Detailed information for compound 1586734

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 736.457 | Formula: C29H28BrF6N5O6
  • H donors: 4 H acceptors: 7 LogP: 3.11 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.Brc1ccc(cc1)N1CNC(=O)C21CCN(CC2)CCNC(=O)c1cnc2c(c1)cccc2
  • InChi: 1S/C25H26BrN5O2.2C2HF3O2/c26-20-5-7-21(8-6-20)31-17-29-24(33)25(31)9-12-30(13-10-25)14-11-27-23(32)19-15-18-3-1-2-4-22(18)28-16-19;2*3-2(4,5)1(6)7/h1-8,15-16H,9-14,17H2,(H,27,32)(H,29,33);2*(H,6,7)
  • InChiKey: LGRJECZSBXFWGM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens phospholipase D2 Starlite/ChEMBL No references
Homo sapiens phospholipase D1, phosphatidylcholine-specific Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica phospholipase D, putative Get druggable targets OG5_128363 All targets in OG5_128363
Echinococcus multilocularis phospholipase D Get druggable targets OG5_128363 All targets in OG5_128363
Schistosoma mansoni phospholipase D Get druggable targets OG5_128363 All targets in OG5_128363
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128363 All targets in OG5_128363
Echinococcus granulosus phospholipase D1 Get druggable targets OG5_128363 All targets in OG5_128363
Entamoeba histolytica phospholipase D active site domain-containing protein Get druggable targets OG5_128363 All targets in OG5_128363
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128363 All targets in OG5_128363
Entamoeba histolytica phospholipase D, putative Get druggable targets OG5_128363 All targets in OG5_128363
Candida albicans Phospholipase D:required for commitment to meiosis Get druggable targets OG5_128363 All targets in OG5_128363
Echinococcus granulosus phospholipase D Get druggable targets OG5_128363 All targets in OG5_128363
Candida albicans Phospholipase D:required for commitment to meiosis Get druggable targets OG5_128363 All targets in OG5_128363
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_128363 All targets in OG5_128363
Echinococcus multilocularis phospholipase D1 Get druggable targets OG5_128363 All targets in OG5_128363
Brugia malayi Phospholipase d protein 1 Get druggable targets OG5_128363 All targets in OG5_128363
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128363 All targets in OG5_128363
Schistosoma japonicum ko:K01115 phospholipase D [EC3.1.4.4], putative Get druggable targets OG5_128363 All targets in OG5_128363
Schistosoma japonicum Phospholipase D1, putative Get druggable targets OG5_128363 All targets in OG5_128363
Schistosoma japonicum expressed protein Get druggable targets OG5_128363 All targets in OG5_128363
Schistosoma japonicum ko:K01115 phospholipase D [EC3.1.4.4], putative Get druggable targets OG5_128363 All targets in OG5_128363
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128363 All targets in OG5_128363
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi MAP kinase sur-1 0.005 0.0446 0.0597
Loa Loa (eye worm) hypothetical protein 0.0033 0.0285 0.2831
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0589 0.0751
Trypanosoma cruzi zinc finger protein kinase, putative 0.0006 0.0018 0.0016
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0446 0.0957
Loa Loa (eye worm) hypothetical protein 0.0015 0.0111 0.1018
Loa Loa (eye worm) hypothetical protein 0.0104 0.0974 1
Leishmania major cytochrome p450-like protein 0.0012 0.0078 0.0241
Brugia malayi hypothetical protein 0.0081 0.0746 0.1012
Trypanosoma brucei differentiation inhibitory kinase 0.0006 0.0018 0.0016
Brugia malayi Cytochrome P450 family protein 0.0012 0.0078 0.0089
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0446 0.1608
Onchocerca volvulus 0.0081 0.0746 0.0734
Trypanosoma brucei ABC transporter, putative 0.001 0.0054 0.0154
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0589 0.0795
Echinococcus multilocularis ATP binding cassette sub family G 0.001 0.0054 0.0054
Brugia malayi Protein K4 0.002 0.0154 0.0194
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0111 0.1018
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0446 0.1608
Schistosoma mansoni hypothetical protein 0.0015 0.0111 0.0238
Brugia malayi ABC transporter family protein 0.0008 0.004 0.0037
Schistosoma mansoni hypothetical protein 0.0015 0.0111 0.0238
Echinococcus granulosus phospholipase d3 0.0023 0.0188 0.0377
Entamoeba histolytica phospholipase D, putative 0.0124 0.1167 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0484 0.4658 0.6061
Trypanosoma brucei phosphatidylglycerolphosphate synthase, mitochondrial 0.002 0.0154 0.0523
Chlamydia trachomatis phospholipase D superfamily protein 0.002 0.0154 0.5
Schistosoma mansoni lipoxygenase 0.0484 0.4658 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0111 0.021
