Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ADAM metallopeptidase with thrombospondin type 1 motif, 4 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Brugia malayi | ADAM-TS Spacer 1 family protein | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Schistosoma japonicum | ko:K08624 ADAM metallopeptidase with thrombospondin type 1 motif, 9, putative | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | Get druggable targets OG5_126771 | All targets in OG5_126771 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | ADAM-TS Spacer 1 family protein | 0.0109 | 0.2148 | 0.2026 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.004 | 0.0154 | 0.5 |
Echinococcus granulosus | carnitine O palmitoyltransferase 1 liver | 0.0217 | 0.525 | 1 |
Echinococcus multilocularis | carnitine O palmitoyltransferase 1, liver | 0.0217 | 0.525 | 1 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0217 | 0.525 | 1 |
Loa Loa (eye worm) | choline/Carnitine O-acyltransferase | 0.004 | 0.0154 | 0.0154 |
Loa Loa (eye worm) | choline O-acetyltransferase | 0.004 | 0.0154 | 0.0154 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | 0.0046 | 0.032 | 0.0327 |
Onchocerca volvulus | 0.004 | 0.0154 | 1 | |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | 0.0046 | 0.032 | 1 |
Onchocerca volvulus | 0.004 | 0.0154 | 1 | |
Trypanosoma brucei | hypothetical protein, conserved | 0.004 | 0.0154 | 0.5 |
Loa Loa (eye worm) | carnitine O-palmitoyltransferase I isoform | 0.004 | 0.0154 | 0.0154 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | 0.0046 | 0.032 | 0.0327 |
Trypanosoma brucei | carnitine O-acetyltransferase, putative | 0.004 | 0.0154 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0154 | 0.0154 |
Leishmania major | choline/Carnitine o-acyltransferase-like protein | 0.0217 | 0.525 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0109 | 0.2148 | 0.2148 |
Trypanosoma cruzi | choline/carnitine O-acyltransferase, putative | 0.0217 | 0.525 | 1 |
Onchocerca volvulus | 0.004 | 0.0154 | 1 | |
Trypanosoma brucei | carnitine O-palmitoyltransferase, putative | 0.004 | 0.0154 | 0.5 |
Trypanosoma brucei | carnitine O-palmitoyltransferase II, putative | 0.004 | 0.0154 | 0.5 |
Onchocerca volvulus | 0.004 | 0.0154 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0383 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 8.2 uM | Inhibition of aggrecanase-1 | ChEMBL. | 21982494 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.