Detailed information for compound 1581413

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1614.97 | Formula: C98H173ClN14O2
  • H donors: 4 H acceptors: 4 LogP: 22.58 Rotable bonds: 42
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCCCCCCCCCCCC1CCN(CCCNC(=O)CCC2=C(C)/C/3=C/c4[nH]c(c(c4C)CC)/C=C/4\N=C(/C=c/5\[nH]/c(=C\C2=N3)/c(CCC(=O)NCCCN2CCCN(C)CCCCN(CCCN(C(CC2)CCCCCCCCCCCCC)C)C)c5C)C(=C4C)CC)CCCN(C)CCCCN(CCCN1C)C.Cl
  • InChi: 1S/C98H172N14O2.ClH/c1-15-19-21-23-25-27-29-31-33-35-37-49-83-55-73-111(71-47-65-107(11)61-41-39-59-105(9)63-45-67-109(83)13)69-43-57-99-97(113)53-51-87-81(7)90-75-89-79(5)85(17-3)93(101-89)76-91-80(6)86(18-4)94(102-91)77-92-82(8)88(96(104-92)78-95(87)103-90)52-54-98(114)100-58-44-70-112-72-48-66-108(12)62-42-40-60-106(10)64-46-68-110(14)84(56-74-112)50-38-36-34-32-30-28-26-24-22-20-16-2;/h75-78,83-84,101,104H,15-74H2,1-14H3,(H,99,113)(H,100,114);1H/b89-75-,90-75-,91-76-,92-77-,93-76-,94-77-,95-78-,96-78-;
  • InChiKey: YUGZRMQREFQDIX-DDXMYLRPSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica protein kinase, putative 0.0032 0.0404 1
Plasmodium vivax hexose transporter 0.0103 0.2094 0.2094
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.051 0.0737
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0201 0.0578
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0037 0.0068
Leishmania major cathepsin L-like protease 0.0017 0.006 0.0087
Schistosoma mansoni glucose transport protein 0.0103 0.2094 0.8997
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.006 0.0286
Brugia malayi Cathepsin L-like precursor 0.0017 0.006 0.0086
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0243 0.0351
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0388 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0757 0.1417
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0037 0.0067
Leishmania major hypothetical protein, conserved 0.0025 0.0243 0.0351
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.051 0.0737
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.051 0.0737
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0404 0.0755
Leishmania major cathepsin L-like protease 0.0017 0.006 0.0087
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.051 0.0737
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0388 0.0727
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0201 0.0961
Onchocerca volvulus Cathepsin L homolog 0.0017 0.006 0.0733
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0856 0.1226
Trypanosoma brucei glucose transporter, putative 0.0032 0.0413 0.0597
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0404 0.0743
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.051 0.0779
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0014 0 0.5
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0404 0.0617
Leishmania major cathepsin L-like protease 0.0017 0.006 0.0087
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.0404 0.0583
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0201 0.0865
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0201 0.3046
Schistosoma mansoni hypothetical protein 0.0016 0.0037 0.0157
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0413 0.1973
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0201 0.0377
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.1191 0.1722
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.1191 0.1722
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0037 0.0068
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0388 0.1855
Trypanosoma cruzi cruzipain precursor, putative 0.0065 0.1191 0.1722
Trypanosoma brucei glucose transporter, putative 0.0032 0.0413 0.0597
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0404 0.0404
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.006 0.011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.006 0.0286
Loa Loa (eye worm) ctsf protein 0.0017 0.006 0.011
Plasmodium vivax vivapain-2 0.0017 0.006 0.006
Plasmodium vivax vivapain-2 0.0017 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.024 0.5343 0.9842
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.1191 0.1722
Schistosoma mansoni glucose transport protein 0.0103 0.2094 0.8997
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0201 0.5182
Plasmodium vivax CDK-related protein kinase 6, putative 0.0437 1 1
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0357 0.0669
Onchocerca volvulus 0.0017 0.006 0.0733
Brugia malayi Cathepsin L-like precursor 0.0017 0.006 0.0086
Loa Loa (eye worm) sugar transporter 0.0103 0.2094 0.3858
Brugia malayi hypothetical protein 0.024 0.5343 0.7653
Loa Loa (eye worm) cysteine protease 0.0017 0.006 0.011
Leishmania major cathepsin L-like protease 0.0017 0.006 0.0087
Schistosoma mansoni hypothetical protein 0.0016 0.0037 0.0157
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.006 0.0112
Plasmodium falciparum mitogen-activated protein kinase 2 0.0166 0.3595 0.3595
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0243 0.0351
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.006 0.0286
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.1191 0.1722
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0757 0.3252
Plasmodium falciparum proline--tRNA ligase 0.0036 0.051 0.051
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.006 0.0286
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0757 0.1085
Loa Loa (eye worm) hypothetical protein 0.0031 0.0388 0.0716
Brugia malayi Cam kinase protein 1 0.0032 0.0404 0.0578
Onchocerca volvulus 0.0017 0.006 0.0733
Leishmania major mitochondrial DNA polymerase beta 0.0307 0.6918 1
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0201 0.5
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0404 0.0404
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0404 0.0617
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.006 0.006
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.006 0.0112
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.006 0.0286
Loa Loa (eye worm) hypothetical protein 0.0016 0.0037 0.0067
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0757 0.3252
Onchocerca volvulus 0.0017 0.006 0.0733
Mycobacterium tuberculosis Conserved hypothetical protein 0.0162 0.3482 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.006 0.0286
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0413 0.1973
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0307 0.6918 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.006 0.011
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.1191 0.1722
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0678 0.098
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.2094 0.392
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.006 0.0257
