Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ataxin 2 | Starlite/ChEMBL | No references |
Homo sapiens | isocitrate dehydrogenase 1 (NADP+), soluble | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | EGF-like domain containing protein | 0.0053 | 0.2084 | 0.2084 |
Schistosoma mansoni | Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] | 0.0053 | 0.2084 | 0.1218 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.2084 | 0.2084 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0986 | 0.0986 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.2084 | 0.2084 |
Brugia malayi | EGF-like domain containing protein | 0.0053 | 0.2084 | 0.2084 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.2084 | 0.1218 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.2084 | 0.2084 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0053 | 0.2084 | 0.2084 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.2084 | 0.2084 |
Leishmania major | hypothetical protein, conserved | 0.003 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.2084 | 0.1218 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.2084 | 0.2084 |
Echinococcus granulosus | laminin | 0.0139 | 1 | 1 |
Brugia malayi | notch-like transmembrane receptor | 0.0053 | 0.2084 | 0.2084 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.2084 | 0.2084 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.2084 | 0.1218 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0986 | 0.0986 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.2084 | 0.1218 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.2084 | 0.1218 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0139 | 1 | 1 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0139 | 1 | 1 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0139 | 1 | 1 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0139 | 1 | 1 |
Schistosoma mansoni | egf-like domain protein | 0.0139 | 1 | 1 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0053 | 0.2084 | 0.2084 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.2084 | 0.2084 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.2084 | 0.2084 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.2084 | 0.2084 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0139 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 1 | 1 |
Echinococcus multilocularis | fibrillin 1 | 0.0139 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.2084 | 0.2084 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.2738 | 0.2738 |
Brugia malayi | Delta serrate ligand family protein | 0.0053 | 0.2084 | 0.2084 |
Echinococcus granulosus | Tolloid protein 1 | 0.0139 | 1 | 1 |
Schistosoma mansoni | notch | 0.0053 | 0.2084 | 0.1218 |
Schistosoma mansoni | cell polarity protein | 0.0053 | 0.2084 | 0.1218 |
Brugia malayi | EGF-like domain containing protein | 0.0053 | 0.2084 | 0.2084 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0139 | 1 | 1 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0139 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.2738 | 0.2738 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0139 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0 | 0.5 |
Giardia lamblia | High cysteine protein | 0.0053 | 0.2084 | 0.5 |
Loa Loa (eye worm) | notch protein | 0.0053 | 0.2084 | 0.2084 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.2084 | 0.2084 |
Brugia malayi | EGF-like domain containing protein | 0.0053 | 0.2084 | 0.2084 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.2084 | 0.1218 |
Brugia malayi | Fibulin-1 precursor | 0.0139 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.2084 | 0.2084 |
Brugia malayi | Muscle positioning protein 4 | 0.0053 | 0.2084 | 0.2084 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.2084 | 0.2084 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.003 | 0 | 0.5 |
Brugia malayi | Cadherin domain containing protein | 0.0053 | 0.2084 | 0.2084 |
Brugia malayi | EGF-like domain containing protein | 0.0053 | 0.2084 | 0.2084 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.2084 | 0.2084 |
Schistosoma mansoni | notch | 0.0053 | 0.2084 | 0.1218 |
Schistosoma mansoni | hypothetical protein | 0.0053 | 0.2084 | 0.1218 |
Brugia malayi | EGF-like domain containing protein | 0.0053 | 0.2084 | 0.2084 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.2084 | 0.2084 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.003 | 0 | 0.5 |
Onchocerca volvulus | Arrow homolog | 0.0139 | 1 | 1 |
Brugia malayi | Cadherin domain containing protein | 0.0053 | 0.2084 | 0.2084 |
Brugia malayi | Transmembrane cell adhesion receptor mua-3 precursor, putative | 0.0053 | 0.2084 | 0.2084 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.2084 | 0.2084 |
Brugia malayi | EGF-like domain containing protein | 0.0053 | 0.2084 | 0.2084 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.2738 | 0.2738 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.003 | 0 | 0.5 |
Schistosoma mansoni | laminin gamma-3 chain | 0.0053 | 0.2084 | 0.1218 |
Schistosoma mansoni | notch | 0.0053 | 0.2084 | 0.1218 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0053 | 0.2084 | 0.2084 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.2084 | 0.2084 |
Schistosoma mansoni | slit | 0.0053 | 0.2084 | 0.1218 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.2084 | 0.2084 |
Echinococcus multilocularis | laminin | 0.0139 | 1 | 1 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0053 | 0.2084 | 0.2084 |
Loa Loa (eye worm) | Notch2 | 0.0053 | 0.2084 | 0.2084 |
Schistosoma mansoni | notch | 0.0053 | 0.2084 | 0.1218 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0 | 0.5 |
Schistosoma mansoni | notch | 0.0053 | 0.2084 | 0.1218 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.2084 | 0.2084 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.2084 | 0.2084 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.2084 | 0.2084 |
Toxoplasma gondii | EGF family domain-containing protein | 0.0053 | 0.2084 | 0.2084 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.003 | 0 | 0.5 |
Schistosoma mansoni | notch | 0.0053 | 0.2084 | 0.1218 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.2084 | 0.2084 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.2738 | 0.2738 |
Schistosoma mansoni | septate junction protein | 0.0053 | 0.2084 | 0.1218 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1.5849 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 9.2 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.