TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 265.263 | Formula: C16H11NO3
H donors: 0 H acceptors: 3 LogP: 3.62 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: [O-][N+](=O)c1ccccc1C=C1Cc2c(C1=O)cccc2
InChi: 1S/C16H11NO3/c18-16-13(9-11-5-1-3-7-14(11)16)10-12-6-2-4-8-15(12)17(19)20/h1-8,10H,9H2
InChiKey: CVCZIDNJPIBPLJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	isocitrate dehydrogenase 1 (NADP+), soluble	Starlite/ChEMBL	No references
Homo sapiens	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G	Starlite/ChEMBL	No references
Human immunodeficiency virus 1	Aberrant vpr protein	Starlite/ChEMBL	No references
Homo sapiens	breast cancer 1, early onset	Starlite/ChEMBL	No references
Homo sapiens	SMAD family member 2	Starlite/ChEMBL	No references
Homo sapiens	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D	Starlite/ChEMBL	No references
Homo sapiens	TAR DNA binding protein	Starlite/ChEMBL	No references
Homo sapiens	nuclear factor, erythroid 2-like 2	Starlite/ChEMBL	No references
Homo sapiens	ataxin 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Loa Loa (eye worm)	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	Get druggable targets OG5_127057	All targets in OG5_127057
Brugia malayi	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Brugia malayi	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Theileria parva	isocitrate dehydrogenase (NADP+), putative	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	Mitochondrial NADP-specific isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium yoelii	isocitrate dehydrogenase, NADP-dependent, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Candida albicans	cytosolic NADP-specific isocitrate dehydrogenase.	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania mexicana	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium yoelii	isocitrate dehydrogenase, NADP-dependent	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma cruzi	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Toxoplasma gondii	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	Isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Brugia malayi	MH2 domain containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Plasmodium berghei	isocitrate dehydrogenase [NADP], mitochondrial, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus granulosus	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	transcription factor SMAD2	Get druggable targets OG5_131716	All targets in OG5_131716
Trypanosoma brucei	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Neospora caninum	hypothetical protein	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	Get druggable targets OG5_127057	All targets in OG5_127057
Leishmania infantum	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	C terminus of cytosolic NADP-specific isocitrate dehydrogenase.	Get druggable targets OG5_127057	All targets in OG5_127057
Loa Loa (eye worm)	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Babesia bovis	isocitrate dehydrogenase, NADP-dependent family protein	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Leishmania donovani	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma brucei gambiense	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	N terminus of cytosolic NADP-specific isocitrate dehydrogenase.	Get druggable targets OG5_127057	All targets in OG5_127057
Brugia malayi	RNA recognition motif domain containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Plasmodium knowlesi	isocitrate dehydrogenase [NADP], mitochondrial, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma japonicum	ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Loa Loa (eye worm)	MH2 domain-containing protein	Get druggable targets OG5_131716	All targets in OG5_131716
Leishmania braziliensis	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma brucei gambiense	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Trypanosoma congolense	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Neospora caninum	Isocitrate dehydrogenase-like protein, related	Get druggable targets OG5_127057	All targets in OG5_127057
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Trypanosoma congolense	isocitrate dehydrogenase, putative	Get druggable targets OG5_127057	All targets in OG5_127057
Candida albicans	Mitochondrial NADP-specific isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057
Toxoplasma gondii	isocitrate dehydrogenase	Get druggable targets OG5_127057	All targets in OG5_127057

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	MH2 domain containing protein	SMAD family member 2	467 aa	405 aa	31.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	SH2 domain containing protein	0.0236	0.6285	0.6285
Loa Loa (eye worm)	TK protein kinase	0.0236	0.6285	0.6285
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0139	0.3466	0.5514
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0098	0.2268	0.2802
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0236	0.6285	1
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0236	0.6285	1
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0236	0.6285	1
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0098	0.2268	0.2802
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0139	0.3466	0.5514
Brugia malayi	integrin-linked kinase	0.0098	0.2268	0.2268
Loa Loa (eye worm)	TK/FER protein kinase	0.0236	0.6285	0.6285
Brugia malayi	Protein kinase domain containing protein	0.0098	0.2268	0.2268
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Brugia malayi	Protein kinase domain containing protein	0.0098	0.2268	0.2268
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Loa Loa (eye worm)	TK protein kinase	0.0098	0.2268	0.2268
Loa Loa (eye worm)	TK/ABL protein kinase	0.0236	0.6285	0.6285
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0139	0.3466	0.5514
Brugia malayi	Guanylyl cyclase protein 23	0.0098	0.2268	0.2268
Loa Loa (eye worm)	hypothetical protein	0.0139	0.3466	0.3466
Brugia malayi	Protein kinase domain containing protein	0.0098	0.2268	0.2268
Entamoeba histolytica	protein kinase domain containing protein	0.0098	0.2268	0.2802