Trypanosoma cruzi hexose transporter 0.0032 0.0413 0.0597
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0388 0.956
Schistosoma mansoni survival motor neuron protein 0.0049 0.0817 0.351
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.051 0.0737
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0037 0.0052
Schistosoma mansoni hypothetical protein 0.0103 0.2094 0.8997
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.006 0.0286
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0388 0.0556
Brugia malayi Cathepsin L-like precursor 0.0017 0.006 0.0086
Loa Loa (eye worm) hypothetical protein 0.0031 0.0388 0.0716
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.1191 0.1722
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.2094 0.392
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.2094 0.392
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0404 0.0755
Brugia malayi hypothetical protein 0.0016 0.0035 0.005
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0404 0.0755
Trypanosoma brucei glucose transporter, putative 0.0032 0.0413 0.0597
Schistosoma mansoni glucose transport protein 0.0103 0.2094 0.8997
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0404 0.0404
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0388 0.1669
Brugia malayi hypothetical protein 0.0025 0.0243 0.0347
Echinococcus granulosus survival motor neuron protein 1 0.024 0.5343 1
Schistosoma mansoni hypothetical protein 0.0035 0.0477 0.2048
Trichomonas vaginalis conserved hypothetical protein 0.0103 0.2094 1
Toxoplasma gondii hypothetical protein 0.0049 0.0828 0.1266
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0307 0.6918 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0201 0.0371
Brugia malayi Cathepsin L-like precursor 0.0017 0.006 0.0086
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0119 0.0343
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.3094 0.4472
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0413 0.0597
Onchocerca volvulus 0.0017 0.006 0.0733
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0413 0.1973
Trypanosoma brucei glucose transporter, putative 0.0032 0.0413 0.0597
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0413 0.0597
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0119 0.0343
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0357 0.0669
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.006 0.0086
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0757 0.3252
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0678 0.098
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0307 0.6918 1
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0103 0.2094 0.392
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0201 0.0578
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.006 0.0286
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0413 0.0597
Trypanosoma brucei glucose transporter 2A 0.0032 0.0413 0.0597
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0404 0.0743
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0404 0.0617
Onchocerca volvulus 0.0017 0.006 0.0733
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0404 0.0404
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.006 0.0286
Leishmania major glucose transporter, lmgt1 0.0032 0.0413 0.0597
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0404 0.0755
Loa Loa (eye worm) hypothetical protein 0.0035 0.0477 0.0878
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0243 0.0243
Trypanosoma brucei glucose transporter, putative 0.0032 0.0413 0.0597
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0037 0.0052
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0413 0.0597
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0201 0.0377
Loa Loa (eye worm) hypothetical protein 0.0032 0.0404 0.0743
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0404 0.1927
Onchocerca volvulus Cathepsin F homolog 0.0017 0.006 0.0733
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0201 0.0291
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0678 0.098
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0757 0.1395
Mycobacterium ulcerans hypothetical protein 0.0162 0.3482 1
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0388 0.0727
Leishmania major cysteine peptidase A (CPA) 0.0017 0.006 0.0087
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0404 0.0404
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.0863 0.1247
Echinococcus granulosus cathepsin l1 0.0017 0.006 0.0112
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0388 0.1669
Loa Loa (eye worm) hypothetical protein 0.0065 0.1205 0.2221
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.006 0.0286
Entamoeba histolytica hypothetical protein 0.0023 0.0201 0.4114
Onchocerca volvulus 0.0017 0.006 0.0733
Toxoplasma gondii cathepsin CPL 0.0017 0.006 0.0092
Schistosoma mansoni protein kinase 0.0032 0.0404 0.1734
Trypanosoma brucei glucose transporter, putative 0.0032 0.0413 0.0597
Echinococcus multilocularis GPCR, family 2 0.0016 0.0037 0.0068
Trypanosoma brucei glucose transporter 1E 0.0032 0.0413 0.0597
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.006 0.0087
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.2094 0.392
Onchocerca volvulus Cathepsin L homolog 0.0017 0.006 0.0733
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.006 0.0286
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0201 0.0865
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0201 0.0291
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0404 0.0404
Echinococcus granulosus General substrate transporter 0.0089 0.1752 0.3279
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.006 0.0286
Onchocerca volvulus 0.0017 0.006 0.0733
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.006 0.0286
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0404 0.0404
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0201 0.0288
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0817 0.117
Leishmania major cathepsin L-like protease 0.0065 0.1191 0.1722
Loa Loa (eye worm) fibroinase 0.0017 0.006 0.011
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.006 0.006
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0757 0.1417
Leishmania major glucose transporter, lmgt2 0.0032 0.0413 0.0597
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0413 0.1973
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.006 0.0286
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0388 1
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0388 0.0556
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.2094 0.392
Echinococcus multilocularis General substrate transporter 0.0089 0.1752 0.3279
