Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.2225 | 1 | 1 |
Trypanosoma cruzi | choline/carnitine O-acetyltransferase, putative | 0.0279 | 0.1167 | 0.2222 |
Leishmania major | carnitine/choline acetyltransferase, putative | 0.0279 | 0.1167 | 0.2222 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0022 | 0 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0279 | 0.1167 | 0.5074 |
Onchocerca volvulus | 0.0279 | 0.1167 | 0.5 | |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.1178 | 0.525 | 1 |
Trypanosoma cruzi | carnitine O-acetyltransferase, putative | 0.0279 | 0.1167 | 0.2222 |
Echinococcus multilocularis | choline O acetyltransferase | 0.0279 | 0.1167 | 0.2222 |
Brugia malayi | MH2 domain containing protein | 0.0138 | 0.0527 | 0.0527 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0279 | 0.1167 | 0.2222 |
Echinococcus granulosus | choline O acetyltransferase | 0.0279 | 0.1167 | 0.2222 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0279 | 0.1167 | 0.1167 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.1178 | 0.525 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0138 | 0.0527 | 0.0527 |
Trypanosoma brucei | carnitine O-acetyltransferase, putative | 0.0279 | 0.1167 | 0.5074 |
Loa Loa (eye worm) | hypothetical protein | 0.0279 | 0.1167 | 0.1167 |
Toxoplasma gondii | exonuclease III APE | 0.0022 | 0 | 0.5 |
Leishmania major | carnitine palmitoyltransferase-like protein | 0.0528 | 0.2299 | 0.438 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0279 | 0.1167 | 0.2222 |
Onchocerca volvulus | 0.0279 | 0.1167 | 0.5 | |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0022 | 0 | 0.5 |
Brugia malayi | Choline O-acetyltransferase | 0.0279 | 0.1167 | 0.1167 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0528 | 0.2299 | 0.2299 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0528 | 0.2299 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | choline o-acyltransferase | 0.0279 | 0.1167 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0279 | 0.1167 | 0.2222 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0279 | 0.1167 | 0.2222 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.1178 | 0.525 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0022 | 0 | 0.5 |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.0528 | 0.2299 | 0.438 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.1178 | 0.525 | 1 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.1178 | 0.525 | 1 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0279 | 0.1167 | 0.5074 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.0528 | 0.2299 | 0.438 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0022 | 0 | 0.5 |
Trypanosoma brucei | carnitine O-palmitoyltransferase, putative | 0.0279 | 0.1167 | 0.5074 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | choline o-acyltransferase | 0.0279 | 0.1167 | 1 |
Trypanosoma cruzi | carnitine/choline acetyltransferase, putative | 0.0279 | 0.1167 | 0.2222 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0022 | 0 | 0.5 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.0528 | 0.2299 | 0.2299 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0279 | 0.1167 | 0.1167 |
Brugia malayi | Choline O-acetyltransferase | 0.0279 | 0.1167 | 0.1167 |
Loa Loa (eye worm) | carnitine O-palmitoyltransferase I isoform | 0.0279 | 0.1167 | 0.1167 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0022 | 0 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0138 | 0.0527 | 0.0527 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0279 | 0.1167 | 0.2222 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.0528 | 0.2299 | 0.438 |
Onchocerca volvulus | 0.0279 | 0.1167 | 0.5 | |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0022 | 0 | 0.5 |
Onchocerca volvulus | 0.0279 | 0.1167 | 0.5 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0279 | 0.1167 | 0.2222 |
Trypanosoma cruzi | carnitine/choline acetyltransferase, putative | 0.0279 | 0.1167 | 0.2222 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0022 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | Antibacterial activity against Mycobacterium luteum b-917 after 24 to 72 hrs by serial dilution technique | ChEMBL. | 22019185 | |
IZ (functional) | = 0 mm | Antibacterial activity against Escherichia coli B-906 at 0.1% after 24 hrs by diffusion technique | ChEMBL. | 22019185 |
IZ (functional) | = 0 mm | Antibacterial activity against Escherichia coli B-906 at 0.5% after 24 hrs by diffusion technique | ChEMBL. | 22019185 |
IZ (functional) | = 0 mm | Antibacterial activity against Mycobacterium luteum b-917 at 0.5% after 24 hrs by diffusion technique | ChEMBL. | 22019185 |
IZ (functional) | = 0 mm | Antibacterial activity against Mycobacterium luteum b-917 at 0.1% after 24 hrs by diffusion technique | ChEMBL. | 22019185 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.