Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ADAM metallopeptidase with thrombospondin type 1 motif, 4 | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 13 (collagenase 3) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Schistosoma japonicum | ko:K08624 ADAM metallopeptidase with thrombospondin type 1 motif, 9, putative | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Brugia malayi | ADAM-TS Spacer 1 family protein | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | matrix metallopeptidase 13 (collagenase 3) | 471 aa | 448 aa | 34.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | carnitine O-palmitoyltransferase I isoform | 0.0057 | 0.0379 | 0.0364 |
Brugia malayi | Choline O-acetyltransferase | 0.0057 | 0.0379 | 0.0379 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0057 | 0.0379 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0058 | 0.0405 | 0.039 |
Trypanosoma brucei | carnitine O-acetyltransferase, putative | 0.0057 | 0.0379 | 0.5 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.0057 | 0.0379 | 0.0421 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.1238 | 0.1224 |
Onchocerca volvulus | 0.0057 | 0.0379 | 0.9329 | |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.031 | 0.4506 | 1 |
Brugia malayi | Choline O-acetyltransferase | 0.0057 | 0.0379 | 0.0379 |
Loa Loa (eye worm) | hypothetical protein | 0.0646 | 1 | 1 |
Brugia malayi | Matrixin family protein | 0.0064 | 0.0491 | 0.0491 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.031 | 0.4506 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.031 | 0.4506 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.031 | 0.4506 | 1 |
Brugia malayi | ADAM-TS Spacer 1 family protein | 0.0109 | 0.1238 | 0.1238 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0057 | 0.0379 | 0.0364 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0096 | 0.1015 | 0.1895 |
Echinococcus granulosus | choline O acetyltransferase | 0.0057 | 0.0379 | 0.0421 |
Brugia malayi | Hemopexin family protein | 0.0037 | 0.0062 | 0.0062 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0057 | 0.0379 | 0.5 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | 0.0046 | 0.0198 | 0.4296 |
Onchocerca volvulus | Matrilysin homolog | 0.0058 | 0.0405 | 1 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.0057 | 0.0379 | 0.0364 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0379 | 0.0364 |
Loa Loa (eye worm) | matrixin family protein | 0.0064 | 0.0491 | 0.0476 |
Echinococcus multilocularis | choline O acetyltransferase | 0.0057 | 0.0379 | 0.0421 |
Onchocerca volvulus | 0.0057 | 0.0379 | 0.9329 | |
Onchocerca volvulus | 0.0057 | 0.0379 | 0.9329 | |
Onchocerca volvulus | 0.0057 | 0.0379 | 0.9329 | |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0057 | 0.0379 | 0.0379 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0096 | 0.1015 | 0.1895 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0057 | 0.0379 | 0.5 |
Schistosoma mansoni | choline o-acyltransferase | 0.0057 | 0.0379 | 1 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0057 | 0.0379 | 0.0379 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.0057 | 0.0379 | 0.0421 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0058 | 0.0405 | 1 |
Schistosoma mansoni | choline o-acyltransferase | 0.0057 | 0.0379 | 1 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.031 | 0.4506 | 1 |
Trypanosoma brucei | carnitine O-palmitoyltransferase, putative | 0.0057 | 0.0379 | 0.5 |
Onchocerca volvulus | 0.0037 | 0.0062 | 0.1172 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.