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.1191 0.1722
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0404 0.1734
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.1191 0.1722
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0201 0.0201
Leishmania major cathepsin L-like protease 0.0065 0.1191 0.1722
Echinococcus multilocularis cysteine protease 0.0017 0.006 0.0112
Loa Loa (eye worm) hypothetical protein 0.0025 0.0243 0.0447
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0037 0.0068
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.006 0.011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.006 0.0286
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.006 0.0286
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0243 0.0243
Trypanosoma brucei glucose transporter, putative 0.0032 0.0413 0.0597
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.006 0.0286
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.006 0.0257
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.1191 0.1722
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.006 0.0112
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.006 0.0286
Loa Loa (eye worm) hypothetical protein 0.0025 0.0251 0.0463
Schistosoma mansoni hypothetical protein 0.0016 0.0037 0.0157
Leishmania major protein kinase, putative 0.0032 0.0404 0.0583
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.1191 0.1722
Toxoplasma gondii protein kinase, putative 0.0291 0.6542 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.006 0.0286
Loa Loa (eye worm) hypothetical protein 0.0131 0.2758 0.5081
Echinococcus granulosus GPCR family 2 0.0016 0.0037 0.0068
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0145 0.3094 0.4472
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0404 0.0404
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.1191 0.1722
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0413 0.0597
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0404 0.0755
Trypanosoma brucei glucose transporter, putative 0.0032 0.0413 0.0597
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.006 0.0112
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0243 0.0371
Brugia malayi Cathepsin L-like precursor 0.0017 0.006 0.0086
Brugia malayi Cathepsin L-like precursor 0.0017 0.006 0.0086
Brugia malayi Sugar transporter family protein 0.0103 0.2094 0.3
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0037 0.0068
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0243 0.0351
Leishmania major cathepsin L-like protease 0.0017 0.006 0.0087
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0413 0.0597
Schistosoma mansoni alzheimer's disease beta-amyloid related 0.0113 0.2328 1
Onchocerca volvulus 0.0049 0.0817 1
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.051 0.051
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0678 0.098
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0477 0.0683
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0413 0.0597
Entamoeba histolytica protein kinase, putative 0.0032 0.0404 1
Toxoplasma gondii facilitative glucose transporter GT1 0.0103 0.2094 0.3201
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.1058 0.1529
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0757 0.1417
Schistosoma mansoni protein kinase 0.0032 0.0404 0.1734
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0404 0.0755
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.006 0.0286
Plasmodium falciparum hexose transporter 0.0103 0.2094 0.2094
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0201 0.0201
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.006 0.0286
Loa Loa (eye worm) hypothetical protein 0.0244 0.5428 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.3094 0.4472
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.2094 0.392
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0856 0.1226
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0134 0.0641
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0201 0.0291
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.1191 0.1722
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.1191 0.1722
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.1191 0.1722
Brugia malayi Amyloid A4 extracellular domain containing protein 0.031 0.6981 1
Plasmodium falciparum protein kinase 7 0.0291 0.6542 0.6542
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.006 0.0286
Echinococcus multilocularis survival motor neuron protein 1 0.024 0.5343 1
Schistosoma mansoni protein kinase 0.0032 0.0404 0.1734
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0902 0.1303
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0243 0.0243
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.006 0.0286
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.006 0.0286
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.006 0.006
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.2094 0.392
Leishmania major glucose transporter, lmgt3 0.0032 0.0413 0.0597
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0404 0.0578
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0166 0.3595 0.5495
Loa Loa (eye worm) hypothetical protein 0.0051 0.0856 0.1577
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0201 0.0308
Echinococcus multilocularis cysteine protease 0.0017 0.006 0.0112
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0404 0.0755
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0413 0.1973
Leishmania major cathepsin L-like protease 0.0065 0.1191 0.1722
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0413 0.1973
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.006 0.0286
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0166 0.3595 0.3595
Schistosoma mansoni hypothetical protein 0.0049 0.0817 0.351
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0856 0.1577
Trypanosoma cruzi hexose transporter, putative 0.0017 0.007 0.0102
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0413 0.1973
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0757 0.1417
Schistosoma mansoni hypothetical protein 0.0016 0.0037 0.0157
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0404 0.0755
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.006 0.0112
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.006 0.0112
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0404 0.0404

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 50 uM Antiproliferative activity against Leishmania donovani DI700 promastigotes ChEMBL. 17116678
Inhibition (functional) = 1.7 % Growth inhibition of Leishmania donovani DI700 promastigotes at 100 uM relative to control ChEMBL. 17116678

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.