TDR Targets

Basic information

Technical information

TDR Targets ID: 1588652
Name: N-[2-[3-(4-chlorophenyl)-1,2,4-oxadiazol-5-yl ]ethyl]benzamide
MW: 327.765 | Formula: C17H14ClN3O2
H donors: 1 H acceptors: 3 LogP: 3.7 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(cc1)c1noc(n1)CCNC(=O)c1ccccc1
InChi: 1S/C17H14ClN3O2/c18-14-8-6-12(7-9-14)16-20-15(23-21-16)10-11-19-17(22)13-4-2-1-3-5-13/h1-9H,10-11H2,(H,19,22)
InChiKey: IJJJSXKYIBNCKO-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

ZINC06661024
CC-PMLSC-PW-04AACA005
MLS000541663
SMR000472254

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	glycogen phosphorylase	0.0896	0.3413	0.4578
Onchocerca volvulus		0.0081	0.0157	0.0236
Brugia malayi	Carboxylesterase family protein	0.0061	0.0078	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0157	0.0213
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0081	0.0157	0.0108
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0081	0.0157	0.0213
Entamoeba histolytica	glycogen phosphorylase, putative	0.0896	0.3413	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0081	0.0157	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0157	0.0213
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0081	0.0157	0.0213
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0081	0.0157	0.0108
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0081	0.0157	0.0157
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0081	0.0157	0.0213
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0081	0.0157	0.0213
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0195	0.0613	0.0734
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0081	0.0157	0.0213
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0157	0.0213
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0157	0.0213
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0157	0.0213
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0078	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0078	0.0107
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0081	0.0157	0.0108
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0081	0.0157	0.0213
Entamoeba histolytica	glycogen phosphorylase, putative	0.0896	0.3413	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0081	0.0157	0.0213
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0081	0.0157	0.0213
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.0076	0.0103
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0157	0.0213
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0061	0.0078	0.0078
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0081	0.0157	0.0213
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0081	0.0157	0.0108
Leishmania major	protein-tyrosine phosphatase 1-like protein	0.0081	0.0157	0.5
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0081	0.0157	0.0157
Brugia malayi	Carboxylesterase family protein	0.0061	0.0078	0.0107
Echinococcus granulosus	glycogen phosphorylase	0.0896	0.3413	0.4578
Schistosoma mansoni	family A2 unassigned peptidase (A02 family)	0.0463	0.1684	0.1684
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0081	0.0157	0.0157
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0081	0.0157	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0157	0.0213
Echinococcus granulosus	carboxylesterase 5A	0.036	0.1272	0.1639
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0157	0.0213
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0195	0.0613	0.0833
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0081	0.0157	0.0213
Onchocerca volvulus		0.0081	0.0157	0.0236
Giardia lamblia	Glycogen phosphorylase	0.0896	0.3413	1
Mycobacterium tuberculosis	Probable glycogen phosphorylase GlgP	0.0387	0.1382	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0081	0.0157	0.0213
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0081	0.0157	0.0108
Schistosoma mansoni	protein tyrosine phosphatase	0.0081	0.0157	0.0157
Onchocerca volvulus		0.0081	0.0157	0.0236
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0081	0.0157	0.0213
Trichomonas vaginalis	pten, drome, putative	0.0081	0.0157	0.0236
Onchocerca volvulus		0.0081	0.0157	0.0236
Onchocerca volvulus		0.0081	0.0157	0.0236
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.0076	0.0103
Leishmania major	tyrosine specific protein phosphatase, putative	0.0081	0.0157	0.5
Onchocerca volvulus		0.0081	0.0157	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0157	0.0213
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0195	0.0613	0.0734
Trichomonas vaginalis	glycogen phosphorylase, putative	0.0896	0.3413	1
Brugia malayi	Protein-tyrosine phosphatase	0.0081	0.0157	0.0213
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0081	0.0157	0.0157
Echinococcus multilocularis	carboxylesterase 5A	0.036	0.1272	0.1639
Loa Loa (eye worm)	carboxylesterase	0.036	0.1272	0.1728
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0078	0.0107
Brugia malayi	hypothetical protein	0.0081	0.0157	0.0213
Echinococcus multilocularis	Glycosyl transferase, family 35	0.0896	0.3413	0.4578
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0157	0.0213
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0081	0.0157	0.0157
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0081	0.0157	0.0157
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0081	0.0157	0.0213
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0157	0.0213
Brugia malayi	Carboxylesterase family protein	0.036	0.1272	0.1728