Loa Loa (eye worm) hypothetical protein 0.0104 0.0974 1
Onchocerca volvulus 0.0081 0.0746 0.0734
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0446 1
Echinococcus multilocularis RUN 0.0081 0.0746 0.0956
Brugia malayi hypothetical protein 0.002 0.0154 0.0194
Echinococcus multilocularis ATP binding cassette sub family G 0.001 0.0054 0.0054
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0234 0.23
Entamoeba histolytica phospholipase D, putative 0.0124 0.1167 1
Trypanosoma brucei cardiolipin synthetase, putative 0.0043 0.0381 0.1369
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0078 0.0674
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0111 0.0135
Plasmodium vivax telomerase reverse transcriptase, putative 0.0282 0.2703 1
Trypanosoma cruzi ABC transporter, putative 0.001 0.0054 0.0154
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0023 0.0221
Loa Loa (eye worm) phospholipase D 0.0023 0.0188 0.1823
Echinococcus granulosus ATP binding cassette sub family G 0.001 0.0054 0.0089
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0005 0.0013 0.0028
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0023 0.0221
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0446 0.0931
Schistosoma mansoni hypothetical protein 0.0008 0.0039 0.0084
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0795 0.7677 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0446 0.1608
Chlamydia trachomatis phospholipase D superfamily protein 0.002 0.0154 0.5
Echinococcus granulosus phospholipase D 0.011 0.1026 0.2181
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0023 0.0221
Brugia malayi Telomerase reverse transcriptase 0.0752 0.7258 1
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0589 0.2141
Loa Loa (eye worm) doublecortin family protein 0.0081 0.0746 0.7631
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0446 0.1608
Toxoplasma gondii RNA-directed DNA polymerase 0.0282 0.2703 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0539 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.0746 0.7631
Brugia malayi Phospholipase D. Active site motif family protein 0.0043 0.0381 0.0508
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0539 0.1954
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0029 0.002
Echinococcus multilocularis ATP binding cassette sub family G 0.001 0.0054 0.0054
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0589 0.124
Echinococcus granulosus RUN 0.0081 0.0746 0.1578
Schistosoma mansoni cpg binding protein 0.003 0.025 0.0536
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0023 0.0221
Echinococcus granulosus ATP binding cassette sub family G 0.001 0.0054 0.0089
Loa Loa (eye worm) hypothetical protein 0.0023 0.0188 0.1823
Plasmodium vivax phosphatidylglycerophosphate synthase, putative 0.002 0.0154 0.0523
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0023 0.0221
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0023 0.0221
Brugia malayi CXXC zinc finger family protein 0.0028 0.0234 0.0305
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0023 0.0221
Echinococcus multilocularis lipoxygenase domain containing protein 0.0081 0.0746 0.0956
Loa Loa (eye worm) ABC transporter 0.0008 0.004 0.0282
Echinococcus multilocularis phospholipase D1 0.0124 0.1167 0.1505
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0078 0.0241
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0446 1
Schistosoma mansoni ABC transporter 0.0008 0.004 0.0086
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0045 0.0335
Trypanosoma cruzi cytochrome P450, putative 0.0012 0.0078 0.0241
Plasmodium falciparum ABC transporter G family member 2 0.001 0.0054 0.0154
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0539 0.1156
Echinococcus granulosus ribosomal protein S6 kinase delta 1 0.0006 0.0018 0.0009
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0023 0.0221
Loa Loa (eye worm) hypothetical protein 0.002 0.0154 0.1465
Toxoplasma gondii phospholipase D active site domain-containing protein 0.0043 0.0381 0.1369
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0479 0.173
Trypanosoma brucei cytochrome P450, putative 0.0012 0.0078 0.0241
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.054 0.116
Loa Loa (eye worm) hypothetical protein 0.0049 0.0435 0.4394
Schistosoma mansoni hypothetical protein 0.0081 0.0746 0.1602
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0435 0.0583
Plasmodium falciparum LCCL domain-containing protein 0.0081 0.0746 0.2725
Echinococcus multilocularis Polycystic kidney disease protein 0.0081 0.0746 0.0956
Schistosoma mansoni polycystin 1-related 0.0081 0.0746 0.1602
Loa Loa (eye worm) hypothetical protein 0.0009 0.0044 0.0323
