Detailed information for compound 1586148

Basic information

Technical information
  • TDR Targets ID: 1586148
  • Name: N-ethyl-N-[4-[(E)-inden-1-ylidenemethyl]pheny l]nitrous amide
  • MW: 276.332 | Formula: C18H16N2O
  • H donors: 0 H acceptors: 1 LogP: 4.5 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(c1ccc(cc1)/C=C/1\C=Cc2c1cccc2)N=O
  • InChi: 1S/C18H16N2O/c1-2-20(19-21)17-11-7-14(8-12-17)13-16-10-9-15-5-3-4-6-18(15)16/h3-13H,2H2,1H3/b16-13+
  • InChiKey: YIMHZKNXDQIPKK-DTQAZKPQSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-ethyl-N-[4-(inden-1-ylidenemethyl)phenyl]nitrous amide
  • N-ethyl-N-[4-(1-indenylidenemethyl)phenyl]nitrous amide
  • N-ethyl-N-[4-[(E)-1-indenylidenemethyl]phenyl]nitrous amide
  • 16699-37-9
  • NSC107526

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0365 0.5205 0.5205
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0038 0.029 0.029
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0153 0.0153
Brugia malayi PHD-finger family protein 0.0035 0.0246 0.0246
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0365 0.5205 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.003 0.003
Loa Loa (eye worm) intermediate filament protein 0.0054 0.0531 0.0531
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.003 0.003
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0684 1 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0684 1 1
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0365 0.5205 0.5205
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0246 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.003 0.003
Entamoeba histolytica hypothetical protein 0.0043 0.037 0.0711
Schistosoma mansoni nuclear hormone receptor 0.0021 0.003 0.003
Trypanosoma cruzi hypothetical protein, conserved 0.0113 0.1409 1
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0059 0.0601 0.1154
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.003 0.003
Trichomonas vaginalis cdc25b, putative 0.0059 0.0601 0.1154
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0113 0.1409 1
Entamoeba histolytica hypothetical protein 0.0043 0.037 0.0711
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.013 0.1669 0.1669
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0684 1 1
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.037 0.037
Trypanosoma cruzi hypothetical protein, conserved 0.0113 0.1409 1
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0365 0.5205 1
Echinococcus granulosus m phase inducer phosphatasecdc25 0.0059 0.0601 0.0601
Onchocerca volvulus 0.0054 0.0531 0.0967
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.029 0.0557
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.003 0.003
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0365 0.5205 1
Brugia malayi jmjC domain containing protein 0.0115 0.145 0.145
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0026 0.011 0.011
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0253 0.3513 1
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.003 0.003
Echinococcus multilocularis thyroid hormone receptor alpha 0.0151 0.1982 0.1982
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.003 0.003
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0357 0.0357
Plasmodium falciparum phd finger protein, putative 0.0035 0.0246 0.5
Schistosoma mansoni lamin 0.0054 0.0531 0.0531
Trichomonas vaginalis cdc25c, putative 0.0059 0.0601 0.1154
Loa Loa (eye worm) hypothetical protein 0.0021 0.003 0.003
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.003 0.003
Brugia malayi Bromodomain containing protein 0.0035 0.0246 0.0246
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.003 0.003
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0246 0.0246
Brugia malayi MH2 domain containing protein 0.0117 0.1469 0.1469
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.003 0.003
Brugia malayi nuclear hormone receptor 0.0021 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0021 0.003 0.003
Brugia malayi Rhodanese-like domain containing protein 0.0059 0.0601 0.0601
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.003 0.003
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.003 0.003
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.037 0.037
Loa Loa (eye worm) hypothetical protein 0.0054 0.0531 0.0531
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0246 0.0246
Echinococcus multilocularis m phase inducer phosphatase(cdc25) 0.0059 0.0601 0.0601
Loa Loa (eye worm) hypothetical protein 0.0059 0.0601 0.0601
Echinococcus granulosus lamin 0.0054 0.0531 0.0531
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0365 0.5205 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0246 0.0246
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0153 0.0153
Schistosoma mansoni coup transcription factor 0.0021 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0025 0.0095 0.0095
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.003 0.003
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0684 1 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.003 0.003
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0059 0.0601 0.1154
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.003 0.003
Schistosoma mansoni hypothetical protein 0.013 0.1669 0.1669
Onchocerca volvulus 0.0059 0.0601 0.1102
Schistosoma mansoni thyroid hormone receptor 0.0151 0.1982 0.1982
Loa Loa (eye worm) hypothetical protein 0.0054 0.0531 0.0531
Loa Loa (eye worm) hypothetical protein 0.006 0.0624 0.0624
Loa Loa (eye worm) hypothetical protein 0.0054 0.0531 0.0531
Schistosoma mansoni thyroid hormone receptor 0.0151 0.1982 0.1982
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.003 0.003
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.003 0.003
Entamoeba histolytica rodhanase-like domain containing protein 0.0059 0.0601 0.1154
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.013 0.1669 0.1669
Entamoeba histolytica rodhanase-like domain containing protein 0.0059 0.0601 0.1154
Echinococcus granulosus intermediate filament protein 0.0054 0.0531 0.0531
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.0059 0.0601 0.1154
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.003 0.003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.003 0.003
Brugia malayi intermediate filament protein 0.0054 0.0531 0.0531
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.0357 0.0357
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0038 0.029 0.0557
Brugia malayi hypothetical protein 0.0043 0.037 0.037
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.029 0.0557
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.145 0.145
Echinococcus granulosus FTZ F1 alpha 0.0021 0.003 0.003
Onchocerca volvulus Alhambra homolog 0.0035 0.0246 0.0417
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0038 0.029 0.029