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0236	0.6285	1
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0139	0.3466	0.3466
Brugia malayi	Variant SH3 domain containing protein	0.0139	0.3466	0.3466
Echinococcus granulosus	ephrin type A receptor 4 A	0.0098	0.2268	0.3608
Schistosoma mansoni	transcription factor LCR-F1	0.0043	0.0705	0.1121
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Trichomonas vaginalis	STE family protein kinase	0.0098	0.2268	0.5
Brugia malayi	MH2 domain containing protein	0.0144	0.3617	0.3617
Loa Loa (eye worm)	TK/ROR protein kinase	0.0098	0.2268	0.2268
Leishmania major	hypothetical protein, conserved	0.0098	0.2268	1
Leishmania major	protein kinase, putative	0.0098	0.2268	1
Echinococcus multilocularis	SH2 domain containing protein 7	0.0139	0.3466	0.5514
Brugia malayi	Protein kinase domain containing protein	0.0098	0.2268	0.2268
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0098	0.2268	0.2268
Schistosoma mansoni	tyrosine kinase	0.0098	0.2268	0.3608
Schistosoma mansoni	SH2A	0.0139	0.3466	0.5514
Schistosoma mansoni	tyrosine kinase	0.0098	0.2268	0.3608
Echinococcus granulosus	SH2 domain containing protein 7	0.0139	0.3466	0.5514
Loa Loa (eye worm)	hypothetical protein	0.0236	0.6285	0.6285
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0139	0.3466	0.5514
Entamoeba histolytica	protein kinase domain containing protein	0.0098	0.2268	0.2802
Entamoeba histolytica	ankyrin repeat protein	0.0098	0.2268	0.2802
Brugia malayi	SH2 domain containing protein	0.0139	0.3466	0.3466
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0098	0.2268	0.2802
Onchocerca volvulus		0.0139	0.3466	0.1549
Brugia malayi	Protein kinase domain containing protein	0.0098	0.2268	0.2268
Giardia lamblia	Kinase, NEK	0.0098	0.2268	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0098	0.2268	0.3608
Brugia malayi	Protein kinase domain containing protein	0.0236	0.6285	0.6285
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0098	0.2268	0.5
Schistosoma mansoni	tyrosine kinase	0.0098	0.2268	0.3608
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0098	0.2268	0.2268
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0098	0.2268	0.3608
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0098	0.2268	0.2802
Entamoeba histolytica	receptor protein kinase, putative	0.0098	0.2268	0.2802
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0043	0.0705	0.1121
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0098	0.2268	0.3608
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.0328	0.1448
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0139	0.3466	0.4948
Echinococcus granulosus	tyrosine protein kinase HCK	0.0098	0.2268	0.3608
Entamoeba histolytica	protein kinase, putative	0.0098	0.2268	0.2802
Entamoeba histolytica	protein kinase, putative	0.0098	0.2268	0.2802
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0236	0.6285	1
Entamoeba histolytica	SH2 domain containing protein	0.0139	0.3466	0.4948
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Brugia malayi	Protein kinase domain containing protein	0.0098	0.2268	0.2268
Schistosoma mansoni	tyrosine kinase	0.0098	0.2268	0.3608
Echinococcus multilocularis	epidermal growth factor receptor	0.0098	0.2268	0.3608
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Entamoeba histolytica	serine/threonine kinase, putative	0.0098	0.2268	0.2802
Schistosoma mansoni	hypothetical protein	0.0043	0.0705	0.1121
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Echinococcus granulosus	tar DNA binding protein	0.0076	0.166	0.2641
Toxoplasma gondii	LsmAD domain-containing protein	0.003	0.0328	0.1448
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0098	0.2268	0.5
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0139	0.3466	0.1549
Brugia malayi	hypothetical protein	0.0139	0.3466	0.3466
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0139	0.3466	0.5514
Trichomonas vaginalis	conserved hypothetical protein	0.0098	0.2268	0.5
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0139	0.3466	0.3466
Loa Loa (eye worm)	hypothetical protein	0.0098	0.2268	0.2268
Entamoeba histolytica	protein kinase domain containing protein	0.0098	0.2268	0.2802
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0236	0.6285	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0098	0.2268	0.2802
Loa Loa (eye worm)	TK protein kinase	0.0098	0.2268	0.2268
Entamoeba histolytica	protein kinase, putative	0.0098	0.2268	0.2802
Brugia malayi	hypothetical protein	0.0098	0.2268	0.2268
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0098	0.2268	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0098	0.2268	0.3608
Brugia malayi	SH2 domain containing protein	0.0236	0.6285	0.6285
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0236	0.6285	1
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Entamoeba histolytica	ankyrin repeat protein	0.0098	0.2268	0.2802
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0139	0.3466	0.5514
Loa Loa (eye worm)	TK/FER protein kinase	0.0098	0.2268	0.2268
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Loa Loa (eye worm)	TK/Met protein kinase	0.0098	0.2268	0.2268
Echinococcus granulosus	SH2 motif	0.0139	0.3466	0.5514
Loa Loa (eye worm)	hypothetical protein	0.0139	0.3466	0.3466
Echinococcus multilocularis		0.0139	0.3466	0.5514
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0236	0.6285	1
Entamoeba histolytica	protein kinase domain containing protein	0.0098	0.2268	0.2802
Brugia malayi	Protein kinase domain containing protein	0.0098	0.2268	0.2268
Trichomonas vaginalis	CAMK family protein kinase	0.0098	0.2268	0.5
Loa Loa (eye worm)	TK/FAK protein kinase	0.0098	0.2268	0.2268
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0098	0.2268	0.2802
Schistosoma mansoni	protein kinase	0.0098	0.2268	0.3608
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Brugia malayi	SH2 domain containing protein	0.0139	0.3466	0.3466
Loa Loa (eye worm)	TK/DDR protein kinase	0.0098	0.2268	0.2268
Brugia malayi	Variant SH3 domain containing protein	0.0139	0.3466	0.3466
Plasmodium falciparum	tyrosine kinase-like protein	0.0098	0.2268	1