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0446 0.1608
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0029 0.0033
Trichomonas vaginalis helicase, putative 0.0006 0.0023 0.0221
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0023 0.0221
Trypanosoma brucei ATP-binding cassette protein, putative 0.001 0.0054 0.0154
Loa Loa (eye worm) hypothetical protein 0.0081 0.0746 0.7632
Brugia malayi Phospholipase D. Active site motif family protein 0.0023 0.0188 0.0242
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0539 0.1131
Entamoeba histolytica phospholipase D active site domain-containing protein 0.0104 0.0974 0.8326
Loa Loa (eye worm) hypothetical protein 0.0081 0.0746 0.7632
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0435 0.0583
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0446 0.0564
Echinococcus multilocularis phospholipase d3 0.0023 0.0188 0.0229
Leishmania major phosphatidylglycerophosphate synthase, putative 0.0023 0.0188 0.0651
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0023 0.0221
Loa Loa (eye worm) hypothetical protein 0.0081 0.0746 0.7631
Echinococcus multilocularis GPCR, family 2 0.0015 0.0111 0.0128
Entamoeba histolytica hypothetical protein 0.0008 0.0037 0.0205
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0023 0.0221
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0446 1
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0589 0.2141
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0023 0.0221
Echinococcus multilocularis dnaJ subfamily B 0.0401 0.3853 0.501
Trypanosoma brucei protein kinase, putative 0.005 0.0446 0.1608
Trypanosoma brucei cardiolipin synthetase 0.0043 0.0381 0.1369
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0029 0.0062
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0539 0.0686
Chlamydia trachomatis phospholipase D endonuclease family protein 0.002 0.0154 0.5
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0285 0.0375
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0324 0.067
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0539 1
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0023 0.0221
Trypanosoma brucei telomerase reverse transcriptase 0.0282 0.2703 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0045 0.0042
Chlamydia trachomatis phospholipase D endonuclease family protein 0.002 0.0154 0.5
Echinococcus granulosus Polycystic kidney disease protein 0.0081 0.0746 0.1578
Schistosoma mansoni sorting nexin 0.0005 0.0013 0.0028
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0446 0.1608
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0539 1
Brugia malayi hypothetical protein 0.0081 0.0746 0.1012
Schistosoma mansoni rab6-interacting 0.0081 0.0746 0.1602
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0078 0.0674
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0029 0.0033
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0484 0.4658 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0435 0.4394
Plasmodium falciparum mitochondrial cardiolipin synthase, putative 0.002 0.0154 0.0523
Schistosoma mansoni hypothetical protein 0.0401 0.3853 0.8272
Loa Loa (eye worm) CYP4Cod1 0.0012 0.0078 0.0674
Schistosoma mansoni hypothetical protein 0.0015 0.0111 0.0238
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0589 0.2141
Schistosoma mansoni sortingnexin-related 0.0005 0.0013 0.0028
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0282 0.2703 1
Toxoplasma gondii ATP-binding cassette G family transporter ABCG84 0.001 0.0054 0.0154
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.001 0.0054 0.0117
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0044 0.0043
Trypanosoma cruzi cardiolipin synthetase, putative 0.0043 0.0381 0.1369
Schistosoma mansoni cpg binding protein 0.0028 0.0234 0.0503
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0589 0.2141
Chlamydia trachomatis phospholipase D endonuclease family protein 0.002 0.0154 0.5
Schistosoma mansoni phospholipase D 0.0124 0.1167 0.2505
Echinococcus multilocularis lipoxygenase domain containing protein 0.0081 0.0746 0.0956
Schistosoma mansoni CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase 0.002 0.0154 0.033
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0589 0.1264
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0111 0.0128
Leishmania major ATP-binding cassette protein subfamily G, member 4, putative 0.001 0.0054 0.0154
Schistosoma mansoni sorting nexin 0.0005 0.0013 0.0028
Echinococcus granulosus dnaJ subfamily B 0.0401 0.3853 0.8267
Plasmodium vivax multidomain scavenger receptor, putative 0.0081 0.0746 0.2725
Schistosoma mansoni rab6-interacting 0.0081 0.0746 0.1602
Schistosoma mansoni lipoxygenase 0.0338 0.3245 0.6966