Leishmania major hypothetical protein, conserved 0.0113 0.1409 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.003 0.003
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0246 0.5
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0054 0.0531 0.0531
Brugia malayi Intermediate filament tail domain containing protein 0.0054 0.0531 0.0531
Loa Loa (eye worm) hypothetical protein 0.0035 0.0246 0.0246
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.003 0.003
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.011 0.011
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0365 0.5205 1
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0059 0.0601 0.1154
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0038 0.029 0.029
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.145 0.145
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.003 0.003
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.003 0.003
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.029 0.206
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.003 0.003
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0059 0.0601 0.0601
Echinococcus multilocularis lamin 0.0054 0.0531 0.0531
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.003 0.003
Giardia lamblia PHD finger protein 15 0.0035 0.0246 0.0473
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.011 0.011
Onchocerca volvulus 0.0054 0.0531 0.0967
Loa Loa (eye worm) hypothetical protein 0.0021 0.003 0.003
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.029 0.0557
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.003 0.003
Schistosoma mansoni lamin 0.0054 0.0531 0.0531
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0357 0.0357
Schistosoma mansoni jumonji domain containing protein 0.0092 0.1094 0.1094
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.003 0.003
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.003 0.003
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.003 0.003
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.003 0.003
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0357 0.0357
Loa Loa (eye worm) hypothetical protein 0.0053 0.0516 0.0516
Echinococcus granulosus ubiquitin specific protease 41 0.0038 0.029 0.029
Onchocerca volvulus 0.0059 0.0601 0.1102
Loa Loa (eye worm) hypothetical protein 0.0021 0.003 0.003
Echinococcus multilocularis musashi 0.0054 0.0531 0.0531
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.003 0.003
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0038 0.029 0.029
Loa Loa (eye worm) hypothetical protein 0.0025 0.0095 0.0095
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0453 0.0453
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0113 0.1409 0.2706
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0021 0.003 0.003
Onchocerca volvulus 0.0059 0.0601 0.1102
Entamoeba histolytica rodhanase-like domain containing protein 0.0059 0.0601 0.1154
Echinococcus multilocularis lamin dm0 0.0054 0.0531 0.0531
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0365 0.5205 1
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.029 0.206
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0038 0.029 0.0557
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.003 0.003
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0365 0.5205 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.003 0.003
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.003 0.003
Onchocerca volvulus 0.0059 0.0601 0.1102
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.003 0.003
Schistosoma mansoni hypothetical protein 0.0035 0.0246 0.0246
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0365 0.5205 1
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.003 0.003
Schistosoma mansoni m-phase inducer phosphatase(cdc25) 0.0059 0.0601 0.0601
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.037 0.037
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.003 0.003
Schistosoma mansoni hypothetical protein 0.0043 0.037 0.037
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0038 0.029 0.029
Echinococcus multilocularis ubiquitin specific protease 41 0.0038 0.029 0.029
Brugia malayi ecdysteroid receptor 0.0021 0.003 0.003
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.081 0.081
Echinococcus granulosus peregrin 0.0035 0.0246 0.0246
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.003 0.003
Schistosoma mansoni intermediate filament proteins 0.0054 0.0531 0.0531
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.1469 0.1469
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0021 0.003 0.003
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0357 0.0357
Brugia malayi Rhodanese-like domain containing protein 0.0059 0.0601 0.0601
Loa Loa (eye worm) hypothetical protein 0.0021 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0021 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0038 0.029 0.029
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0246 0.5
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.003 0.003
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.029 0.206
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0365 0.5205 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0246 0.0246
Echinococcus granulosus lamin dm0 0.0054 0.0531 0.0531
Trichomonas vaginalis cdc25b, putative 0.0059 0.0601 0.1154
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.003 0.003
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.003 0.003
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.003 0.003
Brugia malayi steroid hormone receptor 0.0021 0.003 0.003
Brugia malayi nuclear receptor NHR-88 0.0021 0.003 0.003
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.029 0.029
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.003 0.003
Onchocerca volvulus 0.0365 0.5205 1
Entamoeba histolytica hypothetical protein 0.0043 0.037 0.0711
Entamoeba histolytica hypothetical protein 0.0043 0.037 0.0711
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.003 0.003
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0453 0.0453
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.003 0.003
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.0059 0.0601 0.1154
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.029 0.206
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0113 0.1409 0.2706
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0038 0.029 0.029
Echinococcus multilocularis peregrin 0.0035 0.0246 0.0246
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.1469 0.1469
Brugia malayi jmjC domain containing protein 0.0043 0.0357 0.0357
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0365 0.5205 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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