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0139	0.3466	0.3466
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0098	0.2268	0.3608
Brugia malayi	Protein kinase domain containing protein	0.0098	0.2268	0.2268
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Echinococcus granulosus	N chimaerin	0.0139	0.3466	0.5514
Schistosoma mansoni	nck2/grb4	0.0139	0.3466	0.5514
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Entamoeba histolytica	tyrosin kinase, putative	0.0098	0.2268	0.2802
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0098	0.2268	0.2268
Schistosoma mansoni	tyrosine kinase	0.0098	0.2268	0.3608
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0139	0.3466	0.5514
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0098	0.2268	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0236	0.6285	0.6285
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.166	0.2641
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0098	0.2268	0.2268
Onchocerca volvulus		0.0139	0.3466	0.1549
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0098	0.2268	0.3608
Entamoeba histolytica	serine/threonine kinase, putative	0.0098	0.2268	0.2802
Brugia malayi	Furin-like cysteine rich region family protein	0.0098	0.2268	0.2268
Schistosoma mansoni	tensin	0.0139	0.3466	0.5514
Entamoeba histolytica	protein kinase domain containing protein	0.0098	0.2268	0.2802
Onchocerca volvulus		0.0236	0.6285	0.5196
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0139	0.3466	0.3466
Echinococcus granulosus	tyrosine protein kinase csk	0.0098	0.2268	0.3608
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0098	0.2268	0.3608
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0139	0.3466	0.5514
Entamoeba histolytica	protein kinase, putative	0.0098	0.2268	0.2802
Brugia malayi	Raf kinase	0.0098	0.2268	0.2268
Schistosoma mansoni	tyrosine kinase	0.0098	0.2268	0.3608
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0098	0.2268	0.3608
Entamoeba histolytica	tyrosine kinase, putative	0.0098	0.2268	0.2802
Brugia malayi	Protein kinase domain containing protein	0.0236	0.6285	0.6285
Entamoeba histolytica	protein kinase, putative	0.0098	0.2268	0.2802
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0098	0.2268	0.3608
Echinococcus multilocularis	FL cytokine receptor	0.0098	0.2268	0.3608
Entamoeba histolytica	protein kinase domain containing protein	0.0098	0.2268	0.2802
Brugia malayi	Protein kinase domain containing protein	0.0098	0.2268	0.2268
Loa Loa (eye worm)	hypothetical protein	0.0098	0.2268	0.2268
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0098	0.2268	0.3608
Trichomonas vaginalis	conserved hypothetical protein	0.0098	0.2268	0.5
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0236	0.6285	1
Entamoeba histolytica	protein kinase domain containing protein	0.0098	0.2268	0.2802
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0098	0.2268	0.2268
Trypanosoma cruzi	protein kinase, putative	0.0098	0.2268	1
Loa Loa (eye worm)	RNA binding protein	0.0076	0.166	0.166
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Schistosoma mansoni	suppressor of cytokine signaling	0.0139	0.3466	0.5514
Echinococcus granulosus	tyrosine protein kinase shark	0.0236	0.6285	1
Echinococcus multilocularis	transfer RNA-Thr	0.0098	0.2268	0.3608
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0098	0.2268	0.3608
Brugia malayi	Protein kinase domain containing protein	0.0098	0.2268	0.2268
Brugia malayi	SRC-1	0.0236	0.6285	0.6285
Loa Loa (eye worm)	TK protein kinase	0.0098	0.2268	0.2268
Toxoplasma gondii	protein kinase domain-containing protein	0.0098	0.2268	1
Schistosoma mansoni	protein kinase	0.0098	0.2268	0.3608
Loa Loa (eye worm)	TK/EPH protein kinase	0.0098	0.2268	0.2268
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0236	0.6285	1
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0139	0.3466	0.5514
Echinococcus multilocularis	tyrosine protein kinase csk	0.0098	0.2268	0.3608
Giardia lamblia	Protein 21.1	0.0098	0.2268	0.5
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0098	0.2268	0.3608
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0098	0.2268	0.3608
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Echinococcus granulosus	expressed conserved protein	0.0139	0.3466	0.5514
Onchocerca volvulus		0.0236	0.6285	0.5196
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0236	0.6285	1
Schistosoma mansoni	protein kinase	0.0098	0.2268	0.3608
Echinococcus multilocularis	tar DNA binding protein	0.0076	0.166	0.2641
Schistosoma mansoni	tensin-related	0.0139	0.3466	0.5514
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0098	0.2268	0.2268
Schistosoma mansoni	hypothetical protein	0.0139	0.3466	0.5514
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0098	0.2268	0.2268
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0139	0.3466	0.5514
Echinococcus multilocularis	protein tyrosine kinase	0.0098	0.2268	0.3608
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0098	0.2268	0.3608
Entamoeba histolytica	cysteine surface protein, putative	0.0098	0.2268	0.2802
Loa Loa (eye worm)	SRC-1	0.0236	0.6285	0.6285
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0236	0.6285	1
Schistosoma mansoni	tyrosine kinase	0.0098	0.2268	0.3608
Loa Loa (eye worm)	hypothetical protein	0.0139	0.3466	0.3466
Entamoeba histolytica	hypothetical protein	0.0098	0.2268	0.2802
Echinococcus granulosus	tensin	0.0139	0.3466	0.5514
Entamoeba histolytica	protein kinase, putative	0.0098	0.2268	0.2802
Echinococcus granulosus	raf serine:threonine protein kinase	0.0098	0.2268	0.3608
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0139	0.3466	0.5514
Plasmodium vivax	protein kinase, putative	0.0098	0.2268	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0098	0.2268	0.2268
Entamoeba histolytica	hypothetical protein	0.0098	0.2268	0.2802
Loa Loa (eye worm)	hypothetical protein	0.0365	1	1
Schistosoma mansoni	protein kinase	0.0098	0.2268	0.3608
Echinococcus granulosus	activated cdc42 kinase 1	0.0098	0.2268	0.3608
Trichomonas vaginalis	conserved hypothetical protein	0.0098	0.2268	0.5
Schistosoma mansoni	tyrosine protein kinase	0.0098	0.2268	0.3608
