Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Tolloid protein 1 | 0.0516 | 1 | 1 |
Echinococcus granulosus | Tolloid protein 1 | 0.0516 | 1 | 1 |
Brugia malayi | EGF-like domain containing protein | 0.0197 | 0.1415 | 0.1415 |
Loa Loa (eye worm) | Notch2 | 0.0197 | 0.1415 | 0.1415 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.1415 | 0.1415 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.1415 | 0.1415 |
Brugia malayi | Cadherin domain containing protein | 0.0197 | 0.1415 | 0.1415 |
Loa Loa (eye worm) | notch protein | 0.0197 | 0.1415 | 0.1415 |
Brugia malayi | EGF-like domain containing protein | 0.0197 | 0.1415 | 0.1415 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0516 | 1 | 1 |
Brugia malayi | EGF-like domain containing protein | 0.0197 | 0.1415 | 0.1415 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0516 | 1 | 1 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0516 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.1415 | 0.1415 |
Onchocerca volvulus | Arrow homolog | 0.0516 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.1415 | 0.1415 |
Schistosoma mansoni | egf-like domain protein | 0.0516 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.1415 | 0.1415 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.1415 | 0.1415 |
Brugia malayi | EGF-like domain containing protein | 0.0197 | 0.1415 | 0.1415 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.1415 | 0.1415 |
Brugia malayi | notch-like transmembrane receptor | 0.0197 | 0.1415 | 0.1415 |
Brugia malayi | EGF-like domain containing protein | 0.0197 | 0.1415 | 0.1415 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.1415 | 0.1415 |
Brugia malayi | Cadherin domain containing protein | 0.0197 | 0.1415 | 0.1415 |
Loa Loa (eye worm) | hypothetical protein | 0.0516 | 1 | 1 |
Brugia malayi | Delta serrate ligand family protein | 0.0197 | 0.1415 | 0.1415 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.1415 | 0.1415 |
Brugia malayi | EGF-like domain containing protein | 0.0197 | 0.1415 | 0.1415 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.1415 | 0.1415 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0516 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.1415 | 0.1415 |
Echinococcus multilocularis | fibrillin 1 | 0.0516 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0516 | 1 | 1 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0197 | 0.1415 | 0.1415 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.1415 | 0.1415 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.1415 | 0.1415 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.1415 | 0.1415 |
Loa Loa (eye worm) | hypothetical protein | 0.0516 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.1415 | 0.1415 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0516 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.1415 | 0.1415 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0197 | 0.1415 | 0.1415 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.1415 | 0.1415 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0516 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.1415 | 0.1415 |
Echinococcus granulosus | laminin | 0.0516 | 1 | 1 |
Brugia malayi | Transmembrane cell adhesion receptor mua-3 precursor, putative | 0.0197 | 0.1415 | 0.1415 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.1415 | 0.1415 |
Brugia malayi | Muscle positioning protein 4 | 0.0197 | 0.1415 | 0.1415 |
Brugia malayi | Fibulin-1 precursor | 0.0516 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0516 | 1 | 1 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0197 | 0.1415 | 0.1415 |
Brugia malayi | EGF-like domain containing protein | 0.0197 | 0.1415 | 0.1415 |
Loa Loa (eye worm) | hypothetical protein | 0.0516 | 1 | 1 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0197 | 0.1415 | 0.1415 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.1415 | 0.1415 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.1415 | 0.1415 |
Echinococcus multilocularis | laminin | 0.0516 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0197 | 0.1415 | 0.1415 |
Giardia lamblia | High cysteine protein | 0.0197 | 0.1415 | 0.5 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0516 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 15.8489 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.