Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Calpain 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | calpain C (C02 family) | Calpain 1 | 713 aa | 714 aa | 33.2 % |
Echinococcus multilocularis | hypothetical protein | Calpain 1 | 713 aa | 715 aa | 32.7 % |
Echinococcus granulosus | calpain | Calpain 1 | 713 aa | 692 aa | 39.6 % |
Schistosoma mansoni | calpain (C02 family) | Calpain 1 | 713 aa | 708 aa | 30.5 % |
Echinococcus granulosus | calpain A | Calpain 1 | 713 aa | 752 aa | 31.5 % |
Echinococcus multilocularis | calpain | Calpain 1 | 713 aa | 695 aa | 39.4 % |
Schistosoma japonicum | Calpain-9, putative | Calpain 1 | 713 aa | 669 aa | 33.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0138 | 0.0336 | 0.0811 |
Echinococcus multilocularis | choline O acetyltransferase | 0.0205 | 0.0745 | 0.1202 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.0294 | 0.128 | 0.2186 |
Loa Loa (eye worm) | carnitine O-palmitoyltransferase I isoform | 0.0205 | 0.0745 | 0.0745 |
Leishmania major | carnitine palmitoyltransferase-like protein | 0.0294 | 0.128 | 0.1118 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0997 | 0.5535 | 1 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.0997 | 0.5535 | 1 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.0997 | 0.5535 | 1 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.0294 | 0.128 | 0.128 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.0205 | 0.0745 | 0.0745 |
Schistosoma mansoni | choline o-acyltransferase | 0.0205 | 0.0745 | 1 |
Echinococcus granulosus | choline O acetyltransferase | 0.0205 | 0.0745 | 0.0786 |
Brugia malayi | Choline O-acetyltransferase | 0.0205 | 0.0745 | 0.0458 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0097 | 0.009 | 0.009 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.0997 | 0.5535 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1735 | 1 | 1 |
Echinococcus multilocularis | calpain A | 0.0138 | 0.0336 | 0.0452 |
Onchocerca volvulus | 0.0205 | 0.0745 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0205 | 0.0745 | 0.0745 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0294 | 0.128 | 0.1011 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0997 | 0.5535 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.009 | 0.009 |
Onchocerca volvulus | 0.0205 | 0.0745 | 1 | |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.0294 | 0.128 | 0.1816 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0138 | 0.0336 | 0.0811 |
Echinococcus multilocularis | family C2 unassigned peptidase (C02 family) | 0.0138 | 0.0336 | 0.0452 |
Onchocerca volvulus | 0.0205 | 0.0745 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.021 | 0.021 |
Trypanosoma cruzi | carnitine O-palmitoyltransferase II, putative | 0.0294 | 0.128 | 0.1118 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0132 | 0.03 | 0.03 |
Brugia malayi | Choline O-acetyltransferase | 0.0205 | 0.0745 | 0.0458 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.0205 | 0.0745 | 0.0458 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.0294 | 0.128 | 1 |
Schistosoma mansoni | choline o-acyltransferase | 0.0205 | 0.0745 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0132 | 0.03 | 0.03 |
Onchocerca volvulus | 0.0205 | 0.0745 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 14 nM | Inhibition of rat CAPN1 using BODIPY-labeled casein substrate by fluorometric analysis | ChEMBL. | 21955158 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.