Entamoeba histolytica	protein kinase, putative	0.0098	0.2268	0.2802
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0098	0.2268	0.2802
Schistosoma mansoni	tensin-related	0.0139	0.3466	0.5514
Schistosoma mansoni	protein tyrosine kinase	0.0098	0.2268	0.3608
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Leishmania major	hypothetical protein, conserved	0.003	0.0328	0.1448
Trichomonas vaginalis	conserved hypothetical protein	0.0098	0.2268	0.5
Entamoeba histolytica	protein kinase, putative	0.0098	0.2268	0.2802
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0098	0.2268	0.2802
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Schistosoma mansoni	adapter molecule crk	0.0139	0.3466	0.5514
Echinococcus granulosus	tyrosine protein kinase Blk	0.0236	0.6285	1
Schistosoma mansoni	tyrosine kinase	0.0098	0.2268	0.3608
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0236	0.6285	1
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Echinococcus granulosus	tyrosine protein kinase pr2	0.0098	0.2268	0.3608
Loa Loa (eye worm)	TK/INSR protein kinase	0.0098	0.2268	0.2268
Loa Loa (eye worm)	hypothetical protein	0.0139	0.3466	0.3466
Schistosoma mansoni	vav2	0.0139	0.3466	0.5514
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0098	0.2268	0.3608
Echinococcus multilocularis	integrin linked protein kinase	0.0098	0.2268	0.3608
Trypanosoma brucei	PAB1-binding protein , putative	0.003	0.0328	0.1448
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0098	0.2268	0.5
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0098	0.2268	0.2268
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Schistosoma mansoni	protein kinase	0.0098	0.2268	0.3608
Loa Loa (eye worm)	TK/FER protein kinase	0.0098	0.2268	0.2268
Echinococcus granulosus	tyrosine protein kinase	0.0098	0.2268	0.3608
Loa Loa (eye worm)	hypothetical protein	0.0139	0.3466	0.3466
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Loa Loa (eye worm)	hypothetical protein	0.0098	0.2268	0.2268
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0236	0.6285	1
Echinococcus granulosus	natriuretic peptide receptor 1	0.0098	0.2268	0.3608
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0139	0.3466	0.5514
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.166	0.2641
Echinococcus multilocularis	signal transduction protein lnk realted	0.0139	0.3466	0.5514
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0098	0.2268	0.2802
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0139	0.3466	0.5514
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0098	0.2268	0.2802
Entamoeba histolytica	serine/threonine kinase, putative	0.0098	0.2268	0.2802
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0098	0.2268	0.2802
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0236	0.6285	1
Loa Loa (eye worm)	TK protein kinase	0.0098	0.2268	0.2268
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0139	0.3466	0.3466
Entamoeba histolytica	tyrosin kinase, putative	0.0098	0.2268	0.2802
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0098	0.2268	0.2268
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Entamoeba histolytica	protein kinase, putative	0.0098	0.2268	0.2802
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0098	0.2268	0.3608
Brugia malayi	Variant SH3 domain containing protein	0.0139	0.3466	0.3466
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.166	0.2641
Loa Loa (eye worm)	TK/ALK protein kinase	0.0098	0.2268	0.2268
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0098	0.2268	0.2268
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0098	0.2268	0.3608
Schistosoma mansoni	tyrosine kinase	0.0098	0.2268	0.3608
Entamoeba histolytica	receptor protein kinase, putative	0.0098	0.2268	0.2802
Brugia malayi	Receptor family ligand binding region containing protein	0.0098	0.2268	0.2268
Loa Loa (eye worm)	TK/FER protein kinase	0.0236	0.6285	0.6285
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.0328	0.1448
Loa Loa (eye worm)	hypothetical protein	0.0139	0.3466	0.3466
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0098	0.2268	0.3608
Echinococcus granulosus	tyrosine kinase	0.0236	0.6285	1
Brugia malayi	C-terminal src kinase protein 1	0.0098	0.2268	0.2268
Brugia malayi	Protein kinase domain containing protein	0.0098	0.2268	0.2268
Echinococcus multilocularis	protein kinase	0.0098	0.2268	0.3608
Schistosoma mansoni	tyrosine kinase	0.0236	0.6285	1
Entamoeba histolytica	protein kinase domain containing protein	0.0098	0.2268	0.2802
Loa Loa (eye worm)	hypothetical protein	0.0139	0.3466	0.3466
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0098	0.2268	0.2802
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Schistosoma mansoni	GTPase activating protein	0.0139	0.3466	0.5514
Entamoeba histolytica	protein kinase, putative	0.0098	0.2268	0.2802
Trypanosoma brucei	protein kinase, putative	0.0098	0.2268	1
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Schistosoma mansoni	ephrin receptor	0.0098	0.2268	0.3608
Echinococcus multilocularis	heat shock protein 70	0.0098	0.2268	0.3608
Onchocerca volvulus		0.0236	0.6285	0.5196
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.166	0.2641
Trichomonas vaginalis	conserved hypothetical protein	0.0098	0.2268	0.5
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0236	0.6285	1
Brugia malayi	Sex muscle abnormal protein 5	0.0139	0.3466	0.3466
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0139	0.3466	0.3466
Trypanosoma cruzi	protein kinase, putative	0.0098	0.2268	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0098	0.2268	0.2802
Trypanosoma brucei	Pseudokinase, putative	0.0098	0.2268	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0098	0.2268	0.2268
Loa Loa (eye worm)	hypothetical protein	0.0139	0.3466	0.3466
Loa Loa (eye worm)	TK/FER protein kinase	0.0236	0.6285	0.6285
Brugia malayi	Tyrosine-protein kinase PR2	0.0098	0.2268	0.2268
Schistosoma mansoni	ephrin receptor	0.0098	0.2268	0.3608
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0098	0.2268	0.2802
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Entamoeba histolytica	tyrosin kinase, putative	0.0098	0.2268	0.2802
