Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ADAM metallopeptidase with thrombospondin type 1 motif, 4 | Starlite/ChEMBL | References |
Homo sapiens | matrix metallopeptidase 13 (collagenase 3) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | a disintegrin and metalloproteinase with | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Brugia malayi | ADAM-TS Spacer 1 family protein | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Schistosoma japonicum | ko:K08624 ADAM metallopeptidase with thrombospondin type 1 motif, 9, putative | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | matrix metallopeptidase 13 (collagenase 3) | 471 aa | 448 aa | 34.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | carnitine O-acetyltransferase, putative | 0.038 | 0.0884 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.038 | 0.0884 | 0.0882 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0096 | 0.0159 | 0.0247 |
Onchocerca volvulus | 0.038 | 0.0884 | 1 | |
Onchocerca volvulus | 0.038 | 0.0884 | 1 | |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.038 | 0.0884 | 0.5 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 2 | 0.038 | 0.0884 | 0.165 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0096 | 0.0159 | 0.0247 |
Brugia malayi | Matrixin family protein | 0.0064 | 0.0077 | 0.0077 |
Brugia malayi | Hemopexin family protein | 0.0037 | 0.001 | 0.001 |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.038 | 0.0884 | 0.0884 |
Brugia malayi | ADAM-TS Spacer 1 family protein | 0.0109 | 0.0193 | 0.0193 |
Schistosoma mansoni | choline o-acyltransferase | 0.038 | 0.0884 | 1 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.038 | 0.0884 | 0.0882 |
Schistosoma mansoni | choline o-acyltransferase | 0.038 | 0.0884 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0058 | 0.0063 | 0.069 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.2073 | 0.5201 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0058 | 0.0063 | 0.0061 |
Echinococcus granulosus | carnitine O palmitoyltransferase 2 | 0.038 | 0.0884 | 0.165 |
Brugia malayi | Choline O-acetyltransferase | 0.038 | 0.0884 | 0.0884 |
Loa Loa (eye worm) | carnitine O-palmitoyltransferase I isoform | 0.038 | 0.0884 | 0.0882 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.0193 | 0.0191 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0058 | 0.0063 | 0.069 |
Loa Loa (eye worm) | hypothetical protein | 0.3954 | 1 | 1 |
Brugia malayi | Choline O-acetyltransferase | 0.038 | 0.0884 | 0.0884 |
Trypanosoma brucei | hypothetical protein, conserved | 0.038 | 0.0884 | 0.5 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.038 | 0.0884 | 0.5 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.2073 | 0.5201 | 1 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | 0.0046 | 0.0031 | 0.0244 |
Trypanosoma brucei | carnitine O-palmitoyltransferase, putative | 0.038 | 0.0884 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0064 | 0.0077 | 0.0074 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.2073 | 0.5201 | 1 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.2073 | 0.5201 | 1 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.038 | 0.0884 | 0.0882 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.2073 | 0.5201 | 1 |
Echinococcus multilocularis | choline O acetyltransferase | 0.038 | 0.0884 | 0.165 |
Echinococcus granulosus | choline O acetyltransferase | 0.038 | 0.0884 | 0.165 |
Onchocerca volvulus | 0.038 | 0.0884 | 1 | |
Onchocerca volvulus | 0.0037 | 0.001 | 0.0081 | |
Brugia malayi | Choline/Carnitine o-acyltransferase family protein | 0.038 | 0.0884 | 0.0884 |
Onchocerca volvulus | 0.038 | 0.0884 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.