Onchocerca volvulus	Glycogen phosphorylase homolog	0.0896	0.3413	1
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0078	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0157	0.0213
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0081	0.0157	0.5
Trichomonas vaginalis	glycogen phosphorylase, putative	0.0896	0.3413	1
Schistosoma mansoni	BC026374 protein (S09 family)	0.0061	0.0078	0.0078
Onchocerca volvulus		0.0081	0.0157	0.0236
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0081	0.0157	0.0213
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0081	0.0157	0.0108
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0081	0.0157	0.0213
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0081	0.0157	0.0213
Brugia malayi	Protein-tyrosine phosphatase 1	0.0081	0.0157	0.0213
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.1886	0.7363	1
Echinococcus multilocularis	glycogen phosphorylase	0.0896	0.3413	0.4578
Brugia malayi	Protein-tyrosine phosphatase	0.0081	0.0157	0.0213
Onchocerca volvulus		0.0081	0.0157	0.0236
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0081	0.0157	0.5
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0157	0.0213
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0195	0.0613	0.0734
Onchocerca volvulus		0.0081	0.0157	0.0236
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0195	0.0613	0.0833
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0081	0.0157	0.0213
Schistosoma mansoni	glycogen phosphorylase	0.0896	0.3413	0.3413
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0081	0.0157	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0078	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0157	0.0213
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0081	0.0157	0.0213
Trypanosoma brucei	RNA helicase, putative	0.0216	0.0696	1
Onchocerca volvulus		0.0081	0.0157	0.0236
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0157	0.0213
Loa Loa (eye worm)	hypothetical protein	0.006	0.0076	0.0103
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0081	0.0157	0.0213
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0081	0.0157	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0157	0.0213
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0081	0.0157	0.0108
Brugia malayi	carbohydrate phosphorylase	0.0896	0.3413	0.4635
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0081	0.0157	0.0213
Onchocerca volvulus		0.0081	0.0157	0.0236
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0081	0.0157	0.0213
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0081	0.0157	0.0213
Brugia malayi	hypothetical protein	0.0061	0.0078	0.0107
Onchocerca volvulus		0.0081	0.0157	0.0236
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0081	0.0157	0.0157
Mycobacterium ulcerans	glycogen phosphorylase GlgP	0.0387	0.1382	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0081	0.0157	0.0108
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0081	0.0157	0.0108
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0081	0.0157	0.0108
Brugia malayi	Carboxylesterase family protein	0.0061	0.0078	0.0107
Onchocerca volvulus		0.0081	0.0157	0.0236
Loa Loa (eye worm)	hypothetical protein	0.036	0.1272	0.1728
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0157	0.0213
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.0076	0.0103
Entamoeba histolytica	glycogen phosphorylase, putative	0.0387	0.1382	0.3763
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0081	0.0157	0.0108
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0081	0.0157	0.0213
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0078	0.0107
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0081	0.0157	0.0108
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.036	0.1272	0.1272
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0081	0.0157	0.0213
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0081	0.0157	0.0157
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0081	0.0157	0.0108
Echinococcus granulosus	acetylcholinesterase	0.036	0.1272	0.1639
Brugia malayi	Carboxylesterase family protein	0.036	0.1272	0.1728
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0081	0.0157	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0157	0.0213
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0081	0.0157	0.0213
Onchocerca volvulus		0.0081	0.0157	0.0236
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0081	0.0157	0.0213
Onchocerca volvulus		0.0081	0.0157	0.0236
Schistosoma mansoni	hypothetical protein	0.0216	0.0696	0.0696
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0081	0.0157	0.0108
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0081	0.0157	0.0157
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0157	0.0213
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0157	0.0213
Onchocerca volvulus		0.0081	0.0157	0.0236
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0081	0.0157	0.0108
Onchocerca volvulus		0.0081	0.0157	0.0236
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0081	0.0157	0.0213
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0081	0.0157	0.0213
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0081	0.0157	0.0108
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0081	0.0157	0.0108
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0081	0.0157	0.0213
Schistosoma mansoni	acetylcholinesterase	0.0061	0.0078	0.0078
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0081	0.0157	0.0108