Leishmania major cardiolipin synthetase, putative 0.002 0.0154 0.0523
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0111 0.021
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0446 0.1608
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0446 0.1608
Echinococcus granulosus lipoxygenase domain containing protein 0.0081 0.0746 0.1578
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0446 1
Giardia lamblia ABC transporter 0.001 0.0053 0.015
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0589 0.4992
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0023 0.0221
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0023 0.0221
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0539 0.1156
Trypanosoma cruzi cardiolipin synthetase, putative 0.0043 0.0381 0.1369
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0446 0.0564
Leishmania major telomerase reverse transcriptase, putative 0.0282 0.2703 1
Onchocerca volvulus Putative phospholipase D 0.0023 0.0188 0.0175
Echinococcus multilocularis phospholipase D 0.011 0.1026 0.1322
Echinococcus granulosus cpg binding protein 0.003 0.025 0.0509
Echinococcus granulosus lipoxygenase domain containing protein 0.0081 0.0746 0.1578
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0111 0.0135
Brugia malayi Doublecortin family protein 0.0081 0.0746 0.1012
Schistosoma mansoni cpg binding protein 0.003 0.025 0.0536
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0111 0.0128
Echinococcus granulosus phospholipase D1 0.0124 0.1167 0.2483
Plasmodium falciparum telomerase reverse transcriptase 0.0282 0.2703 1
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0589 0.5995
Wolbachia endosymbiont of Brugia malayi cardiolipin synthase 0.002 0.0154 0.5
Echinococcus granulosus GPCR family 2 0.0015 0.0111 0.021
Echinococcus multilocularis ribosomal protein S6 kinase delta 1 0.0006 0.0018 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0023 0.0221
Schistosoma mansoni sorting nexin 0.0005 0.0013 0.0028
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0539 1
Schistosoma mansoni hypothetical protein 0.0033 0.0285 0.0612
Echinococcus granulosus ATP binding cassette sub family G 0.001 0.0054 0.0089
Leishmania major ATP-binding cassette protein subfamily G, member 6, putative 0.001 0.0054 0.0154
Chlamydia trachomatis phospholipase D endonuclease family protein 0.002 0.0154 0.5
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0324 0.0406
Plasmodium vivax cardiolipin synthetase, putative 0.002 0.0154 0.0523
Giardia lamblia Telomerase catalytic subunit 0.0282 0.2703 1
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0446 0.1608
Echinococcus multilocularis cpg binding protein 0.003 0.025 0.0309
Schistosoma mansoni sorting nexin 0.0005 0.0013 0.0028
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0539 0.1954
Leishmania major zinc finger protein kinase-like 0.0006 0.0018 0.0016
Plasmodium falciparum phosphatidylglycerophosphate synthase 0.002 0.0154 0.0523
Entamoeba histolytica ABC transporter, putative 0.001 0.0054 0.0358
Schistosoma mansoni hypothetical protein 0.0015 0.0111 0.0238
Trypanosoma cruzi ATP-binding cassette protein, putative 0.001 0.0054 0.0154
Schistosoma mansoni loxhd1 0.0081 0.0746 0.1602
Onchocerca volvulus 0.0028 0.0234 0.0221
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0012 0.0078 0.0483
Brugia malayi Cytochrome P450 family protein 0.0012 0.0078 0.0089
Plasmodium vivax ABC transporter G family member 2, putative 0.001 0.0054 0.0154
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0282 0.2703 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0446 0.4503
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0446 0.0931
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0023 0.0221
Brugia malayi Phospholipase d protein 1 0.0124 0.1167 0.1592
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0029 0.002
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0045 0.0069

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) 0.13 uM PUBCHEM_BIOASSAY: PLD2 purified enzyme concentration response. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588854] ChEMBL. No reference
IC50 (functional) 0.36 uM PUBCHEM_BIOASSAY: Cellular PLD2 concentration response. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588854] ChEMBL. No reference
IC50 (functional) 2.7 uM PUBCHEM_BIOASSAY: Cellular PLD1 concentration response. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588854] ChEMBL. No reference
IC50 (functional) 3.04 uM PUBCHEM_BIOASSAY: PLD1 purified enzyme concentration response. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588854] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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