Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | parathyroid hormone 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K04588 secretin receptor, putative | Get druggable targets OG5_139196 | All targets in OG5_139196 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0501 | 0.4608 | 1 |
Brugia malayi | EGF-like domain containing protein | 0.0191 | 0.1116 | 0.2421 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.1116 | 0.2421 |
Schistosoma mansoni | hypothetical protein | 0.0191 | 0.1116 | 0.2421 |
Echinococcus multilocularis | neurogenic locus notch protein 4 | 0.0191 | 0.1116 | 0.1116 |
Echinococcus multilocularis | fat cadherin tumor suppressor | 0.0191 | 0.1116 | 0.1116 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0191 | 0.1116 | 0.1116 |
Loa Loa (eye worm) | hypothetical protein | 0.0501 | 0.4608 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0191 | 0.1116 | 0.2421 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.1116 | 0.2421 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0501 | 0.4608 | 1 |
Echinococcus multilocularis | protein jagged 1 | 0.0191 | 0.1116 | 0.1116 |
Echinococcus granulosus | delta-like protein 1 | 0.0191 | 0.1116 | 0.2421 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.1116 | 0.2421 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.1116 | 0.2421 |
Onchocerca volvulus | 0.0191 | 0.1116 | 0.2421 | |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.1116 | 0.2421 |
Brugia malayi | EGF-like domain containing protein | 0.0191 | 0.1116 | 0.2421 |
Onchocerca volvulus | Arrow homolog | 0.0501 | 0.4608 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.1116 | 0.2421 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0191 | 0.1116 | 0.2421 |
Schistosoma mansoni | notch | 0.0191 | 0.1116 | 0.2421 |
Schistosoma mansoni | egf-like domain protein | 0.0501 | 0.4608 | 1 |
Schistosoma mansoni | notch | 0.0191 | 0.1116 | 0.2421 |
Brugia malayi | EGF-like domain containing protein | 0.0191 | 0.1116 | 0.2421 |
Brugia malayi | Cadherin domain containing protein | 0.0191 | 0.1116 | 0.2421 |
Onchocerca volvulus | Slit protein homolog | 0.0191 | 0.1116 | 0.2421 |
Echinococcus multilocularis | slit 2 protein | 0.0191 | 0.1116 | 0.1116 |
Schistosoma mansoni | hypothetical protein | 0.0191 | 0.1116 | 0.2421 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0191 | 0.1116 | 0.1116 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0191 | 0.1116 | 0.1116 |
Echinococcus granulosus | neurogenic locus protein delta | 0.0191 | 0.1116 | 0.2421 |
Brugia malayi | EGF-like domain containing protein | 0.0191 | 0.1116 | 0.2421 |
Echinococcus granulosus | notch | 0.0191 | 0.1116 | 0.2421 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.1116 | 0.2421 |
Onchocerca volvulus | 0.0191 | 0.1116 | 0.2421 | |
Brugia malayi | Transmembrane cell adhesion receptor mua-3 precursor, putative | 0.0191 | 0.1116 | 0.2421 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.1116 | 0.2421 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.1116 | 0.2421 |
Giardia lamblia | High cysteine protein | 0.0191 | 0.1116 | 0.5 |
Brugia malayi | Cadherin domain containing protein | 0.0191 | 0.1116 | 0.2421 |
Loa Loa (eye worm) | hypothetical protein | 0.0501 | 0.4608 | 1 |
Schistosoma mansoni | septate junction protein | 0.0191 | 0.1116 | 0.2421 |
Brugia malayi | Delta serrate ligand family protein | 0.0191 | 0.1116 | 0.2421 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0501 | 0.4608 | 1 |
Onchocerca volvulus | Putative cubilin | 0.0191 | 0.1116 | 0.2421 |
Schistosoma mansoni | hypothetical protein | 0.0191 | 0.1116 | 0.2421 |
Schistosoma mansoni | notch | 0.0191 | 0.1116 | 0.2421 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.1116 | 0.2421 |
Schistosoma mansoni | hypothetical protein | 0.0191 | 0.1116 | 0.2421 |
Schistosoma mansoni | Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] | 0.0191 | 0.1116 | 0.2421 |
Onchocerca volvulus | Neurogenic locus notch protein homolog | 0.0191 | 0.1116 | 0.2421 |
Echinococcus granulosus | protein jagged 2 | 0.0191 | 0.1116 | 0.2421 |
Echinococcus granulosus | fibropellin Ia | 0.0191 | 0.1116 | 0.2421 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.1116 | 0.2421 |
Schistosoma mansoni | hypothetical protein | 0.0191 | 0.1116 | 0.2421 |
Echinococcus multilocularis | fibropellin Ia | 0.0191 | 0.1116 | 0.1116 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.1116 | 0.2421 |