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0098	0.2268	0.3608
Echinococcus granulosus	epidermal growth factor receptor	0.0098	0.2268	0.3608
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Echinococcus multilocularis	epidermal growth factor receptor	0.0098	0.2268	0.3608
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0043	0.0705	0.1121
Entamoeba histolytica	serine/threonine kinase, putative	0.0098	0.2268	0.2802
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0098	0.2268	0.3608
Trichomonas vaginalis	AGC family protein kinase	0.0098	0.2268	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0098	0.2268	0.2802
Echinococcus granulosus	activated cdc42 kinase 1	0.0098	0.2268	0.3608
Entamoeba histolytica	protein kinase, putative	0.0098	0.2268	0.2802
Schistosoma mansoni	tyrosine kinase	0.0236	0.6285	1
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0139	0.3466	0.3466
Entamoeba histolytica	tyrosine kinase, putative	0.0098	0.2268	0.2802
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0098	0.2268	0.2268
Echinococcus multilocularis	tyrosine protein kinase csk	0.0098	0.2268	0.3608
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0098	0.2268	0.5
Brugia malayi	SH2 domain containing protein	0.0139	0.3466	0.3466
Entamoeba histolytica	protein kinase domain containing protein	0.0098	0.2268	0.2802
Loa Loa (eye worm)	hypothetical protein	0.0139	0.3466	0.3466
Entamoeba histolytica	tyrosine kinase, putative	0.0098	0.2268	0.2802
Brugia malayi	Protein kinase domain containing protein	0.0236	0.6285	0.6285
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0098	0.2268	0.3608
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0236	0.6285	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0236	0.6285	0.6285
Trichomonas vaginalis	conserved hypothetical protein	0.0098	0.2268	0.5
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0098	0.2268	0.3608
Entamoeba histolytica	hypothetical protein	0.0098	0.2268	0.2802
Echinococcus granulosus	insulin receptor	0.0098	0.2268	0.3608
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.166	0.166
Schistosoma mansoni	tyrosine kinase	0.0098	0.2268	0.3608
Loa Loa (eye worm)	hypothetical protein	0.0139	0.3466	0.3466
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Plasmodium falciparum	protein kinase, putative	0.0098	0.2268	1
Entamoeba histolytica	hypothetical protein	0.0098	0.2268	0.2802
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0098	0.2268	1
Entamoeba histolytica	protein kinase, putative	0.0098	0.2268	0.2802
Brugia malayi	Protein kinase domain containing protein	0.0098	0.2268	0.2268
Brugia malayi	Protein kinase domain containing protein	0.0098	0.2268	0.2268
Giardia lamblia	Kinase	0.0098	0.2268	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0098	0.2268	0.2802
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0098	0.2268	0.3608
Onchocerca volvulus		0.0139	0.3466	0.1549
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0098	0.2268	0.3608
Loa Loa (eye worm)	hypothetical protein	0.0098	0.2268	0.2268
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.166	0.166
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0098	0.2268	0.2268
Entamoeba histolytica	tyrosine kinase, putative	0.0098	0.2268	0.2802
Trichomonas vaginalis	conserved hypothetical protein	0.0098	0.2268	0.5
Schistosoma mansoni	tyrosine kinase	0.0098	0.2268	0.3608
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Schistosoma mansoni	tyrosine kinase	0.0098	0.2268	0.3608
Echinococcus multilocularis	SH2 motif	0.0139	0.3466	0.5514
Echinococcus granulosus	tyrosine protein kinase Srms	0.0236	0.6285	1
Entamoeba histolytica	tyrosine kinase, putative	0.0098	0.2268	0.2802
Loa Loa (eye worm)	TK/FER protein kinase	0.0098	0.2268	0.2268
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Brugia malayi	Protein kinase domain containing protein	0.0098	0.2268	0.2268
Entamoeba histolytica	protein kinase domain containing protein	0.0098	0.2268	0.2802
Brugia malayi	Protein kinase domain containing protein	0.0098	0.2268	0.2268
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0098	0.2268	1
Entamoeba histolytica	protein kinase, putative	0.0098	0.2268	0.2802
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0098	0.2268	0.2802
Echinococcus granulosus	protein tyrosine kinase	0.0098	0.2268	0.3608
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0098	0.2268	1
Echinococcus granulosus	c src tyrosine kinase	0.0236	0.6285	1
Schistosoma mansoni	tyrosine kinase	0.0098	0.2268	0.3608
Entamoeba histolytica	hypothetical protein	0.0098	0.2268	0.2802
Loa Loa (eye worm)	hypothetical protein	0.0098	0.2268	0.2268
Schistosoma mansoni	protein kinase	0.0098	0.2268	0.3608
Schistosoma mansoni	tyrosine kinase	0.0098	0.2268	0.3608
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0236	0.6285	1
Brugia malayi	Protein kinase domain containing protein	0.0098	0.2268	0.2268
Onchocerca volvulus		0.0236	0.6285	0.5196
Loa Loa (eye worm)	TK protein kinase	0.0098	0.2268	0.2268
Onchocerca volvulus		0.0139	0.3466	0.1549
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0098	0.2268	0.2268
Entamoeba histolytica	protein kinase, putative	0.0139	0.3466	0.4948
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0098	0.2268	0.3608
Brugia malayi	SH2 domain containing protein	0.0139	0.3466	0.3466
Entamoeba histolytica	protein kinase domain containing protein	0.0098	0.2268	0.2802
Schistosoma mansoni	shc transforming protein	0.0139	0.3466	0.5514
Entamoeba histolytica	protein kinase domain containing protein	0.0098	0.2268	0.2802
Loa Loa (eye worm)	TK/FER protein kinase	0.0236	0.6285	0.6285
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Entamoeba histolytica	hypothetical protein	0.0098	0.2268	0.2802
Loa Loa (eye worm)	hypothetical protein	0.0098	0.2268	0.2268
Echinococcus multilocularis	SH2 motif	0.0139	0.3466	0.5514
Echinococcus multilocularis	SHC transforming protein 3	0.0139	0.3466	0.5514
Echinococcus granulosus	signal transduction protein lnk realted	0.0139	0.3466	0.5514
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Loa Loa (eye worm)	TK protein kinase	0.0098	0.2268	0.2268
