 | 0.5 | |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.0035 | 0.0151 | 0.0602 |
Schistosoma mansoni | DNA polymerase eta | 0.0045 | 0.0294 | 0.0163 |
Trypanosoma brucei | carnitine O-palmitoyltransferase, putative | 0.0035 | 0.0151 | 0.0375 |
Trypanosoma cruzi | carnitine/choline acetyltransferase, putative | 0.0035 | 0.0151 | 0.0602 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0151 | 0.0602 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0035 | 0.0151 | 0.0375 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0035 | 0.0151 | 0.0189 |
Brugia malayi | Choline O-acetyltransferase | 0.0035 | 0.0151 | 0.0189 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.0371 | 0.0462 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0045 | 0.0294 | 0.1171 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.0192 | 0.2513 | 0.2398 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.0371 | 0.0462 |
Trypanosoma cruzi | carnitine/choline acetyltransferase, putative | 0.0035 | 0.0151 | 0.0602 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0035 | 0.0151 | 0.0189 |
Echinococcus multilocularis | geminin | 0.0169 | 0.217 | 0.2049 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0192 | 0.2513 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0192 | 0.2513 | 1 |
Trypanosoma cruzi | choline/carnitine O-acetyltransferase, putative | 0.0035 | 0.0151 | 0.0602 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.069 | 1 | 1 |
Leishmania major | DNA polymerase eta, putative | 0.0031 | 0.0094 | 0.0374 |
Loa Loa (eye worm) | hypothetical protein | 0.0558 | 0.8016 | 1 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0558 | 0.8016 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0151 | 0.0189 |
Echinococcus granulosus | dna polymerase eta | 0.0045 | 0.0294 | 0.0145 |
Onchocerca volvulus | 0.0035 | 0.0151 | 0.5 | |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0035 | 0.0151 | 0.0602 |
Onchocerca volvulus | 0.0035 | 0.0151 | 0.5 | |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0031 | 0.0094 | 0.0374 |
Onchocerca volvulus | 0.0035 | 0.0151 | 0.5 | |
Schistosoma mansoni | hypothetical protein | 0.0293 | 0.4034 | 0.3953 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0035 | 0.0151 | 0.0189 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0151 | 0.0602 |
Schistosoma mansoni | choline o-acyltransferase | 0.0035 | 0.0151 | 0.0018 |
Trypanosoma brucei | carnitine O-acetyltransferase, putative | 0.0035 | 0.0151 | 0.0375 |
Leishmania major | carnitine/choline acetyltransferase, putative | 0.0035 | 0.0151 | 0.0602 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.0035 | 0.0151 | 0.0189 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0133 | 0.0166 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.217 | 0.2064 |
Echinococcus granulosus | geminin | 0.0169 | 0.217 | 0.2049 |
Leishmania major | DNA polymerase eta, putative | 0.0045 | 0.0294 | 0.1171 |
Leishmania major | carnitine palmitoyltransferase-like protein | 0.0035 | 0.0151 | 0.0602 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0031 | 0.0094 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0133 | 0.0166 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0151 | 0.0602 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0035 | 0.0151 | 0.0375 |
Schistosoma mansoni | hypothetical protein | 0.0169 | 0.217 | 0.2064 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0025 | 0 | 0.5 |
Trypanosoma brucei | RNA helicase, putative | 0.0293 | 0.4034 | 1 |
Brugia malayi | Choline O-acetyltransferase | 0.0035 | 0.0151 | 0.0189 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0 | 0.5 |
Trypanosoma cruzi | carnitine O-acetyltransferase, putative | 0.0035 | 0.0151 | 0.0602 |
Echinococcus multilocularis | dna polymerase eta | 0.0045 | 0.0294 | 0.0145 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0294 | 0.0367 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0045 | 0.0294 | 0.0729 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0035 | 0.0151 | 0.0375 |
Schistosoma mansoni | choline o-acyltransferase | 0.0035 | 0.0151 | 0.0018 |
Schistosoma mansoni | microtubule-associated protein tau | 0.069 | 1 | 1 |
Loa Loa (eye worm) | carnitine O-palmitoyltransferase I isoform | 0.0035 | 0.0151 | 0.0189 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.0192 | 0.2513 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0151 | 0.0602 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0045 | 0.0294 | 0.0367 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0151 | 0.0602 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.0371 | 0.0462 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0025 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.