Brugia malayi | Fibulin-1 precursor | 0.0501 | 0.4608 | 1 |
Echinococcus granulosus | protein jagged 2 | 0.0191 | 0.1116 | 0.2421 |
Brugia malayi | EGF-like domain containing protein | 0.0191 | 0.1116 | 0.2421 |
Schistosoma mansoni | laminin gamma-3 chain | 0.0191 | 0.1116 | 0.2421 |
Schistosoma mansoni | notch | 0.0191 | 0.1116 | 0.2421 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0191 | 0.1116 | 0.2421 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.1116 | 0.2421 |
Schistosoma mansoni | notch | 0.0191 | 0.1116 | 0.2421 |
Schistosoma mansoni | slit | 0.0191 | 0.1116 | 0.2421 |
Onchocerca volvulus | 0.0191 | 0.1116 | 0.2421 | |
Brugia malayi | Muscle positioning protein 4 | 0.0191 | 0.1116 | 0.2421 |
Echinococcus multilocularis | notch | 0.0191 | 0.1116 | 0.1116 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0501 | 0.4608 | 1 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0191 | 0.1116 | 0.1116 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0191 | 0.1116 | 0.2421 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0191 | 0.1116 | 0.2421 |
Schistosoma mansoni | notch | 0.0191 | 0.1116 | 0.2421 |
Onchocerca volvulus | 0.0191 | 0.1116 | 0.2421 | |
Loa Loa (eye worm) | hypothetical protein | 0.0501 | 0.4608 | 1 |
Onchocerca volvulus | 0.0191 | 0.1116 | 0.2421 | |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.1116 | 0.2421 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0191 | 0.1116 | 0.2421 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.1116 | 0.2421 |
Schistosoma mansoni | hypothetical protein | 0.0191 | 0.1116 | 0.2421 |
Echinococcus granulosus | neurogenic locus notch protein 4 | 0.0191 | 0.1116 | 0.2421 |
Brugia malayi | EGF-like domain containing protein | 0.0191 | 0.1116 | 0.2421 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.1116 | 0.2421 |
Loa Loa (eye worm) | notch protein | 0.0191 | 0.1116 | 0.2421 |
Loa Loa (eye worm) | Notch2 | 0.0191 | 0.1116 | 0.2421 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0501 | 0.4608 | 1 |
Brugia malayi | EGF-like domain containing protein | 0.0191 | 0.1116 | 0.2421 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0191 | 0.1116 | 0.2421 |
Mycobacterium ulcerans | hypothetical protein | 0.0092 | 0 | 0.5 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0501 | 0.4608 | 1 |
Echinococcus multilocularis | neural cadherin | 0.0191 | 0.1116 | 0.1116 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.1116 | 0.2421 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.1116 | 0.2421 |
Echinococcus multilocularis | protein jagged 2 | 0.0191 | 0.1116 | 0.1116 |
Schistosoma mansoni | cell polarity protein | 0.0191 | 0.1116 | 0.2421 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0501 | 0.4608 | 1 |
Brugia malayi | notch-like transmembrane receptor | 0.0191 | 0.1116 | 0.2421 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.1116 | 0.2421 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0501 | 0.4608 | 1 |
Echinococcus multilocularis | laminin | 0.0501 | 0.4608 | 0.4608 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0501 | 0.4608 | 0.4608 |
Echinococcus granulosus | neural cadherin | 0.0191 | 0.1116 | 0.2421 |
Echinococcus granulosus | Tolloid protein 1 | 0.0501 | 0.4608 | 1 |
Echinococcus granulosus | laminin | 0.0501 | 0.4608 | 1 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0501 | 0.4608 | 1 |
Onchocerca volvulus | Neurogenic locus notch homolog | 0.0191 | 0.1116 | 0.2421 |
Echinococcus granulosus | protein jagged 1 | 0.0191 | 0.1116 | 0.2421 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.1116 | 0.2421 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.1116 | 0.2421 |
Echinococcus multilocularis | protein jagged 1 | 0.0191 | 0.1116 | 0.1116 |
Echinococcus granulosus | slit 2 protein | 0.0191 | 0.1116 | 0.2421 |
Loa Loa (eye worm) | hypothetical protein | 0.0501 | 0.4608 | 1 |
Echinococcus granulosus | protein jagged 1 | 0.0191 | 0.1116 | 0.2421 |
Echinococcus multilocularis | fibrillin 1 | 0.0501 | 0.4608 | 0.4608 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 0.1116 | 0.2421 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0046 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 3.5481 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] | ChEMBL. | No reference |
Potency (functional) | 95.2834 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.