Loa Loa (eye worm)	TK/FER protein kinase	0.0236	0.6285	0.6285
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.166	0.166
Schistosoma mansoni	serine/threonine protein kinase	0.0098	0.2268	0.3608
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0098	0.2268	0.2268
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0098	0.2268	0.2268
Schistosoma mansoni	protein kinase	0.0098	0.2268	0.3608
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0098	0.2268	0.3608
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0098	0.2268	0.2802
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0236	0.6285	1
Echinococcus granulosus	tyrosine kinase	0.0236	0.6285	1
Schistosoma mansoni	tensin	0.0139	0.3466	0.5514
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0098	0.2268	0.3608
Entamoeba histolytica	tyrosine kinase, putative	0.0098	0.2268	0.2802
Echinococcus multilocularis	tyrosine kinase	0.0098	0.2268	0.3608
Loa Loa (eye worm)	hypothetical protein	0.0098	0.2268	0.2268
Loa Loa (eye worm)	hypothetical protein	0.0139	0.3466	0.3466
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Trichomonas vaginalis	protein kinase atn1, putative	0.0098	0.2268	0.5
Brugia malayi	Protein kinase domain containing protein	0.0098	0.2268	0.2268
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0139	0.3466	0.3466
Brugia malayi	hypothetical protein	0.0236	0.6285	0.6285
Entamoeba histolytica	protein kinase, putative	0.0098	0.2268	0.2802
Loa Loa (eye worm)	hypothetical protein	0.0139	0.3466	0.3466
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0098	0.2268	0.2268
Schistosoma mansoni	serine/threonine RGC	0.0098	0.2268	0.3608
Plasmodium falciparum	tyrosine kinase-like protein	0.0098	0.2268	1
Brugia malayi	RhoGAP domain containing protein	0.0139	0.3466	0.3466
Echinococcus multilocularis	protein kinase	0.0098	0.2268	0.3608
Entamoeba histolytica	hypothetical protein	0.0098	0.2268	0.2802
Trypanosoma cruzi	PAB1-binding protein , putative	0.003	0.0328	0.1448
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0098	0.2268	0.3608
Loa Loa (eye worm)	TK/CSK protein kinase	0.0098	0.2268	0.2268
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0098	0.2268	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0098	0.2268	0.2268
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0098	0.2268	0.2802
Entamoeba histolytica	tyrosine kinase, putative	0.0098	0.2268	0.2802
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0098	0.2268	0.3608
Brugia malayi	Protein kinase domain containing protein	0.0098	0.2268	0.2268
Loa Loa (eye worm)	serine/threonine protein kinase	0.0098	0.2268	0.2268
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0098	0.2268	0.3608
Echinococcus granulosus	NCK adaptor protein	0.0139	0.3466	0.5514
Echinococcus granulosus	SH2 motif	0.0139	0.3466	0.5514
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0236	0.6285	1
Onchocerca volvulus		0.0365	1	1
Schistosoma mansoni	serine/threonine protein kinase	0.0098	0.2268	0.3608
Onchocerca volvulus		0.0139	0.3466	0.1549
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0236	0.6285	1
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0098	0.2268	0.3608
Echinococcus multilocularis	tensin	0.0139	0.3466	0.5514
Schistosoma mansoni	protein kinase	0.0098	0.2268	0.3608
Brugia malayi	Protein kinase domain containing protein	0.0098	0.2268	0.2268
Echinococcus multilocularis	tyrosine protein kinase	0.0098	0.2268	0.3608
Schistosoma mansoni	tyrosine kinase	0.0098	0.2268	0.3608
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0098	0.2268	0.3608
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0236	0.6285	1
Brugia malayi	hypothetical protein	0.003	0.0328	0.0328
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0139	0.3466	0.5514
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0098	0.2268	1
Schistosoma mansoni	tyrosine kinase	0.0098	0.2268	0.3608
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0098	0.2268	0.3608
Entamoeba histolytica	protein kinase domain containing protein	0.0098	0.2268	0.2802
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0236	0.6285	1
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0019	0	0.5
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.3617	0.3617
Brugia malayi	Protein kinase domain containing protein	0.0236	0.6285	0.6285
Brugia malayi	ephrin receptor 1 precursor	0.0098	0.2268	0.2268
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0139	0.3466	0.5514
Schistosoma mansoni	tyrosine kinase	0.0098	0.2268	0.3608
Brugia malayi	TAR-binding protein	0.0076	0.166	0.166
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0098	0.2268	0.2268
Schistosoma mansoni	tyrosine kinase	0.0098	0.2268	0.3608
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0236	0.6285	1
Brugia malayi	Variant SH3 domain containing protein	0.0139	0.3466	0.3466
Loa Loa (eye worm)	hypothetical protein	0.0098	0.2268	0.2268
Entamoeba histolytica	tyrosine kinase, putative	0.0098	0.2268	0.2802
Loa Loa (eye worm)	SH2 domain-containing protein	0.0139	0.3466	0.3466
Schistosoma mansoni	tyrosine kinase	0.0098	0.2268	0.3608
Loa Loa (eye worm)	TK/FER protein kinase	0.0236	0.6285	0.6285
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0098	0.2268	0.3608
Brugia malayi	Protein kinase domain containing protein	0.0098	0.2268	0.2268
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Echinococcus granulosus	kinase suppressor of Ras 1	0.0098	0.2268	0.3608
Schistosoma mansoni	protein kinase	0.0098	0.2268	0.3608
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0098	0.2268	0.2802
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0139	0.3466	0.5514
Echinococcus multilocularis	c src tyrosine kinase	0.0236	0.6285	1
Echinococcus granulosus	integrin linked protein kinase	0.0098	0.2268	0.3608
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0236	0.6285	1
Schistosoma mansoni	growth factor receptor-bound protein	0.0139	0.3466	0.5514
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0098	0.2268	0.2268
Entamoeba histolytica	protein kinase, putative	0.0098	0.2268	0.2802
Brugia malayi	RNA binding protein	0.0076	0.166	0.166
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0098	0.2268	0.2268