Chlamydia trachomatis	glycogen phosphorylase	0.0896	0.3413	0.5
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0081	0.0157	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0157	0.0213
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0061	0.0078	0.0078
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0061	0.0078	0.0078
Loa Loa (eye worm)	carboxylesterase	0.0061	0.0078	0.0107
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0081	0.0157	0.0213
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0157	0.0213
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0081	0.0157	0.0108
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0081	0.0157	0.0213
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0157	0.0213
Loa Loa (eye worm)	carboxylesterase	0.0061	0.0078	0.0107
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0157	0.0213
Echinococcus multilocularis	acetylcholinesterase	0.036	0.1272	0.1639
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0157	0.0213
Echinococcus multilocularis		0.0081	0.0157	0.0108
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0081	0.0157	0.0213
Echinococcus granulosus	acetylcholinesterase	0.036	0.1272	0.1639
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0081	0.0157	0.0213
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0081	0.0157	0.0213
Onchocerca volvulus		0.0081	0.0157	0.0236
Echinococcus granulosus	Glycosyl transferase family 35	0.0896	0.3413	0.4578
Loa Loa (eye worm)	acetylcholinesterase 1	0.036	0.1272	0.1728
Entamoeba histolytica	glycogen phosphorylase, putative	0.0387	0.1382	0.3763
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0081	0.0157	0.0157
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.1886	0.7363	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0061	0.0078	0.0078
Brugia malayi	Carboxylesterase family protein	0.0061	0.0078	0.0107
Brugia malayi	hypothetical protein	0.0081	0.0157	0.0213
Onchocerca volvulus		0.0081	0.0157	0.0236
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.1886	0.7363	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0081	0.0157	0.0108
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0081	0.0157	0.0213
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0081	0.0157	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0061	0.0078	0.0107
Brugia malayi	hypothetical protein	0.0081	0.0157	0.0213
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0081	0.0157	0.0108
Echinococcus granulosus	glycogen phosphorylase	0.0896	0.3413	0.4578
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0081	0.0157	0.0108
Loa Loa (eye worm)	glycogen phosphorylase	0.0896	0.3413	0.4635
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0081	0.0157	0.5
Schistosoma mansoni	protein tyrosine phosphatase	0.0081	0.0157	0.0157
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0081	0.0157	0.0108
Echinococcus multilocularis	acetylcholinesterase	0.036	0.1272	0.1639
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0081	0.0157	0.0157
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0195	0.0613	0.0613
Entamoeba histolytica	glycogenphosphorylase, putative	0.0387	0.1382	0.3763
Onchocerca volvulus		0.0081	0.0157	0.0236
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0081	0.0157	0.0108
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0081	0.0157	0.0213
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0081	0.0157	0.0213
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.1886	0.7363	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0081	0.0157	0.0213
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	0.1886	0.7363	0.7363
Schistosoma mansoni	glycogen phosphorylase	0.0896	0.3413	0.3413
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0081	0.0157	0.0108
Schistosoma mansoni	pcd6 interacting protein-related	0.0081	0.0157	0.0157
Schistosoma mansoni	protein tyrosine phosphatase	0.0081	0.0157	0.0157
Onchocerca volvulus		0.0081	0.0157	0.0236
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0081	0.0157	0.0157
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0081	0.0157	0.0108
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0081	0.0157	0.0108
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0081	0.0157	0.0213
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0157	0.0213
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0081	0.0157	0.0108
Onchocerca volvulus		0.0081	0.0157	0.0236
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0195	0.0613	0.0734
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0081	0.0157	0.0157
Loa Loa (eye worm)	hypothetical protein	0.036	0.1272	0.1728
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0081	0.0157	0.0213
Schistosoma mansoni	glycogen phosphorylase	0.0387	0.1382	0.1382
Brugia malayi	hypothetical protein	0.0081	0.0157	0.0213
Brugia malayi	hypothetical protein	0.0081	0.0157	0.0213
Onchocerca volvulus		0.0081	0.0157	0.0236
Schistosoma mansoni	gliotactin	0.0061	0.0078	0.0078
Onchocerca volvulus	4.1 G protein, putative homolog	0.0081	0.0157	0.0236
Echinococcus multilocularis	hypothetical protein	0.0081	0.0157	0.0108
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0081	0.0157	0.0213

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	14.1254 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	70.7946 uM	PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	100 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1890949

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1588652