Loa Loa (eye worm)	hypothetical protein	0.0098	0.2268	0.2268
Loa Loa (eye worm)	TK/FER protein kinase	0.0236	0.6285	0.6285
Loa Loa (eye worm)	TK/FER protein kinase	0.0098	0.2268	0.2268
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.3617	0.3617
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0139	0.3466	0.5514
Brugia malayi	Tyrosine-protein kinase abl-1	0.0236	0.6285	0.6285
Schistosoma mansoni	protein kinase	0.0098	0.2268	0.3608
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0098	0.2268	1
Echinococcus multilocularis	NCK adaptor protein	0.0139	0.3466	0.5514
Schistosoma mansoni	hypothetical protein	0.0139	0.3466	0.5514
Echinococcus multilocularis	activin receptor type	0.0098	0.2268	0.3608
Echinococcus granulosus	hypothetical protein	0.0139	0.3466	0.5514
Echinococcus multilocularis	SH2 motif	0.0139	0.3466	0.5514
Plasmodium falciparum	ataxin-2 like protein, putative	0.003	0.0328	0.1448
Echinococcus granulosus	tyrosine protein kinase csk	0.0098	0.2268	0.3608
Echinococcus granulosus	epidermal growth factor receptor	0.0098	0.2268	0.3608
Onchocerca volvulus		0.0139	0.3466	0.1549
Onchocerca volvulus		0.0236	0.6285	0.5196
Toxoplasma gondii	protein kinase	0.0098	0.2268	1
Plasmodium vivax	ataxin-2 like protein, putative	0.003	0.0328	0.1448
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0098	0.2268	0.2802
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0139	0.3466	0.5514
Loa Loa (eye worm)	TK/FER protein kinase	0.0236	0.6285	0.6285
Echinococcus multilocularis	insulin receptor	0.0098	0.2268	0.3608
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Echinococcus granulosus	protein kinase	0.0098	0.2268	0.3608
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0098	0.2268	0.5
Schistosoma mansoni	tyrosine kinase	0.0236	0.6285	1
Leishmania major	protein kinase, putative	0.0098	0.2268	1
Entamoeba histolytica	protein kinase domain containing protein	0.0098	0.2268	0.2802
Entamoeba histolytica	tyrosine kinase, putative	0.0098	0.2268	0.2802
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0098	0.2268	0.3608
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Schistosoma mansoni	tyrosine kinase	0.0098	0.2268	0.3608
Loa Loa (eye worm)	TK/RYK protein kinase	0.0098	0.2268	0.2268
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0139	0.3466	0.5514
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Brugia malayi	hypothetical protein	0.0098	0.2268	0.2268
Onchocerca volvulus		0.0236	0.6285	0.5196
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0098	0.2268	0.3608
Schistosoma mansoni	suppressor of cytokine signaling	0.0139	0.3466	0.5514
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Brugia malayi	protein-tyrosine kinase	0.0236	0.6285	0.6285
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Entamoeba histolytica	hypothetical protein	0.0098	0.2268	0.2802
Plasmodium falciparum	protein kinase, putative	0.0098	0.2268	1
Entamoeba histolytica	tyrosine kinase, putative	0.0098	0.2268	0.2802
Loa Loa (eye worm)	hypothetical protein	0.0139	0.3466	0.3466
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Trichomonas vaginalis	TK family protein kinase	0.0098	0.2268	0.5
Brugia malayi	hypothetical protein	0.002	0.0017	0.0017
Echinococcus multilocularis	tyrosine protein kinase csk	0.0098	0.2268	0.3608
Schistosoma mansoni	protein kinase	0.0098	0.2268	0.3608
Entamoeba histolytica	serine/threonine kinase, putative	0.0098	0.2268	0.2802
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0236	0.6285	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0098	0.2268	0.2802
Entamoeba histolytica	tyrosine kinase, putative	0.0098	0.2268	0.2802
Loa Loa (eye worm)	TK/ACK protein kinase	0.0098	0.2268	0.2268
Echinococcus granulosus	tyrosine kinase	0.0098	0.2268	0.3608
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0098	0.2268	0.3608
Entamoeba histolytica	protein kinase domain containing protein	0.0098	0.2268	0.2802
Brugia malayi	SH2 domain containing protein	0.0139	0.3466	0.3466
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Entamoeba histolytica	protein kinase, putative	0.0098	0.2268	0.2802
Echinococcus multilocularis	tyrosine protein kinase shark	0.0236	0.6285	1
Giardia lamblia	Kinase, NEK	0.0098	0.2268	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0098	0.2268	0.2802
Echinococcus granulosus	receptor type guanylyl cyclase	0.0098	0.2268	0.3608
Loa Loa (eye worm)	TK protein kinase	0.0098	0.2268	0.2268
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0098	0.2268	1
Echinococcus multilocularis	tyrosine kinase	0.0236	0.6285	1
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0098	0.2268	0.3608
Brugia malayi	SH2 domain containing protein	0.0139	0.3466	0.3466
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Brugia malayi	Protein kinase domain containing protein	0.0098	0.2268	0.2268
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0098	0.2268	0.3608
Echinococcus granulosus	growth factor receptor bound protein 2	0.0139	0.3466	0.5514
Entamoeba histolytica	protein kinase domain containing protein	0.0098	0.2268	0.2802
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0098	0.2268	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0236	0.6285	1
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0236	0.6285	1
Loa Loa (eye worm)	hypothetical protein	0.0098	0.2268	0.2268
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0139	0.3466	0.5514
Loa Loa (eye worm)	SH2 domain-containing protein	0.0139	0.3466	0.3466
Entamoeba histolytica	hypothetical protein, conserved	0.0098	0.2268	0.2802
Schistosoma mansoni	tyrosine kinase	0.0098	0.2268	0.3608
Loa Loa (eye worm)	TK protein kinase	0.0098	0.2268	0.2268
Entamoeba histolytica	tyrosin kinase, putative	0.0098	0.2268	0.2802
Brugia malayi	Protein kinase domain containing protein	0.0098	0.2268	0.2268
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0098	0.2268	0.3608
Brugia malayi	hypothetical protein	0.0043	0.0705	0.0705
Loa Loa (eye worm)	STAT protein	0.0139	0.3466	0.3466
Schistosoma mansoni	tensin	0.0139	0.3466	0.5514
Schistosoma mansoni	tyrosine kinase	0.0236	0.6285	1
Echinococcus multilocularis	tensin	0.0139	0.3466	0.5514
Brugia malayi	Protein kinase domain containing protein	0.0098	0.2268	0.2268
Entamoeba histolytica	hypothetical protein	0.0098	0.2268	0.2802
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0098	0.2268	0.3608
Loa Loa (eye worm)	hypothetical protein	0.0139	0.3466	0.3466
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0236	0.6285	1
Echinococcus granulosus	activin receptor type	0.0098	0.2268	0.3608
Echinococcus multilocularis	N chimaerin	0.0139	0.3466	0.5514
Brugia malayi	SH2 domain containing protein	0.0139	0.3466	0.3466
Loa Loa (eye worm)	hypothetical protein	0.003	0.0328	0.0328
Entamoeba histolytica	hypothetical protein	0.0098	0.2268	0.2802
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Entamoeba histolytica	tyrosine kinase, putative	0.0098	0.2268	0.2802
Entamoeba histolytica	protein kinase domain containing protein	0.0098	0.2268	0.2802
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0098	0.2268	0.2802
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0098	0.2268	0.3608
Schistosoma mansoni	tyrosine kinase	0.0236	0.6285	1
Schistosoma mansoni	tyrosine kinase	0.0098	0.2268	0.3608
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0139	0.3466	0.3466
Entamoeba histolytica	protein kinase, putative	0.0098	0.2268	0.2802
Schistosoma mansoni	growth factor receptor-bound protein	0.0139	0.3466	0.5514
Loa Loa (eye worm)	TK/FER protein kinase	0.0098	0.2268	0.2268
Brugia malayi	Protein kinase domain containing protein	0.0098	0.2268	0.2268
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0236	0.6285	1
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Entamoeba histolytica	protein kinase domain containing protein	0.0098	0.2268	0.2802
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0098	0.2268	0.3608
Schistosoma mansoni	hypothetical protein	0.0098	0.2268	0.3608
Entamoeba histolytica	tyrosine kinase, putative	0.0098	0.2268	0.2802
Schistosoma mansoni	signal transduction protein lnk-related	0.0139	0.3466	0.5514
Brugia malayi	Protein kinase domain containing protein	0.0236	0.6285	0.6285
Loa Loa (eye worm)	hypothetical protein	0.0139	0.3466	0.3466
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0139	0.3466	0.5514
Trichomonas vaginalis	TKL family protein kinase	0.0098	0.2268	0.5
Schistosoma mansoni	tyrosine kinase	0.0098	0.2268	0.3608
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0098	0.2268	0.3608
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0139	0.3466	0.5514
Loa Loa (eye worm)	hypothetical protein	0.0098	0.2268	0.2268
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0139	0.3466	0.1549
Loa Loa (eye worm)	SH2 domain-containing protein	0.0139	0.3466	0.3466
Schistosoma mansoni	tyrosine kinase	0.0236	0.6285	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0098	0.2268	0.2802
Schistosoma mansoni	tyrosine kinase	0.0098	0.2268	0.3608
Schistosoma mansoni	serine/threonine protein kinase	0.0098	0.2268	0.3608
Schistosoma mansoni	tyrosine kinase	0.0098	0.2268	0.3608
Loa Loa (eye worm)	hypothetical protein	0.0098	0.2268	0.2268
Echinococcus granulosus	SHC transforming protein 3	0.0139	0.3466	0.5514
Echinococcus granulosus	tyrosine protein kinase csk	0.0098	0.2268	0.3608
Loa Loa (eye worm)	TK protein kinase	0.0098	0.2268	0.2268
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0098	0.2268	0.3608
Brugia malayi	Protein kinase domain containing protein	0.0098	0.2268	0.2268
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0098	0.2268	0.2268
Brugia malayi	Tensin	0.0139	0.3466	0.3466
Entamoeba histolytica	protein kinase, putative	0.0098	0.2268	0.2802
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0098	0.2268	0.3608
Entamoeba histolytica	hypothetical protein	0.0098	0.2268	0.2802
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0098	0.2268	0.2268
Toxoplasma gondii	STE kinase	0.0098	0.2268	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0139	0.3466	0.5514
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0139	0.3466	0.3466
Plasmodium falciparum	protein kinase, putative	0.0098	0.2268	1
Echinococcus multilocularis	activated cdc42 kinase 1	0.0098	0.2268	0.3608
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0139	0.3466	0.5514
Entamoeba histolytica	protein kinase, putative	0.0098	0.2268	0.2802
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0098	0.2268	0.2268
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0098	0.2268	0.3608
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.166	0.2641

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	2.2387 uM	PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	2.5119 uM	PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	3.9811 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	4.6109 uM	PubChem BioAssay. qHTS of Nrf2 Activators: Hit Validation in Primary Assay. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	5.3582 uM	PubChem BioAssay. qHTS of Nrf2 Activators: Hit Validation in Secondary FLuc Assay. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	7.0795 uM	PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	11.2202 uM	PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	12.5893 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]	ChEMBL.	No reference
Potency (functional)	12.5893 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	15.8489 uM	PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	16.3601 uM	PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	17.7828 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]	ChEMBL.	No reference
Potency (functional)	18.3564 uM	PubChem BioAssay. qHTS for inhibitors of Vif-A3F interactions: Cherry picks. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	20.5962 uM	PubChem BioAssay. qHTS for inhibitors of Vif-A3F interactions: Cherry picks counterscreen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	29.0929 uM	PubChem BioAssay. qHTS for inhibitors of Vif-A3G interactions: Cherry picks counterscreen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	112.2018 uM	PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1885470

Bibliographic References

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Detailed information for compound 1585379